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Volume 169 (1993)
- Issue 4 Pages 261-
- Issue 3 Pages 179-
- Issue 2 Pages 91-
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Volume 169, Issue 4
Displaying 1-10 of 10 articles from this issue
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NOBUYUKI TAKAHASHI, YOSHIAKI KONDO, KEI KUDO, YUTAKA IGARASHI, OSAMU I ...1993 Volume 169 Issue 4 Pages 261-270
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKAHASHI, N., KONDO, Y., KUDO, K., IGARASHI, Y., ITO, O. and ABE, K. Lack of Direct Action of Atriopeptidase Inhibitor on Cellular pH Regulation in Rabbit S2 Proximal Straight Tubules. Tohoku J. Exp. Med., 1993, 169 (4), 261- 270-While the in vivo diuretic and antihypertensive effects of the newly- developed drug Candoxatril (UK-79300), a prodrug of a selective atriopeptidase inhibitor UK-73967 (API) are well established, the mechanism of its diuretic action is not yet fully understood due to the lack of information about its direct effects on proximal tubules. To elucidate whether this atriopeptidase inhibitor has any direct effects on proximal tubules, we examined the effect of API on intracellular pH (pHi) of the in vitro microperfused proximal S2 segment of rabbit kidney, using the pH-sensitive fluorescent dye, (2', 7')-bis(carboxyethyl)-(5, 6)- carboxyfluorescein (BCECF). In the steady-state condition, pHi was 7.13±0.02 (n=19). Atriopeptidase inhibitor (API) at 100μM added to the bath changed pHi by only 0.02±0.07 unit (n=7, p>0.05) in 10min. The same concentration of API in the lumen changed pHi by 0.03±0.02 unit (n=6, p>0.05). To test whether the synergistic effects of API on the luminal and basolateral transport systems prevented the apparent change in pHi, we also examined the effect of API in the presence of amiloride in the lumen. The inhibition of Na+/H+ antiporter by the addition of 1mM of amiloride to the lumen caused no change in pHi response to basolateral API application. API was without effect on pHi also in the presence of atrial natriuretic polypeptide (ANP). These results suggest that API per se has no significant effect on the process of proximal acidification over a short time period.-UK-79300; atrial natriuretic polypeptide; kidney; proximal tubuleView full abstractDownload PDF (991K) -
MINORU YASUJIMA, MASAYUKI KANAZAWA, KAZUNORI YOSHIDA, MASAHIRO KOHZUKI ...1993 Volume 169 Issue 4 Pages 271-277
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYASUJIMA, M., KANAZAWA, M., YOSHIDA, K., KOHZUKI, M., WATANABE, H., HIWATARI, M., SATO, T, and ABE, K. The Augmented Blood Pressure Response to Chronic Angiotensin II Infusion in Partially Nephrectomized Rats. Tohoku J. Exp. Med., 1993, 169 (4), 271-277-To assess potential roles of circulating levels of angiotensin II (Ang II) in the regulation of blood pressure in rats with reduced functional renal mass, we studied the blood pressure response to chronic infusion of Ang II at a subpressor dose in partially nephrectomized rats. Male Sprague- Dawley rats were subjected to 1/6, 2/6, 3/6, 4/6 and 5/6 nephrectomy, and sham operation a week before the infusion of Ang II at a rate of 400μg/kg/day delivered intraperitoneally by osmotic minipumps for 14 days, or vehicle alone served as controls. Infusion of Ang II was associated with a slight but significant increase in systolic blood pressure in 1/6 nephrectomized rats (p<0.05), whereas it did not induce a significant change in systolic blood pressure in sham-operated rats. Hypertension during Ang II infusion was more prominent in 2/6 nephrectomized rats than that in 1/6 nephrectomized rats (p<0.05). However, there was no significant difference in hypertension during Ang II infusion among groups in 2/6, 3/6, 4/6 and 5/6 nephrectomized rats. Blood urea nitrogen and serum creatinine levels, endogenous creatinine clearance, urinary excretion of protein as indices of renal function, and urinary sodium excretion were not affected by chronic infusion of Ang II in 1/6, 2/6, 3/6, 4/6 and 5/6 nephrectomized, and sham-operated rats. There was also no significant difference in circulating levels of Ang II among Ang II infused-groups in 1/6 and 2/6 nephrectomized rats. These results indicate that elevated levels of circulating Ang II are capable of causing a sustained hypertension in rats with reduced functional renal mass. In addition, they also suggest that circulating levels of Ang II could play a more important role in the regulation of blood pressure in rats with incipient impairments of renal function.- Ang II; renal impairment; nephrectomized rats; blood pressure regulation; renal hypertensionView full abstractDownload PDF (795K) -
