Quantitative changes of the pancreatic islets in diabetes mellitus were analyzed by a stereological method. 26 maturity-onset and 5 growth-onset diabetics, and 37 nondiabetics including 9 hypertensives were selected from autopsy materials and the pancreases were subjected to histometry. The total islet volume
Vi was 0.974cm
3 in the control, whereas it was only 0.596 and 0.255 cm
3 in the maturityonset and growth-onset diabetic groups, respectively. The hypertensive group gave almost the same value as the control. There was an obvious negative correlation between
Vi and the maximum blood sugar level during glucose tolerance test, whether the case was diabetic or not. Moreover, in the diabetic group
Vi diminished with descending age of onset. These findings indicate the importance of
Vi in the pathophysiology of diabetes and support the classical concept of insulin deficiency as the primary pathogenetic role. On the other hand, the total islet number
Ni decreased with increasing mean radius_??_, and the diabetic and control cases shared a common regression of
Ni on _??_. The diabetic pancreas was not characterized by
Ni, _??_ or by the distribution pattern of
r.
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