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Volume 133 (1981)
- Issue 4 Pages 365-
- Issue 3 Pages 245-
- Issue 2 Pages 121-
- Issue 1 Pages 1-
Volume 133, Issue 4
Displaying 1-17 of 17 articles from this issue
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YUZURU KAGAWA, KOICHI TABAYASHI, NAOSHI SATO, TOGO HORIUCHI1981 Volume 133 Issue 4 Pages 365-370
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKAGAWA, Y., TABAYASHI, K., SATO, N. and HORIUCHI, T. Division of Patent Ductus Arteriosus by “Isthmus Taping Method”. Tohoku J. exp. Med., 1981, 133 (4), 365-370 -“Isthmus taping method” as the safe and simple technique for division of patent ductus arteriosus (PDA), along with surgical and follow-up results were reported. 175 patients with PDA and without other cardiac anomalies were operated by this technique. Most of the patients were operated by junior surgeons as a first step in cardiac surgery. The left chest was entered through posterolateral thoracotomy in the third or fourth intercostal space. Tapes were placed around the isthmus of aorta and PDA. Intercostal arteries were not divided. PDA was divided in-between Potts' clamps. Pulmonary and aortic stumps of the -PDA were closed with two rows of continuous over and over suture. Of the 175, one patient (0.6%) with pulmonary hypertension died of postoperative respiratory failure. No surigcal hazards of bleeding were noted. No deaths were noted among 131 patients without pulmonary hypertension. Follow-up results in 174 patients up to 14 years were excellent.View full abstractDownload PDF (505K) -
YUSHIN FUJIMURA, MASAHIKO KAWAMURA, HIROSHI NARUSE1981 Volume 133 Issue 4 Pages 371-378
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSFUJIMURA, Y., KAWAMURA, M. and NARUSE, H. A New Method of Blood Galactose Estimation for Mass Screening of Galactosemia. Tohoku J. exp. Med., 1981, 133 (4), 371-378 -A new method for quantitative determination of galactose in blood by fluorescence of NADH was described. The assay system consisted of β-galactose dehydrogenase, NAD, buffer and a denatured blood disc (3mm diameter), and the reaction was carried out for 1 hr at 37°C. Denaturation of hemoglobin was accomplished by exposing the blood disc to a vapor of formic acid in an air-tight container; this procedure completely eliminated false positive cases of galactosemia. This method can be applied in a wide range of galactose concentration from low (0mg%) to high levels (200-1, 000mg%) with the accuracy of 8.0±0.3mg% from a coefficient of variation of 3.5%. Semi-quantitative assay was also possible by using a spot test like Beutler's method. The galactose content in one disc paper (3mm diameter) of blood containing 5mg% galactose is approximately 0.1μg. The newly developed method is satisfactorily applicable in neonatal mass screening and clinical cases.View full abstractDownload PDF (805K) -
KENICHI KITANI, SETSUKO KANAI, REIKO MIURA1981 Volume 133 Issue 4 Pages 379-388
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKITANI, K., KANAI, S. and MIURA, R. The Effect of Bucolome on the Blood Circulation of Splanchnic Organs in Rats with and without Pentobarbitone Anesthesia. Tohoku J. exp. Med., 1981, 133 (4), 379-388 -Using carbonized microspheres, either 15μm or 50μm in diameter and labeled with 85Sr, 51Cr or 141Ce, the effect of bucolome (1-cyclohexyl-5-n-butyl-2, 4, 6-trioxoperhydropyrimidine), a non-steroid anti-inflammatory agent and potent choleretic, on the splanchnic blood circulation was studied in rats with and without pentobarbitone sodium anesthesia. Pentobarbitone sodium caused a significant increase in the distribution of cardiac output in the major splanchnic organs, in particular in the small and large intestines. An i.p. injection of bucolome (20mg/100g) produced a significant increase in the cardiac output distribution in the small intestine, and a significant decrease in the pancreatic fraction in both rat groups with and without pentobarbitone anesthesia, in spite of the large increase in the base-line values caused by anesthesia.View full abstractDownload PDF (942K) -
