A. If Koch's old tuberculin is subcutaneously injected in the amount of 0.1 c. c. per kilo of body weight into normal
b-classed rabbits, a definite picture will be produced. The blood picture is described below:
1. Total white cell count. Up to the 1st or the 2nd hour a leucopenia; then a marked leucocytosis up to the 5th hour.
2. Lymphatic cells. Up to the 5th hour a marked lymphopenia, absolutely as well as relatively, which becomes marked still more as time passes on.
3. Myeloid cells. Up to the 5th hour a very marked myelocytosis, absolutely as well as relatively, which becomes marked still more with the passing of time.
4. Nuclear shift. Cells of Class I reach approximately four or five times the percentage in the 4th or the 5th hour after the injection.
B. If yakriton is subcutaneously injected in the amount of _??_ R. A. U. per kilo of body weight into normal
b-classed rabbits, 30 minutes before Koch's old tuberculin injection (0.1 c. c. per kilo of body weight), the blood picture will be changed as below:
1. Total white cell count. Up to the 1st or the 2nd hour, normal or a slight leucocytosis. A temporarily marked leucocytosis in the 2nd or the 3rd hour, then up to the 5th hour normal, or, a slight leucocytosis again.
2. Lymphatic cells. Gradually a lymphopenia, reaching the maximum in the 5th hour. This decrease is not so pronounced as in the case of tuberculin injection alone. Up to the 1st or the 2nd hour no change, or, a slight increase in the absolute number.
3. Myeloid cells. Gradually a myelocytosis, absolutely as well as relatively, reaching the maximum in the 5th hour. This increase is not so marked as in the case of tuberculin injection alone.
4. Nuclear shift. Cells of Class I reached, about twice the percentage in the 3rd or the 4th hour. Up to the 1st or the 2nd hour, cells of Class I decrease and those of Types IV and V increase.
Contrary to what the above mentioned authors state,
1)2)3)4) I have obtained a definite change of blood picture resulting from the injection of old tuberculin. The reason is, I believe, very simple. I have used selectively only
b-classed animals. It would have been interesting to do the same experiment in
f-classed ones too, but unfortunately I was unable to obtain a sufficient number of such rabbits during the present work.
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