KOEDA, T., AMANO, K., ICHIKAWA, T., SUZUKI, T., ISHIKAWA, M., SATO, M., MIURA, S., SUZUKI, T. and KATO, M.
Changes in the Mixed Venous Blood Oxygen Saturation during the Acute Phase of Myocardial Infarction and Administration of Dobutamine. Tohoku J. Exp. Med., 1990,
160 (1), 55-65-Clinical significance of the continuous monitoring of mixed venous oxygen satuation (SvO
2) by Catheter Oxymetry System was evaluated in 45 patients with acute myocardial infarction (AMI). Patients with AMI were classified into 4 groups acccording to Forrester's hemodynamic classification. The mean SvO
2 value for each group was 70.4±4.1% for subset I, 54.7±6.9% for subset II, 55.8±9.8 for subset III, and 47.0±8.0% for subset IV. Subsets II, III, and IV showed significantly low values compared to subset I (
p<0.01). The relationship between PCW and SvO
2 level was expressed by the negative regression line y=-0.8x+73.8 (r=-0.64,
p<0.01). The curve representing the relationship between CI and SvO
2 level was expressed by the equation y=53.8 logx+42.7 (r=0.68,
p<0.01). The SvO
2 level of the 14 patients who showed a significantly low value of 56.9±8.2% before administration of 5μg/kg/min dobutamin, increased to a mean value of 66.8±7.9%, as well as the CI after 60min. However, PCW demonstrated no pronounced changes because of dobutamin administration. Since the SvO
2 level highly correlated to the cardiac pumping function in acute phase of myocardial infarction, polygraphic monitoring of SvO
2 was found to be a useful index for evaluating changes in the hemodynamics. It was also a very useful measure in evaluating the effects of dobutamin.
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