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Volume 122 (1977)
- Issue 4 Pages 303-
- Issue 3 Pages 199-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 122, Issue 4
Displaying 1-14 of 14 articles from this issue
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TOSHIO SATO, TAKASHI MATSUSHIRO, NORIYOSHI SUZUKI, WATARU TAKAHASHI1977 Volume 122 Issue 4 Pages 303-312
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSOn the basis of the results of our surgical treatment of 85 patients with intrahepatic gallstones, effective methods for surgical treatment of this disease were discussed. The operative mortality rate for these patients was 10.6 %. Most of the fatal cases had long duration of symptoms and showed evidence of hepatic fibrosis or biliary cirrhosis at the time of operation. The results emphasize that, in cases of long duration of symptoms, it is generally necessary to examine thoroughly prior to operation the presence or absence of liver parenchymal injury and to pay deliberate attention to minimizing operative intervention. Especially, in hepatic lobectomy, its indication must be scrutinized carefully assessing the condition of the patient. In our follow-up study, 80% of the patients were found living with almost no complaints, 5 patients having occasional bouts of cholangitic attack included 3 patients who had left the hospital having residual gallstones. Including these 3 patients, 7 of 9 patients with residual gallstones showed severe hepatic dysfunction. In general, indications of our operations for different types of patients with intrahepatic gallstones have been evaluated as satisfactory. For the favorable management of intrahepatic gallstones, two points are specially emphasized: thorough scrutinization of liver parenchymal disorder prior to operation, and long-term observation for care of survivors with residual gallstones.View full abstractDownload PDF (554K) -
MAKOTO HAYAKARI, YOSHIKAZU KONDO1977 Volume 122 Issue 4 Pages 313-320
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA rapid, simple and sensitive method is described for the fluorornetric assay of angiotensin-converting enzyme using Fluorescamine. The critical factors such as optimal pH, incubation time, chloride ion, and inactivation by EDTA and 8 -hydroxyquinoline were examined. The Km value for hippuryl-L-histidyl-L-leucine was 0.5mM. This method was applied to the assay of angiotensin-converting enzyme in the rat serum and the reproducible values were obtained with a 10 μl of the rat serum.View full abstractDownload PDF (396K) -
ICHIJI SUMITOMO, Michio SUGITANI, KITSUYA IWAMA1977 Volume 122 Issue 4 Pages 321-329
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEffects of chronic ablation of the visual cortex (VC) were studied in the perigeniculate reticular neurons (POE neurons) which were located in the thalamic reticular nucleus immediately adjacent to the dorsal nucleus of the lateral geniculate body and identified as the I-cells of Burke and Sefton. In rats with the intact VC the PGR neurons responded to single shock stimulation of the optic tract (OT) with bursts of spike spaced regularly. During the inter-burst period the neurons were inhibited, indicat-ing that except for the primary spike burst, others were postinhibitory rebound excitation. In the VC-ablated PGR neurons there were no changes in the primary spike burst, but the remaining ones were very weak or sometimes missing, suggesting that the inhibition was poorly developed. With double shock stimulation of OT it was established that after showing the primary spike burst, the VC-ablated POR neurons suffered a less intense inhibition than control. To a diffuse, sustained illumination, the normal PGR neurons showed on- and off-responses, whereas the VC-ablated ones were tonically activated during the presence of illumination. These findings were taken as indicating that the inhibitory mechanism for the PGR neurons were made less active after the VC had been ablated chronically.View full abstractDownload PDF (1578K) -
TAKEO KUROYANAGI, KAZUO KURA1977 Volume 122 Issue 4 Pages 331-336
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe difference between total plasma volume determined with a substance which escapes from vascular beds in the presence of an increase of general capillary permeability and that determined with a substance which is confined to blood even in the presence of an increased capillary permeability may reflect the degree of an increase of general capillary permeability. The total plasma volume was determined by simultaneous injections of 131I-HSA and 51Cr tagged red cells. The capillary permeability was evaluated by calculating the difference (ΔTPV) between total plasma volume determined with 131I-HSA and that determined with 51Cr tagged red cell. ΔTPV averaged -4±20ml/m2 in 20 normal controls. The reproducibility of TPV was good. ΔTPV in patients with systemic lupus erythematosus, idiopathic thrombocytopenic purpura, chronic active hepatitis, liver cirrhosis and subacute bacterial endocarditis was larger than that of controls, averaging 204ml/m2, 178ml/m2, 82ml/m2, 131ml/m2 and 179ml/m2, respectively. The increase of ΔTPV was considered to indicate the increase of capillary per-meability in these patients. A permeability increasing factor was present in serum of patients with an elevated ΔTPV. There was a significant correlation between ΔTPV and the titer of serum capillary permeability increasing factor in these patients.View full abstractDownload PDF (300K) -
