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Volume 175 (1995)
- Issue 4 Pages 219-
- Issue 3 Pages 143-
- Issue 2 Pages 77-
- Issue 1 Pages 1-
Volume 175, Issue 4
Displaying 1-8 of 8 articles from this issue
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HIDEAKI MITSUI, MASAYUKI ZUGUCHI, SHOKI TAKAHASHI, IZURU YOSHIDA, SHIN ...1995 Volume 175 Issue 4 Pages 219-223
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMITSUI, H., ZUGUCHI, M., TAKAHASHI, S., YOSHIDA, I., MARUOKA, S., SHIMANUKI, Y., SATOH, A. and SAKAMOTO, K. A Simple Maneuver in Follow-Up Digital Subtraction Angiography for Multiple Coronary-Aorta Bypass Grafts. Tohoku J. Exp. Med., 1995, 175 (4), 219-223 - A simple maneuver in intraarterial digital subtraction angiography (DSA) is proposed to improve the images of left internal thoracic artery bypass grafts (LITAGs). A contrast flush in the left subclavian artery, using a catheter that had been percutaneously introduced from the left brachial artery, was carried out in 14 patients with multiple coronary-aorta bypass grafts (CABGs) after aortic DSA. The side-hole portion of the catheter tip was positioned in the proximal left subclavian artery as the coiled portion remained in the aortic arch. Nonionic contrast medium (350mg/ml of iodine) was injected with an automatic injector in a volume of 6-8ml and at a flow rate of 3- 4ml/sec. Left subclavian arterial flush DSA delineated the LITAGs excellently in 11, well in 3, and fairly or poorly in none of the 14 cases. There were no complications in any of these cases. A supplemental contrast flush of the left subclavian artery with a pigtail catheter following aortic DSA improves the diagnosis of multiple CABG patency.View full abstractDownload PDF (1018K) -
HIROYUKI SUZUKI, KAZUHIRO TAKAHASHI, SHIGEKI SHIBAHARA1995 Volume 175 Issue 4 Pages 225-233
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSUZUKI, H., TAKAHASHI, K. and SHIBAHARA, S. Evidence for the Presence of Two Amino-Terminal Isoforms of Neurofibromin, a Gene Product Responsible for Neurofibromatosis Type 1. Tohoku J. Exp. Med., 1995, 175 (4), 225-233-Neurofibromatosis type 1(NF1) is a common autosomal dominant disorder, primarily affecting cells of neural crest origin, and is characterized by cafeé-au-lait skin spots, multiple neurofibromas, and higher incidence of malignancy. A gene linked to NF1 encodes neurofibromin, an established function of which is to stimulate intrinsic GTPase activity of ras protein. The neurofibromin gene gives rise to multiple transcripts generated by alternative splicing, that encode various neurofibromin isoforms. In this study, we have cloned a cDNA encoding a newly identified species of a putative amino-terminal isoform which lacks a large portion of neurofibromin, including the domain related to GTPase-activating protein. This clone carries the insert of 2.7kb, coding for a protein of 593 amino acid residues, tentatively termed N-isoform 11, whose amino-terminal 574 residues are identical to those of authentic neurofibromin encoded by the eleven exons located at the 5' portion of the gene. Previously, we cloned a cDNA coding for a similar isoform of 551 amino acid residues, termed N-isoform 10, whose amino-terminal portion is encoded by the first ten exons. The molecular weights of these two deduced N-isoforms are consistent with the values determined by in vitro translation of the mRNA transcribed from each N-isoform cDNA. The presence of the amino-terminal isoform(s) suggests the physiological significance of the amino-terminal portion of neurofibromin.View full abstractDownload PDF (1298K) -
AKIRA WATANABE, KOTARO OIZUMI, KAZUHIRO MATSUNO, TAKESHI NISHINO, MASA ...1995 Volume 175 Issue 4 Pages 235-247
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWATANABE, A., OIZUMI, K., MATSUNO, K., NISUINO, T., MOTOMIYA, M. and NUKIWA, T. Antibiotic Susceptibility of the Sputum Pathogens and Throat Swab Pathogens Isolated from the Patients Undergoing Treatment in Twenty-one Private Clinics in Japan. Tohoku J. Exp. Med., 1995, 175 (4), 235-247 - Bacteriology of the respiratory isolates from 2, 539 patients with respiratory infections in 21 primary care clinics was documented. Of a total of 1, 887 strains of potential pathogens recovered from 1, 507 patients, 996 were gram-positive and 891 were gram-negative. Major pathogens were Staphylococcus aurus, Haemophilus influenzae, Streptococcus pneumoniae and Streptococcus pyogenes. The MIC's against microbial isolates of six antimicrobial agents were determined. Ciprofloxacin and ofloxacin were more active against S. aurues, Moraxella catarrhalis and Pseudomonas aeruginosa, and ampicillin and cefteram were more active against S. pneumoniae and S. pyogenes than four other antimicrobials tested, respectively, in this experiment. New quinolones and new generation cephems were active against H. influenzae and Enterobacteriaceae. Only one strain of S. auruus was methicillin-resistant. As regards other pathogens, 6.5% of S. pneumoniae and 14.9% of H. influenzae were resistant to ampicillin, and 26.7% of H. influenzae were β-lactamase-positive. MRSA was found infrequently. But ampicillin-resistant S. pneumoniae and H. influenzae were found in primary care clinics almost as frequently as in intensive-medication-oriented clinics.View full abstractDownload PDF (1054K) -
