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Volume 117 (1975)
- Issue 4 Pages 299-
- Issue 3 Pages 203-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 117, Issue 1
Displaying 1-14 of 14 articles from this issue
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HIROSHI AKIBA, TAIZO KATO, HIROYURI NAKANO, MAKOTO SEIJI1975 Volume 117 Issue 1 Pages 1-13
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPrimary fibroblast cultures were obtained from 9 patients with xeroderma pigmentosum of various clinical types. Repair replication of the UV-damaged DNA in fibroblasts was studied by means of 3H-thymidine labeling and radio-autography. A DNA repair replication was found to be decreased in all xeroderma pigmentosum fibroblasts as compared with the control cells obtained from normal donors. The repair activities in cells from patients ranged from nearly 0% in two infant cases and one case of De Sanctis-Cacchione syndrome to approximately 100% in an adult moderate case. There was, however, no correlation between the level of repair replication and the severity of clinical symptoms. Since two cases which showed a lack of repair DNA replication were infant, it is assumed that these cases may develop De Sanctis-Cacchione syndrome in future. On xeroderma pigmentosum cells, a genetic analysis was performed with cell fusion methods using irradiated HVJ virus in order to determine the type of the complementation group. XP-1, XP-4 and XP-9 may be classified into the group D; XP-2, XP-7 and XP-8 into the group A; and XP-5 into the group E.View full abstractDownload PDF (3175K) -
AKIRA ISHIMORI, YOSHIKUNI MIURA, HIROYUKI SAKURADA, SUSUMU YAMAGATA, K ...1975 Volume 117 Issue 1 Pages 15-21
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSVarious criteria in gastric analysis currently used for the diagnosis of the Zollinger-Ellison syndrome were assessed in cases of endoscopically normal gastric mucosa, gastric ulcer and duodenal ulcer. New criteria consisting of BSV>350ml/hr, BAO>25mEq/hr, MAO>60mEq/hr, and BAO/MAO>0.7 were proposed to differentiate the Zollinger-Ellison syndrome and peptic ulcer.View full abstractDownload PDF (373K) -
YASUMASA HAYASHI, TETSU NAGATA1975 Volume 117 Issue 1 Pages 23-37
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSInfluences of saccadic eye movements upon excitability of cat superior colliculus (SC) were examined in chronic cats carrying implanted electrodes and in encephale isole cats. Excitability of SC was assessed by recording orthodromic responses of SC (SC ortho-response) to electrical stimulation of the optic chiasm. The SC ortho-response consisted of four components; i. e. presynaptic Tl and post-synaptic C1, C2 and C3. Eye movements suppressed the first two components (T1 and C1) and enhanced the latter two (C2 and C3). Retinal impulses caused by movements of images were found responsible for suppression of T1 and C1: 1) This was seen when cats moved eyes seeing external objects in light. In dark, neither Tl nor Cl received any influence from eye movements. 2) By moving visual stimuli rapidly before eyes of paralysed cats the same suppression of Tl and Cl was obtained. Suppression of Cl was deemed as a postsynaptic sign of SC for saccadic suppression.
In contrast to suppression of T1 and C1, enhancement of C2 and C3 was dependent upon a central factor: 1) Enhancement of C2 and C3 followed eye movements, independent of the ambient illumination. 2) Saccade-like movements of a slit of light in front of immobilized eyes never induced enhancement of C2 and C3. 3) PRF stimulation, effective to cause saccade-like eye movements, always elicited enhancement of C2 and C3, independent of the ambient condition and even after eyes had been immobilized. This phenomenon was interpreted as indicating that corollary discharges are sent to SC.View full abstractDownload PDF (904K) -
MASATUGU TAKAHASHI1975 Volume 117 Issue 1 Pages 39-47
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe principal cells of the geniculate nucleus are generally classified into two types in terms of their anatomical connection with the optic nerve fibers; the contralateral geniculate cell on which the contralateral optic nerve fibers make excitatory synapses and the homolateral geniculate cell on which homolateral optic nerve fibers synapse. In the present experiments, the organization of binocular inhibition in the two different types of geniculate cells was investigated in the cats anesthetized with a chloralose-urethane mixture. In homolateral geniculate cells, an action spike produced by a volley in the ipsilateral optic nerve was often suppressed by a conditioning volley in the contralateral optic nerve (binocular inhibition). In the contralateral geniculate neurons, a conditioning volley in the homolateral optic nerve only occasionally inhibited the generation of an action spike produced by a contralateral optic nerve volley. Intracellular recording from the geniculate cells confirmed the results obtained by extracellular studies. It was concluded that binocular interaction at the lateral geniculate level was seen more commonly in the homolateral geniculate cells than in the contralateral cells.View full abstractDownload PDF (523K) -
