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Volume 53 (1950 - 195･･･
- Issue 3-4 Pages 207-
- Issue 1-2 Pages 1-
Volume 53, Issue 3-4
Displaying 1-25 of 25 articles from this issue
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Akira Urayama1951 Volume 53 Issue 3-4 Pages 207-215
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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CXXXIV. Mucosin. First ReportTyuiti Isikawa1951 Volume 53 Issue 3-4 Pages 217-222
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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III. On Ascitic Fluid. Third ReportHirosi Tiba, Isao Takaku, Yoiti Satoh1951 Volume 53 Issue 3-4 Pages 223-236
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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CXXXV. Paper Partition Chromatograms of Sugar Components in Glucidamins and Glycoproteins. IIHajime Masamune, Zensaku Yosizawa, Masahiro Maki1951 Volume 53 Issue 3-4 Pages 237-241
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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Mitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 243-249
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. In human gastric mucosa besides peptic action, are found cathepsin action (pH 4.0-5.0, casein, egg albumin and serum albumin ) and catheptic _??_ pepton splitting action (cathopeptonase). And casein is also at pH 8.5 hydrolized (72 hrs.).
2. I have succeeded also with human gastric mucosa to separate the pepsin action from the cathepsin action, and also the cathopeptonase action from the erepsin action by means of acid and alkaline treatment respectively according to the methods of Utzino and Sakai.3)
3. In human gastric mucosa halogen-acylase action (pH 7.8, chlor-acetyl-1-leucin and chloracetyl-1-phenylalanin) is found, but carboxy-peptidase action (pH 7.8, benzoyl-diglycin, with kinase) or hippuricase action (pH 7.8, benzoyl-glycin) not. The hydrolysis of chlor-acetyl- _??_ diglycin at pH 7.8 by gastric mucosa from ulcer stomach is certain extent recognized.
4. Neither acid carboxy-peptidase action nor. acid acyldipeptidase action (pH 4.2-4.6, benzoyl-diglycin, chloracetyl-diglycin) despite of the cystein activation is still yet found. The hydrolysis of diglycin, chlor-acetyl-l-leucin, chloracetyl-phenylalnin and benzoyl-glycin at pH 4.5 with cystein, all of these are negative.View full abstractDownload PDF (314K) -
II. Its Tryptase ActivityMitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 251-258
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. In human gastric mucosa tryptase activity (pH 7.2-8.4, casein & gelatin) is surely present, but against it serum albumin and egg albumin are usually resistent.
2. Tryptase of human gastric mucosa may partially find itself in desmo-form and its activity remains also in the presence of not dialyzed serum albumin or egg albumin unaffected. The hydrolysis of gelatin seems to undergo some retardation in the presence of human serum but that ofcasein surely not. The tryptase activity is rather inhibited by cystein, but no effect of kinase activation is found.
3. Tryptase activity of human gastric mucosa undergoes activation in the presence of dialyzed albumin, with which such a protein as egg albumin or serum albumin comes to be hydrolyzed, though it is usually resistent to the tryptase activity.View full abstractDownload PDF (345K) -
First Report. Inhibition Mechanism of Serum against Tryptic ProteolysisMitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 259-267
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThrough my experiments no difference could be noticed between serum and serum albumin with regard to their inhibition mechanism.
1. No difference can be observed between serum and serum albumin with regard to their inhibition mechanism against proteolysis.
2. Goldstein's theory3) is applicable to the substrate-trypsin-serum system, too.
3. In the inhibition of serum against tryptic proteolysis the reversible compound is formed, according to the law of mass action, between enzyme and inhibitor in serum.
4. I have built an equation representing these relations.View full abstractDownload PDF (404K) -
Second Report. A New Clinical Method by Formal-Titration of Measuring Antitryptic Index of SerumMitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 269-273
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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Third Report. Chemical Nature of Antitryptic Activity of Serum. I. Its Relation to Serum ProteinMitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 275-281
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. Tryptase activity in serum (pH 7.8, hydrolysis of casein). is generally inhibited by serum itself and is not to be recognized directly.
2. The inhibitory action against pancreas trypsin can be demonstrated not only in albumin fraction but also in globulin fraction of serum.
3. The smaller the pH value (under pH 4.2) employed for the acid treatment is, the more evident is it that the antitryptic activity of serum after the treatment disappears in proportion to the degree of degeneration of serum protein. The appearance of serum tryptase activity is distinct after the treatment rather at more than pH 4.8.
