This patient had marked polyclonal hyperimmunoglobulinemia associated with mesothelioma in the right sub-phrenic space. Histopathologically the lymph nodes around the mesothelioma showed marked plasma cell proliferation intermingled with infiltration of mesothelioma cells. The plasma cell proliferation was observed even in distant lymph nodes not infiltrated by the tumor cells. The review of the literature disclosed rather frequent occurrences of hyperimmunoglobulinemia in mesothelioma and significance of this association should be stressed.
Urine samples were collected from fasting subjects after maintaining posture for 2 hr in early morning. Urinary angiotensin II was extracted with SE-Sephadex. The extracts, after being dissolved in phosphate buffer, pH 7.5, were measured by radioimmunoassay. Recovery, sensitivity and accuracy were found to be satisfactory. The normal values obtained from 6 subjects were 52-280 pg/2 hr. The values were almost normal in essential hypertension and in chronic glomerulonephritis. They were high in 3 out of 6 cases with renovascular hypertension and subsequently dropped after surgery. In 6 cases with primary aldosteronism, very low levels were found. These increased after the removal of adrenal adenomas. No positive correlation between simultaneous plasma and urinary angiotensin samples was apparent. Also no positive correlation between urinary angiotensin and urine volume was found. In renovascular hypertension, during glucose infusion, lower values in urine volume and angiotensin excretion were observed on the stenotic side as compared to the intact side. Thus, the angiotensin excretion rate does not appear to be regulated by arterial angiotensin cencentration, but rather by the angiotensin perfusion rate.
The conversion mechanism of prothrombin into thrombin was studied with purified factors in the limited proteolysis system. The purified prothrombin was utilized for the reaction of conversion of prothrombin into thrombin by Russell's viper venom, and the molecular weights of products were determined as follows by SDS polyacrylamide disc electrophoresis: Peak I, 32, 000±500; Peak II, 62, 000±1, 000; Peak III, 28, 000±500. Peak I contained a thrombin activity. Peak II contained a prothrombin activity. Peak III was suggested to contain a degraded product of prothrombin.
Effects of low-frequency stimulation of thalamic midline nuclei (MID) upon unitary activities of principal (P) and internuncial (I) cells of the lateral geniculate body were examined in urethane-anesthetized rats. P-cells responsed to single shocks to the optic tract (OT) with single spikes at short latencies (initial spike, IS), followed by a phase of inhibition which lasted for more than 150 msec and ended with a burst of grouped discharges (late discharge, LD). Excitability of P-cells, assessed with the response probability of IS to testing OT shocks, was reduced for about 300 msec after single shock stimulation of MID. Usually this excitability depression became evident about 20 msec after MID shocks and was maximum from 50 to 100 msec. LDs were made more vigorous when MID shocks were given almost simultaneously with testing OT shocks. This was interpreted that MID stimulation induced an inhibition in P-cells and it summed with that induced by OT stimulation. That the MID-induced inhibition of P-cells was due to IPSPs was proved by the quasi-intracellular recording. I-cells, the units fired repetitively by single OT shocks and have been presumed to be inhibitory neurons acting upon P-cells, were found to receive from MID stimulation an excitatory effect followed by an inhibitory one of long duration. It was suggested that the primary inhibition of P-cells by low-frequency stimulation of MID would be a direct consequence of the primary excitation of I-cells.
Comparison between the pancreozymin-secretin test and the parotid saliva test was made in regard to the reliability as diagnostic means for pancreatic disorders on 22 subjects in total, consisting of 12 patients with pancreatic disorders and 10 with non-pancreatic disorders. The data indicated that in this series a positive parotid saliva test is 90.9% accurate in diagnosing pancreatic disorders, whereas a positive pancreozymin-secretin test is only 50%. It was noteworthy that the pancreozymin-secretin test gave false positive results in 8 of 10 patients with non-pancreatic disorders, whereas the parotid saliva test gave negative results in all these cases.
