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Volume 106 (1972)
- Issue 4 Pages 311-
- Issue 3 Pages 213-
- Issue 2 Pages 109-
- Issue 1 Pages 5-
Volume 106, Issue 4
Displaying 1-10 of 10 articles from this issue
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TAMOTSU TAKISHIMA, HIDETADA SASAKI, TAKASHI NAKAMURA1972 Volume 106 Issue 4 Pages 311-327
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe made a two-dimensional-flow model composed of two bands in parallel, the roof of which was made up with the condome rubber collapsible and segmented into five parts to keep interdependence in movement of each segment and the bottom with the plastic plate. In this model, pressure flow relationships demonstrated the flow to reach its maximum at a certain driving pressure, and the lower the compliance of the elastic roof, the higher the maximum flow rate established. Displacement of the collapsible roof toward the bottom occurred just at a very limited segment near the outlet of the airway. Combining the theoretical analysis with our experimental findings on dogs, it is concluded that the maximum flow has an inverse relation with both compliance and resistance of the bronchi. The fact that displacement of the collapsible roof toward the bottom appears at very limited segment, means stress on the membrane to focus into much narrower segment and might indicate “expiratory check valve” to occur also at a very limited segment of bronchi.View full abstractDownload PDF (780K) -
HIDEO SUZUKI1972 Volume 106 Issue 4 Pages 329-342
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of vitamin E deficiency and a combined high salt intake on pathological changes in the kidney and testis were studied with young rats given linseed oil and cod liver oil for 10 and 27 weeks, respectively, as a preliminary attempt to investigate the relation between vitamin E deficiency and lipid metabolism involving cell membrane fragility. Vitamin E deficiency caused by linseed oil resulted in degenerative renal changes and post-mortem renal autolysis. Supplementation with vitamin E partially protected the animals against the renal pathological changes. When cod liver oil was given, atrophy of the kidney and testis was observed. In both cases, renal autolysis and other signs of vitamin E deficiency were noted. The high salt intake had further effect on kidney changes when linseed oil was given and promoted testicular changes seen with cod liver oil but had less influence on other deficient signs. A decrease in lecithin and linoleic acid of the phospholipids of both organs was shown to be related to vitamin E deficiency.View full abstractDownload PDF (781K) -
MASAO ABE, TOYOAKI AKINO1972 Volume 106 Issue 4 Pages 343-355
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSLung and liver slices were incubated with 2-3H-glycerol and U-14C-palmitate and the incorporation of radioactivities into various lipid classes and their subfractions with both precursors were examined. (1) The incorporation of both precursors into phosphatidic acid and diglyceride was much smaller in lung than in liver, but the incorporation into phosphatidylcholine and triglyceride was exactly the opposite. (2) The incorporation of 3H-glycerol into various subfractions was highest in the oligoenoic fraction both in phosphatidic acid and diglyceride, in dienoic subfraction in phosphatidylcholine, and in the polyenoic subfraction in phosphatidylethanolamine and phosphatidylinositol in both liver and lung. (3) The ratios of 14C/3H were higher in phosphatidylcholine than in phosphatidic acid and diglyceride, both in lung and liver. The highest ratio was found in the saturated species of phosphatidylcholine among these lipids in lung. (4) Some discussions were made concerning the formation pathways of dipalmitoyl species in lung.View full abstractDownload PDF (771K) -
MASAKUNI SUZUKI, MASAHIKO HIROI, KATSUYUKI TAKAHASHI1972 Volume 106 Issue 4 Pages 357-362
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to know the mode of action of ethynodiol diacetate (SC 11800) in comparison with actions of progesterone, estradiol benzoate and testosterone propionate, several doses of SC 11800 were administered to mature female rats, and the estrous cycle and gonadotropin content in the hypophysis were observed. The pituitary gonadotropin changed periodically during the normal cycle, and FSH showed each maximal level in the proestrus, while prolactin showed its maximum level in the estrus. Administration of SC 11800 in a dose of 0.01mg/kg caused no changes in the estrus cycle, but the increased dose of 0.5mg/kg or 1.0mg/kg caused a continuous diestrus and marked increase of pituitary LH. In cases of administration of several steroids, progesterone and testosterone caused a continuous diestrus, while estradiol caused a continuous estrus. The contents of pituitary gonadotropin after the administration of what were greatly different from those after SC 11800. Accordingly, SC 11800 was assumed to have a mode of action different from the steroids.View full abstractDownload PDF (376K) -
SHOJI YAMADA, SATOSHI HORIO, SHUICHI KIMURA1972 Volume 106 Issue 4 Pages 363-371