KENICHI KITANI, SETSUKO KANAI, MUNETAKA NOKUBO1981 Volume 133 Issue 4 Pages 389-397
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKITANI, K., KANAI, S. and NOKTJBO, M. The Effect of Bucolome on the Biliary Excretion of Colchicine in the Rat. Tohoku J. exp. Med., 1981, 133 (4), 389-397 -The biliary excretion of intravenously administered [14]-colchicine was compared for 2hr between control rats and rats treated with Bucolome (5-n-butyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine, 200mg/kg, i.p.). In the first 10-min period after colchicine injection, the bile flow rate was 70 percent higher (p<0.01) in bucolome treated rats than in control rats. The bile flow rate in bucolome treated rats gradually decreased and 1hr later, the difference between control and Bucolome treated rats was no longer significant (p>0.05). The percent of the administered colchicine dose recovered in the first 2hr in Bucolome treated rats given an i.v. injection of 70 or 700μg/kg colchicine was significantly higher than in control rats. The difference was primarily due to the higher excretion rate in the former group in the first 10-min period. When the biliary radioactivity was examined by thin layer chromatography, it was found that the excretion of free colchicine was significantly increased in bucolome treated rats which accounted for the observed increase in the biliary excretion of radioactivity in bucolome treated rats. It was concluded that Bucolome is effective in increasing the biliary excretion of free colchicine.View full abstractDownload PDF (965K) -
SHIRO TOMINAGA, MATSUTARO MURAKAMI, NORIO ABE, KAZUO UEMURA, TAKASHI K ...1981 Volume 133 Issue 4 Pages 399-412
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTOMINAGA, S., MURAKAMI, M., ABE, N., UEMURA, K., KUTSUZAWA, T, and NAKAMURA, T. Cyclic AMP Concentrations in Plasma, Cerebrospinal Fluid and Urine in Patients with Acute Cerebral Hemispheric Infarction. Tohoku J. exp. Med., 1981, 133 (4), 399-412 -Plasmas, cerebrospinal fluid and urine were sampled from 22 patients with cerebral hemispheric infarction and analyzed for cyclic AMP. The following observations were made: (1) In mild cases with slight dysarthria and/or hemiparesis but without disturbance of consciousness (Group I), cyclic AMP in peripheral venous plasma (PVP) remained over the normal lowest level more than 10 days after the onset. Patients with apparent neurological deficits could be divided into two groups. In one group, cyclic AMP in PVP decreased to a subnormal level within about 5 days after the onset of stroke (Group II). In another group (Group III), such a decrease was not observed. Brain isotope scintigrams were revealed negative in Group I. The size of brain infarct as judged by isotope uptake was larger in Group III than in Group II, except for a few cases in which the lesion was restricted in the basal ganglionic region. (2) No clinical significance was, however, found in the time course of cyclic AMP levels in internal jugular venous or femoral arterial plasma, or in cerebrospinal fluid, or of the daily amount of cyclic AMP excretion into urine. (3) Cerebral arterio-venous difference of cyclic AMP was negative in most of the cases.View full abstractDownload PDF (1319K) -
YASUKO NAGATSUKA, KATSUMI SATO, SHIGEO SATAKE, ZENSAKU YOSIZAWA1981 Volume 133 Issue 4 Pages 413-416
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAGATSUKA, Y., SATO, K., SATAKE, S. and YOSIZAWA, Z. Excretion Pattern of Urinary Glycosaminoglycans from Orthopedic Patients. Tohoku J. exp. Med., 1981, 133 (4), 413-416 -To obtain a clue for the metabolic disorder of glycosaminoglycans (GAG) in connective tissue diseases, a screening test for excretion pattern of urinary GAG was applied to urines from orthopedic patients. The results showed a wide variety of excretion pattern of urinary GAG from various orthopedic patients. Several cases gave irregular bands. Also, most cases of bone tumor showed abnormal excretion patterns different from the normal range of percent distribution of bands 1, 2 and 3. The data suggested abnormal metabolism of GAG in these diseases. Percent distribution of band 1 or bands 1+2 tended to increase in rheumatoid arthritis (RA), suggesting an elevation of the metabolic rate of chondroitin sulfates in RA. In cases of other orthopedic diseases, a half of them showed an abnormal excretion pattern of urinary GAG, but the excretion pattern of the remaining ones was within the normal range.View full abstractDownload PDF (373K) -
