The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 58, Issue 1
Displaying 1-16 of 16 articles from this issue
  • Tatuo Saito
    1953 Volume 58 Issue 1 Pages 1-9
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Shigetsugu Katsura, Yoshinobu Ishikawa
    1953 Volume 58 Issue 1 Pages 10
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • M. C. Li
    1953 Volume 58 Issue 1 Pages 11-21
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Two sets of rabbits, normal individuals as the control and those long surviving depriviation of the splanchnici or the adrenals, were heated by means of combination of the heat-puncture and the heating in a special heating chamber. The head of rabbits was kept out of chamber, so that the animal breathe in the common air, not of abnormally high temperature.
    1. When the environmental temperature was adjusted at 50°, the hyperthermia and hyperglycemia, such as mean 42°-43°C. and 0.15-0.17%, were brought about in the control animals, and those of 41°-41.5°C. and 0.11-0.12% in the animals, suffered from splanchnicotomy or adrenalectomy.
    2. The chamber temperature be raised to 60, ° the hyperthermia and hyperglycemia were estimated as 43°-44°C. and 0.14-0.17% in the control animals, and 42.5°-43°C. and 0.14% in the individuals operated on.
    Otherwise expressed:
    (A) While the heat-puncture alone cannot produce such a high temperature as 42° or more, and induce a blood sugar increase, except the so-called operation hyperglycemia, it effects a considerable hyperthermia and hyperglycemia as well, if artificial heating of animal body be combined to it. 50° and 60° of the environmental temperature act so.
    (B) Splanchnicotomy and adrenalectomy effect to reduce the hyperthermia and hyperglycemia, thus occurring. These effects are conspicuous when 50°-heating is applied whereby both the variations are of lesser degree. Especially the effect upon the hyperglycemia is distinct. But the splanchnicotomy and adrenalectomy can not reduce so strongly the hyperglycemia and hyperthermia, when the environmental temperature be arranged high as 60°.
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  • Masahiko Kuroya, Yoshiro Yoshinari, Nakao Ishida, Ki-ichiro Noda, Eiji ...
    1953 Volume 58 Issue 1 Pages 22
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • IX. Multiple Follicularcyste (Bosselini)
    Jirô Iisawa
    1953 Volume 58 Issue 1 Pages 23-26
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
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  • Kihachi Unoura
    1953 Volume 58 Issue 1 Pages 27-38
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
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  • Seventh Report Response of the Intragastric Temperature to Histamine
    Hisayuki Masuda
    1953 Volume 58 Issue 1 Pages 39-48
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Response of the intragastric temperature of men of various age groups, who were in healthy as well as several pathologic states, to subcutaneous injection of histamine was studied, in comparison with changes in the cardiovascular system and gastric juice; and the following facts were confirmed.
    1. By histamine the intragastric temperature is lowered following increases in the pulse rate and pulse pressure and a drop in the diastolic blood pressure, which are accompanied by a flush of the face, heat sensation and palpitation.
    2. After reaching the maximum drop, it recovers in a manner following the recoveries of the above mentioned changes.
    3. It drops on account of flowing of the blood, which is cooled down at the body surface, into the gastric vessels; and the drop is determined chiefly by the changes in the pulse rate and diastolic blood pressure.
    4. It is not related with the change in the gastric free acidity.
    5. Both age and injected dose of histamine act upon the change in the intragastric temperature indirectly through those in the pulse rate and diastolic blood pressure.
    6. Disease is one of the factors which influence the change in the intragastric temperature.
    7. Room temperature has no correlation with the change in the intragastric temperature.
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  • Eighth Report Influence of Cold Bathing on the Intragastric Temperature
    Hisayuki Masuda, Mitsuo Ohara, Shigeaki Katsura
    1953 Volume 58 Issue 1 Pages 49-55
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Changes in the intragastric temperature of healthy men by cold bathing were studied, varying the part to be immersed, and the following facts were confirmed.
    1. The intragastric temperature at first rises by cold bathing. This rise is inversely proportional to the area to be immersed.
    2. Following this rise it falls and in the fall two types are distinguished -one is the seeming fall due to recovery of the rise and the other the true fall by the cold bath. The former appears when the area to be immersed is small and the latter when the area is wide.
