The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 132, Issue 1
Displaying 1-17 of 17 articles from this issue
  • SHINTARO SAITO, TOSHIRO SAKURADA, MAKIKO YAMAMOTO, KATSUMI YOSHIDA, KA ...
    1980 Volume 132 Issue 1 Pages 1-10
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    To evaluate the long-term results of 131I treatment for Graves' disease, the thyroid function was studied in 331 patients 5-17 years after this therapy. Twenty-five patients were hypothyroid and had already been on thyroid medication. Among the remaining 306 patients without any treatment for thyroid disorder, 188 patients (61.4%) had a normal thyroid-stimulating hormone (TSH) level (less than 10μU/ml) of whom 151 were euthyroid with normal thyroxine (T4) and triiodothyronine (T3) level. 118 patients (38.6%) had a high TSH level, of whom 22 were hypothyroid with low T4 and T3 levels and 38 were with normal T3 and low T4 levels, and 14 patients out of this 38 were clinically hypothyroid. Although all of the patients with high TSH levels do not per se require the replacement therapy for hypothyroidism, the overt hypothyroidism seems to occur sooner or later in patients with a lower T4 level. Among 331 patients studied, 61 (18.4%) were clinically hypothyroid. The incidence of hypothyroidism was 20.7% after 10 years of 131I treatment and 33% after 15-17 years. The incidence of patients with high TSH levels was 50% after 10 years of 131I treatment and 60% after 15-17 years. Both of cumulative incidence of hypothyroidism and patients with high TSH levels increased linearly with years after the treatment, which coincided with the linear decrease of mean T4 and T3 levels and linear increase of mean TSH level with years after the treatment. The difference of positive incidence of antithyroid antibodies between cases of normal TSH level and high TSII, level was not significant.
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  • MASAHIKO ENDO, OSAMU NAMIKI, ZENSAKU YOSIZAWA
    1980 Volume 132 Issue 1 Pages 11-16
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    To elucidate the reducing terminals and the molecular weights of urinary glycosaminoglycans (GAG), the reducing power of the GAG in the acidic subfractions obtained in a previous paper (Endo et al. 1980a) was determined by the methods of Park and Johnson and of Milner and Avigard. Number-average molecular weight was calculated from the value obtained by the Park-Johnson method according to the equation of Partridge et al. The results suggested that xylose and hexuronic acid were present at the reducing terminals of the carbohydrate chains of urinary GAG, and also that 10-65% of the reducing terminals were occupied by the hexuronic acid residues. This finding strongly suggested the exertion of endoglycuronidase activity in the catabolism of the tissue GAG, specifically of chondroitin sulfate isomers. On the other hand, number-average molecular weights of urinary GAG in the subfractions ranged from 5, 600 to 15, 500, although most of them were within the range between 6, 000 and 7, 500.
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  • KIYOHIKO YOSHIKAWA, HARUKI WAKASA
    1980 Volume 132 Issue 1 Pages 17-29
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A case of hypoglycemia resulting probably from aberrant islet cell tumor which appeared after removal of the spleen is reported. The case had been followed up for 16 years. During the clinical course, two times of operation of the pancreas for searching lesions causing hypoglycemia were performed but failed to find a tumor. The autopsy revealed an aberrant islet cell tumor in the perilienal tissue. The tumor was composed of monotonous neoplastic cells containing moderate to large nuclei and abundant eosinophilic cytoplasm. The relation of hypoglycemia to the aberrant islet cell tumor was discussed.
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  • HIROSHI UEDA, AKIRA NAKANISHI, MOTOHIKO ICHIJO
    1980 Volume 132 Issue 1 Pages 31-35
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The following results were obtained by analyzing serum IgG, IgM and IgA of blood from the umbilical cord chiefly of small-for-date infants (term SFD infants): (1) The serum IgG level was higher in the infant's blood than in the mother's blood in the cases of appropriate-for-date infants (term AFD infants). Its fetus/ mother ratio was 1.25±0.22. (2) The fetus/mother ratios of IgG in term SFD infants and premature infants were lower than in term AFD infants. (3) The placental transmission of IgG increased as the gestation weeks went by, and its fetus/mother ratio reached 1.0 by the 38th week of pregnancy. (4) The serum IgM level was lower in term SFD infants than in term AFD infants. (5) Term SFD infants showed no difference of serum IgA level from that of term AFD infants.