MASATO MIZOBUCHI, KOHJI SHIRAI, NOBUO MATSUOKA, YASUSHI SAITO, AKIRA K ...1981 Volume 133 Issue 4 Pages 417-421
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMIZOBUCHI, M., SHIRAI, K., MATSUOKA, N., SAITO, Y. and KUMAGAI, A. Regulation of Lipase Activities in Rat Brain in Vitro. Tohoku J. erp. Med., 1981, 133 (4), 417-421 -Regulation of acid and neutral lipase activities in rat brain was examined in vitro. Both activities were decreased by SDS, CuCl2and ZnCl2 and by delipidation. The neutral lipase activity was also markedly reduced by N-methylmaleimide and PbCl2. The activity of delipidated preparation was increased by addition of phosphatidyl choline at both pH 5.5 and 7.5 and by phosphatidyl serine at acidic pH value. Pretreatments of the enzyme preparation with phospholipase A and trypsin reduced the lipase activities at both pH values. It is suggested that phospholipids play an important role on lipase activity in brain.View full abstractDownload PDF (449K) -
TADASHI HARADA, HIROMICHI OHMURA, OSAMU NISHIZAWA, SEIGI TSUCHIDA1981 Volume 133 Issue 4 Pages 423-429
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHARADA, T., OHMURA, H., NISHIZAWA, O. and TSUCHIDA, S. Regional Arterial Infusion of an Anticancer Drug Combined with Direct Hemoperfusion. Tohoku J. exp. Med., 1981, 133 (4), 423-429 -The capacity of activated charcoal to adsorb anticancer drugs, Mitomycin C, Adriamycin and Bleomycin was examined in vitro in a closed circuit through a perfuser containing uncoated activated charcoal. Samples were obtained from the inlet and outlet of the perfuser every 30min. As in vivo experiments, regional arterial infusion of anticancer drugs combined with direct hemoperfusion was performed on dogs. In 20 male mongrel dogs a polyethylene catheter was indwelt in the internal iliac artery and anticancer drugs were infused through the catheter for 1hr. By using the femoral vessels for the blood access, direct hemoperfusion was performed for 3hr. The adsorptive capacity of activated charcoal was high in both in vitro and in vivo experiments. These results indicate that regional arterial infusion of anticancer drugs combined with direct hemoperfusion would be useful for preventing their toxicity.View full abstractDownload PDF (525K) -
SHIGERU MATSUKAWA, SAYOKO MIHARA, TOICHIRO HOSOYA1981 Volume 133 Issue 4 Pages 431-443
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMATSUKAWA, S., MIHARA, S. and HOSOYA, T. Thyrotropin-Dependence of the Distribution of Peroxidase in Rat Thyroid Gland. Tohoku J. exp. Med., 1981, 133 (4), 431-443 -After male rats were injected daily with propylthiouracil, whale thyrotropin, or thyroxine for several days, the thyroid glands were examined for their ultrastructural localization of peroxidase. The propylthiouracil treatment caused a marked increase in the number of round, peroxidase-positive vesicles in the apical and middle regions of cytoplasm, and brought about a formation of granular reaction products in the colloid lumen adjacent to the elongated microvilli. Such changes became evident after 2 days of the drug treatment and increased with the time of the effect, until the whole colloid lumen was filled with the reaction products and very elongated microvilli. The effect of exogenous thyrotropin was essentially similar, to a lesser degree, to the drug effect mentioned above. The thyroxine treatment diminished the population of the small vesicles, as usually seen in the case of normal rat thyroids. When the thyroids of thyrotropin-stimulated and unstimulated rats were homogenized and fractionated into particulates fractions and a soluble fraction, almost all the peroxidase activity was contained in the former in both cases. Based on these results, the dynamics and the physiological role of the intracellular peroxidase are discussed.View full abstractDownload PDF (4590K) -