KISABURO AKASAKA, KIMIO KONNO, YASUO ONO, SUETSUGU MUE, CHOZO ABE, MUT ...1975 Volume 117 Issue 1 Pages 49-54
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe contribution of the bronchial smooth muscles to asthmatic attack has been supposed by many studies such as measurement of the intrabronchial pressure and bronchographical studies, but electromyographical evidence has not been established yet. A new bipolar platinum-ring electrode fixed on polyethylene catheter was invented in order to record action potentials from the bronchial smooth muscle through the intrabronchial lead. Action potentials obtained by this electrode were compared with those obtained by the direct peribronchial needle electrode during either artificial or spontaneous respiration in dogs and a monky. Electrophotographical analysis confirmed that action potentials obtained by our new electrode were similar in discharge pattern to those obtained by the direct peribronchial needle electrode. The active contribution of the bronchial smooth muscle to the maintenance of the bronchial caliber during spontaneous respiration was observed by our new electrode. Accordingly, this electrode is applicable to electromyo-graphical studies of the bronchial smooth muscle.View full abstractDownload PDF (1082K) -
KISABURO AKASAKA, KIMIO KONNO, YASUO ONO, SUETSUGU MUE, CHOZO ABE, MUT ...1975 Volume 117 Issue 1 Pages 55-59
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe succeeded in recording action potentials from the bronchial smooth muscles in 10 healthy males and 20 cases of bronchial asthma by means of the new electrode described by us in the preceding paper (Akasaka et al. 1975). From these electromyographic studies, we presented the direct evidence of spasm of the bronchial smooth muscles as one of the etiological factors responsible for the airway narrowing in asthmatic attack.View full abstractDownload PDF (1748K) -
KATUHIKO TOKITA, KYUHEI IKEDA, KUNIAKI KANNO, KENICHI SAITO, KEIZO CHI ...1975 Volume 117 Issue 1 Pages 61-67
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to evaluate low serum alpha- l-antitrypsin level as a contributory factor of combined emphysema in silicotic patients, serum alpha- l-antitrypsin analysis was carried out in 80 patients with silicosis. Low serum alpha-l-antitrypsin level was found in 5 patients. Large opacities were observed roenty genologically in only 1 out of these 5 cases in contrast to 31 of the other 75 cases. Also the suggestive findings for the emphysema were showed in 4 of these 5 cases while such findings were found on their chest X-ray films in only 43 of the other 75 cases. FEV1.0% below 50 were calculated in 3 of the 5 cases, on the contrary in 22 of the other 75 cases. RV above 50% predicted value was showed by all the 5 low antitrypsin patients, in contrast to only 25 of other 74 cases. The silicotic patients with low serum alpha- l-antitrypsin concentration are most likely to have an association with a high incidence of complicated emphysema.View full abstractDownload PDF (431K) -
HIROMICHI OHKAWA, MASAO WATANABE1975 Volume 117 Issue 1 Pages 69-77
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEffects of externally applied dopamine and other adrenergic stimulants on the electrical and mechanical activities of the cat small intestine were observed by using pressure electrodes. DOPA and dopamine reduced the spike and mechanical activities. The effects of dopamine were suppressed by treatment with phentolamine, phenoxybenzamine or propranolol. It seems that β-response is predominant. Noradrenaline and adrenaline also blocked the spike generation and depressed the mechanical activity. Inhibitory actions caused by noradrenaline and adrenaline were blocked by adrenergic blockers. However, no significant effects of normetanephrine and metanephrine were detected. Dose-response curves for acetylcholine with and without dopamine, isoprenaline, phenylephrine and noradrenaline were obtained. The curves with adrenergic stimulants were shifted to higher concentrations of acetylcholine. Possible actions of dompanine were discussed in relation to adrenergic receptors of the cat small intestine. It is concluded that dopamine acts on α- and β-receptors, and separate dopamine receptors could not be proposed by obtained results.View full abstractDownload PDF (548K) -
TAKAYOSHI TOYOTA, KANJI ABE, MIKIHIKO KUDO, KENICHI KIMURA, YOSHIO GOT ...1975 Volume 117 Issue 1 Pages 79-83