HAJIME TAMURA, ISAO YANAGAWA, TAKEO HIKICHI, KO MATSUMOTO, SHOKI TAKAH ...1995 Volume 175 Issue 4 Pages 249-267
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAMURA, H., YANAGAWA, I., HIKICHI, T., MATSUMOTO, K., TAKAHASHI, S. and SAKAMOTO, K. T1 Measurements with Clinical MR Units. Tohoku J. Exp. Med., 1995, 175 (4), 249-267 - To improve accuracy and feasibility of the proton spin-lattice relaxation time (T1) measurements in routine Magnetic Resonance Imaging (MRI), a phantom with polyvinyl alcohol gels and gadrinium diethylene triamine pentaacetic acid solutions was imaged with 1.5T clinical MR units and T1s were calculated by fitting several models to the observed signal intensities. When an inversion-recovery sequence was applied, we were able to measure T1 with a high degree of precision by taking into account the imperfection of the inversion pulse. With a Turbo-fast low angle shot sequence, we were able to obtain T1 in a short time, but low signal-to-noise ratio limited the precision. Signal intensity with SE sequence was susceptible to variation with the effective flip angle of 90° RF pulse and not suited for T1 measurement.View full abstractDownload PDF (1590K) -
MAKOTO MIKI, TOYOHARU ISAWA, TAKEO TESHIMA, YOSHIKI ANAZAWA, ASIF MUJT ...1995 Volume 175 Issue 4 Pages 269-278
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMIKI, M., ISAWA, T., TESHIMA, T., ANAZAWA, Y., MAHMUD, A.M. and NUKIWA, T. Establishment of a Cell Line from an Adenocarcinoma of the Lung Producing Carcinoembryonic Antigen (CEA) and CAJ9-9. Tohoku J. Exp. Med., 1995, 175 (4), 269-278 - An adenocarcinoma cell line was established from pleural effusion of a 67-year-old woman and designated as TK-SA. The population doubling time of the cells was 100.4hr. Chromosomal analysis revealed the TK-SA to have human aneuploid chromosomes with a near-triploid mode. Ultrastructurally, the TK-SA was compatible with adenocarcinoma. The cell line was highly tumorigenic. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide dye assay demonstrated resistance of the cell line to Cis-platin (CDDP), Cyclophosphamide (CPM) and Tegafur/Uracil (UFT). High carcinoembryonic antigen (CEA) and CA19-9 levels were similar in patient's serum and conditioned medium.View full abstractDownload PDF (2112K) -
WAKO NAKAJIMA, KIKUO SAKEMI, KAZUO KOMATSU, TOSIHIRO OKAMURA1995 Volume 175 Issue 4 Pages 279-284
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKAJIMA, W., SAKEMI, K., KOMATSU, K. and OKAMURA, T. Partial 6p Trisomy with Abnormal ABR and Hypogenesis of the Corpus Callosum. Tohoku J. Exp. Med., 1995, 175 (4), 279-284 - A case of 4-month-old male infant with the karyotype 46, XY, -21, +der(21), t(6;21)(p22; p13) mat is reported. His cranial magnetic resonance imaging (MRI) suggested hypoplastic corpus callosum and auditory brain stem response (ABR) revealed brain stem dysfunction.View full abstractDownload PDF (1381K) -
AKIRA NAITO, MICHIHIRO YAJIMA, HIDEHIKO FUKAMACHI, KOJI USHIKOSHI, YIN ...1995 Volume 175 Issue 4 Pages 285-288
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAITO, A., YAJIMA, M., FUKAMACHI, H., USHIKOSHI, K., SUN, Y.-J. and SHIMIZU, Y. Electromyographic (EMG) Study of the Elbow Flexors during Supination and Pronation of the Forearm. Tohoku J. Exp. Med., 1995, 175 (4), 285-288 - Activities of the elbow flexors during supination and pronation of the forearm in a normal human volunteer were studied by an electromyography (EMG). The volunteer performed the movement slowly or quickly holding elbow flexion at various angles with or without a load. The biceps brachii showed an increase and a decrease of EMG activities during supination and pronation, respectively. The brachialis and brachioradialis showed a reduction and an increment of EMU activities accompanied by an increase and a decrease of EMG activities in the biceps brachii, respectively. These findings seem to indicate that reciprocal contractions among the elbow flexors permit the biceps brachii to work for supination without an induction of elbow flexion.View full abstractDownload PDF (394K) -
SHINICHI OKUYAMA1995 Volume 175 Issue 4 Pages 289-292
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKUYAMA, S. Antibiotic Pasting for Foul Putrefactive Cancers. Tohoku J. Exp. Med., 1995, 175 (4), 289-292 - Putrefaction of cancers is infrequent. Nonetheless, it presents a difficult clinical problem of foulness. We prepared 5% antibiotic pastes by adding sodium polyacrylate to aliquots of antibiotic solutions, and applied them to putrefactive lesions in 4 cases of rectal cancer, 2 of breast cancer and 1 of tongue cancer. The putrefaction was promptly brought under control in all of them, permitting an improved QOL. Concomitant application of anticancer pastes was also found remarkably effective. Use of sulperazone may offer a better chance of overcoming the β lactamase barrier in cases of prolonged useView full abstractDownload PDF (5179K)
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