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Volume 81 (1963 - 196･･･
- Issue 4 Pages 297-
- Issue 3 Pages 207-
- Issue 2 Pages 107-
- Issue 1 Pages 1-
Volume 81, Issue 4
Displaying 1-7 of 7 articles from this issue
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Haruo Sato, Hiroshi Satoh, Keiji Fujii1964 Volume 81 Issue 4 Pages 297-314
Published: January 25, 1964
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe resistance phenomenon of the hosts against the tumor growth was investigated by using Yoshida sarcoma and Donryu rats. The animals were treated in various ways such as by giving heterograft (transplantation of mouse tumors), injection of cell suspension of various organs, injection of B. C. G., or administration of trypan-blue, typhoid-paratyphoid vaccine, zymosan or india ink, prior to transplantation of Yoshida sarcoma. The acquired resistance was clearly demonstrated especially when small number of tumor cells were inoculated.
Heterografting was the most effective to induce the resistance of the host against the tumor growth, while the resistance was moderately induced by injec-tion of B. C. G. or typhoid-paratyphoid vaccine.
Based on the data obtained, correlation between the resistance of the host against tumor growth and the role of the reticulo-endothelial system was discussed.View full abstractDownload PDF (847K) -
Yukio Omori1964 Volume 81 Issue 4 Pages 315-321
Published: January 25, 1964
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe author studied the host-tumor relationship with the cellular and humoral response of the R. E. S. in the patients with gastric carcinoma. The cases with in-creased function of the R. E. S. showed low grade spread and metastasis of carcinoma to lymph nodes, and also better 5 years survival rate. Consequently, disorders of the local and general R. E. S. showed a marked effect on the growth and prognosis of tumor.
The author considers that these responses of the R. E. S. in the cancer patient seem to be anti-tumor like result.View full abstractDownload PDF (380K) -
Kiyosharu Takikawa1964 Volume 81 Issue 4 Pages 322-329
Published: January 25, 1964
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSReticulo-endothelial cells of liver, spleen, bone marrow, lymph nodes, thymus, subcutaneous connective tissue, omentum, mesentery, adrenal and hypophysis were demonstrated and defined by the classical vital staining technique with lithion carmine. Further, the increase of vitally stained cells and that of vital staining in a single cell by repeated injection of the dye-stuff or carbon particles were demonstrated and discussed, and it was shown clearly by the radio-auto-graphic technique with tritiated thymidine that Kupffer's stellate cells possessed more active mitotic activity than that of the liver cells.
Cytochemical stainings adopted for demonstration of functional states of the reticulo-endothelial cells in fresh section cut with a criostat were PAS, Sudan black B, succinic dehydrogenase, labile and stable oxidase, peroxidase, phosphorylase, acid and alkaline phosphatase, esterase and aminopeptidase stain-ings, and it was concluded that esterase and acid phosphatase were mainly localized in the reticulo-endothelial cells and represented their functional states well.View full abstractDownload PDF (1383K) -
Takeo Yamori, Yoshitaka Mori1964 Volume 81 Issue 4 Pages 330-339
Published: January 25, 1964
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSReticulum cells in the lymph nodes and the spleen, and histiocytes in the subcutaneous connective tissue were both studied with electron microscope.
Reticulum cells showed marked development of endoplasmic reticules both rough and smooth varieties, and were classified with their fine structures into the mature, ingesting, immature and productive types. In the productive in-flammatory lesions, the proliferation of the cell ensued from both mitotic division of the productive type and differentiation from the immature type and lymphoblast-like cells.
Subcutaneous histiocytes had originally no or few rough surface endoplasmic reticula and well developed smooth surfaced ones. When the animal was sensitized or stimulated, however, histiocytes showed rather marked developing of rough surfaced endoplasmic reticula resembling the reticulum cells. These findings seemed to suggest the ability to synthesize some protein-like antibody.
As for plasma cells, the most immature type showed a large nucleus with distinct nuceloli, and scanty cytoplasm with poorly developed endoplasmic reticula, rich free RNP granules and large mitochondria. The transformation from reticulum cells, however, were not observed in the lymph nodes.View full abstractDownload PDF (1755K) -
Fine Structures of the Cells of the Reticuloendothelial System and Their Correlation to the FunctionTamenori Onoé, Hideyuki Tsukada1964 Volume 81 Issue 4 Pages 340-349
Published: January 25, 1964
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSOutstanding traits of fine structures of the reticuloendothelial cells comprise the following triad: the presence of complicated cytoplasmic processes, abundance in the agranular endoplasmic reticulum profils, and the presence of the specific granules as well as phagocytotic granules.
These characteristics are regarded as morphological evidences of the specific function of this cell species, pinocytosis and phagocytosis. Besides complicated cytoplasmic processes and phagocytotic granules which are undoubtedly manifestations of phagocytotic activity of the cells, an abundance in the agranular endoplasmic reticulum profils might be emphasized as a reflex of active pinocytosis, as is suggested by the images in the early phase of the saccharated iron uptake by the cell.
The specific granules are identified as dense granules bounded by a single membrane and 0.2-0.3μ in diameter, and are considered to be comparable to those of neutrophilic leukocytes.
In connection with correlation between fine structures and function, intracellular distribution of acid phosphatase and beta-glucuronidase was biochemically examined to show that these lysosomal enzymes localize predominantly in the cytoplasmic particulate fractions in which phagocytotic granules are mostly confined.View full abstractDownload PDF (2041K) -
Kinichiro Kajikawa1964 Volume 81 Issue 4 Pages 350-365
Published: January 25, 1964
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSElectron microscopic studies have been made on the ultrastructure of his-tiocytes of the subcutaneous connective tissue, in normal development of the cells and in various pathological conditions.
The histiocytes are morphologically characterized by predominance of the smooth components of the endoplasmic reticulum and abundance of cytoplasmic inclusion bodies. The cytoplasmic inclusion bodies observed in the present study can be divided into three types by their structure and origin. The first type called “H-granule (histiocyte granule)” in this study, is produced by accumulation of dense materials into the vesicles separated from the smooth-surfaced reticulum. The second type, “cytolysome”, results from sequestration of the focal cyto-plasmic degeneration. The third type, “phagosome”, originates in the vacuoles containing phagocytized materials. All these heterogenous inclusion bodies are considered to be involved in the digestion of materials of both exogenous and endogenous origins.View full abstractDownload PDF (4653K) -
Eiji Suda1964 Volume 81 Issue 4 Pages 366-372
Published: January 25, 1964
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe author tried the therapy of epidemic kerato-conjunctivitis with local-instillation of convalescent serum in 47 patients. Other 12 patients were given normal serum as controls. The following are the results from the con-valescent serum therapy: The conjunctival inflammation was reduced day by day, and the subjective symptoms also became less. Of 34 cases of monocular infection, 30 (88%) stayed unaffected in the other eye, and four were affected during the course of the disease. No corneal lesion (complication) was seen in 26 cases. There were six cases where the corneal lesion was seen already at the first visit and disappeared with the treatment. Thus, no corneal complication was seen in 32 cases (68%). Even when the complication was seen, it was not as severe as in cases treated otherwise. The average period for the cure was 16 days from the onset of the disease.
The following are the results from normal serum therapy: Of the 12 cases, only five cases (42%) showed no contagion to the other eye. Eight cases (67%) showed the corneal complications. The average period for the cure was 19 days. The author concluded that the convalescent serum therapy is remarkably effective in the treatment of EKC. And, it is highly recommended that the convalescent serum be stored routinely.View full abstractDownload PDF (347K)
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