(1) In the cava pocket experiments on the dogs under ether the bleeding of one fifth of the total blood quantum called forth a small, but definite augmentation in the secretion rate of epinephrine from the suprarenals. The bleeding of one tenth was not certain to cause the hypersecretion of epinephrine.
(2) In the lumbar route experiments on the non-fastened, non-anaes-thetized dogs the haemorrhage of one fifteenth of the total blood quantity was almost effective in evoking the increase of epinephrine discharge, though weak. When one tenth of the whole blood was lost, the velocity of liberation two to ten times as rapid as the initial was invariably measured, and the hypersecretion continued for about three hours. When one third or two fifths of the total amount was shed, the output rate ten to thirty times as quick was noted, and the hyperactivity of the medullisuprarenal gland lasted for a considerable length of time. At the fourth or sixth hour after the bleeding the epinephrine secretion had a definitely exaggerated velocity. In general, the greater the haemorrhage, the greater and the longer the hypersecretion of epinephrine from the suprarenal capsule.
(3) For the material difference between the two sets of experiments above mentioned the narcosis is responsible, at least chiefly.
View full abstract