JUNKO SUDA, SHUNICHI NAKAJIMA, MARIKO OKANIWA, SHIGEHIKO KAMOSHITA1981 Volume 133 Issue 4 Pages 445-450
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSUDA, J., NAKAJIMA, S., OKANIWA, M. and KAMOSHITA, S. Neonatal Hepatitis and Extrahepatic Biliary Atresia in the Same Sibship. Tohoku J. exp. Med., 1981, 133 (4), 445-450 -An instance of the rare occurrence of neonatal hepatitis and extrahepatic biliary atresia in the same sibship is reported. The older brother with neonatal hepatitis developed jaundice at the age of 4 days and had clay-colored stools from early infancy. Cholangiography by exploratory laparotomy at the age of 3 months showed a normal bile duct pattern. After laparotomy, jaundice rapidly disappeared, and stools became yellow. His liver function has been normal since age 6 months to the present (6 years old). The younger brother developed jaundice and clay-colored stools at the age of 1 month. The diagnosis of extrahepatic biliary atresia was made at laparotomy at the age of 4 1/2 months. Hepatojejunostomy was performed with successful bile drainage, although he had frequent attacks of ascending cholangitis since operation. These cases support a recent hypothesis that neonatal hepatitis and extrahepatic biliary atresia may be produced by the same disease process.View full abstractDownload PDF (1202K) -
MASAYUKI TOKUNAGA, EIKICHI WAKAMATSU, MASAMITSU SATO, OSAMU NAMIKI, AT ...1981 Volume 133 Issue 4 Pages 451-456
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTOKUNAGA, M., WAKAMATSU, E., SATO, M., NAMIKI, O., YOKOSAWA, A. and MOTOMIYA, M. Lipid Composition of Adipose Tissue from “Membranous Lipodystrophy”. Tohoku J. exp. Med., 1981, 133 (4), 451-456 -The lipid composition of the adipose tissue from the bone marrow and that of the subcutaneous depot fat of four patients of membranous lipodystrophy were investigated. It was found that the lipid composition of the samples from the cases of membranous lipodystrophy was almost similar to that in controls. Also discussions were made on mechanism related to the accumulation of abnormal depot fat.View full abstractDownload PDF (608K) -
MUNEO TSUJIKAWA, SHUICHI KIMURA1981 Volume 133 Issue 4 Pages 457-460
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTSUJIKAWA, M. and KIMURA, S. Effect of Exposure to Cold on Pantothenic Acid Metabolism in Rat Liver. Tohoku J. exp. Med., 1981, 133 (4), 457-460 -Exposure to a cold environment increased the incorporation of labeled pantothenic acid (PaA) into the liver and total PaA content. These increases were mainly due to an increase of free coenzyme A (CoA). The specific activity of the free CoA fraction was particularly high. These results suggest that exposure to a cold environment accelerates the rate of synthesis of CoA from PaA in the liver.View full abstractDownload PDF (289K) -
SHIGETOSHI CHIBA, YASUYUKI FURUKAWA, MIYOHARU KOBAYASHI1981 Volume 133 Issue 4 Pages 461-465
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSCHIBA, S., FURUKAWA, Y. and KOBAYASHI, M. Cardiac Effects of Clonidine on Isolated Dog Atria. Tohoku J. exp. Med., 1981, 133 (4), 461-465 The effect of clonidine on pacemaker activity and contractility was studied in the isolated dog atrium which was perfused with arterial blood of the support dog. Clonidine caused dose-dependent negative chronotropic and inotropic effects, and a large dose of clonidine slightly suppressed the positive chronotropic and inotropic responses to norepinephrine and sympathetic cardiac nerve stimulation (5 and 30Hz) but not consistently.View full abstractDownload PDF (459K) -
TADASHI TATEYAMA, TAKASHI MATSUSHIRO1981 Volume 133 Issue 4 Pages 467-475