KAZUO SHIKANO, HIRONOBU SASANO, KIYOSHI ITO, NOBUYOSHI OZAWA, TORU TAS ...1993 Volume 169 Issue 4 Pages 279-288
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSHIKANO, K., SASANO, H., ITO, K., OZAWA, N., TASE, T., SATO, S. and YAJIMA, A. The Correlation between HPV Infection and Cell Proliferative Activity in Uterine Cervical Adenocarcinoma. Tohoku J. Exp. Med., 1993, 169 (4), 279-288 -To investigate the correlation between human papillomavirus (HPV) infection and cell proliferative activity in uterine cervical adenocarcinoma, in situ hybridization of HPV DNA and immunostaining of proliferative cell nuclear antigen (PCNA) were performed on serial sections of the carcinoma. HPV 16 and 18 DNA was detected in 10 of 33 cases of cervical adenocarcinoma and adenocarcinoma in situ. PCNA was detected in 30 cases. In all 10 HPV-positive cases, PCNA was also demonstrated, and the number of PCNA-positive cells tended to be higher than that in HPV-negative cases. With 1:1 correlation between HPV and PCNA on the nuclei, the coincidence rate was 72% (p<0.01). These results indicate that HPVs play a role in cell proliferation.-uterine cervical adenocarcinoma; HPV; PCNA; in situ hybridizationView full abstractDownload PDF (1802K) -
Hirokazu NAKANO1993 Volume 169 Issue 4 Pages 289-297
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKANO, H. Cephalometric Study on the Influence of Vertical Traction of Teeth on Maxillofacial Bones in Young Dogs. Tohoku J. Exp. Med., 1993, 169 (4), 289-297-The influence of one-sided vertical traction of teeth on maxillofacial bones was investigated using cephalometric radiographs and tetracycline-labeling in young dogs. On the frontal view of the dry skull, traction resulted in a downward distortional deformity of the maxilla including the nasal floor. Cephalometry of radiographs revealed a downward displacement of the upper premolar and incisor teeth, medial maxillary region, and alveolar process of molar, canine and incisor on the right side, where traction was applied. Displacement was from 2.2±0.4 (mean±S.D.)mm at P3 to 0.8±0.2mm at I1. In the control group without traction, it was 0.0±0.0 at P3 and 0.2±0.1 at I1. Tetracycline- labeling disclosed, in the frontal cut surface of maxillofacial bones at P3, that traction affected not only the periodontal tissue and alveolar processes, but also the neighboring bones and midpalatal suture. The ratio of the labeled area in the bone, measured using an image analyzer in 6 sectors of the cut surface, was 1.2± 0.3% in the left upper sector to 13.0±4.3% in the right lower sector. In the control group, it was 1.2±0.4% in the left upper and 4.8±1.1% in the right lower sector. In conclusion, vertical traction of teeth induces a vertical deformation of the maxilla.-vertical traction of teeth; maxillofacial deformity; cephalometric radiography; tetracycline-labelingView full abstractDownload PDF (3216K) -
RYUICHI SANO, AKIHISA FUJINO, TSUNEYOSHI SAITO, KEIJI TAKENAKA, YOSHIK ...1993 Volume 169 Issue 4 Pages 299-307
