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Volume 124 (1978)
- Issue 4 Pages 297-
- Issue 3 Pages 197-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 124, Issue 1
Displaying 1-13 of 13 articles from this issue
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HITOSHI UEDA, HIDEYUKI IKEDA, YASUHIKO SASAKI, RYUJI SHIOJI1978 Volume 124 Issue 1 Pages 1-11
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of oral administration of calcium carbonate, aluminum hydroxide gel, dihydrotachysterol (DHT) and sodium bicarbonate on metabolic acidosis and plasma calcium and phosphate were studied in 7 patients with chronic renal failure. Single administration of calcium carbonate alleviated the acidosis and increased the urinary bicarbonate excretion. These effects were potentiated when aluminum hydroxide gel was administered in combination with calcium carbonate. The plasma calcium was increased by this combination therapy. The effects of these two agents on acidosis and plasma calcium were further enhanced by the additional administration of DHT. Urinary bicarbonate excretion was less during the treatment with aluminum hydroxide gel and calcium carbonate than with aluminum hydroxide gel and sodium bicarbonate, when the excretions were compared at the similar concentrations of plasma bicarbonate. Aluminum hydroxide gel and DHT are likely to enhance the effect of calcium carbonate, which works as an alkalinizing salt on acidosis, probably through increasing calcium absorption in the intestine. And the three agents suppress the leak of bicarbonate into the urine contributing to the improvement of acidosis.View full abstractDownload PDF (567K) -
MASAO TANAKA1978 Volume 124 Issue 1 Pages 13-20
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe murine virus-infected erythroleukemia cells (MELC) has been used as a useful tool to examine the regulatory mechanism of the cytodifferentiation by the genetic approach. Addition of dimethylsulfoxide (DMSO) to the MELC culture induces erythroid differentiation. A study was made to assess whether stimulation of histone synthesis is associated with DMSO-induced differentiation of MELC during 4 days of culture in vitro. The synthesis of histone increased 2-fold in the 48hr-incubated cells while the synthesis of non-histone protein was not stimulated. The histone synthesis was maximal at 48hr and declined by 72hr. 3H-leucine-labeled cells treated with DMSO was mixed with an equal weight of 14C-labeled control cells. Histones were isolated and fractionated on polyacrylamide gel. A 3.6-fold increase in 3H/14C ratio occurred in histone fraction 3 and 3. 4-fold in histone fraction 2b. The data indicate that the stimulation of histone synthesis is an early event following DMSO treatment of MELC cells.View full abstractDownload PDF (472K) -
YUKIO YAMADA, SEIKI ITO, TORU WATANABE, SHINSAKU IMAIZUMI1978 Volume 124 Issue 1 Pages 21-31
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIm munization with antigen-antibody complex of ACTH produced sensitive ACTH antibody applicable to the radioimmunoassay. The antibody prepared by immunization with the synthetic 1-24 ACTH was mixed with the antigen porcine ACTH, and the mixture was incubated to form the antigen and antibody complex. Two rabbits were initially immunized with this complex, then further immunized with only the porcine ACTH. Both rabbits produced the ACTH antibody with a titer of 1:25, 000, which could detect ACTH of 5 pg per tube when applied to the radioimmunoassay of the human ACTH. This antibody showed a strong crossreaction with the synthetic 1-24 ACTH, which was confirmed by radioimmunoassay method and immunostaining technique. On the other hand, control animals immunized with only procine ACTH from the beginning showed no production of ACTH antibody. It was concluded that addition of ACTH antibody to the antigen for the first immunization took an important role in eliciting production of the antibody. Possible roles of the antigen-antibody complex for immunization were discussed.View full abstractDownload PDF (1661K) -
TOYOHARU ISAWA, TAKEO TESHIMA, TOMIO HIRANO, KOICHIRO SHIRAISHI, TAKAS ...1978 Volume 124 Issue 1 Pages 33-46
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn experimental model for studying changes in regional perfusion distribution in the lungs of a dog was described. The right upper lobe was separated in vivo from the rest of the lungs by a balloon catheter and gas exchange of the lobe was artificially done asynchronously with the rest of the lungs by using a gas of interest at a prescheduled alveolar pressure. 99mTc-albumin microsphere was the agent of choice for multiple sequential studies in one dog. Alveolar gas composition reached a plateau after the 4th inflation of the right upper lobe. Effect of alveolar pressure on regional perfusion distribution was studied by using nitrogen and air as exchange gases. Perfusion distribution in the right upper lobe was the least at the maximal alveolar pressure of 14 to 19cm H2O, while it was the greatest at the tidal maximal alveolar pressure of 1 to-1cm H2O with either gas. Alveolar hyperinflation in a localized lung region due to the increase in regional alveolar pressure reduced regional perfusion distribution.View full abstractDownload PDF (2416K) -