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTATEYAMA, T. and MATSUSHIRO, T. Bile Acid Composition Affecting Cholesterol Dissolution Rate: A Use of Multiple Regression Analysis. Tohoku J. exp. Med., 1981, 133 (4), 467-475 -The dissolution rate of cholesterol in human gallbladder bile was measured by a rotating-disk method using 14C-labeled cholesterol, and was compared with concentrations of the biliary lipids. Computed multiple regression analysis of the results showed that the dissolution rate of cholesterol could be presented as a function of the concentrations of deoxycholic and chenodeoxycholic acid (multiple correlation 0.905; F-value 51.8 (p<0.001)). To examine the effect of different kinds of bile acids on cholesterol solubilization, the cholesterol solubility in a gallbladder bile with addition of a conjugated bile acid was determined. Greater solubilization of cholesterol was observed in the bile with addition of sodium deoxycholylglycine and chenodeoxycholylglycine than that with addition of sodium cholylglycine. There was no additional enhancement of the solubility with addition of sodium ursodeoxycholylglycine. These results suggest that the cholelitholytic effect of chenodeoxycholic acid may be greater than that of ursodeoxycholic acid, since the administration of chenodeoxycholic or ursodeoxycholic acid to patients with cholesterol gallstones induced different alterations of biliary bile acid composition.View full abstractDownload PDF (880K) -
NOBUHIKO SAJIKI, ATSUSHI ISAGODA, RYUICHI NAKAMURA1981 Volume 133 Issue 4 Pages 477-478
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSAJIKI, N., ISAGODA, A. and NAKAMURA, R. The Interference Effect of Simultaneous Vocalization on Reaction Time of Hand and Foot. Tohoku J. exp. Med., 1981, 133 (4), 477-478 -Reaction times (RTS) of 14 normal subjects were examined in two tasks; the extension of the right middle finger, or of the right toe or the vocalization responding to the sound stimulation (single tasks), and the simultaneous responses of the two mentioned above (simultaneous tasks). RT of each part was longer on the simultaneous response than on the separate one. Slowing of the vocal response combined with the foot was larger than that with the hand and slowing of the foot with the vocalization was larger than that with the hand. The results were interpreted as indicating that the slowing of RT in the simultaneous responses should occur at the levels of the premotor associations, including the basal ganglia and cerebellum, but not at the level of the motor cortex.View full abstractDownload PDF (225K) -
KAZUO MORI, SOHZOH SUZUKI, KOJI SUGAI, SHIZUE HISA, HIDEAKI SAKAI, YAS ...1981 Volume 133 Issue 4 Pages 479-480
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMORI, K., SUZUKI, S., SUGAI, K., HISA, S., SAKAI, H. and KOBAYASHI, Y. New Morphological Findings on Platelets in Bernard-Soulier Syndrome. Tohoku J. exp. Med., 1981, 133 (4), 479-480 -Bernard-Soulier Syndrome is characterized morphologically by many giant platelets in the peripheral blood. However, the mechanism of large platelet production has not yet been clarified. Our electron microscopic examinations revealed that some platelets have two or three definite circumferential bundles of microtubules, whereas no pathological findings were obtained in the liberation of platelets from megakaryocytes by light microscopy. From these observations, we consider that the giant platelets of Bernard-Soulier Syndrome are formed by fusion of two or three platelets while they are circulating in the peripheral blood stream.View full abstractDownload PDF (589K) -
MASAHIRO ARAKAWA, JIN SEINO, TAKASHI FURUYAMA1981 Volume 133 Issue 4 Pages 481-482
Published: 1981
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSARAKAWA, M., SEINO, J. and FURUYAMA, T. 'Nephritic Factor' May Be an Autoantibody to C3b or C4b. Tohoku J. exp. Med., 1981, 133 (4), 481-482-We attempted to clarify the character of 'Nephritic Factor' in the alternative (NeFA) and classical pathways (NeFC) of the complement, using an agglutinating and a hemolytic activity assay. The results suggested a possibility that NeFA and NeFC were different in their ability but might appear at the same time in some cases, and that NeFA was anti-C3b autoantibody and NeFC anti-C4b autoantibody.View full abstractDownload PDF (202K)
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