YOSHICHIKA KITAGAWA, TSUTOMU MATSUMOTO, EIJI OKUHARA, EISHIRO SHIKATA1977 Volume 122 Issue 4 Pages 337-343
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing rice dwarf virus (RDV)-RNA which was extracted from RDV and further purified by MAK-column chromatography, anti-RDV-RNA antibodies were produced in rabbits immunized with RDV-RNA-methylated bovine serum albumin complexes. The antisera, as analzyed by complement fixation, cross-reacted with synthetic double stranded RNAs (poly (A)•poly (U), poly (I)•poly (C)), but not with native or denatured DNA, rRNA, tRNA, 5 S RNA and nucleic acids from rice plants. RDV-RNA treated with heat or dimethylsulfoxide was markedly reduced in reactivity to the antisera. When RDV-RNA was digested with RNase A at low salt concentration, its complement fixation activity was abolished. In double diffusion tests, two different precipitation lines were demonstrated between the antiserum and RDV-RNA. One of the precipitation lines connected with those was formed between the antisera, poly (A)•poly (U) and poly (I)•poly (C). As regards immunoglobulin classes of the antibodies, one of the two rabbits employed had antibody activity only in IgM and the other, exclusively in IgG.View full abstractDownload PDF (888K) -
NAOFUMI YOSHIOKA, KENKICHI TAKAHASHI1977 Volume 122 Issue 4 Pages 345-348
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPregnancy-associated globulin (PAG) in saliva, urine and amniotic fluid was investigated just before and after delivery by Ouchterlony's method and im-munoelectrosyneresis. In saliva, the incidence was more than 60%; 12 out of 18 samples by immunoelectrosyneresis and 11 out of 18 by Ouchterlony's method. In urine, 8 (33%) and 6 (25%) out of 24 samples were positive by immunoelectro-syneresis and Ouchterlony's method, respectively. In amniotic fluid, only 3 out of 21 were positive by Ouchterlony's method, but 19 out of 21 samples (91%) were positive by immunoelectrosyneresis. Of 12 pregnant women in whom serum, saliva, urine and amniotic fluid were tested by immunoelectrosyneresis, four showed positive reaction in the above four samples and 11 in three samples except urine.View full abstractDownload PDF (818K) -
SHIRO KOSAKA1977 Volume 122 Issue 4 Pages 349-353
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing the immunofluorescent staining for detection of surface membrane immunoglobulin and the spontaneous rosette formation with sheep erythrocytes, B- and T-lymphocytes were identified in lymphocyte populations obtained from the peripheral blood of 36 patients with classical or definite rheumatoid arthritis and 13 normal adults. In all of three immunoglobulin subclasses, the mean percentage of B-lymphocytes in the peripheral blood of the patients was significantly higher than that of the normal subjects. On the other hand, the mean percentage of blood T-lymphocytes in the patients was remarkably low as compared with that of the normal controls.View full abstractDownload PDF (311K) -
Pathology of Lupus Nephritis with Special Reference to the Immunological Bases of Glomerular ChangesTERUO FUJIMOTO, TAKANOBU KITAMURA1977 Volume 122 Issue 4 Pages 355-374
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSGlomerular changes, and cellular and tissue responses of antibody-forming organs in 37 cases (20 cases with nephrotic syndrome and 17 cases without the syndrome) of systemic lupus erythematosus (SLE) were described. The glomerular changes were classified into 3 types, i.e., proliferative glomerulitis, membranous transformation, and wire-loop lesion from the standpoint of glomerular functional structure and its alterations. As to the responses of antibody-forming organs, hypoplasia of myeloid tissue, atrophy of lymph follicles of spleen and lymph nodes, atrophy and decrease in numbers of lymphocytes of thymus, proliferation and infiltration of plasma cells and plasmocytoid basophilic mononuclears, and proliferation of basophilic reticulum cells at the cost of differentiated antibody-forming organ tissues of bone marrow, spleen, lymph nodes, etc. were noted. Immunological bases of glomerular changes were considered and discussed in the light of pathological findings of SLE presented here and suggestions from experimental pathological studies in this field. Pathogenic roles of antigen-antibody complexes as well as anti-glomerular basement membrane (anti-GBM) antibody were considered in relation to the histologic manifestations of glomeruli in SLE or lupus nephritis.View full abstractDownload PDF (5070K) -
KOZUI MIYAZAWA, TAKASHI HANEDA, KUNIO SHIRATO, KAI TSUIKI1977 Volume 122 Issue 4 Pages 375-381
