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Volume 92 (1967)
- Issue 4 Pages 325-
- Issue 3 Pages 221-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 92, Issue 2
Displaying 1-6 of 6 articles from this issue
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Yoshikyo Ueda1967 Volume 92 Issue 2 Pages 109-140
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSp-Dimethylaminoazobenzene (D. A. B.) was fed to rats for periods of 4 to 24 weeks. The treatment was followed by repeated injections of carbon tetra-chloride (CCl4). The groups thus treated were compared with groups which were fed on basal diet after D.A.B. was discontinued.
1) CCl4 was found to act as a promoting factor and to accelerate the carcinogenic process of D. A. B.
2) In comparison with the groups which were fed on basal diet after D. A. B. was discontinued, the groups in which D. A. B. was followed by repeated administra-tion of CCl4, showed significantly higher incidence rates of liver carcinoma, liver cirrhosis, liver carcinoma with liver cirrhosis, and nodular hyperplasia. It was further ascertained that this was especially remarkable in the groups given D. A. B. for 8, 10 or 12 weeks.
3) The administration of CCl4 did not influence the histological pattern of D. A. B. -induced liver carcinoma.
4) Positive correlation was found between the incidence of liver carcinoma with liver cirrhosis and nodular hyperplasia. The possibility was pointed out that liver carcinoma developed on the basis of liver cirrhosis and nodular hyper-plasia.
5) The modification of hepatic changes in the course of D. A. B. carcinogenesis by the administration of CCl4 was described, and its effect on the development of liver carcinoma was discussed.View full abstractDownload PDF (19703K) -
Toshihisa Kusano, Isao Yamane1967 Volume 92 Issue 2 Pages 141-150
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe cells obtained from 15 to 19 day old embryonal brain tissues of random bred strains of golden hamsters (Mesocrisetus auratus) were inoculated with high titer adenovirus type 12 (Huie strain). In 20 days foci of transformed cells appeared in the cultures when inoculated with more than 106 TCID50 per ml of virus. They were circumscribed by the surrounding cells and remained adherent to one another. It was demonstrated that three of these foci had adenovirus type specific T antigens. Four cell lines obtained from each focus were examined for their tumor producing capacity. All the lines tested were highly malignant.View full abstractDownload PDF (1630K) -
Toshihisa Kusano, Isao Yamane1967 Volume 92 Issue 2 Pages 151-160
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFrom in vivo induced tumors by adenovirus type 12, four cell lines were established in vitro (H-1, H2-1, H2-2 and H-4) and from the in vitro transformed foci in embryonal hamster brain tissue culture by the same virus, 7 lines were successfully subcultivated (HT-1, HT-2 so on). There was no gross differences in their characteristics. Morphologically they were tenaciously adherent small epithelioid cells. They needed large inoculum to subculture in rubber stoppwred culture system. Cellular aggregations were frequently observed in the static culture conditions and calcium concentration suggested to bear it. The attempt to isolate the infectious virus from tumor cells and transformed cells at various passage levels has failed so far.View full abstractDownload PDF (2243K) -
Kozo Sato1967 Volume 92 Issue 2 Pages 161-173
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe grade and distribution of mineralization in the postmortal human vertebral body were examined with the technique of quantitative microradiography. The grade of mineralization was indicated by the value of absorption of x-ray through a tested bone, and the trabecular density was shown by the number and width of the trabeculae on the microradiograms. Correlations between the grade of miner-alization or trabecular density and ages or pathological conditions were statisti-cally studied.
The grade of mineralization in respective parts of the vertebral body was apt to show almost the same pattern in each case. The trabecular density reached the maximum value in the third decade of life, and thereafter it was lowered by aging, particularly after the fifth decade.
The present study has also revealed that the vertebral body in cases of lung cancer and renal insufficiency has high grade of mineralization, whereas that in liver cirrhosis is lower than normal.View full abstractDownload PDF (1106K) -
Yoshikyo Ueda1967 Volume 92 Issue 2 Pages 175-206
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSp-Dimethylaminoazobenzene (D. A. B.) was fed to rats after preliminary in-jections of carbon tetrachloride (CCl4), and the following results were obtained.
1) The preliminary injections of CCl4 accelerated and intensified D. A. B. -induced early histological changes in the liver. The carcinogenic action of D. A. B. on the liver was also reinforced by CCl4 pretreatment.
2) Liver cirrhosis due to CCl4 pretreatment had an accelerating action on the development of D. A. B. -induced liver carcinoma. This accelerating action of CCl4-induced liver cirrhosis on the hepatic carcinogenesis by D. A. B. was sustained, even when the cirrhogenie action of D. A. B. was suppressed by appropriate change in the composition of D. A. B. containing diet.
3) The relationship between lowered protein-bound azo-dye levels in the liver on account of preliminary CCl4 injection and the increased incidence of D. A. B. -induced hepatic carcinoma was discussed.View full abstractDownload PDF (8509K) -
Masashi Nakamura, Takeyoshi Kawagoe, Yukio Ogino, Kunitaka Nishiyama, ...1967 Volume 92 Issue 2 Pages 207-219
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBy measuring BMR and the skin temperature following exposure to cold, and estimating the blood vitamin C levels after daily intake of 200mg of ascorbic acid for 17 days, the authors obtained the following results:
1) The concentration of blood ascorbic acid reached 1.2 mg/100ml in the group treated with ascorbic acid, but it remained between 0.6 and 0.7mg/100ml in the non-treated group.
2) BMR increased simultaneously with the rise in the ascorbic acid level.
3) There was no essential difference in the differential count of white cells between the two groups.
4) The skin temperature of the subjects with high blood ascorbic acid concentration was lowered less than that of the control by exposure to cold.
5) Ascorbic acid seemed to enhance the resistance to cold by raising the body temperature and the BMR.View full abstractDownload PDF (553K)
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