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  • MASAHIKO ENDO, OSAMU NAMIKI, ZENSAKU YOSIZAWA
    1980 Volume 132 Issue 1 Pages 37-41
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    To elucidate the mode of the exertion of glycosidase activities in the catabolism of the tissue glycosaminoglycans (GAG), the terminal monosaccharides of the carbohydrate chains of urinary GAG in the most prominent subfraction (40% Fr-1.25 M Fr) among the subfractions obtained in a previous paper (Endo et al. 1980a) were investigated. The results of determination of the reducing hexuronic acid and N-acetylhexosamine before and after digestion of the subfraction with β-glucuronidase and β-N-acetylhexosaminidase, together with previous data indicated that 0.36 and 0.37 mol of glucuronic acid and N-acetylgalactosamine, respectively, per mol of the subfraction were located at the non-reducing terminals of the carbohydrate chains. The remaining portion (0.27 mol per mol) of the non-reducing ends might be mostly occupied by the sulfated N-acetylgalactosamine residues. On the other hand, 0.25, 0.16 and 0.34 mol of glucuronic acid, N-acetylgalactosamine and xylose, respectively, per mol of the subfraction were indicated to be present at the reducing terminals of the carbohydrate chains. The remaining portion (0.25 mol per mol) of the reducing ends might be mostly occupied by the galactose residues and/or the N-acetylgalactosamine 4-sulfate residues. The present observations provided with evidence for the action of endo-β-glucuronidase and endo-β-N-acetylhexosaminidase on the tissue GAG, specifically on chondroitin sulfates.
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  • EIZO YAMASHITA, SANAE KIKYO, YOKO SASAKI
    1980 Volume 132 Issue 1 Pages 43-47
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    EEG records were obtained from 9 blinds under several types of stimulation. The occipital alpha rhythm was much reduced in them, whereas small parietal activity in the alpha range was often observed in the later blind. Any type of stimulation did not produce beta rhythm, but accelerated the background alpha rhythm.
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  • KIYOHIKO Yoshikawa, HARUKI WAKASA
    1980 Volume 132 Issue 1 Pages 49-60
    Published: 1980
    Released on J-STAGE: November 17, 2010
    JOURNAL FREE ACCESS
    YOSHIKAWA, K. and WAHASA, H. Hypoglycemia by Adrenocortical Carcinoma with Cushing's Syndrome. Tohoku J. exp. Med., 1980, 132 (1), 49-60-A case of adrenocortical carcinoma, a 18-year-old female with Cushing's syndrome and later hypoglycemia, was reported. Cushing's syndrome was corroborated by clinical signs of moon face, obesity, hirsutism and amenorrhea as well as by elevated urinary steroid levels. A huge tumor in the right adrenal region weighing 171 gwas removed and histologically diagnosed as adrenocortical carcinoma. Shortly after the surgery, urinary levels of steroid excretion became within normal ranges. However, hypoglycemia with elevated levels of urinary steroid appeared in 6 months postoperatively. She died of massive hemorrhage from gastric ulcer. Autopsy revealed a huge tumor in the right hypochondrial region pressing the liver and right kidney. Tumor cells of autopsy material showed much more anaplastic feature than those of surgical one. Several possible mechanisms for hypoglycemia were discussed.-hypoglycemia; adrenocortical carcinoma; Cushing's syndrome
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  • SHUICHI INOUE, TERUHIKO NAKAGAWA
    1980 Volume 132 Issue 1 Pages 61-67
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The serum gastrin responses after ingestion of hard boiled eggs and Nutrient Broth solution were examined in peptic ulcer patients and normal subjects. The values observed of the serum gastrin response to these test meals were compared and contrasted. A significant enhancement of gastrin release in response to protein was obtained. There were no significant differences between the releases of gastrin after the two test meals.
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  • RYUNGCHAN KWAK, HIROSHI NIIZUMA, JIRO SUZUKI
    1980 Volume 132 Issue 1 Pages 69-73
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Cerebral angiography revealed that hypoplasia of the A1 portion of the anterior cerebral artery is more frequent in patients with aneurysms of the anterior communicating artery than in those with aneurysms of other intracranial arteries. As for the hypoplasia of the A1, the angiographic findings corresponded to the surgical findings in 86.9% of all the patients. In patients with anterior communicating artery aneurysms, the incidence of hypoplasia of the A1 portion was about 3 times higher on the right side than on the left side.
