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Volume 117 (1975)
- Issue 4 Pages 299-
- Issue 3 Pages 203-
- Issue 2 Pages 103-
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Volume 117, Issue 4
Displaying 1-12 of 12 articles from this issue
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MASATOSHI SAKKA, HAJIM KATSUTA, TOSHIKO TAKAOKA1975 Volume 117 Issue 4 Pages 299-309
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe time of cell destruction was determined by pedigree analysis before macrocolony formation immediately after irradiation of gamma rays (400-900R) in cultured rat hepatoma cells. Cell destruction occurred and was distributed to various generations in proportion to dose. The loss of reproductive integrity resulting in an extinction of a clone was limited in earlier generations, 0 to 2, but the loss of reproductive capacity was observed in later generations. It seems probable that two types of loss of reproduction come from random transmission of lethal signals produced in parent cells irrespective of the pattern of pedigrees.View full abstractDownload PDF (576K) -
TOSHIO NAKAMURA, TOSHIYUKI NAKAJIMA, TAMOTSU TAKISHIMA, NORIO SUZUKI, ...1975 Volume 117 Issue 4 Pages 311-321
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA sensitive index was proposed for the determination of left ventricular compliance. In the isolated potassium-arrested canine left ventricle, the pressure-volume (P-V) relationship was expressed as ΔV =a-be-cp throughout the range of filling pressure from 0 to 40cmH2O, where ΔV and P were the actual volume change and intraventricular pressure, and a, b and c were constants. Then, half-inflation pressure (h) was calculated from h=[ln (2b/a)]/c. Left ventricular weight (LVW), intraven-tricular volume (LVV), ventricular external radius (r0) and internal radius (ri) were obtained from the measurements on the left ventricle, fixed at a filling pressure of 10cmH2O. Then, LVVp=h, ro and ri at h were calculated. In the normal canine hearts, h was well correlated to LVW/LVVp=h and [(r0- ri)/ri]p=h. On the other hand, h/LVW/LVVp=h and h/[(r0-ri)/ri]p=h were constant and independent of LVW within a range of 40 to 150g. These ratios rose markedly in the state of rigor mortis. From these results, it was concluded that h/LVW/LVVp=h and h/[(r0-ri)/ri]p=h depended on the left ventricular wall stiffness. And h was influenced by changes in LVW/LVVp=h and [(r0-ri)/ri]p=h in the absence of changes in intrinsic muscle stiffness.View full abstractDownload PDF (602K) -
KISABURO AKASAKA, KIMIO KONNO, YASUO ONO, SUETSUGU MUE, CHOZO ABE, MUT ...1975 Volume 117 Issue 4 Pages 323-333
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSChanges in the breathing sounds such as stridor and dry and wet tales in asthmatic patients were studied. The breathing sounds were recorded with the small transistor warp type microphone inserted through the nasal orifice into the trachea, main bronchi and segmental bronchi, and were analyzed with sound analyzer. The results were as follows: The whistling rales were caused by the resonance of the bronchial wall, when the vibrating frequency was coincident with its specific frequency. Snoring rales were explained as the sound caused by the air flow passing promptly through contracted bronchi with little secretion. Resonance of either bronchial wall or highly viscous sputum was considered to be responsible for the sonorous rales. Sibilant rales were audible when bronchi promptly repeated dilation and contraction. Stridor was picked up at the upper part of the air tract, from the main bronchus to the trachea, and noise was the main component on the sonogram, presumably caused by the air turbulence due to the narrowing and deformity of bronchial tube or to the sputum adhering to the inner surface of the air tract.View full abstractDownload PDF (4091K) -
KENJI KOYAMA, SEIICHI KASHIMURA, HIDEMI YAMAUCHI, YASUSHI TAKAGI, YASU ...1975 Volume 117 Issue 4 Pages 335-341
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn an attempt to clarify the hepatic insufficiency in obstructive jaundice, hepatic metabolic rate of n-butyric acid, ketogenesis and CO2 formation from butyric acid were investigated using liver slices obtained from rats subjected to choledochal ligation or carbon tetrachloride (CCl4) injection. The hepatic metabolic rate of n-butyric acid was reduced with the prolongation of biliary obstruction, and the reduction was presumed to be caused for the most part by the reduced ketogenesis and in part by the impairment of the citric acid cycle (TCA-cycle). In 3_??_4 weeks after biliary obstruction, the metabolic rate reduced to a level comparable to liver necrosis produced by CCl4. This reduction of the metabolic rate of n-butyric acid is postulated as one of the pathogenic factors for fatal liver insufficiency in many cases of obstructive jaundice. While the reduction is mild and mobile in the early stage of jaundice, it may be of significance for preventing fatal liver insufficiency to relief the obstruction as early as possible.View full abstractDownload PDF (348K) -