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPulmonary arterial pressure-flow relation was studied in 142 patients with atrial septal defect (ASD) and was compared with that of 139 patients with ventricular septal defect (VSD) and 54 patients with patent ductus arteriosus (PDA). The incidence of pulmonary arterial mean pressure (PAm) over 25 mmHg was 21% in ASD, 36% in VSD and 43% in PDA, and that over 40 mmHg was 3%, 23% and 19%, respectively. Large left to right shunt over 50% was found more frequently in ASD (58%) than in VSD (22%) and PDA (30%). When patients were separated into 2 groups at a PAm of 40 mmHg, lower pressure group showed a positive correlation between PAm and left-to-right shunt in each disease, although the correlation was poor in ASD (r=0.23) as com-pared with VSD (r=0.49) and PDA (r=0.47). The slope of the regression line was less steep in ASD (0.08) than in VSD (0.17) and PDA (0.14). It is considered that pulmonary hypertension in ASD develops on the basis of pulmonary vascular changes caused by prolonged hyperkinetic circulation.View full abstractDownload PDF (350K) -
NAOFUMI YOSHIOKA, KENKICHI TAKAHASHI, TOSHIKATSU OSHIMA, TATSUO WATANA ...1977 Volume 122 Issue 4 Pages 383-385
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPregnancy-specific beta-1-glycoprotein (SP1) is said to be found only in sera of pregnant females. In this paper, SP1 in the sera of malignant tumor patients was investigated by means of Ouchterlony's method and counter immunoelectrophoresis (CIEP). On the examination by Ouchterlony's method, all samples were negative, but by CIEP, 34 out of 90 samples (38%) showed positive reaction; 25 out of 61 (41%) in males and 9 out of 29 (31%) in females. There was no indication that the patients with a certain type of cancer tend to have a high incidence of SP1, but the examination of SP1 in the sera of patients with cancer or suspicious cancer had some clinical significance.View full abstractDownload PDF (162K) -
YOSHIRO YOSHIDA, MORIKUNI FUKUDA, TAKASHI SASAKI, HISAO HOSHINO, TETSU ...1977 Volume 122 Issue 4 Pages 387-392
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA case of straddling mitral valve associated with double outlet right ventricle and coarctation of the aorta is presented. Radical operation (Jatene's procedure) was performed under the diagnosis of complete transposition of the great arteries associated with coarctation of the aorta. The patient could not survive the operation. Autopsy revealed that both of the great vessels originated in the right ventricle (double outlet right ventricle). In addition to this abnormality, some of the chordae of the mitral leaflet were attached to the right ventricular wall through the ventricular septal defect (straddling mitral valve). Echocardiograms recorded prior to the operation revealed features corresponding to the anatomical abnormalities, including that the anterior mitral leaflet moved far anterior to the ventricular septum. This is the first case of echocardio-graphic features of straddling mitral valve.View full abstractDownload PDF (1746K) -
RYOJI MINAMI, MASAHIRO SUZUKI, TOORU KUDOH, SIGEO SATO, KAZUHIKO OYANA ...1977 Volume 122 Issue 4 Pages 393-396
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSα-L-Iduronidase activity was determined in established lymphoblastoid cells, which were transformed in vitro by Epstein-Barr virus, of lymphocytes-rich cell populations isolated from peripheral blood of patients with Hurler and Scheie syndromes. α-L-Iduronidase activities in established lymphoblastoid cells from patients were undetectable, while activities of control subjects were clearly detected. These results suggest that established lymphoblastoid cells are useful for the enzymatic study of genetic mucopolysaccharidoses.View full abstractDownload PDF (221K) -
OSAMU MASAMUNE, TSUNEO TAKAHASHI, AKIO NAGASAKI, JUNJI IWABUCHI, MAKAT ...1977 Volume 122 Issue 4 Pages 397-402
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo evaluate the diagnostic significance of the Sudan III staining for the fecal fat, the quantitative relationship between the number of fecal fat droplets examined microscopically and the amount of the fecal fat determined chemically was examined. In 43 out of 60 cases, the results of the chemical determination and the microscopic examination were in agreement and the accuracy was 72%. On the other hand, the false positive cases totaled 9 out of the 24 cases (37%) and 8 out of 9 false positive cases were diagnosed as showing a slight increase. In contrast, the false negative cases were only 2 out of 36 cases (6%). In addition, the comparative study of the various procedures of the Sudan III staining indicated the importance of the processing with acid and heating even in cases of steatorrhea caused by pancreatic insufficiency.View full abstractDownload PDF (346K) -
SHIGEJI KONDO1977 Volume 122 Issue 4 Pages 403-404
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSMyroridin, a new basic peptide antibiotic was isolated from culture filtrate of a strain of Myrothecium, No. 285F. The present paper describes the production, isolation and characterization of this antibiotic.View full abstractDownload PDF (117K)
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