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of synthetic rat C-peptide 1 on insulin secretion from the isolated perfused rat pancreas was studied. The perfusion technique was according to the procedure described by Grodsky et al. (1963) with a few modifications. After about 20 min of stabilization, the pancreas was perfused for 40 min with synthetic rat C-peptide 1 (100ng/ml), during which (at 20 min) glucose concentration was switched from 2.7 to 16.6mM. Insulin response to glucose (16.6mM) was significantly decreased by the addition of the rat C-peptide 1 in advance when compared with those not pretreated with the C-peptide. In other experiments, the pancreas was exposed to glucose infusion (16.6mM) for 60 min. 20 min after the start of glucose infusion, the C-peptide (100ng/ml) was interposed for 20 min. The insulin secretion was reduced by the addition of the C-peptide. It is postulated that the C-peptide may have a role in the regulatory mechanism of the insulin secretion.View full abstractDownload PDF (253K) -
TAKUYA SAITO, MICHIYA TAKADA, KUNIHIRO OKAMURA, NAKAO ISHIDA1975 Volume 117 Issue 1 Pages 85-88
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe supernatant of phytohemagglutinin (PHA)-stimulated lymphocyte culture derived from pregnant women in the first two trimesters inhibited DNA synthesis of normal human lymphocytes after PHA induction. This soluble factor was heat-labile and the same factor could not be found in the supernatant generated from lymphocytes of pregnant women in 3rd trimester as well as from those of the non-pregnant. In contrast, the heatstable factor in the supernatant generated from lymphocytes of non-pregnant and pregnant women in all trimesters contained an stimulating factor on the DNA synthesis of normal human lymphocytes after PHA induction. An endogenous alternation in lymphocyte competence or an alternation in subpopulation of lymphocytes was suggested at the early stage of pregnancy.View full abstractDownload PDF (213K) -
KAZUYO HONDA, SACHIKO SHISHIDO, TSUGUYOSHI SUZUKI, HIDEO KUBO, REN CHI ...1975 Volume 117 Issue 1 Pages 89-91
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe plasma level of bromine was measured by a proton-induced X-ray emission spectroscopy. Since bromine is the most difficult halogen to be determined and appears only in trace quantities, powerful techniques are required. The excellent reproducibility was obtained on 19 measurements on a sample of a single individual; the coefficient of variation was 6.3%. The average and standard deviation of plasma bromine levels on 47 young women were 0.50 and 0.10mg/100ml, respectively. Results by other methods in the literature were briefly reviewed.View full abstractDownload PDF (191K) -
ISAMU YASUDA, KENICHI IWATSUKI1975 Volume 117 Issue 1 Pages 93-97
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSExperiments were carried out in isolated dog heart muscle to determine the direct effect of acryl bone cement monomer on the myocardial contractility. The monomer caused a dose-dependent decrease in the maximum velocity of shortening (Vmax) and the maximum force development (Fm), consequently resulting in a leftward shift of the force-velocity relation curves. There was also a concomitant decrease in work, power, the maximum rate of force development (max dF/dt) and time to peak force (TPF) from the onset of force development. These results indicate that acryl bone cement monomer exerts a direct negative inotropic effect on the myocardium and that the myocardial depression due to free monomer absorbed from the mixed bone cement into the systemic circulation during operation seems to be one of the major causes of the cardiovascular complications associated with the clinical application of bone cement.View full abstractDownload PDF (252K) -
TADAO ORII, KAZUKO SUKEGAWA, TOORU NAKAO1975 Volume 117 Issue 1 Pages 99-100
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA patient considered to represent a variant of GM1-gangliosidosis type 2 is described. Enzymic differences between the two clinical types 1 and 2 in GM1-gangliosidosis could be detected by Sephadex gel filtration procedure.View full abstractDownload PDF (115K) -
HIROSHI IZUMI, MAKOTO HAYAKARI, YOSHIKAZU KONDO, TSUNEMATSU TAKEMOTO1975 Volume 117 Issue 1 Pages 101-102
Published: 1975
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDopamine-β-hydroxylase was partially purified from bovine adrenal medulla and the effect of carnosine on the dopamine-β-hydroxylase activity was investigated. Carnosine significantly inhibited the enzyme activity at the concentrations higher than 0.5mM. According to the Lineweaver-Burk plots, the inhibition observed appeared to be a non-competitive type with the substrate, tyramine.View full abstractDownload PDF (125K)
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