Analyses of liver lipids revealed that triglyceride was increased significantly but not other lipids in patients with endogenous hypertriglyceridemia. Oleic acid was most increased among the fatty acids of liver triglyceride. The liver triglyceride content was varied from patient to patient. No significant correlation was found between the increase in liver triglyceride and the degree of hypertriglyceridemia.
The coronary sinus and the aortic root were catheterized in ten patients without heart disease. Cardiogreen dye was injected into the aortic root and the dye-dilution curve was recorded from the coronary sinus. Coronary circulation time calculated as mean transit time of the dye ranged from 4.7 to 11.2 sec with an average of 8.1±2.1 sec. The appearance time and peak concentration time of the dye were 3.8±1.2 sec and 4.7±1.8 sec, respectively. Although coronary circulation time had no significant correlations with age, body surface area, heart rate, aortic blood pressure, arterial oxygen saturation, oxygen content of arterial or coronary sinus blood, myocardial oxygen consumption, coronary vascular resistance, and coronary sinus blood flow, it correlated with coronary arteriovenous oxygen difference. It is suggested that coronary circulation time may be shorter than the circulation time through kidney or liver and longer than that through lung or brain, and that coronary circulation time may be an important index in the evaluation of coronary circulation.
Soluble tyrosinase isolated from the Harding-Passey mouse melanoma was incubated with 14C-dopa and the time course of disappearance of dopa was measured by radioactivity assay at various tyrosinase concentrations. At the end of certain incubation periods, the tyrosinase activity was lost and the dopa concentration reached at stationary levels depending on the initial tyrosinase concentrations. The kinetic studies were carried out in order to analyze the relationship between the amount of tyrosinase incubated and the amount of dopa disappeared at various incubation periods. The results of the kinetic treatments indicated that inactivation of tyrosinase occurred mainly in proportion to the total concentration of tyrosinase present and the inactivation due to the binding with reaction products did not seem to play an important role in the mechanism. In other words, the inactiva-tion mechanism involved appears to be simlar to the reaction inactivation, which is known to occur in the reaction of plant tyrosinase.
In immobilized rabbits the fatal course asphyxiated by the cessation of artificial respiration was characterized by the sequence of events: disappearance of surface EEG, final bradycardia on ECG, disappearance of deep EEG (midbrain reticular formation) and final tachycardia. It was demonstrated that the stage of final tachycardia virtually might coincide with the stage of deprivation of brain stem function.
Size and weight of prostates were measured in 95 cases by means of transrectal ultrasonotomography. It was found that transrectal ultrasonotomography was the best method for this purpose. The measured sizes and weights of the prostate in normal subjects and in patients with several prostatic diseases were then compared. It was not always possible, however, to decide whether the prostate was normal only from these measurements.
Dyschondrosteosis, also known as Lèri-Weill syndrome, is characterized by mesomelic dwarfism and Madelung's deformity. The association of this disorder with various endocrine, metabolic or intelligence abnormalities has not been described. We have, however, recently seen two such cases of dyschondro-steosis. One had goiter, diabetes mellitus, hydronephrosis and mental deficiency since childhood; the other had hyperthyroidism. Our observation suggests that dyschondrosteosis may not only be related to Madelung's deformity but also to various endocrine dysfunctions through genetic involvement.
Tonoko, which is broadly used in processing wooden furnitures in Japan, has not been accepted as a causal substance of pneumoconiosis. Three cases of pneumoconiosis were found among four workers who have been engaged in wooden furniture painting and have dealt with tonoko daily for more than ten years. The atmosphere in their working room is always dusty and it is supposed that the main content of the dust is tonoko. Analysis revealed that tonoko was a soil substance which contained about 50% quartz. The results support the assumption that their disease may be referable to tonoko inhalation.
An improved type of silicone prosthesis is inserted just below the tunica albuginea penis into the cavernosum of the penis. Soft silicone constitutes the tip and base of the prosthesis to avert intra-vaginal impacts. The base with soft silicone helps the intrapenial prosthesis bend freely around the pubis, and can be cut short to make the length match the individual penis. These advantages of our new flexible silicone penile prosthesis relieve the patients with organic impotence from distress.