TAKEO KUROYANAGI, KAZUO KURA, TOSHIO ARAO1978 Volume 124 Issue 1 Pages 47-56
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe have found a new permeability factor in serum of patients with systemic lupus erythematosus. It is non-dialyzable, heat stable, and long acting as compared to histamine or bradykinin which is short acting. It has no esterolytic nor smooth muscle contracting activities. It is not inhibited by anti-histamine drugs, soy bean trypsin inhibitor, DFP or CI esterase inhibitor. It is independent of the kallikrein system. It has the common antigenicity with IgG Fe fragments. Its approximate molecular weight is about 55, 000. So we tentatively call this permeability factor IgG-PF. Intravenous injections of HGG-anti-HGG immune complex, which has been formed by antigenantibody reactions in 20 times antigen excess, into rats resulted in no immune complex nephritis. However, intravenous injections of HGG-anti-HGG immune complex with IgG-PF resulted in immune complex nephritis in rats. The above immune complex nephritis was inhibited by administrations of sulfapyridine but not by administrations of anti-histamine. These results indicate that IgG-PF plays some roles in the mechanism of immune complex nephritis.View full abstractDownload PDF (1007K) -
SEIKI ITO, YUKIO YAMADA, MUTSUKO HAYASHI, YOICHI MATSUBARA1978 Volume 124 Issue 1 Pages 57-64
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSomatostatin-, glucagon- and insulin-containing cells in the rat and horse pancreatic islets were investigated by an indirect immunofluorescent technique using antibodies to insulin, glucagon and somatostatin. In the rat pancreatic islets, insulin-containing cells were located centrally, and glucagon and somatostatin or somatostatin-like substance (SLS)-containing cells were peripherally disposed and glucagon-containing cells were situated more peripherally as compared with distribution of somatostatin-containing cells. On the other hand, in the horse pancreatic islets, insulin-containing cells were found in the peripheral area and glucagon and somatostatin-containing cells were distributed centrally. Insulincontaining cells were most numerous among the three types of cells in the islets of both the rat and horse. Somatostatin or SLS-containing cells in the horse were about equal in number to the glucagon-containing cells while those in the rat seemed to be smaller in number than the glucagon-containing cells. The present study clearly demonstrates that the somatostatin and glucagoncontaining cells are located, in relation to the bloodstream, on the upstream side of the insulin-containing cells in the islets of Langerhans of both the rat and the horse though these two animal species are known to have completely reverse bloodstream pattern in the islets. According to the mechanism of glucagon and insulin secretions from the islets, we proposed the hypothesis that the somatostatin-containing cells regulate the neighbouring glucagon and insulincontaining cells by an intercellular transport mechanism which provides somatostatin through the junctional complex, while other insulin-containing cells which are too remote from the somatostatin containing cells to be affected by such a mechanism are regulated by a fraction of somatostatin released and carried down by the bloodstream.View full abstractDownload PDF (1501K) -
MITSUO SATOH, KEIJI KAYA, IKUO YAMANAKA, ASAHIKO KASAMA, MITSUHIKO YAN ...1978 Volume 124 Issue 1 Pages 65-72
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn aortic strips, the dose-response curves for phenylephrine were obtained before and after addition of droperidol. Droperidol caused a parallel shift of the curves dose-dependently toward the right side and its grade of the shift was greater than caused by phentolamine at the same concentration. In the left atrial strip, the potentiation of contraction by tyramine was markedly depressed by droperidol. In the reserpinized preparation, the effect of tyramine was depressed markedly and there was no norepinephrine fluorescence. After incubation with norepinephrine they were restored to the same level as in non-reserpinized preparations. However, incubation with droperidol before norepinephrine blocked the restoration. It is postulated that droperidol may have both alpha-adrenergic blocking action and inhibitory action on norepinephrine uptake by adrenergic terminals.View full abstractDownload PDF (901K) -
RYUJI YAMAGUCHI, NAOYUKI SHIMOZATO1978 Volume 124 Issue 1 Pages 73-82