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSANO, R., FUJINO, A., SAITO, T., TAKENAKA, K., YAHATA, K., OGYU, A. and TOYOTA, T. Reduction by Niceritrol Treatment of Serum Lipoprotein(a) in Normolipidemic Patients with Coronary Artery Disease. Tohoku J. Exp. Med., 1993, 169 (4), 299-307-The effect of niceritrol at an ordinary dose (1500mg/ day) on the serum lipoprotein(a) (Lp(a)) concentration was investigated in 25 normolipidemic patients with coronary artery disease. The serum Lp(a) level was reduced by approximately 21% after 3 months of treatment (before treatment, 30.3±4.1mg/100ml; during treatment, 22.6±2.4mg/100ml; p<0.01). By one month after the drug was discontinued, the Lp(a) returned to a pretreatment level (30.8±2.8mg/100ml). The levels of LDL-cholesterol and apoB were decreased significantly by the drug therapy; LDL-cholesterol increased closely to a pretreatment level after withdrawal of the drug. The percentage reduction of Lp(a) was significantly correlated with that of fibrinogen (r=0.763, p<0.01). Plasma concentration of fibrinogen was decreased in the patients whose reduction rate of Lp(a) was 30% or more. These results indicate that niceritrol has Lp(a)-lowering effect; sufficient reduction of Lp(a) may improve dyscoagulopathy of patients with coronary artery disease.-coronary artery disease; normolipidemia; lipoprotein(a); plasminogen activator inhibitor-1; fibrinogen; NiceritrolView full abstractDownload PDF (793K) -
KOZO ITO1993 Volume 169 Issue 4 Pages 309-317
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSITO, K. Clinical and Pathological Investigation of Microscopic Mole. Tohoku J. Exp. Med., 1993, 169 (4), 309-317-To clarify the pathological significance of the quasi-mole lesions of the placenta, morphological and morphometrical study of villi was undertaken. The material comprised products of conception in 70 cases of artificial abortion, 110 cases of spontaneous abortion and 11 cases of complete mole: The artificially aborted material was regarded as having normal villi. The products, after being observed with a stereo microscope, were subjected to microscopic examination of paraffin sections. A vascular villi with central liquefaction and proliferation of trophoblasts were found not only in the group of overt mole but also in spontaneously aborted and even in artificially aborted material, though less frequently. By morphometry, villi were shown to be involved in these changes even when macroscopically there seemed to be no significant abnormalities, a condition we prefer to call “microscopic mole.” This was prevailing particularly in cases in which the average minor axis of villi exceeded 1mm; it became more predominant with enlarging axis, gradually approaching the shape of complete mole. Some of the cases with enlarged villi proved to develop later invasive mole. Thus, whether or not the average minor axis exceeds 1mm is likely to have a profound clinical significance.- microscopic mole; complete mole; spontaneous abortion; stereoscopic microscopeView full abstractDownload PDF (5152K) -
KAZUYA KITAMURA, TOSHIO TAKAHASHI, TOSHIHARU YAMAGUCHI, AKINORI NOGUCH ...1993 Volume 169 Issue 4 Pages 319-323
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKITAMURA, K., TAKAHASHI, T., YAMAGUCHI, T., NOGUCHI, A., OTSUJI, E., TSURUMI, H., YAMAOKA, N., MIYAGAKI, T. and KOTANI, T. Enhanced Lymphatic Delivery of Monoclonal Antibody Following OK432 Pretreatment. Tohoku J. Exp. Med., 1993, 169 (4), 319-323-The effect of OK432 on the lymphatic delivery of monoclonal antibody (Mab) was investigated by injecting [125I]-Mab A7 into BALB/c mice pre-treated with OK432, and measuring the radioactivity in the regional lymph nodes. The [125I]-Mab A7, when administered subcutaneously to the foot pad, preferentially accumulated in the ipsilateral popliteal and para-aortic lymph nodes. Treatment with OK432 prior to antibody injection significantly enhanced the accumulation of Mab A7 in these regional lymph nodes. These findings suggest that pretreatment with OK432 may constitute a promising method of enhancing the lymphatic delivery of Mab, and improving the efficacy of therapy directed against lymphatic malignancies.-monoclonal antibody A7; OK432; lymphatic deliveryView full abstractDownload PDF (444K) -
KENZABURO TANI, KEIYA OZAWA, HIROMI OGURA, SATOSHI TAKAHASHI, KEISUKE ...1993 Volume 169 Issue 4 Pages 325-334