    3. In some cases it falls from the beginning of the bath, because the preceding rise is covered with the true fall.
    4. There are considerable individual variations in the above stated rise and fall.
    5. Appearance of this variation is also in intimate relation with the area to be immersed.
    6. The gastric secretion is increased by the cold bath.
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  • I. The Clinical Observation
    Tamotsu Sano, Iwaki Niitsu, Isawo Nakagawa, Takashi Ando
    1953 Volume 58 Issue 1 Pages 56
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Ninth Report Relation of the Intragastric Temperature to Gastric Secretion
    Hisayuki Masuda, Mitsuo Ohara, Shigeaki Katsura
    1953 Volume 58 Issue 1 Pages 57-61
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Gastric secretion, originated by only introducing of a thermometer into the stomach, in healthy and several pathologic states was studied, simultaneously with the change in the intragastric temperature; and the following facts were confirmed making reference to the results reported previously1)-3).
    1. Gastric secretion both originated by only introducing of the thermometer and stimulated by the injection of drugs, especially histamine, has no significant relation to the change in the intragastric temperature.
    2. The intragastric temperature does not change significantly by introducing of the thermometer regardless of the patients and healthy men.
    3. Gastric secretion after introducing of the thermometer increases pathologically in gastric and duodenal ulcers, and decreases in gastric cancer and cholelithiasis in comparison with healthy state, while it does not occur, as a rule, in gastrectomized state.
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  • II. The Isolation of A New Virus
    Masahiko Kuroya, Nakao Ishida, Takehiko Shiratori
    1953 Volume 58 Issue 1 Pages 62
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • (Studies on Rotatography. 9th Report)
    Shinji Takahashi
    1953 Volume 58 Issue 1 Pages 63-68
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
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    The mechanism of occurrence of blurred images or obstructive shadows in Rotatory Cross Section Radiography has been analysed from the theoretical as well as the experimental point of view, and the following are the conclusions reached.
    1. A point beyond the plane to be traversed is blurred into a locus of a circle:
    (X-r2 cos α)2+(Y-r2 sin α)2=r12.
    The center of this circle is determined as co-ordinates (r2 cos α, r2sin α) of this formula.
    2. When a line is blurred, the result is an image of two characteristic shaodws. This was called a line shadow.
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  • Toshihiko Oikawa
    1953 Volume 58 Issue 1 Pages 69-81
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Retinal processes were studied by the method of electrostimulation at 20° and 50° from the fovea.
    1. At the light-threshold there appear three processes of different time courses. The slowest one represents the excitation of rods. The other two processes correspond to the yellow and the blue process respectively, judging from their crest times. Therefore, they are denoted by Y and B.
    2. At the light-threshold and in the photochromatic interval, the two processes, Y and B appearing always hand in hand, are equal to each other in magnitude and remain constant irrespective of the wave-lengths of illuminating lights. Therefore, they are called “ a twin-process.” This process subserves scotopic colorless sensations in conjunction with the rod-process.
    3. At the color-threshold, either Y or B component of the twin-process is depressed according to whether the wave-length of illuminating light is shorter or longer than 505mμ, but the other component remains intact. This finding corresponds to the psychological fact that at the color-threshold spectral lights give rise to yellow or blue sensation.
    4. The twin-process is a scotopic process having some properties similar to those of photopic processes. It differs from the rod-process in the following points; i) it originates in ofd elements or on/off-elements, ii) it exists only below the color-threshold, iii) its spatial distribution corresponds to the density distribution of cones, iv) its time constants
    are much shorter than that of the rod-process.
    5. The important role played by inhibition in the formation of color sensations is discussed.
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  • III. Pathological Study
    Ki-ichiro Noda
    1953 Volume 58 Issue 1 Pages 82
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
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  • I. Influences of the pH Value of Enema on the Absorption of Calcium in the Large Intestine
    Teruo Mochizuki
    1953 Volume 58 Issue 1 Pages 83-93
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    By actively changing the pH of the enema solution of calcium preparations, especially of calcium chloride, the influences of the varying pH of the enema solution on the absorption of calcium in the large intentine was investigated in the first place.