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to establish an effective diagnostic method for placental function using HSAP, the authors formulated two expressions to predict HSAP values for their rise before 38.7 weeks of gestation and declining after that; logey=1.03a-3.37+0.123x (i), and y=Y(l+d/100) (ii), respectively. Further they prepared a chart of curves for these predicting expressions. The results obtained are as follows: (1) In normal pregnancies the deviation of prediction from measured values of HSAP was ±15% in 94% of the cases examined. (2) Many of cases of abnormal pregnancy showed a low level of HSAP, -15% or lower, and abnormal signs in HSAP pattern were found several days or weeks prior to the onset of fetal troubles. (3) Prolonged pregnancy with fetal troubles was able to be distinguished from “false” prolonged pregnancy. (4) In two consecutive pregnancies in the same woman, the courses of HSAP were strikingly consistent as far as both pregnancies were normal. The last fact suggests that the placental production of HSAP and its release into the maternal blood may be influenced by the individual constant a in expression (i). (5) It is recommended that the HSAP prediction curve is worthy to use as an easy screening method for placental function in the third trimester of pregnancy.View full abstractDownload PDF (578K) -
KATSUNORI OGURO, KOROKU HASHIMOTO1978 Volume 124 Issue 1 Pages 83-90
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSince cyclocytidine (2, 2'-anhydro-1-beta-arabinofuranosyleytosine hydrochloride) was introduced as an antineoplastic agent for the treatment of lymphatic leukemia, sinus acceleration and an increase in systemic blood pressure has been reported as its systemic effects in the clinical cases. These cardiovascular effects of cyclocytidine were observed also in anesthetized dogs, but not in reserpine-pretreated animals. Increases in heart rate and in systemic blood pressure were prevented by propranolol and phentolamine, respectively. The mechanism of these sympathomimetic effects was further analysed in the excised, blood-perfused canine sinoatrial node and papillary muscle preparations with a support dog. Positive chronotropic and inotropic responses to cyclocytidine were abolished by desipramine, propranolol, and pretreatment with reserpine but not by tetrodotoxin and hexamethonium. The tyramine-like actions of cyclocytidine at adrenergic neuronal terminals were discussed in conjunction with the uptake mechanism of the drug into the tumor cells.View full abstractDownload PDF (1940K) -
MINORU IGARASHI, MAKOTO SEIJI, ZENSAKU YOSIZAWA1978 Volume 124 Issue 1 Pages 91-92
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA biochemical study was carried out on the urine of an 18-year-old woman with epidermolysis bullosa dystrophica recessive type (E. b. d. r.). The urinary acid glycosaminoglycans were separated and subjected to quantitative and qualitative analyses by gel filtration and column chromatography. A hyaluronic acid and the 0.5M NaCl elution fraction were increased characteristically in the acid glycosaminoglycan.View full abstractDownload PDF (109K) -
SEIGI TSUCHIDA, TAKASHI MORITA, OSAMU YAMAGUCHI1978 Volume 124 Issue 1 Pages 93-94
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA new in vitro method which enables the simultaneous recording of the electromyogram from various regions of the renal pelvis and the pressure changes associated with those electrical activities is described in an experiment on canine kidney. At the proximal end of the renal pelvis, the interval of the electromyogram was constant and pelvic pressure changes showed rhythmic activity, while the discharge interval of the proximal end was the same as the pressure interval. However, the discharge intervals of both the pelvic center and the pelviureteric junction were found to be multiples of that of the proximal end of the pelvis.View full abstractDownload PDF (510K) -
The First Case in Miyagi PrefectureTAKUSEI UMENAI, YOSHIHIKO SAITOH, TATSUYA SASAKI, SHINGI NAKAE, NARIO ...1978 Volume 124 Issue 1 Pages 95-96
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA rare type of brain abscess formation caused by infection with Listeria monocytogenes was observed in a 2-year-old boy. The patient did not respond to treatment with various antibiotics. The isolated organisms were found to be sero-type 4b. This is the first report of Listeria monocytogenes infection in Miyagi Prefecture.View full abstractDownload PDF (131K) -
ICHIRO NAKAZAWA, EIETSU OUCHI, NAKAO ISHIDA, KENJI OUCHI, KEIKICHI MAG ...1978 Volume 124 Issue 1 Pages 97-98
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAmB/NCS combination therapy against cancer was evaluated. Seven gastric cancer and 2 gastric polyp cases were treated in this manner and in addition 2 gastric cancer patients were treated with NCS alone, to serve as the control. AmB dissolved in glucose solution was administered intravenously as was NCS, which was given at the onset of gastric surgery. Lesion tissues and healthy tissues were collected from each patient and the NCS titers measured by bioassay. It was shown in the majority of the gastric cancer cases that the NCS levels in the lesion tissues were substantially higher than in the surrounding normal tissues, whereas in the gastric polyp and the gastric cancer patients who received NCS alone, no significant differences were found between the tissues.View full abstractDownload PDF (108K)
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