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Volume 163 (1991)
- Issue 4 Pages 233-
- Issue 3 Pages 149-
- Issue 2 Pages 77-
- Issue 1 Pages 1-
Volume 163, Issue 4
Displaying 1-9 of 9 articles from this issue
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SEIICHI KATO, IKUO KONNAI, YOSHINORI HARADA, KAZUHISA KOMATSU, HIROSHI ...1991 Volume 163 Issue 4 Pages 233-238
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKATO, S., KONNAI, I., HARADA, Y., KOMATSU, K, and NAKAGAWA, H. Pyloric Narrowing with Increased Fibrous Tissue of the Mucosa in an Infant. Tohoku J. Exp. Med., 1991, 163 (4), 233-238- An infant with pyloric narrowing following bilious vomiting is described. Barium meal studies demonstrated fixed narrowing of the pyloric canal similar to infantile hypertrophic pyloric stenosis. However, sonographic examination failed to prove significant muscular hypertrophy of the pylorus. Histology of the pre-pyloric mucosal biopsy specimens showed nonspecific inflammation with increased fibrous tissue of the mucosa. Repeated histological examination revealed regression of mucosal inflammation; the patient became symptom free and normal growth was confirmed at 2 years of age. It is possible that antral/pyloric mucosal inflammation, the pathogenesis of which remains unclear, was the cause of pyloric narrowing and then led to nonbilious vomiting.View full abstractDownload PDF (2480K) -
EIICHI SAKURAI, SEIJI YAMASAKI, NOBORU HIKICHI, KENJI ONODERA1991 Volume 163 Issue 4 Pages 239-244
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSAKURAI, E., YAMASAKI, S., HIKICHI, N. and ONODERA, K. Effects of d-, l- and dl-Chlorpheniramine on Dopamine and 3, 4-Dihydroxyphenylacetic Acid Levels in the Regional Parts of Rat Brain. Tohoku J. Exp. Med., 1991, 163 (4), 239-244 -The purpose of this study was to further investigate the differences in the effects of optical isomers of chlorpheniramine (d-, l- and dl-forms) on the levels of dopamine (DA) and 3, 4-dihydroxyphenylacetic acid (DOPAC) in the regional parts of rat brain. After the intravenous administration of each form of chlorpheniramine at a dose of 20mg/kg, the DA and DOPAC levels were measured by HPLC system. Each form of chlorpheniramine is effective in reducing DOPAC, but not DA levels in the brain of rats. The degree of reducing DOPAC levels does not correlate with the antihistaminic potency of these drugs. Thus, the present results indicate that there is a lack of stereospecificity in reducing DOPAC levels, suggesting the lack of stereospecificity in inhibiting DA reuptake.View full abstractDownload PDF (655K) -
MASAHIRO OHTA, TOKIHISA KIMURA, KOZO OTA, MASARU SHOJI, MINORU INOUE, ...1991 Volume 163 Issue 4 Pages 245-254
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOTA, M., KIMURA, T., OTA, K., SHOJI, M., INOUE, M., SATO, K., YAMAMOTO, T., ENDO, K., NARITA, M., ABE, K. and YOSHINAGA, K. Glucocorticoid-Induced Central Diabetes Insipidus in a Case of Malignant Lymphoma. Tohoku J. Exp. Med., 1991, 163 (4), 245-254- A 37-year-old man was diagnosed as malignant lymphoma infiltrating in the central nervous system with hypopituitrism and secondary glucocorticoid deficiency. In this case, plasma arginine vasopressin (AVP) increased, but glucocorticoid administration decreased plasma AVP and increased urine volume with a reduction in urinary osmolality, indicative of the presence of glucocorticoid-induced diabetes insipidus. At the terminal stage, plasma AVP did not increase in response to the withdrawal of glucocoticoid and urine volume remained decreased, suggesting the presence of masked diabetes insipidus. Autopsy showed an infiltration of lymphoid cells around the cerebral ventricles and necrosis in the hypothalamo-hypophyseal system. These findings suggested that glucocorticoid might centrally play an important role in the regulation of AVP release, and its deficiency potentiated AVP release.View full abstractDownload PDF (2711K) -
MASATOMO WATANABE, SHUKO TAKAGI, JUNKO MAGARA, HIROSHI MANO, MASASHI T ...1991 Volume 163 Issue 4 Pages 255-261