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  • MOTOKO OJIMA, AKIRA KAMBEGAWA
    1980 Volume 132 Issue 1 Pages 75-85
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A method for the simultaneous measurement of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) and 18-hydroxycorticosterone (18-OH-B) in human peripheral plasma has been developed. The present method consists of extracting plasma with dichloromethane, separating the 18-OH-DOC and 18-OH-B from other steroids on a Sephadex LH-20 column and quantitating each steroid by radioimmunoassay. The mean plasma level of 18-OH-DOC at 8:00 a. m. was 8.2±3.9ng/100ml (mean±s. D. ) in normal males. It was 7.8±2.6ng/100ml in the follicular phase of normal females and 11.5±2.8ng/100ml in the luteal phase. The corresponding level of 18-OH-B in normal males was 10.3±4.2ng/100ml and in the follicular and luteal phases of normal females was 12.4±4.5ng/100ml and 13.8±4.1ng/100ml, respectively. No sex differences nor difference between the phases of the menstrual cycle was confirmed. Plasma levels of the two steroids were not rarely high in patients with Cushing syndrome due to adrenocortical hyperplasia and carcinoma, primary aldosteronism, idiopathic hyperaldosteronism and congenital 17α-hydroxylase deficiency, while they were usually within the normal range in cases of Cushing syndrome due to adrenocortical adenoma. These steroid levels were significantly low in patients with Addison's disease.
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  • NOBUAKI FURUHASHI, VICTOR S. FANG
    1980 Volume 132 Issue 1 Pages 87-92
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Using feminizing adrenal neoplastic gland (FANG) cells we showed that hPRL stimulated cGMP biosynthesis. Also we could clearly demonstrate a stimulatory effect of db-cGMP plus theophylline on estrogen production without concomitant stimulation of cell growth. These findings indicate that a stimulatory effect of hPRL on estrogen biosynthesis by Fang-8 cells may act via increased cGMP concomitant with depressed CAMP.
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  • KAZUO MORI, HIKARU WATANABE, NOBUO HIWATASHI, KOHJI SUGAI, YOSHIO GOTO
    1980 Volume 132 Issue 1 Pages 93-101
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    An investigation was made on 23 aspects of coagulation in 14 cases of ulcerative colitis, 5 cases of Crohn's disease and 3 cases of related diseases using a classification of increased and decreased coagulability. Of the 14 cases of ulcerative colitis, 10 were total colitis and 4 were left-sided colitis; 12 were on the active stage and 2 were in a state of remission. Treatment at the time of the investigation included prednisolone and/or Salazopyrin. In these cases, increased fibrinogen content, increased Factor VIII and Factor IX activity, increased platelet count, accelerated platelet aggregation rate and platelet retention rate were found. This hypercoagulability is thought to contribute to the clinical picture of these diseases and may prove useful as an index for determining the severity and prognosis of such cases and for deciding the indication for surgery. Furthermore, in cases where there is a marked increase in coagulability, combined anticoagulant therapy is thought necessary to improve the course of both ulcerative colitis and Crohn's disease.
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  • OSAMU NAMIKI, MASAAKI MASUBUCHI, HIROMICHI TOYOSHIMA, MASAHIKO ENDO, Z ...
    1980 Volume 132 Issue 1 Pages 103-109
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    To elucidate precise chemical nature of urinary keratan sulfate (KS) of Morquio's disease, crude glycosaminoglycans (GAG) were separated from 24-hr urines of 3 patients with Morquio's disease and from pooled urine of a healthy boy, using cetylpyridinium chloride. KS fractions were then separated from the crude GAG after removal of other GAG and acidic glycopeptide by successive digestion with testicular hyaluronidase and chondroitinase ABC, and by nitrous acid treatment, followed by Dowex 1 column chromatography. The distribution of KS in several fractions (1.5 M Fr-5.0 M Fr) obtained by Dowex 1 column chromatography suggested polydispersity of urinary KS. The relative amounts (μg/24-hr urine/kg body weight) of the KS fractions excreted into Morquio's urine were 52-63 times as much as that excreted into normal urine. The KS fractions contained galactose, glucosamine and sulfate as the major constituents, together with fairly amounts of galactosamine and sialic acid, and small amounts of mannose, L-fucose and glucose. The KS fractions resembled sulfated glycopeptide with respect to the sugar composition. The contents of sulfate and sialic acid in each KS fraction from Morquio's urine were higher than those in the corresponding one from normal urine, whereas opposite was the case for the ratio of glucosamine to galactosamine. The sulfate contents in the KS fractions from Morquio's urine indicated that the patient excreted oversulfated KS into urine. The chemical compositions of the KS fractions from Morquio's urine suggest that the sulfatase specific for 6-sulfate linked to sugars with the galactose configuration may act in a early step of the catabolism of over-sulfated KS in the normal tissues.
