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Volume 91 (1967)
- Issue 4 Pages 315-
- Issue 3 Pages 209-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 91, Issue 1
Displaying 1-10 of 10 articles from this issue
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Seigi Tsuchida, Yukio Kimura1967 Volume 91 Issue 1 Pages 1-12
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe present study deals with the pathogenesis of vesicoureteral reflux. It was found from the electro-ureterographic and urometric examinations that no active contraction was present in the intramural portion of the ureter and that the urine was passively transported through the portion by peristaltic contraction in the extravesical ureteral portion.
The occurrence of reflux in the ureter after its ureterovesical junction had been kept constantly patent by insertion of a polyethylene tube was observed by fluoroscopy with an image-intensifier. From this observation it was noticed that relux occurred in the ureter during its resting phase without participation of retrograde peristalsis.
Further, functional and histological examinations were carried out on the ureter after uretero-cystostomy. The results obtained suggested that the implanted portion of the ureter functioned essentially in the same way as in the natural ureterovesical junction.View full abstractDownload PDF (4126K) -
Ichiji Sumitomo, Yasumasa Hayashi1967 Volume 91 Issue 1 Pages 13-30
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSElectrical responses of the superior colliculus (SC), elicited by single shock stimulation of the optic tract (CT), were studied in unanesthetized immobilized cats and in one chronic preparation. 1) When recorded from deep points of the SC, the electrical response con-sisted of an initial spike complex and a following positive-negative biphasic wave. Among these, the earliest spike with a latency of 0.6 msec was identified as representing a presynaptic volley. The onset latency of the positive wave was 3-6 msec.
2) In response to a single OT shock, units of the SC discharged singly or repetitively. The latency histogram of the unitary responses had two peaks, one at 2-3 msec and the other at 8-9 msec. The configuration of the latency histo-gram was about the same as the positive wave response.
3) Conditioning stimulation of the mesencephalic reticular formation (MRF) enhanced the positive wave response. This effect was maximum at 150 msec and lasted up to 500 msec after the MRF activation. With about the same time course as this, the reactivity of the SC units was increased.
4) The antidromic response of the OT was enhanced following the MRF activation, the maximum being reached at 40 msec. In association with this a slow negative potential change was found to occur at the optic chiasm. Its time course was similar to the facilitation curve of the antidromic CT response.
5) It was seen in one chronic preparation that the SC response was augmented during deep sleep as compared with those during light sleep and resting arousal.View full abstractDownload PDF (3849K) -
Toshio Yoshida1967 Volume 91 Issue 1 Pages 31-34
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFor the detection of homocystine in urine specimens, a simple thin-layer chromatographic method was devised. Thirty μ1 of urine specimens without any prior treatment were applied onto a silica gel-G plate, and developed by ascending chromatography using a phenol water mixture (3:1) containing 0.05% potassium cyanide. After developing and drying the plate, a slightly modified potassium iodoplatinate reagent was sprayed. Homocystine, cystine, methionine, cystathionine and histidine were clearly separated with different Rf values of 23-27, 12-13, 59-64, 14-16 and 44-4, respectively.View full abstractDownload PDF (1450K) -
Michio Arai1967 Volume 91 Issue 1 Pages 35-40
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCataase activity of synovial fluid was estimated in 140 patients with various joint diseases by using a simple gasometric technique. Very high levels of the enzyme activity of synovial fluid were found in patients with inflammatory joint diseases, such as rheumatoid arthritis and infectious arthritis. With the exception of blood-mixed fluid, non-inflammatory fluids showed low levels. The results obtained by our gasometric procedure were in good accordance with those by other methods. The technique was simple, but accurate enough for practical use i n the screening of joint diseases.View full abstractDownload PDF (327K) -
Seishi Tsuchiya, Tsuyoshi Aoki1967 Volume 91 Issue 1 Pages 41-52
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe localization of cholinesterase activity in the tongue of albino rats was histochemically demonstrated by the thiocholine technique of Koelle and Friedenwald, modified by Gomori. The taste nerve fibers innervating the taste buds in the vallate and fungiform papillae contained cholinesterase of both true and pseudo types, the former being predominant. The taste buds themselves failed to show definite cholinesterase activity. True and pseudo cholinesterases were also found in the different sensory nerve endings in the lingual papillae, in the subepithelial nerve plexus, in the motor end plates of the lingual muscle, and in the autonomic nerve fibers innervating the serous Ebner's gland, mucous Weber's gland and the arterioles.
The cholinesterase activity in the taste bud areas was found to be in-hibited by several kinds of bitter-tasting substances, including quinine hydro-chloride, methantheline bromide, berberine hydrochloride, L-methylephedrine hydrochloride, phenobarbital sodium and sodium dehydrocholate. Among the bitter substances tested, only phenylthiocarbamide, a substance with dual taste reaction, failed to inhibit the cholinesterase. Sweet-tasting substances such as sucrose, sodium cycloheylsulfamate and saccharin sodium were all ineffective in inhibiting cholinesterase. It was suggested that the inhibition of cholinesterase activity in the vicinity of taste buds may be associated with the mechanism of bitter taste.View full abstractDownload PDF (2285K) -
Isao Yamane, Noboru Nakano1967 Volume 91 Issue 1 Pages 53-59
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThree cell lines were established from the spleens of adult 0311 mice, In the primary cultures, the cell growth appeared in a few days and gradually ceased. However, medium exchange procedure was still continued every 2 to 4 days thereafter. After various lag periods, the multiple fibroblastic colonies were observed and could be subeultured into all subsequent generations. Those cells of eleven months' culture produced subcutaneous tumors in C3H mice. Modal numbers of the three cell lines were in the (near) diploid range and all chromosomes were telocentric.View full abstractDownload PDF (1019K) -
Yutaka Shibota, Yuzuru Kagawa, Michitoshi Ottomo, Ken Sudo1967 Volume 91 Issue 1 Pages 61-83
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. Results of 19 thymectomies in patients with myasthenia gravis, performed during the period from August 1961 to July 1964, were reported.