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTANI, K., OZAWA, K., OGURA, H., TAKAHASHI, S., TAKAHASHI, K., TSURUTA, T., OKANO, A., AKIYAMA, Y., YOSHIKUBO, T., SHIMANE, M. and ASANO, S. The Production of Granulocyte Colony-Stimulating Factor and Interleukin 6 by Human Bone Marrow Stromal Cells in Aplastic Anemia. Tohoku J. Exp. ed., 1993, 169 (4), 325-334-Stromal cells are known to produce granulocyte colony- stimulating factor (G-CSF) and interleukin 6 (IL-6). To assess the function of bone marrow Stromal cells in the pathological state, we studied their in vitro ability to produce G-CSF and IL-6 in 9 patients with aplastic anemia and 5 normal volunteers, using an enzyme immunoassay method. Constitutive production of IL-6, but not G-CSF, was detected in almost all cases. Interestingly, the inducible production of G-CSF and IL-6 by stromal cells after stimulation with Interleukin-1 and/or lipopolysaccharides was severely depressed in 3 patients with aplastic anemia. Our results may reflect poor hematopoietic activity in the bone marrow in some cases of aplastic anemia.-bone marrow stromal cells; granulocyte colony-stimulating factor; interleukin-6; aplastic anemiaView full abstractDownload PDF (1014K) -
MORIHIRO MUSHA, FUMIO TANAKA, MASAHIRO OHUTI1993 Volume 169 Issue 4 Pages 335-344
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMUSHA, M. TANAKA, F. and OHUTI, M. Psychoses in Three Cases with Myasthenia Gravis and Thymoma-Proposal of a Paraneoplastic Autoimmune Neuropsychiatric Syndrome. Tohoku J. Exp. Med., 1993, 169 (4), 335-344- Three patients with neuropsychiatric symptoms (NPSs) associated with thymoma, high serum titers of antiacetylcholine receptor (AchR) antibody and generalized myasthenia gravis (MG) are reported. The NPSs were homogeneous; (1) Altered consciousness as manifested by dreamy state with paramnesia, (2) psychosensory symptoms (the sudden change of senses of smell and taste with behavior abnormalities, auditory and visual hallucinations, deja experiences, microteleopsia and derealization), (3) cognitive disturbances (recent memory loss with compulsive behaviors), (4) emotional disturbances (agitation, fear and anger), and (5) psychotic symptoms (secondary delusions and hallucinations) were characteristic. The NPSs preceded by several months to years the onset of MG, and thereafter they were closely related to worsening and relapse of MG. A typical patient showed repeatedly abnormal electroencephalograms (EEG) indicative of cerebral dysfunction. Another showed improvement of the NPSs after thymectomy and immunosuppressive therapy. The organicity of the phenomenology of psychoses with the same NPSs was suggested and it appears to comprise a unique paraneoplastic syndrome by central autoimmune mechanism. We proposed an autoimmune psychiatric syndrome and the genesis of psychosis due to the central cholinergic dysfunction in MG.-myasthenia gravis; thymoma; psychosis; paraneoplastic syndrome; cholinergic systemView full abstractDownload PDF (1173K) -
MASARU MIYAO, MASASHI FURUTA, KAZUO OZAWA, TAKA-AKI KONDO, HISATAKA SA ...1993 Volume 169 Issue 4 Pages 345-350
Published: 1993
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMIYAO, M., FURUTA, M., OZAWA, K., KONDO, T., SAKAKIBARA, H., ISHIHARA, S. and YAMANAKA, K. Morbidity of Allergic Rhinitis Based on the National Health Insurance Records of Japan. Tohoku J. Exp. Med., 1993, 169 (4), 345-350, -The morbidity of allergic rhinitis (AR) based on Japan National Health Insurance records was calculated from 1981 to 1990. The data shows a three-fold increase of the rate for AR patients in those 10 years. Additionally, Aichi Prefecture's morbidity of AR was analysed for May 1991. When cross-sectional methods were used for May 1991, it was found that the morbidity of AR showed little correlation with the pollen count for Japanese cedars and Japanese cypresses. However, the results suggested possible correlations between the morbidity of AR and the mean yearly levels of the pollutant components SPM and NO2.- air pollution; allergic rhinitis; Japanese cedar pollinosis; pollenView full abstractDownload PDF (593K)
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