KAZUO ABE, HIDEE FUJIMOTO, EIKO ENDO, YOSHIO FUKUOKA, JUNEJI KHATO, HA ...1975 Volume 117 Issue 4 Pages 343-350
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe level of serum fibrinogen degradation products (FDP) in rat was quantified by hemagglutination-inhibition immunoassay which utilized anti-rat-fibrinogen antiserum of rabbit and fibrinogen-coated rat erythrocytes. The sensitivity of this method was high enough to detect minute amounts of serum FDP in rats. The normal value ranged from 1.25 to 10μg/ml with a mean value of 5.7μg/ml as expressed as fibrinogen equivalents. The changes in FDP level were noted in tumor-bearing rats which were transplanted subcutaneously with 106 tumor cells (AH-109A, a strain of Yoshida rat ascites hepatoma). The FDP level was unchanged in an early stage, elevated to 56μg/ml on 12th day and to 92μg/ml on 16th day on an average. These elevations were statistically signfiicant.View full abstractDownload PDF (1021K) -
TAKAHITO KONDO, NAOYUKI TANIGUCHI, YOSHIKAZU KAWAKAMI, HAJIME IDE, KAZ ...1975 Volume 117 Issue 4 Pages 351-356
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe levels of carbonic anhydrase B and C isozymes in human red cells were determined using a quantitative immunological technique in patients with chronic obstructive lung disease. A significant increase in the level of carbonic anhydrase B was observed in these patients, while the level of carbonic anhydrase C did not change substantially. Positive correlations were found between the level of carbonic anhydrase B and arterial CO2 tension and plasma HCO3- concentration. A negative correlation was observed between the levels of carbonic anhydrase B and blood pH. These findings suggest that the synthesis or degradation of carbonic anhydrase B isozyme is affected by arterial CO2 tension or plasma HCO3- concentration. The clinical significance was also discussed in relation to these isozyme levels in red cell.View full abstractDownload PDF (308K) -
HITOSHI FUKASAWA1975 Volume 117 Issue 4 Pages 357-372
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSOn the autopsy findings of the 140 consecutive stroke cases, some characteristics of cerebrovascular diseases in this district were discussed. Predominance of intracranial hemorrhage (cerebral hemorrhage and subarachnoid hemorrhage) over cerebral infarction was still evident. Ruptured intracranial aneurysms were demonstrated in 98% of fatal subarachnoid hemorrhage. Compared with the autopsy data of other institutions, the age of death was generally low, the median age for cerebral hemorrhage, subarachnoid hemorrhage and cerebral infarction falling in the fourth, fifth, and sixth decade, respectively. Cerebellar hemorrhage was relatively frequent, while blood dyscrasias and other symptomatic hemorrhage constituted only a small part in contrast with the report of American authors. A dominant role of hypertension in causing strokes was concluded from both the heart weight and the clinical records.View full abstractDownload PDF (2673K) -
TAKASHI MIURA, WAKIO TORINUKI, YOSHIO TANAHASHI1975 Volume 117 Issue 4 Pages 373-380
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCat scratch disease developed on a 40-year-old wife was reported. Umbilicated papules closely resembling those in herpetic skin infection developed on the areas which had been scratched by a cat a week ago. Obtained findings in the present case led us to a speculation that this disease was caused by herpes virus. 72 cases of this disease have been reported in Japan, and they were reviewed in the present paper.View full abstractDownload PDF (3048K) -
Enhancement of Gustatory Neural Response to Salts Following Adaptation of Frog Tongue to Quinine-HClTOSHIHIDE SATO1975 Volume 117 Issue 4 Pages 381-384