2. Based on the severity of symptoms, the cases were divided into the following three groups. Grade I included four cases of a localized myasthenia with ocular symptoms. Grade II included six cases of moderately advanced generalized myasthenia with not only ocular but also bulbar symptoms. Grade III included nine cases of far advanced generalized myasthenia with muscular weakness of neck, trunk, and extremities beside the ocular and bulbar symptoms.
3. Routine laboratory examination did not reveal any pathognomonic findings or confirm any difference among Grades I, II and III. On the contrary, examinations directly connected with muscle functions, such as per cent vital capacity, Tensilon test, Curare test and electromyographic study, showed an apparent difference among the three groups. This classification is advantageous not only for decision of indication for surgery, but also for pre-and postoperative management.
4. Out of 19 cases, five males and one female were accompanied with thymoma. They belonged to Grade III and myasthenic symptoms were
extensive and grave. 5. Indication for surgery was concluded in: 1) the cases with thymoma, 2) the cases of Grade III, regardless of the presence or absence of thymoma, and 3) the cases of Grade II, where conservative treatment was not effective or caused severe side-effect.
6. Anterior mediastinum was entered through sternal splitting method. The whole thymus including the cervical portion should be excised, preserving the pleura and phrernic nerves as much as possible.
7. The most important measure for postoperative respiratory crisis is the maintenance of airway, and prophylactic tracheotomy is far superior to delayed forced tracheotomy. The indication for tracheotomy was decided in: 1) the cases of Grade III, and 2) the cases of Grade II whose per cent vital capacity were less than 59 per cent. Furthermore, 3) the cases of Grade II, where there was an increase in inspiratory capacity at preoperative Tensilon test even though per cent vital capacity was more than 50 per cent should be included. Tracheotomy is unnecessary for Grade I cases.
8. Follow-up results of 17 cases, excluding two recent cases, were: marked improvement in six cases, improvement in seven, and no change in four. The symptoms were improved in 76.5 per cent in total, and unchanged in two of Grade I and in two of Grade III with thymoma. No deaths related to surgery nor myasthenic deaths were observed. Results of female cases were better than those of male cases, and four of six cases with thymoma showed marked improvement.
9. Objection to thymeetomy for myasthenia gravis is mainly due to apprehension for risk of surgical intervention. So far as thymectom.y is performed as safely as the other mediastinal surgeries in co-operation with internists, anesthesiologists, surgeons and nursing members, thymectomy is the treatment of choice for this grave disease, in which otherwise only symptomatic therapy is possible.View full abstractDownload PDF (1642K) -
Seiju Onodera, Akira Shibata, Akira B. Miura, Atsuo Suzuki, Shinobu Sa ...1967 Volume 91 Issue 1 Pages 85-93
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSQuantitation of serum immunoglobulin was made in 14 cases of multiple myeloma and in one case of Waldenström's macroglobulinemia, using an antibody-agar plate method.
Most of the patients with multiple myeloma showed a monoclonal increase of gamma globulin. One case of multiple myeloma and the case of Waldenstrom's macroglobulinemia demonstrated a specific increase of gamma AA and of gamma M, respectively.
The imm_??_moelectrophoretic patterns of these serums were compared with the results of quantitative analysis by the antibody-agar plate. In most of the cases both methods recognized paraprotein, but in some cases only one of these two immunological methods could detect paraprotein. Therefore, both methods seem useful in diagnosing a paraproteinemia.
It should be stressed that Waldenström's macroglobulinemia in this study was diagnosed by the antibody-agar plate method prior to the ultracentrifugal analysis.View full abstractDownload PDF (2672K) -
Kizuku Kuramoto, Kazuhiko Murata, Jun Fujii, Hiroshi Kurihara, Shin-ic ...1967 Volume 91 Issue 1 Pages 95-101
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSympathetic control of the coronary circulation was studied by eliminating the inotropic and chronotropic effects of sympathetic stimulation with adrenergic beta blockade. A remarkable vasoconstrictor effect of the left sympathetic nerve stimulation was observed after an intracoronary injection of propranolol, while the effect of the right sympathetic nerve stimulation was less prominent. The late increase in coronary flow after the cessation of the stimulation was observed to a lesser extent after the adrenergic beta blockade, while the blood pressure and heart rate remained unchanged. The sympathetic coronary vasoconstriction was almost abolished by adrenergic alpha blockade.View full abstractDownload PDF (1703K) -
Robert W. Miller1967 Volume 91 Issue 1 Pages 103-107
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSStudy was made of mortality rates for 5 leading childhood cancers over 2 time intervals in the U.S. nd 3 in Japan. The U.S. rates changed very little over time, and, though the Japanese rates increased progressively, they still were well below those for the U.S. for each site considered. A peak in leukemia mortality appears to be emerging at 3 years of age in Japan as it did 25 years ago among U.S. white children. Kidney neoplasia (principally Wilms' tumor) appears from mortality data to be much less frequent and to have an earlier peak in Japan than in the U. S. The explanation of this difference awaits the accumulation of additional information through Japanese childhood cancer registries. Preliminary results from these registries suggest that the large differences between the U.S.A.nd Japan in mortality from neuroblastoma may be a consequence of dissimilar diagnostic or classification practice.View full abstractDownload PDF (291K)
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