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Volume 129 (1979)
- Issue 4 Pages 311-
- Issue 3 Pages 207-
- Issue 2 Pages 105-
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Volume 129, Issue 4
Displaying 1-11 of 11 articles from this issue
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AKIRA YAJIMA, HISASHI HIGASHIIWAI, AKIRA SATO, MASAAKI WATANABE, TOSHI ...1979 Volume 129 Issue 4 Pages 311-317
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCytologic specimens presenting primarily superficial or intermediate dysplastic cells in the smear obtained by scraping the uterine cervix were defined as mild dysplasia, and those presenting primarily parabasal (or deep layer) dysplastic cells were defined as severe dysplasia. The rate of agreement of the above cytologic diagnosis to the histological diagnosis by target biopsy using the colposcope was 50% and 51% in mild and severe dysplasia, respectively. Specimens containing a few atypical cells which were strongly suspected to be malignant were classified as IIIb. From this group, malignant lesions were found in 48% and severe dysplasia in 35%.View full abstractDownload PDF (1434K) -
KUNIO SUWA, FUSAKO MATSUSHITA, KAZUEI OHTAKE, HIDEO YAMAMURA1979 Volume 129 Issue 4 Pages 319-326
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA hypothesis was established that, during emergence of inhalational anesthesia, hyperventilation and accompanying hypocapnia beyond a certain limit may actually disturb rather than enhance the washout of inhalational anesthetics from the brain because of a decreased cerebral blood flow. Two mathematical models were constructed and the washout of nitrous oxide, halothane and methoxyflurane were studied. In model 1, the whole body consisted of a single compartment, and blood flow to this compartment was assumed to change proportionally with the PaCO2. In model 2, the body was divided into two compartments, brain and the rest of the body. It was assumed that the blood flow to the brain compartment varies proportionally with the PaCO2 while that to the rest of the body remains constant. The analysis indicated that there indeed existed the PaCO2 values at which the washout of anesthetics from the brain can be maximally achieved. In model 1, they were 49.0, 22.1 and 9.7 mmHg for nitrous oxide, halothane, and methoxyflurane, respectively. In model 2, these PaCO2 values varied with time. While the hypothesis was proven to be valid, we conclude that it is of limited clinical significance. For halothane and methoxyflurane, these theoretically optimum PaCO2 values are sufficiently low. For nitrous oxide, the variation of PaCO2 makes little difference clinically, because its washout is fast enough regardless of PaCO2View full abstractDownload PDF (370K) -
YASUHIRO SUZUKI1979 Volume 129 Issue 4 Pages 327-336
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe variation of fluorine concentration by sex and age in bones of Japanese subjects was estimated. The subjects had lived in districts virtually with no fluoride in drinking water and air. The rib bone and the iliac crest were selected for investigation. The fluorine concentration in bones was about 100 ppm in dry (fat-free) weight and 200-230 ppm in ash weight from birth to 19 in both sexes, and increased in their twenties, reaching a plateau level in the 60's. The fluorine concentra-tion in rib bones, however, was 610 ppm in dry (fat-free) weight and 1100 ppm in ash weight, which was slightly higher than that in ilia with 530 ppm in dry (fat-free) weight and 960 ppm in ash weight, respectively. The bones of males contained more fluorine than those of females. The concentration of Ca, P and Mg in bone tissue did not correlate with fluorine concentration.View full abstractDownload PDF (568K) -
TOSHIO KUROKAWA, ISAO NAKAO, KAZUSUKE FURUKAWA, TAKAO KANKO, TADASHI Y ...1979 Volume 129 Issue 4 Pages 337-345
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThree-drug therapy with Mitomycin-C (MMC), 5-fluorouracil (5-FU), and a nitrosourea derivative, ACNU, was carried out in 72 cases of carcinoma patients, mostly of stomach carcinoma. 1) According to Karnofsky's criteria, an effect of above I-A was observed in 10 of 35 cases (29%) treated with MFU-I (0.08 mg/kg of MMC, 10 mg/kg of 5-FU and 0.4-0.8 mg/kg of ACNU twice a week for the first two weeks and once a week thereafter for a total of six weeks as one course), 5 of 14 cases (36%) with MFU-I-O (MFU-I plus 0.2-2.0 KE of OK-432 i.m. three times a week), and 6 of 20 cases (30%) with MFU-II (0.2 mg/kg of MMC once in two weeks, 5 mg/kg of 5-FU every day, 2 mg/kg of ACNU once in six weeks as one course). 2) According to the criteria of the group of Grant-in-Aid for Cancer Rsearch from the Ministry of Health and Welfare, a partial response was seen in 29% of the cases treated with MFU-I, in 38% of the cases treated with MFU-I-O, and 30% of the cases treated with MFU-II. 3) Side effect was slight in the digestive organs but the bone marrow suppression was remarkable. Leukopenia and thrombocytopenia were seen in the majority of patients under treatment. The hematological side effect appeared early in MFU-II therapy, but it was not severe and recovered quickly. Combined use of OK-432 seemed to be effective to shorten the period of hemato-logical disorders. Thus, three-drug combination treatment with MMC, 5-FU, and ACNU seems to be useful for patients with malignant tumor, chiefly of the digestive organs. Especially, MFU-II treatment schedule seems to be a combination therapy that has relatively small hematological side effects.View full abstractDownload PDF (527K) -
HIROSHI MATSUO, KATSUMI MURATA1979 Volume 129 Issue 4 Pages 347-349
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe mitogenic effect of the novel lectin prepared from an animal source on human lymphocytes was examined in comparison with that of phytohemagglutinin-p (PHA-p) by the uptake of 3H-thymidine. The uptake of 3H-thymidine by lympho-blasts was enhanced by the treatment with the lectin as well as with PHA-p, though the effect of the lectin was difficult to compare exactly with that of PHA-p.View full abstractDownload PDF (186K) -
SHOZO NAKAMURA, YOSHIAKI TAKEZAWA, TAKASHI SATO, KIYOSHI KERA, TOSHIYU ...1979 Volume 129 Issue 4 Pages 351-355
