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Volume 119 (1976)
- Issue 4 Pages 297-
- Issue 3 Pages 201-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 119, Issue 3
Displaying 1-10 of 10 articles from this issue
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TAKESHI HOSHI, YUICHI SUZUKI, TSUNETA KUSACHI, YUTAKA IGARASHI1976 Volume 119 Issue 3 Pages 201-209
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe relationship between changes in the transmural potential induced by actively transported sugars (ΔPD's) and influxes of the sugars (Js's) was investigated in the isolated guinea pig small intestine. Under the condition that medium electrical conductivity remains unchanged, ΔPD and Js were closely correlated, e. g., both showed very similar patterns of regional difference along the intestine, and the values of the half saturation concentration (Km) for a sugar estimated from electrical and flux measurements were nearly identical. No such correlation was observed when medium conductivity varied. However, a simple correction of the sizes of ΔPD's for medium conductivity restored a close parallelism between ΔPD's and Js's. The sugar-induced increase in Na+ flux estimated from the increase in short-circuit current varied in parallel with Js regardless of the medium conductivity, and a fixed stoichiometrical relationship (approximately one-to-one coupling) was seen between Na+ and sugar fluxes. It is concluded that the dominant factor affecting the interrelation between ΔPD and Js is the resistance of the paracellular shunt which is directly proportional to medium electrical conductivity.View full abstractDownload PDF (557K) -
RYUJI YAMAGUCHI, YOSHIO NISHIKAWA, SATORU TSUBOMOTO, KATSTIYUKI UEHA, ...1976 Volume 119 Issue 3 Pages 211-221
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo prevent postoperative dysuria, which occurs inevitably after the radical hysterectomy, several surgical procedures have been tried. The principal method is to suture adnexal flaps to the bladder trigone and fundus. Of four procedures so far tried sequentially, the best one was to fix the bladder trigone and to support it with round ligament flaps sutured with the bladder fundus covered by tubal flaps (Type IV). In follow-up studies, Type IV proved more preferable than the other three types or the non-sutured control group in regard to the following aspects: (1) days necessary for the disappearance of residual urine, (2) appearance of urinary sensation, (3) acquirement of urinary sensation, (4) incidence of urinary incontinence, (5) residual urine/bladder capacity ratio, (6) cystometrie findings, and others. Effectiveness of our procedures, particularly of Type IV, may be ascribed to the supported bladder trigone and fundus by sutured tissues and to the acquirement of urinary sensation, rather than to the restoration of nervous contact between the bladder and the micturition center in the spinal cord.View full abstractDownload PDF (528K) -
ATSUSHI KIMURA, TADASHI TAMURA, TOORU NAKAO1976 Volume 119 Issue 3 Pages 223-236
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt has been generally accepted that capsids found in the cytoplasm of infected fibroblasts by adapted strain human cytomegalovirus (CMV) have bristle-like surface coating on them. This coating was said to be one of the important differences of CMV from herpes simplex virus. As well known, capsids of CMV increased in their over-all diameter through the process of moving from the nucleus to the cytoplasm. In some instances, however, uncoated capsids were detected in the cytoplasmic portions especially in the vicinity of tubular structures in the cytoplasm. It seemed that these uncoated capsids might be formed in the cytoplasm but had not emigrated from the nucleus.View full abstractDownload PDF (6282K) -
TAKEO KUROYANAGI, KAZUO KURA1976 Volume 119 Issue 3 Pages 237-244
