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Volume 127 (1979)
- Issue 4 Pages 301-
- Issue 3 Pages 201-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
Volume 127, Issue 2
Displaying 1-15 of 15 articles from this issue
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TOKIHISA KIMURA, KUNIAKI MATSUI, KOZO OTA, KAORU YOSHINAGA1979 Volume 127 Issue 2 Pages 101-111
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA 23-year-old man, diagnosed as having a pituitary adenoma at the age of 17 and received an operation 1 month ago showed a fluctuating hypernatremia and hypodipsia. The water deprivation, water load and hypertonic saline infusion tests were carried out. After a 14-hr water deprivation test, plasma osmolality was 310 mOsm/kg, plasma ADH was 1.5 μU/ml, and urine osmolality was 591 mOsm/kg. On the water load test subsequently performed, the plasma osmolality decreased to 297 mOsm/kg, but the urine was still hypertonic. Infusion of 2.5% saline solution elicited paradoxically a marked diuresis and dilution of urine depsite the elevation of plasma osmolality. On the treatment with carbamazepine and clofibrate, the urinary osmolality increased, the hypernatremia was normalized, and a marked natriuresis was elicited with a gain in body weight. These results suggested that the secretion of ADH is regulated by changes in blood volume rather than by the plasma osmolality in this patient. The hypernatremia may be explained as a disturbance or lack of osmoreceptor function for ADH release and the loss of thirst sensation, though the volume receptor still remains functioning for ADH secretion. Depletion of the extracellular fluid volume may be another contributing factor to the elevation of serum sodium level by enhancing the reabsorption of sodium from renal tubules.View full abstractDownload PDF (666K) -
KIMMO KYÖSOLA1979 Volume 127 Issue 2 Pages 113-117
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe presence of adrenergic axons within the sphincter of Oddi of the cat and dog was demonstrated using the glyoxylic acid-induced fluorescence histochemical method. After vagotomy (in cats), no reduction was observed in the number of the adrenergic axons or in the fluorescence intensity. It is concluded that the sphincter of Oddi receives direct adrenergic neural control derived from the sympathetic plexuses and ganglia, whereas the vagal contribution of adrenergic axons is negligible, if it exists at all.View full abstractDownload PDF (748K) -
TAKESHI YOSHIDA, YUTAKA HATTORI, HIROSHI SUZUKI, KIICHIRO NODA1979 Volume 127 Issue 2 Pages 119-122
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSChanges in serum prolactin concentration were investigated in women taking an oral contraceptive pill and patients treated with combined estrogen-gestagen regimens for uterine endometriosis. The serum prolactin value increased more than twice the initial level one week after the beginning of medication and continued to increase over succeeding three weeks, and it returned to the normal value at one week after discontinuation of the medication. The results obtained demonstrate that an inverse correlation of prolactin and gonadotropin secretions occurred during administration of the steroid sex hormones as seen in post partum period or patients with galactorrhea-amenorrhea. Side effects which may be associated with such combined steroid hormone has also been discussed.View full abstractDownload PDF (230K) -
SEIKI ITO, YUKIO YAMADA, MUTSUKO HAYASHI, YOUICHI IWASAKI, YOUICHI MAT ...1979 Volume 127 Issue 2 Pages 123-131
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBy using immunoperoxidase and immunofluorescence techniques, the localization of neurotensin-positive cells and somatostatin-positive cells in the canine gut was examined on the same sections. Neurotensin-positive cells were found only in the jejunum and ileum, while somatostatin-positive cells were distributed throughout the stcmach and all parts of the small intestine. These two types of cell in the jejunum and the ileum had no direct cellular contact with each other. Based on the hypothesis that somatostatin may inhibit the release of some peptide hormones through junctional complexes of cells, the possibility of functional interaction between neurotensin and somatostatin was discussed.View full abstractDownload PDF (2484K) -
MASAKAZU SAKITA, YUKINOBU NISHIMURA, ATSUSHI TAKENAKA, OSAMU KOJIMA, B ...1979 Volume 127 Issue 2 Pages 133-141