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAfter a frog tongue was adapted to 0.001M quinine-HCI (Q-HCl), a change in the gustatory neural responses to salts was investigated. The initial phasic response to a variety of salt solutions such as 0.1M NaCI, KCI, LiCl, MgCl2 and CaCl2 was greatly potentiated as a result of the Q-HCl adaptation. A weaker enhancement of the response to salts was observed after the tongue was adapted to deionized water, compared with the control response to salts during Ringer adaptation. Therefore, the Q-HCl-induced enhancement of salt responses is due to the summated effect of Q-HCl solute and water solvent. Concerning the enhancing mechanism of Q-HCl, it is postulated that the membrane potential of some salt-sensitive taste cells will be displaced in the hyperpolarizing direction during the Q-HCl adaptaion, and that large depolarization, which may be related to the enhanced nerve response, will be produced by applying salts after Q-HCl.View full abstractDownload PDF (229K) -
HIKARU WATANABE, TOSHIKI NARASAKA, SHOICHI YAMAGATA1975 Volume 117 Issue 4 Pages 385-396
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe Machida type fibercolonoscope, or FCS, devised by us is an anterior direct vision type of fiberscope. The most important feature of this new fiberscope consists of a tip of 5cm size which is capable of being directed by flection up to 120 degrees in any direction and the tip up to 30cm possessing a fishing-rod-like flexibility and elasticity by means of a special spiral spring. This angle-regulating mechanism makes it possible to insert this instrument along the course of the intestine under direct visual control. The fishing-rod-like construction where the maximal flexibility is greatest at the tip makes it considerably easier to pass sites of marked flexure in the colon. At examination the insertion of the instrument is guided by direct observation and by roentgenoscopy. The results in 200 cases in 1970 and thereafter, when operative techniques No. I, II and III devised previously by us were used, showed that successful insertion into the cecum was possible in 139 out of 173 cases (80%) except 27 cases of pathological stenosis due to cancer and other reasons. Thus fibercolonoscopy now enables the direct observation of the colon beyond the reach of the sigmoidoscope, providing a useful diagnostic procedure. Further-more, a medium-long S.bercolonoscope or FCS-M has been produced by us for examination of the lower portion of the large intestine. This is used in the inverted position without roentgenoscopic guidance as in conventional sigmoidos-copy. When this method, fibersigmoidoscopy, was used in 120 cases, it was possible to examine up to the transverse colon in 19 cases, the splenic flexure in 22 cases and the descending colon in 39 cases without the use of special techniques I, II or III. Thus in the majority of cases it is possible to carry out the examination of the left colon in this manner. The usefulness of fibersigmoidoscopy in the practical clinic is, therefore, rather larger than that of fibercolonoscopy.View full abstractDownload PDF (4520K) -
TSUGUYOSHI SUZUKI, SACHIKO SHISHIDO1975 Volume 117 Issue 4 Pages 397-398
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUrine of mercury-exposed workers in a chlorine manufacturing factory and of staffs of our laboratory was separated into the supernatant solution and the precipitate by a centrifugation of 105, 000 ×g for 60min. The ratio of the amount of inorganic mercury in the precipitate to that in the supernatant solution ranged from 0.23 to 4.84, and was dependent upon the level of urinary mercury. The role of the desquamation of tubular cells is suggested as a possible route of urinary excretion of mercury.View full abstractDownload PDF (105K) -
YASUHIKO HASHIMOTO, TAKESHI SHIMA, SHUH MATSUKAWA, KENICHI IWATSUKI1975 Volume 117 Issue 4 Pages 399-400
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSNeuromuscular blocking properties of ribostamycin (1gm), dibecacin (100mg) and tobramycin (60mg) were studied in man during anesthesia and surgery by observing the effects of these antibiotics on muscle twitch tension. These drugs alone did not show any neuromuscular blocking action in those therapeutic doses. However, during the recovery phase of d-tubocurarine block the intravenous administration of 1gm of ribostamycin caused a fairly rapid decrease in twitch tension. Tobramycin 60mg did not show any remarkable effect, but dibecacin 100mg produced a slight potentiating effect on the action of d-tubocurarine. The enhancement of the action of dtubocurarine was antagonized promptly by edrophonium and more slowly by calcium.View full abstractDownload PDF (716K)
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