Cadmium (Cd) is a toxic element ubiquitous in the environment, and general populations have been exposed to this element primarily via foods. Thus, the critical level of non-occupational Cd exposure to cause any health effects among general populations is of public health as well as toxicological concern. The objectives of the present study were to examine the quantitative relationship between cadmium (Cd-U) and β
2-microglobulin in urine (β
2-MG-U) as a marker of exposure to Cd and as a marker of renal tubular dysfunction, respectively, and to identify a threshold Cd-U, if present, in causing a substantial increase in β
2-MG-U. Thus, paired data on geometric mean (GM) Cd-U
cr (i.e., Cd-U as corrected for creatinine [cr] concentration) and GM β
2-MG-U
cr (β
2-MG-U
as corrected for cr) of residents in polluted as well as nonpolluted areas in Japan were retrieved in international and domestic sources. In practice, 245 cases of the data pairs were obtained in 51 articles published since 1975. Statistical analysis on ordinary scales disclosed that β
2-MG-U
cr increased markedly when Cd-U
cr exceeded a certain level. The relation between the two parameters after double-logarithmic conversion was in a shape of the letter J or a stick for ice hockey. Analysis for Cd-U
cr at the flexion point gave Cd-U
cr of 4 (on double logarithmic scales) or 7 μg / g cr (on ordinary scales). Cd-U
cr levels that correspond to a β
2-MG-U
cr of 1,000 μg / g cr were estimated to be 8-9 μg / g cr, by ordinary and logarithmic assumption as well as by the 3rd degree regression analysis. Thus, it is concluded that there is a threshold Cd-U
cr level that leads to a substantial increase in β
2-MG-U
cr, and that the threshold level is greater than 4 μg / g cr.
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