    When the reaction of the enema was shifted to the alkaline side with NaOH, the absorption of calcium chloride in the large intestine was evidently enhanced at pH 8.0. At pH 7.0 or pH 9.0, the absorption remained the same as in the control tests with the solution without adjustment of pH, and there was no enhancement of absorption note-d
    When the reaction of the enema was shifted to the acid side with acetic acid, lactic acid or hydrochloric acid, the absorption of calcium chloride in the large intestine was remarkably enhanced at pH 2.8 in all cases. Especially, when the reaction was adjusted with hydrochloric acid, the absorption was most distinctly enhanced, and all the rabbits used demonstrated intoxication symptoms and became fatal. As already reported by Hitomoto and Kato, the calcium content in the peritoneal fluid in such cases was found extremely increased.
    Previously, Kato reported a very interesting result that when calcium preparations combined with the mixture of glycocoll and glucose is administered as enema, the absorption of calcium chloride in the large intestine is greatly enhanced, and further, that calcium lactate and calcium sulfate, which are usually not absorbed from the large intestine, are
    also absorbed. Whereas, I confirmed that, when calcium sulfate solution is acidified to pH 2.8 with acetic acid, calcium sulfate is absorbed in the large intestine, though slower compared with calcium chloride, and the serum calcium content is somewhere about 24mg/dl even after 210 minutes. Adjustment of the reaction to pH 2.8-3.0 combined with ox bile does not particularly enhance the absorption compared with the above results, but when too much ox bile is combined, intoxication death caused by abnormal absorption of biliary acid and excess of calcium content in the serum is observed.
    In the case of oral administration, even doubled amount of calcium chloride solution of the case of enema (20cc. per kg. of 5% calcium chloride solution) generally increase the serum calcium content only slightly. Whereas, when ox bile is combined, the serum calcium content increases rapidly indicating the enhanced absorption of calcium in the small intestine. Differing from the case of enema, in the case of oral application, no particular enhancement of the absorption of calcium is observed even the reaction of calcium chloride solution is adjusted to pH 2.8 with acetic acid, lactic acid or hydrochloric acid. Further, when ox bile is combined with calcium chloride solution with adjusted pH, no particular difference is noted in the influence of bile from that in the case combined with the same solution without pH adjustment. Despite the fact that the absorption of calcium in the small intestine does not demonstrate any difference between that of calcium solution with adjusted pH or without pH adjustment combined with ox bile, the absorption of calcium administered in combination with ox bile induces much more rapid and distinct enhancement of calcium absorption compared with that of the application of calcium alone. Consequently, it became essential to know calcium absorption in the stomach. When calcium chloride solution was orally administered after the pylorus of stomach was ligatured, the fact, that the serum calcium content did not increase during the elapse of 210 minutes from the administration even in the combined application with ox bile, was confirmed. By the above fact, it is presumed that the rapid increase in serum calcium content in the case of combined application with ox bile may be induced by rapid transfer of calcium chloride solution from the stomach to the small intestine and enhancement of calcium absorption in the small intestine by ox bile.
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  • II. Influences of Various Narcotics on the Absorption of Calcium and Histamine in the Large Intestine
    Teruo Mochizuki
    1953 Volume 58 Issue 1 Pages 95-103
    Published: June 25, 1953
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Summarizing the results of the above experiments, it was learnt that, under urethane anesthesia, the absorption patterns of calcium are almost the same as those of under non-anesthetic condition in the cases of oral administration, duodenal infusion and enema of calcium chloride solution, and that urethane itself was considered not to have exercised any influences on the calcium absorption. Similarly to the case of urethane, under anesthetic condition with chloral hydrate or magnesium sulfate, the calcium absorption in the large intestine was not generally influenced. Kondo reported that, the combined enema with chloral hydrate enhances remarkably the calcium absorption in the large intestine, but not with magnesium sulfate. In view of the above fact, it was clarified that the calcium absorption in the large intestine is greatly influenced by the combined enema of appropriate narcotic and calcium preparation.
    is similarly enhanced by the combined enema with urethane.
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