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to elucidate the effect of surgical removal of the regional nodes on the immunological defence of the host against the tumor, as well as on the cure rate of C3H/He mice transplanted with MH 134, three separate experiments were carried out, and the following results were obtained: 1) The cure rates of mice treated by removal of the primary tumor with regional lymph nodes were significantly lower than that of mice treated by simple amputation without regional lymphadenectomy. 2) It was demonstrated by a bioassay of the regional node that viable tumor cells presented in the nodes prior to the operation disappeared after removal of the primary tumor, whereas in 60Co irradiated mice prior to the tumor inoculation, such phenomena were not observed. 3) Observation utilizing in vivo neutralization revealed that regional lymph node cells were capable of interfering with growth of tumor cells. These findings suggest that removal of the regional nodes impairs the restraint to the growth of residual tumor after the removal of the primary tumor, and this is probably due to a derangment of the iuismunologic response of the host.View full abstractDownload PDF (1050K) -
SOHEI MAKINO, CHARLES E. REED1979 Volume 127 Issue 2 Pages 143-149
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSpleen fragments of Balb/C mice were immunized with sheep red blood cells in vitro and hemolytic plaque forming cells (PFC) were assayed on the 5th day of immunization. Epinephrine in culture medium diminished the number of PFC dose-dependently over the range from 10-6M to 2.7×10-4M. Incubation with 9×10-5M epinephrine diminished PFC response only when the epinephrine was present on the first day of the culture. No suppression was found for treatment during any other 24-hr periods. Three beta-adrenergic stimulating catecholamines, epinephrine, isoproterenol, and norepinephrine, suppressed PFC response in similar degree. It is concluded that beta-adrenergic stimulation suppressed 19-S antibody formation mainly by inhibiting induction of immune response.View full abstractDownload PDF (383K) -
KENICHI KITANI, REIKO MIURA, MASAHIKO IUCHI1979 Volume 127 Issue 2 Pages 151-156
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFifty six patients with chronic Schistosomiasis japonica were given skin tests with preparations made of Schistosora mansoni and Schistosoma japonicum. There was a high, significant positive correlation between the results of both antigens. Among 47 serum samples tested with indirect hemagglutination (IHA) 27 had the antibody titer 1:16 or higher, which was diagnostically significant in combination with positive skin test results. The results indicate a definite cross reactivity of japonicum and mansoni anitgens in patients with Schistosomiasis japonica.View full abstractDownload PDF (326K) -
SHIRO KOSAKA1979 Volume 127 Issue 2 Pages 157-160
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA new antigen which is different from Epstein-Barr virion antigen was detected in NC-37 cells infected with Epstein-Barr virus (EBV). A significant elevation of the titer of antibody to this new antigen was observed in the sera of the patients with rheumatoid arthritis (RA), but not in the sera of controls. From the standpoint of the etiologic role of EBV in RA, it is interesting that the antibody to the new antigen is not detected in the healthy persons in contrast to other viral antibodies. Therefore, it differs from any other viral antibodies so far reported.View full abstractDownload PDF (236K) -
TATSUHITO TONO-OKA, MASAYUKI NAKAYAMA, EIKI GOTOHDA, TAKEO TAKEDA1979 Volume 127 Issue 2 Pages 161-167
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAgents known to increase intracellular levels of cyclic 3', 5'-adenosine monophosphate (cyclic AMP) were examined for their effect on tissue factor generation by mononuclear cells cultured with E. coli endotoxin. Aminophylline, an inhibitor of phosphodiesterase, and epinephrine, a β-adrenergic agent, showed an inhibitory effect, and these effects were reversible. Moreover, dibutyryl cyclic AMP also exhibited the effect. Dibutyryl cyclic GMP, however, did not enhance the tissue factor generation by mononuclear cells. On the basis of these observations, it was concluded that the phenomenon of tissue factor generation by mononuclear cells is a biological event, and that intracellular cyclic AMP has a possible role in modulating this phenomenon.View full abstractDownload PDF (381K) -
HIROSHI KANEDA, JUN MATSUMOTO, TAKESHI HARUYAMA, KIYOHIKO YOSHIKAWA, M ...1979 Volume 127 Issue 2 Pages 169-175
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe have seen 11 diabetic uremic patients who had long history (for 12 years on an average) of diabetes mellitus and were under long-term dialysis treatment (for 16.5 months on an average). Ten out of 11 patients had severe hypertension. In addition, 61 non-diabetic uremics and 10 non-diabetic uremics treated with β-blocker were subjected to the present study in an attempt to analyze the mechanisms of the low levels of resting (pre-dialysis) plasma renin activity (PRA) and post-dialysis PRA of the diabetic uremic patients. In diabetic uremics, resting PRA was positively correlated to the pulse pressure/diastolic blood pressure ratio, but negatively correlated to ΔPRA/removed-sodium and ΔPRA/removed-water which were very low levels in these patients. These facts indicate that the stimulation of renin release by the preceding dialysis cannot positively influence the resting PRA before the next dialysis, and that hypertension in these patients was partly related to the resting PRA. Post-dialysis PRA in diabetic uremics was significantly correlated to ΔPRA/removed-water, but not to ΔPRA/removed-sodium. The suppressed levels of post-dialysis PRA in these patients might be caused by low ΔPRA/removed-water and ineffective stimulation of sodium removal to the renin release. We suspected the possibility that the common cause of low levels of both resting and post-dialysis PRA might be partly related to the diabetic neuropathy.View full abstractDownload PDF (443K) -