4. After the adsorption with kaolin at nearly isoelectric point of a serum protein, antitryptic activity of serum disappears not proportionally to the decrease in N-amount of the serum.View full abstractDownload PDF (334K) -
Fourth Report. Chemical Nature of Antitryptic Activity of Serum. II. Its SymplextheoryMitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 283-289
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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Fifth Report. Serum Antitryptic Index of the Patients with Castric or Duodenal Ulcer and with Gastric CancerMitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 291-301
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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Mitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 303-307
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. The hydrolysis of casein at pH 4.5-5.0 by gastric mucosa of a rabbit is activated apparently in the presence of serum or plasma, while that of pepton and also that of casein or serum albumin at pH near 2.0 always remain unaffected.
2. The hydrolysis of casein at pH 4.5 by rabbit liver is inhibited by serum but that of pepton at pH 4.5 or 7.8 is not. These two pepton splitting activities can be separated from each other by alkaline or acid treatment.
3. The hydrolysis of casein and serum albumin at pH 4.4-5.0 by gastric mucosa (human) are to some extent inhibited by serum or scarecely undergo influence, while that of egg albumin is activated by serum. The hydrolysis of pepton at pH 4.6 and that of casein or serum albumin at pH 2.0, all remain without being influenced.
4. Catheptic pepton splitting enzyme action (cathopeptonase) may presumably be in a rabbit's liver, in its gastric mucosa and also in human gastric mucosa.View full abstractDownload PDF (225K) -
Mitsuhisa Hayakawa1951 Volume 53 Issue 3-4 Pages 309-316
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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Hisao Sato1951 Volume 53 Issue 3-4 Pages 317-324
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1) The cardiac rhythms of dogs, the respiratory arrhythmias in particular, were studied by “Cardiotachograph” in experimentally induced hyper- and hypo-thyroidism.
2) In hyperthyroidism, besides tachycardias, marked decrease and finally complete disappearance of respiratory arrhythmias were noticed These can be looked upon as characteristics in hyperthyroidism.
3) In hypothyroidism, on the contrary, bradycardias were accom-panied by exaggerated respiratory arrhythmias.
4) There was noticed a distinct correlation between the respiratory arrhythmias and pulse rates throughout the experimental conditions.
5) These changes in respiratory arrhythmia were found to be due mainly to changes in the expiratory pulse intervals, the inspiratory pulse intervals, on the other hand, being modified but little.View full abstractDownload PDF (2754K) -
Hisao Sato1951 Volume 53 Issue 3-4 Pages 325-330
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. The pattern of cardiac rhythm of man as observed by means of cardiotachograph, is to some extent, a characteristic to each individual.
2. By repeated and careful observations on twenty normal individuals there were recognized three main components of cardiac rhythm which characterized its pattern. That is 1) the respiratory arrhythmias, 2) the slow waves and 3) the irregular waves.
3. The features of these three components except the respiratory arrhythmias were described and discussed.View full abstractDownload PDF (3355K) -
Akira Sato1951 Volume 53 Issue 3-4 Pages 331-332
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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First ReportYasuaki Matuda1951 Volume 53 Issue 3-4 Pages 333-339
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. From human liver group active lipoids were separated. Of them A and B group substance inhibited isoagglutination of erythrocytes at a dilution from 1:1600_??_3200 specifically.
2. These group lipoids dissolved in water, benzene, chloroform, tetralin and glacial acetic acid, but not in ethanol, ether, petroleum ether and -acetone. They dissolved in methanol scarcely in the cold but to a certain extent when boiled.
3. The group lipoids contained galactose, hexosamine, P and N in equivalent proportions of roughly 1:1(most probably): 10:10. Their minimum molecular weight (The substances were presumed as nearly pure) of 6500 was computed out from galactose content. N. E., 600_??_700.View full abstractDownload PDF (369K) -
Koiti Motokawa, Kituva Iwama1951 Volume 53 Issue 3-4 Pages 341-349
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe change in electrical excitability of excised frog eyes was investigated with action potentials of optic nerves as the index of excitation.
1. The excitability-time curve or excitability curve after an illumination by white light shows three humps at about 1.5, 3, and, 5 minutes after, the end of the illumination at room temperature of 15-20°C. These humps are called R, G and B elevations.
2. When colored light is used instead of white light for pre-illumination the three elevations appear in different proportions according to the wave-length of the light. Predominant elevations of curves obtained by pre-illumination with red, green and blue lights are R, G and B respectively.
3. Percentage increases of electrical excitability above its resting level are denoted by ζ. Between the maximum ζ and the logarithm of the intensity of pre-illuminating light a linear relation holds in a wide range of intensities.