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn 1972-1977, 130 patients with alcoholic liver disease (123 men and 7 women) were admitted. A half of the women had occupations which are related with alcohol consumption and a half were housewives. Daily consumption of alcohol in the women was the same as in the men. Duration of excessive drinking was 11. 4 years in the women and 17. 1 years in the men, but the difference was not statistically significant. Though the difference of the incidence of alcoholic hepatitis in the women (57%) and in the men (27%) was not statistically significant, frequency of ascites was significantly higher in the women (43%) than in the men (7%). Women seem to be more susceptible to severe form of alcoholic liver damage.View full abstractDownload PDF (292K) -
SOROKU YAGIHASHI, MUNEO MATSUNAGA1979 Volume 129 Issue 4 Pages 357-366
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSural nerve lesions in patients with clinically manifest diabetic neuropathy were investigated electron microscopically. Myelinated nerve fibers were reduced in all the diabetic patients. Axonal degeneration of both myelinat-ed and unmyelinated nerve fibers was most conspicuous finding in the diabetic sural nerves. Structural changes of the axons were represented by axonal dwindling, depletion of axoplasmic organelles, vacuolarization and an increase in neurofilaments. Accumulation of glycogen-like particles and deposition of electron homogeneous amorphous materials were noted within a few axons. On the other hand, there could also be found degenerative changes of myelin sheaths, various kinds of cytoplasmic inclusion bodies (crystalloid, lamellar inclusion bodies and lipids-like droplets), aggregates of glycogen particles in the Schwann cell cytoplasm and basement membrane hyperplasia of Schwann cells in all the subjects. Furthermore, multiplication and thickening of the basement membrane of vasa nervorum were constant findings of the diabetic sural nerves. The vascular changes, demyelination and axonal degeneration of the cases were not apparently correlated with each other. There was no special relationship between nerve tissue changes and clinical symptoms or laboratory findings. These results indicated that the peripheral nerve lesions in human diabetics were mainly due to metabolic impairment of nerve fibers, accompanying dysmetabolism of Schwann cells and diabetic microangiopathy, and that these changes proceeded independentlyView full abstractDownload PDF (4092K) -
KEIGO YASUDA, TOSHIRO SAKURADA, MAKIKO YAMAMOTO, MASAKUNI KIKUCHI, MAK ...1979 Volume 129 Issue 4 Pages 367-372
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCarbohydrate metabolism was studied in eight patients with Down's syndrome, aged 8 to 18 years. Diabetic glucose tolerance was observed in only one patient with obesity. This impaired glucose tolerance was improved with the weight reduction due to diet restriction. The flat glucose tolerance curves with low peak values were also observed in the other two patients. In the remaining five patients, normal glucose tolerance was obtained. Insulin response and free fatty acid levels during oral glucose load were not characteristic except for the diabetic patient with obesity. The sera of Down's syndrome showed normal binding capacity for insulin. These results suggest that obesity might partly participate in the impaired glucose tolerance in Down's syndrome.View full abstractDownload PDF (313K) -
KEIICHI OIKAWA1979 Volume 129 Issue 4 Pages 373-387
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe three-dimensional fine structures of several tissue components of the liver in normal mice were studied by scanning electron microscopy. The tissue components observed were as follows: hepatocytes, sinusoidal endothelial cells, the Kupffer cells, fat-storing cells, reticulin fibers and epithelial cells of the bile duct. Two types of fenestrations were found in the sinusoidal endothelial cells. One was smaller and clustered, and the other larger and scattered. Both of them were distributed equally throughout the hepatic lobule. Intercellular gaps were found at the endothelial junction. The Kupffer cell which was localized in a large gap between the endothelial cells was characterized by numerous vinous projections, and by the absence of fenestrations which were observed in the endothelial cells. Fat-storing cells were located between hepatocytes. They elongated their processes into the space of Disse, but never protruded into the sinusoidal lumen. They were clearly distinguished from the endothelial cells and the Kupffer cells by their morphological feature and location. No transitional form was seen among the endothelial cells, the Kupffer cells, and the fat-storing cells.View full abstractDownload PDF (4810K) -
KEIICHI OIKAWA1979 Volume 129 Issue 4 Pages 389-404
Published: 1979
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSNo significant changes in the structure of the liver were seen until 9 hr after the inoculation of mouse hepatitis virus-2 (MHV-2) into mice. At the 24 hr stage, distinct swelling of hepatocytes and narrowing of sinusoidal lumina were observed from the middle to the central area of the hepatic lobules. Most of the Kupffer cells were swollen. Their villous projections were decreased in number, and the remaining projections became like blebs. Virus particles appeared from this stage in the hepatocytes, the Kupffer cells and the space of Disse. At the 48 hr stage, parenchymal necrotic foci were present in the central and the middle area of the lobules. The necrotic change was increased from 72 hr after inoculation, and was followed by submassive or massive necrosis. It is suggested that hepatic necrosis in both the central and the middle area, or in either area, of the lobules was advanced by aggravation of the sinusoidal micro-circulation, as a result of the swelling of the hepatocytes and the Kupffer cells in addition to the direct affection by virus. Fine granulation was observed on the surface of most of the central flagella of the bile duct. Some flagella were degenerated, and came in part to be a fibrillar net.View full abstractDownload PDF (6006K) -
1979 Volume 129 Issue 4 Pages e1
Published: 1979
Released on J-STAGE: November 28, 2008
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