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWATANABE, M., TAKAGI, S., MAGARA, J., MANO, H., TSUNODA, M., NAKADAIRA, H., ENDOH, K., YAMAMOTO, M., KATO, K. and AKAI, S. Cytogenetic Analysis of Human Bile for Mutagenicity and Co-Mutagenicity. Tohoku J. Exp. Med., 1991, 163 (4), 255-261- Cytogenetic analysis was used to test whether or not human bile induced chromosome abnormalities in lymphocytes grown in culture. Bile was obtained from gallbladders resected for various reasons such as cholecystitis, cholelithiasis, polypus and cancers of the biliary tract, stomach and pancreas. After adding human bile to a final concentration of 25μl/ml or 12.5μl/ml, the culture medium was incubated at 37°C for 72hr. Air-dried slides were stained with conventional Giemsa and the numerical and structural chromosome abnormalities were scored. Positive and negative controls in terms of chromosome abnormalities were established by using 0.03μg/ml mitomycin C (MMC) and 0.9% normal saline, respectively. Cytogenetic analysis was successfully performed in 6 out of 10 bile samples (60.0%). Bile alone did not induce numerical or structural chromosome abnormalities. Structural abnormalities increased significantly in the 25μl/ml bile +0.03μg/ml MMC group, compared with the 0.03μg/ml MMC group: 36.0% vs. 20.7% in the chromatid-type gaps and breaks, 27.8% vs. 22.7% in the chromosome-type gaps and breaks, and 8.3% vs. 3.2% in the exchange-type abnormalities. It is likely that the interaction between bile and MMC is synergistic rather than additive.View full abstractDownload PDF (750K) -
HIDEAKI TAKEMATSU, HACHIRO TAGAMI1991 Volume 163 Issue 4 Pages 263-268
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKEMATSU, H. and TAGAMI, H. Complement Fragment C4d and Bb Levels in Inflammatory Skin Diseases (e.g. SLE, Atopic Dermatitis, Erythroderma and Pustulosis Palmaris et Plantaris) for Assessment of Complement Activation. Tohoku J. Exp. Med., 1991, 163 (4), 263-268- The complement is one of the major effector system in the process of inflammation. Complement activation has been shown to occur in inflammatory dermatoses such as systemic lupus erythematosus, aopic dermatitis, erythroderma of unknown origin, and pustulosis palmaris et plantaris by the elevated blood levels of complement fragments. To clarify the complement activation, especially the alternative pathway involvement, we have measured the concentrations of classical pathway-specific C4d and alternative pathway-derived Bb in the plasma of patients with these inflammatory disorders at a mild to exacerbated stage. Only the SLE plasma showed significantly elevated Bb levels. These results suggest that assessments of plasma C4d and Bb levels may be of value in monitoring the involvement of the complement system in patients with inflammatory dermatoses with significant complement activation.View full abstractDownload PDF (499K) -
KOHTARO TOMURA, HOIL KANG, KOH MITAMURA, MASAMI TAKEI, KEIJI YAMAGAMI, ...1991 Volume 163 Issue 4 Pages 269-277
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTOMURA, K., KANG, H., MITAMURA, K., TAKEI, M., YAMAGAMI, K., KARASAKI, M., NISHINARITA, S., HAYAMA, T., SAWADA, S. and HORIE, T. Correlations between IL-2 Enhancing Activity and Clinical Parameters in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus. Tohoku J. Exp. Med., 1991, 163 (4), 269-277- In a previous paper (Tomura, K. et al. Tohoku J. Exp. Med., 1989, 159, 171-183), we discovered IL-2 enhancing factor(s) designated B cell derivedgrowth enhancing factor-2 (BGEF-2), which enhanced IL-2 dependent cell proliferation, and reported that BGEF-2 was produced by B cells of the patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) only when they were in the active stage of the disease. In this paper, we studied relationship between each IL-2 enhancing activity from B cell supernatant of the patients with these diseases and clinical parameters. IL-2 enhancing activities did not correlate with erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), but correlated with plasma concentrations of γ-globulin from the patients with RA and SLE in the active stages. IL-2 enhancing activities correlated with hypocomplementemia and leukocytopenia in the patients with SLE, and also correlated with RAHA titer in the patients with RA. Moreover, on several patients with RA or SLE in the active stages, diminution of IL-2 enhancing activity was found when they were in the remission stage after treatments. These findings suggested that IL-2 enhancing activity (i.e., BGEF-2 activity) correlated with activity of these diseases and supported the hypothesis that BGEF-2 played an important role in the polyclonal B cell activation and autoantibody production in patients with these diseases.View full abstractDownload PDF (806K) -