4. The excitability curve for white light is markedly deformed when the eye is continuously exposed to weak colored light after removal of the pre-illuminating white light. This phenomenon is due to an inhibitory effect exerted by the continuous light upon color processes. Red, green and blue lights have a selective inhibitory action upon the R, G and B processes respectively.
5. When pre-illuminating white light is preceded by any colored light, an excitability curve is obtained which is similar to that obtained when the eye is illuminated by the complementary color alone. For example, in this respect white light preceded by blue light is equivalent to yellow light. This is evidently a physiological phenomenon underlying successive color contrast.View full abstractDownload PDF (429K) -
A Contribution to the Study of Argyrophil FibersGiichiro Ishigaki, Takeshi Kurobane1951 Volume 53 Issue 3-4 Pages 351-358
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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Taizo Suzuki1951 Volume 53 Issue 3-4 Pages 359-365
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS(1) It was confirmed that the successive injection of cobalt into rabbits day after day brings about a definite increase of reticulocyte, followed by an increase of erythrocyte and hemoglobin content, There is no change in leukocyte count.
(2) There was observed a little difference in degree but not in nature between the polycythemia producing effects of the intravenous and subcutaneous injections.
(3) The injection of a large dose of cobalt salt at a time did not bring about an increase in erythrocyte count. Only successive, daily in-jections brought about the effect.
(4) Splanchnic nerve plays no part in the cobalt polycythemia.
(5) There was no difference in oxygen carrying capacity between . the hemoglobin of normal and polycythemic blood.View full abstractDownload PDF (332K) -
Taizo Suzuki1951 Volume 53 Issue 3-4 Pages 367-371
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe hematopoietic actions offour complex salts of cobalt were examined on rabbits. Purpureo salt did not bring about any significant altering in blood findings but other three salts, that is, Carbonatotetrammine cobaltic nitrate, Flavo salt and Croceo salt, produced polycythemias. Among these complex salts which revealed itself to be effective, there were noticed a certain differences in its effects quantitatively as well as qualitatively.
The auther takes pleasure in expressing his sincere thanks to Prof. K. Matsuda for his advice and interest throughout the work. The costs of this work were defrayed by a grant offered to him from the Foundation for Promotion of Scientific Research of the Education Department.View full abstractDownload PDF (187K) -
Second ReportYasuaki Matuda1951 Volume 53 Issue 3-4 Pages 373-382
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA preparation of Group A lipoid of human liver was hydrolyzed and fractioned. Separated were glucosamine (as hydrochloride), galactose (as methylphenylhydrazone), choline (as chioroplatinate), palmitic acid, an unsaturated hydroxyacid, a probable keto-alcohol and three substances containing N and P. Moreover qualitative tests suggested the presence of formic acid, tyrosine, xanthine and hypoxanthine or guanine among the cleavage products. Sphingosine, glycerol, glycerophosphoric acid and acetic acid were absent.
A short discussion was made regarding the results.View full abstractDownload PDF (661K) -
CXXXVI. A Hexosamine-containing Carbohydrate and a Glucidamin from Human LiverYasuaki Matuda1951 Volume 53 Issue 3-4 Pages 383-388
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFrom normal human liver two hexosamine-involving substances, one a carbohydrate and the other a glucidamin, were separated. The carbo-hydrate was blood-group (ABO system)-active and the glucidamin inert in this respect. Their composition was discussed.View full abstractDownload PDF (338K) -
Masao Tamura1951 Volume 53 Issue 3-4 Pages 389-398
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
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Koiti Motokawa, Kituya Iwama, Susumu Tukahara1951 Volume 53 Issue 3-4 Pages 399-406
Published: March 25, 1951
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSColor processes at single retinal elements or at a restricted number of elements of Japanese toads were investigated with the aid of microelectrodes, taking well-isolated spikes as the index. The electrical excitability of a single retinal element as a function of time after cessation of pre-illuminating white light shows a maximum at 1.5, 3 or 5 minutes. These values of crest time correspond respectively to those of the R, G and B elevations which are found on the excitability curve for white light determined with action potentials of the whole optic nerve as the index. From retinal elements responding with isolated spikes to optic and electric stimuli sometimes an excitability curve having two distinct humps was obtained.
A histogram concerning crest times of excitability curves of these isolated elements shows that there are three groups of retinal elements. The number of elements belonging to each group was 23 for the R group, 21 for the G group and 21 for the B group. When red light was used instead of white light for pre-illumination all the 19 elements tested in this series of experiments showed excitability curves of the R type. The retinal elements so far studied are to be identified with Granit's modulators.View full abstractDownload PDF (1206K)
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