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  • HIROSHI UEDA, AKIRA NAKANISHI, MOTOHIKO ICHIJO
    1980 Volume 132 Issue 1 Pages 111-116
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Components of complement (protein concentrations of Clq, C3, C3-activator, C4, C5 and C9 and whole complement (hemolytic activity) ) were measured in sera from full-term small-for-date (SFD) and appropriate-for-date (AFD) infants and their mothers. (1) Half the SFD infants showed lower Clq levels than the AFD infants. (2) SFD infants showed the same levels of C3 as AFD infants. (3) Although SFD infants showed slightly higher levels of C3-activator than AFD infants, there was no significant difference. (4) SFD infants and AFD infants showed the same level of C4. (5) With respect to C5, half the SFD infants showed lower levels than the AFD infants. (6) Levels of C9 in the SFD infants were essentially the same as those in the AFD infants. (7) The amount of protein in every complement component of an infant was smaller than that of the mother. In AFD infants, the infant-maternal ratios were 0.64 for Clq, 0.45 for C3, 0.29 for C3-activator, 0.43 for C4, 0.54 for C5 and 0.12 for C9. (8) The whole complement titers of umbilical cord sera from the AFD infants were approximately one half of those of the maternal sera. This is due to the smaller amount of complement protein itself in the infant sera. (9) The whole complement titers of umbilical cord serum agreeably correlate with gestational weeks and birth weight of the infants. (10) The whole complement titer in full-term SFD infants was lower than that in normal full-term AFD infants.
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  • KEISHI ABE, TORU ITOH, YUTAKA IMAI, MAKITO SATO, TOSHIKAZU GOTO, YOICH ...
    1980 Volume 132 Issue 1 Pages 117-118
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The antihypertensive mechanism of orally active angiotensin I-converting enzyme inhibitor, SQ 14225 (SQ), in low renin hypertension was investigated. In the SQ-responder with low renin hypertension, the hypotensive effect of SQ was abolished after the inhibition of endogenous prostaglandin (PG) synthesis with indomethacin, while no significant change in blood pressure was found in the SQresponder with normal renin hypertension. These results suggest that SQ may potentiate the vasodilating PG system, contributing to the antihypertensive mechanism in SQ-responders with low renin hypertension.
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  • KAI TSUIKI, ERIK L. RITMAN
    1980 Volume 132 Issue 1 Pages 119-120
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Incompressibility of left ventricular myocardium was tested utilizing isolated canine working left ventricular preparations. This ventricle functioned at levels comparable to the intact heart. The ventricular muscle volume was calculated with the videometric border recognition technique, which is probably the most satisfactory among the presently available techniques to measure left ventricular volume. The calculated wall mass throughout the cardiac cycle varied ranging between about ±5%. The difference between the calculated and weighed myocardial mass was within ±7% of the true weight. These findings warrant the idea that myocardial muscle mass is incompressible throughout systole and diastole; the assumption used to calculate some variables of left ventricular function.
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  • SHIN-ICHI MASU, MICHIKO HOSOKAWA, MAKOTO SEIJI
    1980 Volume 132 Issue 1 Pages 121-122
    Published: 1980
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Skin specimens obtained from two cases of primary localized cutaneous amyloidosis (PLCA) were subjected to study with an indirect im-munofluorescence technique using anti-keratin antibody. Distinct fluorescence was observed in stratum corneum, and in spinous and basal cells of the epidermis and also in amyloid masses located in the upper dermis. These results appear to indicate that keratinous protein is one of the constituents of amyloid masses of cutaneous amyloidosis.
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