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Volume 91 (1967)
- Issue 4 Pages 315-
- Issue 3 Pages 209-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 91, Issue 2
Displaying 1-8 of 8 articles from this issue
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Toshio Kuroki, Masayoshi Goto, Haruo Sato1967 Volume 91 Issue 2 Pages 109-118
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the present study, hamster embryonic cells were successfully transformed by 4-hydrw yaminoquinoline N-oxide (4HAQO), an active metabolite of 4-nitroquinoline N-oxide (4NQU). The transformed cells were characterized by randomly oriented arrangement of fusiform cells and continuous proliferation in vitro over 200 days. The transformed cells, cultured for 56 days in vitro and transplanted into newborn and adult hamsters, produced tumor and finally killed the animals. Histologically, the tumor was identified as fibrosarcoma.
In untreated cultures, the cells revealed a limited growth and failed to produce tumor in animals.View full abstractDownload PDF (2943K) -
Kosei Ishii, Kazuko Ishii1967 Volume 91 Issue 2 Pages 119-128
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe chemical transmission in chemosensory apparatus of the carotid labyrinth of toads was studied. In the carotid labyrinth which was perfused using the isolated heart, the stimulation of the cardiac sympathetic nerve remarkably increased chemosensory impulses in the carotid nerve. In view of ineffectiveness of noradrenaline administration, the increase of chemosensory impulses might be attributed neither to the oxygen lack nor to the accumulation of metabolic substances associated with the acceleration of the heart beat, but rather to the effect of a sympathomimetic substance released in the heart. It was found that dopamine was a stimulant substance to the chemosensory apparatus.
The electron microscopic observation of the chemoreceptor of the carotid labyrinth supports the view that the adrenergic transmission ecists in the carotid chemosensory apparatus of the toad.View full abstractDownload PDF (2626K) -
Tsuneo Abe, Katsumi Endo, Uzuhiko Imagawa, Shigeyoshi Obuchi, Takeshi ...1967 Volume 91 Issue 2 Pages 129-142
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (683K) -
Tsuneo Arakawa, Masako Fujii, Tadashi Hayashi1967 Volume 91 Issue 2 Pages 143-148
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSMicrocephaly and dilatation of cerebral ventricles not accompanied with other gross malformations were induced in rat offsprings by an intraperitoneal administration of 6-mercaptopurine in a dose of 24 mg/kg on the eleventh day of gestation of dams.View full abstractDownload PDF (1335K) -
Tohru Takahashi, Tokutaro Hayama1967 Volume 91 Issue 2 Pages 149-176
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSLiver specimens from three cases of the so-called intrahepatic cholestasis were submitted to graphic reconstruction of the cholangiolar system by means of serial histological sections and were examined for obstructive changes of the system. The results were evaluated in comparison with those obtained with a normal liver.
Although routine histological examinations failed to demonstrate any signi-ficant change of the bile duct, the three-dimensional analysis revealed a striking disturbance in the continuity of biliary pathways. Remarkable structural derangements of the cholangiolar system were found in all the examined cases. This was interpreted as a result of disseminated cholangiolar lesions followed by regeneration of bile ductules, which was, however, unsuccessful to restore sufficient passage to bile flow.
The same pattern of cholangiolar derangement was also demonstrated in cases of subacute serum hepatitis. This indicated that viral hepatitis was commonly accompanied by a cholestatic mechanism, which was exaggerated in intrahepatic cholestasis. The so-called intrahepatic cholestasis, characterized by jaundice of obstructive character and by absence of other serious functional impairment of the liver, was regarded as a sequela of hepatitis, most frequently of viral origin, when the cholangiolar derangement persisted long after recovery of liver cell injuries. Consequently, it was not acknowledged as an independent pathological entity, and ‘cholangiolar derangement syndrome’ was proposed to designate the condition.View full abstractDownload PDF (11608K) -
Sukemoto Katsura, Ryoichi Satodate1967 Volume 91 Issue 2 Pages 177-190
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESShe metallophil cells of round, branching and foamy types were found in the subcutaneous nodes of Yoshida sarcoma in rats of Wistar strain by the ammoniacal silver impregnation method. The metallophil cells showed positive results for vital staining, iron reaction and various histocheniical reactions. In electron microscopy, silver granules were deposited selectively in the matrix of the cytoplasm. These findings led to the conclusion that the metallophil cells belonged to the reticuloendothelial system.
The branching and the foamy metallophil cells were found chiefly in the tumor, and the round metallophil ones in the surrounding tissue.
At the 12th hour of the transplantation, the number of metallophil cells rapidly increased, but it decreased at the 24th hour. The cells then increased again and reached a level which exceeded the initial increase after the transplanta-tion. The second high level was maintained until the 14th day. Thereafter, the number of the cells returned to a low level. The changes of the metallophil cells were very similar in both the tumor and the surrounding tissue. The second rise and decline of metallophil cells seemed to be related to the develop-ment of the tumor.View full abstractDownload PDF (2317K) -
Fumio Kondo, Eiji Abe, Masao Ikeda, Suetsugu Mue1967 Volume 91 Issue 2 Pages 191-199
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUrine analysis of patients with progressive muscular dystrophy (PMD) revealed that one of these patients excreted a considerable amount of diphos-phopy ridine nucleotide (DPN) in urine. DPN in urine was identified by column chromatography using Dowex 1×10 (formate type), paper chromato-graphy, absorption spectrum, and by absorbency changes after being reacted with potassium cyanide and with yeast alcohol dehydrogenase. DPN excretion in urine in some other PMD eases was evidenced by the alcohol dehydrogenase method. Numerous urine specimens from normal and diseased individuals were also examined for DPN, but urinary DPN could be demonstrated in no case other than those of PMD.
The significance of DPN excretion in PMD was discussed in view of the fact that DPN is an important coenzyme in cellular metabolism and that so far no report has appeared on the occurrence of appreciable amounts of DPN in human urine.View full abstractDownload PDF (475K) -
Hisao Aoba, Yukichi Hariu, Ryuji Yamaguchi1967 Volume 91 Issue 2 Pages 201-207
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe activity of serum alkaline phosphatase of normal and abnormal pregnant females were determined by the method of Neale. Heat-stable alkaline phosphatase was one of the isozynes derived from the placenta and was defined as the enzyme which retained its activity after heating at 50°C for 30 minutes. The activity of this enzyme was determined by Kind and King's method using disodium phosphate as the substrate at pH 10.0, and the results were expressed in King and Armstrong's units per 100ml of serums. The activity of the total alkaline phosphatase in normal pregnant females increased progressively with the advance of pregnancy, and this increase was regarded as the result of enhanced activity of heat-stable alkaline phosphatase, whereas heat-labile alkaline phosphatase was almost constant in its activity throughout pregnancy. Umbilical blood had practically no activity of heat-stable alkaline phosphatase. The values of this enzyme activity in complicated pregnancy including toxemia, twin pregnancy and intra-uterine fetal death did not differ from those of the normal pregnancy. Two cases of polyhydramnios showed significantly low values. The possible clinical use of this method was briefly discussed.View full abstractDownload PDF (391K)
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