Hammarsten procedure of separating pseudomucin was adapted to 6 viscid ovarial cysts, and the products fractioned by electrodialysis and by the aid of acetic (concentrated) and trichloroacetic acid. Thus the con-clusion was reached that substances obtainable after Hammarsten are mostly a mixture of proteins and carbohydrates. The writer wants to retain the name ‘pseudomucin’ to call the glucidamin which precipitates on electrodialysis of such preparations.
A mixture of pseudomucin (Maki) and two ordinary simple proteins (obtained from a viscous ovarial cyst fluid by the procedure of Hammarsten for preparing his pseudomucin) was hydrolyzed and fractioned to isolate the sugar components. And galactose and L-fucose were isolated as a-methylphenylhydrazones, and the latter identified also as p-toluenesulfonyl-hydrazone and benzylphenylhydrazone. In addition, glucosamine-and chondrosamine-hydrochloride could be separated, but no sugar else. The present experiment afforded a proof of the findings by paper chromato-graphy in the foregoing report of this series of investigations.
A basic antibiotic, active selectively against acid fast organisms, was isolated in a crystalline helianthate (d. p. 243-247 C), from the filtrate of Str. aureus, No. 364. The converted hydrochloride was also highly active against Mycob. tuberculosis (human type) in Dubos's medium, and showed no toxicity to mice.
1. Two familial cases of dyschromatosis universalis hereditaria are reported. 2. In the same family the occurrence of similar dermatoses is noted in five generations. 3. Unexposed parts of the body is as strongly affected as the exposed area. And even the palm and sole are involved. 4. The pigmentary disturbance is caused by genotype with epistases of some other factors than photosensitivity. 5. Thus the relationship with dyschromatosis symmetrica hereditaria is rejected in spite of clinical resemblance.
Studying the changes of the intragastric temperature by locally cool-ing and warming the epigastrium and cooling the heart area, the following facts were confirmed. 1. The intragastric temperature does not change significantly for at least 30 minutes by introducing the thermometer in the stomach. 2. It falls by cooling the epigastrium and rises by warming. 3. It falls also by cooling the heart area, but its fall is smaller than by the epigastrium. 4. The processes both per continuitatem and through the blood circulation play an important role in its fall by cooling the epigastrium.
1. We found that the penicillin injection in the animal and in the human causes a marked activation of white blood cell function (phagocy-tosis and motility). 2. After the extirpation of the carotid sinus bodies, this penicillin action on the white cell function is markedly reduced or entirely dis-appeared. 3. In vitro experiment (penicillin and fresh blood are mixed in a test-tube) the above mentioned activation of the white cell function can-not be confirmed. 4. In the patients with marked liver disturbance the activation of white cell function through the penicillin injection is greatly decreased. 5. The activation of the white cell function through penicillin is similarly reduced in the animal with experimental liver disturbance caused by CCl4 olive-oil injection. 6. The activation of white cell phagocytosis and motility seems to be regulated by the neurohumoral mechanism.
1. The stimulation of the N. splanchnicus results in the temporary increase of the antibody-titer in the immunized dogs. 2. The peripheral blood and especially lymphocytes show marked quantitative and qualitative changes with the development of immuniza-tion as well as after the stimulation of the N. splanchnicus in the same im-munized animal. 3. After the interception of the venous blood flow from the adrenal gland by the ligation of the bilateral adrenal veins, the stimulation of the N. splanchnicus gives no significant effect to the antibody-titer and to the lymphocytes. 4. We discussed on the possible roles of the splanchnic nerve and anterior pituitary-adrenocortical system concerning the above-said find-ings.
1. The fibres 'of the intrapontine facial nerve do not only take the schematic course-the so-called first part, genu and second part, as hither-to said, but passing through or passing over all the sides of the abducens nucleus in various directions, surround the abducens nucleus and then assemble into the second part. 2. A part of the fibres of the facial nerve decussates at the genu. 3. Some of the fibres derived from the trapezoid body end in the motor nucleus of the facial nerve. 4. Some of the fibres derived from the lateral portion of the abducens nucleus seem to join the second part of the facial nerve. 5. Some of the fibres derived from the spinal tract of the trigeminal nerve end in the motor nucleus of the facial nerve. 6. A part of the fibres of the dorsal longitudinal fasciculus (Schutz's bundle) seems to join the second part of the facial nerve. 7. The Mendel's so-called upper facial nerve, originating in the nucleus of the oculomotor nerve, can be seen in my observation, too.