MARIKO KAMBE, RYUNOSUKE KANAMARU, YASUSHI MITACHI, AKIRA WAKUI1991 Volume 163 Issue 4 Pages 279-288
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKAMBE, M., KANAMARU, R., MITACHI, Y. and WAKUI, A. Inductiopn of Natural Killer (NK) Activity in Mice by Injection of Chromomycin A3. Tohoku J. Exp. Med., 1991, 163 (4), 279-288- Intravenously or intraperitoneally administered Chromomycin A3 (CHRM), an anticancer drug, augmented natural killer (NK) activity of both spleen cells and peritoneal exudate cells in BALB/c mice. When CHRM was administered intravenously, NK activity increased to about five fold that in nontreated mice on the 3rd to the 5th day, then rapidly decreased by the 7th day. On the other hand, when CHRM was administered by the intraperitoneal route, a peak of increased NK activity was observed on 5th to 7th day followed by a more gentle decrease. Augmentation of NK activity by CHRM was enhanced by additional administration of Interferon- γ (IFN-γ). Experimental evidence that NK activity could be augmented by CHRM in various strains of mice, independent of H-2 haplotype, suggested that involvement of genetic control within class I region of major histocompatibility complex could be excluded. When BALB/c mice inoculated subcutaneously with Meth A cells were treated with i.p. injection of CHRM, or CHRM in combination with IFN-γ, the growth of the tumor cells was inhibited, indicating in vivo significance for the increased NK activity. Since this inhibitory effect was decreased by the injection of anti Asialo GM1 antibody (α-ASGM1), the effector cells presumably exerting killing activity against Meth A cells were concluded to be Asialo GM1 antigen positive.View full abstractDownload PDF (817K) -
SHIGERU TSUCHIYA, HIROMI FUJIE, TASUKE KONNO1991 Volume 163 Issue 4 Pages 289-294
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTSUCHIYA, S., FUJIE, H. and KONNO, T. B-Lineage Phenotype of Lymphoblastoid Cell Lines from Patients with X-Linked Agammaglobulinemia. Tohoku J. Exp. Med., 1991, 163 (4), 289-294- Epstein-Barr virus (EBV)-induced precursor B-cell lines were established from bone marrow cells of patients with X-linked agammaglobulinemia (X-LA). Using seven B-lineage specific monoclonal antibodies marker profiles of these cell lines were examined in order to know developmental stage specific and/or X-LA specific changes of B-cell related cellsurface antigens. CD19, CD20, CR2 (CD21), Fc ε receptor (CD23) and HLA-DR antigens were consistently found on the X-LA derived precursor B-cell lines as well as mature lymphoblastoid cell lines from healthy adults. These results suggest that immortalisation of B-cells with EBV is always accompanied by expression of pan-B cell markers and B-cell activation antigen (Fc ε receptor) even though the cell lines have precursor B-cell phenotypes as defined by immunoglobulin expression.View full abstractDownload PDF (620K) -
ATSUSHI TAKEDA, JUN MATSUNAGA, YASUSHI TOMITA, HACHIRO TAGAMI, SHIGEKI ...1991 Volume 163 Issue 4 Pages 295-297
Published: 1991
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKEDA, A., MATSUNAGA, J., TOMITA, Y., TAGAMI, H. and SHIBAHARA, S. Nucleotide Sequence of the Putative Human Tyrosinase Pseudogene. Tohoku J. Exp. Med., 1991, 163 (4), 295-297- We have cloned and sequenced the putative human tyrosinase pseudogene, which shares more than 98% nucleotide homology with exon 4 and exon 5 of the human tyrosinase gene including their flanking introns. Because of such a high homology, both the tyrosinase gene and its pseudogene could be amplified from genomic DNA by polymerise chain reaction. The nucleotide sequences presented thus enable us to discriminate the tyrosinase gene from its related sequences and are invaluable for a gene diagnosis of oculocutaneous albinism.View full abstractDownload PDF (265K)
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