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAdsorption of vitamin B12, with and without gastric mucosa extract (GME), to intestinal mucosa homogenates from rats was studied at various stages of growth. The development of the activities of producing gastric HCl and pepsinogen was also investigated. The intestine from newborn animals showed extremely high adsorption of vitamin B12 in the absence of GME. The GME-independent vitamin B12 adsorption fell rapidly with time, approaching adult level at about 20 days of age. Stimulation of vitamin B12 adsorption by adult GME and the gastric HCl secretion reached adult levels at about 20 days. On the other hand, intrinsic factor formation and pepsinogen formation did not reach adult levels until about 30 days. Histologic investigations of the gastric gland and ileal villus agreed with the above-mentioned experimental results. The intrinsic factor-dependent vitamin B12 absorption became a predominant system at about 30 days after birth.View full abstractDownload PDF (2552K) -
KAORU SAGISAKA, KAZUO TOKIWA, NAOHUMI YOSHIOKA1972 Volume 106 Issue 4 Pages 373-379
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the previous paper, the present authors reported on diminution in agglutinability of trypsin-treated M and MN red cells with anti-M IgG antibody. This paper deals with the time course of changes in agglutinability and quantitative differences of M agglutinogen of red cells. M agglutinogen of M red cells disappeared much faster than that of MN, and the lowest titer of anti-M IgG antibody to agglutinate M red cells was higher than that to agglutinate MN red cells. The significant difference of agglutination scores was observed in the frequency distribution in 100 cases of M and MN red cells each. Subgroups such as M1 and M2 in M agglutinogen of trypsin-treated red cells reacting with anti-M IgG antibody were unsettled.View full abstractDownload PDF (362K) -
SHIGETOSHI CHIBA, TAMIO NAKAJIMA1972 Volume 106 Issue 4 Pages 381-385
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSConstant pressure perfusion of the sinus node artery in situ was performed in 9 dogs anesthetized with i. v. sodium pentobarbital, 30mg/kg. Sodium pentobarbital, 30μg to 10mg, was injected directly into the sinus node artery. Doses of more than 100μg of sodium pentobarbital usually induced a negative chronotropic response. The injection of more than 3mg of pentobarbital frequently caused sino-atrial block followed by AV nodal rhythm. Control sinus rhythm was restored within 5 minutes after pentobarbital injection. The pentobarbitalinduced bradycardia was not blocked by atropine or propranolol. The pentobarbital effect, 100μg to 3mg, was antagonized by norepinephrine, although a large amount of pentobarbital, 10mg, was not antagonized by large amounts of norepinephrine. When heart rate was accelerated by the continuous infusion of norepinephrine, the negative chronotropic pentobarbital effect was more readily induced. It is concluded that sodium pentobarbital directly depresses SA nodal pacemaker activity of the dog in situ and the depression is partially antagonized by norepinephrine.View full abstractDownload PDF (314K) -
SHUNZO CHIBA, SHIGERU IKEDA, YASUO CHIBA, YOSHITAKA AGATSUMA, MASAMI O ...1972 Volume 106 Issue 4 Pages 387-389
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe epidemic of cytomegalovirus (CMV) occurred among forty-nine infants residing in an infant home between October and November of 1968. The incidence of infants having complement-fixing antibody to CMV increased from 23.7% to 91.8% during this period. CMV was isolated from saliva of 81% of the infants. The isolation rate decreased to 26% 4 months later. All of the virus excreters were apparently healthy.View full abstractDownload PDF (167K) -
YASUHIKO ITO, SHINICHI OKUYAMA, KUNIBUMI TAKAHASHI, TAKAYUKI AWANO, TA ...1972 Volume 106 Issue 4 Pages 391-398
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn estimation of the bone marrow blood flow was undertaken by introducing various radioisotope preparations into the iliac marrow of the rabbit and measuring T1/2 obtained from their wash-out curves. In the normal animals, the right and left symmetry was obvious; with 113mIn-EDTA, T1/2 was 4.46±1.00min in the left iliac marrow and 4.42±1.06min in the right. Studies with 133Xe showed the same results. Vasodilation and vasoconstriction affected the disappearance rate of 113mIn-EDTA. With a vasodilator drug, a pronounced reduction in T1/2 was observed, and with a vasopressor, an extreme elongation. An extreme elongation to 21.28±7.24min was seen in experiments with 113mInCl3. A rough estimate with 113mIn-colloids revealed an identical result. These suggest a mechanism of clearance of 113mIn-EDTA and 133Xe from the marrow other than phagocytosis by the marrow reticuloendothelial system. Thus, measurement of the disappearance rate, T1/2, of 113mIn-EDTA and 133Xe from the marrow cavity appears to be an appropriate estimation of the bone marrow blood flow.View full abstractDownload PDF (329K) -
OTOTAKA HIGASHI, YOKO KIKUCHI, KIMIICHI KONNO1972 Volume 106 Issue 4 Pages 399-409
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA six-year-old girl with a congenital hemorrhagic disorder characteristic of thrombasthenia or Glanzmann's disease was reported. A special study on platelet aggregation was performed. It was found that patient's platelets failed to aggregate in response to hydrogen peroxide (H2O2), while normal platelets were readily aggregated by this agent. This H2O2 induced aggregation of normal platelets can be inhibited by adenosine, suggesting a possible mechanism that H2O2 might stimulate platelets to release ADP, which in turn causes platelet aggregation.View full abstractDownload PDF (764K)
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