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSLevels of serum fibrin degradation products (FDP) were determined in patients with acute nephritis, chronic nephritis, lupus nephritis and toxemia of pregnancy by the passive hemagglutination inhibition test. Serum FDP levels were less than 10μg/ml in normal control adults, averaging 3. 2±1. 2μg/ml. The incidence of serum FDP positive patients (more than 10μg/ml) in those with acute nephritis, chronic nephritis, lupus nephritis and toxemiaa of pregnancy was 28%, 73%, 100% and 10000, respectively. Their serum FDP levels averaged 8. 4±5. 6μg/ml, 16. 0±5. 9μg/ml, 21. 4±7. 6μg/ml and 35μg/ml, respectively. Plasma fibrinogen levels, prothrombin time, partial thromboplastin time, euglobulin lysis time and platelet counts were within normal limits in serum FDP positive patients with renal diseases, indicating that there was no severe disseminated intravascular coagulation. All FDP positive patients with renal diseases of immunological origin demonstrated the deposition of fibrin within glomeruli with complement and immunoglobulin deposits. However, FDP positive patients with toxemia of pregnancy demonstrated fibrin depositions within glomeruli without complement and immunoglobulin deposits. FDP D fragments of urine from lupus nephritis patients showed no changes in immunoelectrophoretic patterns by heat treatment, indicating that urine FDP was derived from secondary fibrinolysis.View full abstractDownload PDF (1087K) -
TOSHIO NAKAMURA, TOSHIYUKI NAKAJIMA, NORIO SUZUKI, SHIGERU ARAI, NORIO ...1976 Volume 119 Issue 3 Pages 245-256
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPressure-overloaded hypertrophy of the left ventricle (LV) was produced by coarctation of the ascending aorta in 7 dogs. The overall mean weight of the left ventricle (LVW) was 7.86±1.49 (S.D.) g/kg body weight; (normal, 5.99±0.70 g/kg: p<0.05). After potassium arrest, pressure-volume (P-V) relationships were examined with the left ventricles isolated from the normals and from the dogs of left ventricular hypertrophy (LVH-dogs). In both groups, the P-V relationships could be expressed by an equation ΔV =a-be-cP throughout the range of filling pressure of 2.5 to 35 cmH2O, where ΔV was the actual volume change of LV, P intraventri-cular pressure, and a, b and c constants. A sensitive index of LV stiffness, the half-inflation pressure (h), was defined as In (2b/a)/c. In hypertrophied hearts, h was 10.5±0.7cmH2O; (normal, 8.0±0.4 cmH2O; p<0.001). The ratio of LVW to LVVp=h (the left ventricular volume at h) in hypertrophy, which was related to the LV chamber geometry, was 3.1±0.6 in contrast with the normal value of 2.0±0.3. The development of concentric hypertrophy was thus demonstrated. Moreover, h was closely correlated with LVW/LVVp=h in both the normals and the LVH-dogs (r=0.83; p<0.01). On the other hand, an index of LV wall stiffness h/LVW/LVVp=h was relatively constant. Therefore, the increase of LV stiffness in the LVH-dogs was attributed to the change in chamber geometry.View full abstractDownload PDF (685K) -
SUETSUGU MUE, TADAO ISE, SHIGEKI SHIBAHAPA, MAKOTO TAKAHASHI, TAMOTSU ...1976 Volume 119 Issue 3 Pages 257-264
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSChanges in adenosine triphosphatase (ATPase) activity of the peripheral blood leukocytes were investigated in patients with bronchial asthma. Estimation of the leukocyte Mg++. and Ca++. dependent ATPases was carried out according to Hadden's method, incubating ATP with the membrane fraction of the leukocyte. The leukocyte ATPase activity was signifi-cantly elevated among asthmatic patients compared with control subjects. This elevated ATPase was seen in all asthmatics irrespective of acute attacks or the drug treatment. There was no clear correlation between the activity of ATPase and the percentage of leukocytes, neutrophils and eosinophils. There was no relationship between ATPase activity and adenyl cyclase activity of the same leukocytes from asthmatic patients.View full abstractDownload PDF (504K) -
HIKARU WATANABE, KENICHI SHOJI, SHOICHI YAMAGATA1976 Volume 119 Issue 3 Pages 265-274