SATOSHI KITAMURA, YOKO ISHIHARA, KINORI KOSAKA1979 Volume 127 Issue 2 Pages 177-181
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSRadioimmunoassay of 5α, 7α-dihydroxy-11-keto-tetra-norprosta-1, 16-dioic acid, main urinary metabolite of prostaglandin F2α (PGF2α-MUM), was performed in patients with various respiratory diseases including diffuse interstitial fibrosing pneumonitis (DIFP, fibrosing alveolitis). Twenty-four hr excretion of PGF2α-MUM in patients with primary lung cancer, pulmonary fibrosis secondary to collagen diseases and stationary DIFP was normal. On the other hand, 24 hr excretion of PGF2α-MUM in patients with carcinomatous pleuritis was high and that in patients with aggravating DIFP was markedly high. There was no correlation between serum LDH levels and 24 hr excretion of PGF2α-MUM.View full abstractDownload PDF (212K) -
KENICHI KOHNO, TOSHIHARU YAMAGUCHI, TOSHIO TAKAHASHI1979 Volume 127 Issue 2 Pages 183-188
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIntralymphatic inoculation of rat ascites hepatoma AH 130 was carried out to elucidate the function of the regional lymph node as a barrier against tumor spread. Tumor cells reaching regional lymph nodes decreased in number 48 to 72 hr after inoculation. Ten percent of tumor cells injected into lymphatic vessels appeared in the thoracic duct within 3 hr after injection. Bioassay tests revealed that transnodal tumor cells were viable in the thoracic duct.View full abstractDownload PDF (270K) -
EIJI ISHIZAWA, TOGO HORIGUCHI, TAKASHI ITO, SHIGEO YAMAKI, KIYOHARU SA ...1979 Volume 127 Issue 2 Pages 189-195
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThis paper presents our recent results of the Mustard procedure (intra-atrial baffle operation) for the complete transposition of the great arteries performed in 24 infants and children during the past 6 years at the Tohoku University Hospital. All intracardiac repairs were performed using “bypass hypothermia” (surfaceinduced deep hypothermia, circulatory arrest, and limited cardiopulmonary bypass). The hospital mortality rate was 8% in patients with simple transposition without pulmonary hypertension (Group I, one death in 12 patients), 50% in patients with ventricular septal defect (VSD) and pulmonary hypertension (Group II, 3 deaths in 6 patients), and 20% in patients with VSD and pulmonary stenosis (Group III, one death in 5 patients). Various types of longstanding dysrhythmia were found in 6 out of 18 long-term survivors, and subsequent pace-maker implantation was necessary in one infant. Postoperative pulmonary venous obstruction occurred in 3 infants, and surgical relief of the obstruction was successfully undertaken in 2 of them. Prevention of postoperative dysrhythmia, pulmonary venous obstruction, and possible brain damage are also discussed.View full abstractDownload PDF (458K) -
TETSUHIRO OHMI, SUETSUGU MUE, MAKOTO TAKAHASHI, SHIGEKI SHIBAHARA, KOH ...1979 Volume 127 Issue 2 Pages 197-198
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAsthmatic patients who showed an allergic skin reaction to house-dust antigen (HD) were injected intradermally with a mixture of HD and a various dose of isoproterenol (Isopr) or propranolol (Propr). In some cases Isopr clearly suppressed the formation of the wheal, but in some others Isopr did not much affect the allergic skin reaction. Also Propr increased markedly the skin reaction of some patients, or had little effect on it. The sensitivity of the skin of asthmatic patients to these drugs was closely correlated with the general response of the patients to adrenaline, such as changes in heart rate, diastolic blood pressure, blood glucose level, and blood triglyceride level.View full abstractDownload PDF (145K) -
YOSHIRO YOSHIDA, ASAO TOMOE, MORIKUNI FUKUDA, SHIGEO YAMAKI1979 Volume 127 Issue 2 Pages 199-200
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe ratio of the right ventricular preejection period to the right ventricular ejection time was calculated from the echocardiogram of the pulmonic valve before and after inhalation of a high concentration of oxygen in pulmonary hypertensive patients. The results showed that this non-invasive method could differentiate pulmonary vascular disease from non-pulmonary vascular disease and hence useful for evaluating the change of the pulmonary vascular bed in the pulmonary hypertensive patients.View full abstractDownload PDF (768K)
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