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDiagnostic methods for the cancer of the colon and rectum were compared in two groups of patients, i. e., patients of stage A malignancy in the Dukes classification, and those with the so-called “early cancer of the colon and rectum”, and the best way to find cancer of the colon and rectum in its early stage was investigated. At the same time, the prognosis of early cancer of the colon and rectum was studied by the use of the relative survival rate. The following results were obtained. 1) The so-called “early cancer of the colon and rectum”, of which invasion was limited to the mucosa and submucosa, can be correctly diagnosed by the combined application of both biopsy and exfoliative cytology under direct vision even before surgery and/or polypectomy. 2) Cancer of the colon and rectum is considered to be a curable disease, if discovered and resected at or before the stage A in the Dukes classification, in which the cancerous pro-liferation is limited to the wall of the colon and rectum without any metastasis.View full abstractDownload PDF (480K) -
HIKARU WATANABE, MAKOTO NUMAZAWA, SHOICHI YAMAGATA1976 Volume 119 Issue 3 Pages 275-281
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS7, 679 proctosigmoidoscopies were performed on 6, 293 patients during a period from 1962 to 1974 at the Third Department of Internal Medicine, Tohoku University Hosptial. Results were summarized as follows: Polyps were observed in 470 patients (7.5%) and cancer was found in 178 patients (2.8%). 129 patients (2.0%) were observed to have ulcerative colitis. There were 57 patients with melanosis coli, 12 radiation proctitis, 7 amebic colitis, 5 granulomatous colitis, 2 endometriosis coli, 2 carcinoid and 2 intestinal tuberculosis. Thus, 879 out of 6, 293 patients examined had some forms of disease, an over-all incidence being 14. 0%. Biopsies were performed under the proctosigmoidoscopic observation in 82.4% out of 273 patients with polyps during the 6-year period from 1969 to 1974 and 105 patients (46.7%) were observed to have adenomatous polyps. The age-specific distribution pattern and incidences of these patients with adenomatous polyps were mostly consistent with those of 178 patients with cancer of the large bowel, which were observed by proctosigmoidoscopy during the 13-year period from 1962 to 1974. Thus, it is suggested that etiological correlation exists between polyps of adenomatous type and cancer of the large bowel.View full abstractDownload PDF (323K) -
Peripherally and Centrally Mediated Bradycardiac Effects of Clonidine in Anesthetized or Spinal RatsHIKARU OZAWA, TOSHIO UEMATSU1976 Volume 119 Issue 3 Pages 283-291
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe bradycardia-inducing effects of clonidine were examined in anesthetized or spinal rats by injecting the drug intracisternally (i. c.) or intravenously (i. v.). Clonidine (1-25μg i. c.) caused a bradycardia dose-dependently in anesthetized rats. The bradycardia in response to clonidine (5 μg i. e.) was Sig-nificantly reduced after a treatment with phentolamine (100 μg i. c.), but not influenced with atropine (1 mg i. v.) or sectioning bilateral cervical vagal nerves. In spinal rats, an acceleration in heart rate by electrical stimulation of cervical sympathetic nerves was frequency-dependent and that due to desmethylimipramine (DMI) was dose-dependent. Clonidine (30 μg i. v.) significantly inhibited the acceleration induced by electrical stimulations only at a low frequency (0.3-3 Hz) or DMI (0.3 mg i.v.). This inhibition by clonidine was antagonized by phentolamine (5 mg i. v.). Clonidine (30 μg i. v.) did not significantly influence the acceleration in heart rate of spinal rats induced by norepinephrine (1 μg i. v.), tyramine (100μg i. v.) or 1, 1-dimethyl-4-phenylpiperazinium (DMPP, 50 μg ix.). Therefore, it is suggested that clonidine causes a bradycardia by stimulating both peripheral and central α-adrenoceptors, the sympathetic trunk is the main pathway, and that the peripheral mechanism for elonidine-induced bradycardia is different from the action of guanethidine or hexamethonium on a release of catecholamines from the cardiac nerve terminals.View full abstractDownload PDF (537K) -
JUNJI FURUNO, SETSUO KOMURA1976 Volume 119 Issue 3 Pages 293-295
Published: 1976
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt appears possible to utilize the inorganic phosphorus content in the aqueous humor for estimation of postmortem interval, especially if the factors relating to the body temperature are known in detail.View full abstractDownload PDF (145K)
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