All issues
Volume 130 (1980)
- Issue 4 Pages 311-
- Issue 3 Pages 209-
- Issue 2 Pages 105-
- Issue 1 Pages 1-
Volume 130, Issue 3
Displaying 1-13 of 13 articles from this issue
- |<
- <
- 1
- >
- >|
-
YUSAKU TAZAWA, TASUKE KONNO1980 Volume 130 Issue 3 Pages 209-217
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSera from 83 infants with biliary atresia or neonatal hepatitis were examined for the presence of lipoprotein-X (Lp-X). All the infants examined with biliary atresia were positive for Lp-X. Forty-three percent of infants with neonatal hepatitis were positive for Lp-X. The semiquantitative assay of serum Lp-X revealed that it was higher in the group of biliary atresia than in the group of neonatal hepatitis. Out of 37 infants with biliary atresia 18 were positive for Lp-X in an eight-fold or greater dilution of serum. On the other hand, only one of 46 infants with neonatal hepatitis was Lp-X positive in the same dilution. The semiquantitative values of Lp-X were well correlated with quantitative levels of Lp-X, and the sera positive for Lp-X in eight-fold or greater dilutions had Lp-X levels of higher than 300 mg/100 ml. From these results the semiquantitative assay of serum Lp-X may be of value in helping to differentiate biliary atresia from neonatal hepatitis, especially in the early stage of the disease.View full abstractDownload PDF (1253K) -
KENICHI SHIMADA, WAKAKO ISHIGAKI, TEIJI HASHIMOTO, MICHIO YATABE, GOIC ...1980 Volume 130 Issue 3 Pages 219-226
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt was revealed in the present study that flavine adenine dinucleotide (FAD) could inhibit both collagen- and ADP-induced aggregation of human platelets in vitro at the final concentrations of micromolar level. Also flavine mononucleotide and riboflavin showed a moderate degree of inhibition on the ADP-induced platelet aggregation. FAD may enhance further the inhibition of platelet aggregation by aspirin, suggesting different mechanism. The possible mechanism under-lying the inhibition of platelet aggregation in vitro by FAD and related sub-stances was discussed. Also, a preliminary study has suggested that the inhibitory effect of FAD on the platelet aggregation was observable not only in vitro, but also in vivo. The intravenous administration of a relatively high dose of FAD to a few patients with various diseases was followed by a slight and transient decrease of the collagen-induced platelet aggregation.View full abstractDownload PDF (351K) -
AKIRA OHNEDA, SHOJI ISHII, HIROSHI ITABASHI, KEN HORIGOME1980 Volume 130 Issue 3 Pages 227-237
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo see the direct effect of individual amino acids upon glucagon secretion, experiments were conducted, using in situ perfusion preparations of the canine pancreas. Twelve amino acids, alanine, arginine, glycine, leucine, histidine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine, were infused in a dose of 2. 3 mmoles over a 10-min period into the pancreatic artery of a group of 4 to 7 dogs, and plasma glucagon (IRG) and insulin (IRI) in the pancreatic vein were determined. After the infusion of the individual amino acids, blood glucose in the femoral artery did not change at all. Although the amino acids stimulated the insulin secretion, there were differences between the amino acids in the pattern of IRI response and in the IRI stimulating activity. The individual amino acids caused different responses of plasma IRG. The administration of arginine and threonine resulted in a remarkable rise of IRG, whereas leucine, tryptophan, isoleucine or lysine failed to enhance plasma IRG. Although there was no significant correlation between the increment areas of IRI and IRG, potency of the amino acids to stimulate both insulin and glucagon was roughly parallel. The results of the present experiment indicate that there are differences in a glucagon-stimulating activity of the individual amino acids, among which arginine and threonine are most potent. Furthermore, discrepancy observed in the enhancement of both IRI and IRG suggests the complicated mechanism in the secretion of islet hormones and does not support the intrainsular interaction of insulin and glucagon.View full abstractDownload PDF (603K) -
SEIICHI OHIRA, TOMIO ONUMA, KAZUO TAKEBE1980 Volume 130 Issue 3 Pages 239-242
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe study was performed on 12 male rabbits, which were divided into two groups; one group of 7 rabbits fed on commercial rabbit pellet mixed with 2 mg of glibenclamide per kg of the food (G-group), and the other of 5 rabbits fed on rabbit pellet only without mixing glibenclamide as the control group (C-group). The food intake was limited to 200 g daily. Three months later, the blood was collected from these rabbits in fasting state for determination of blood sugar and IRI, and lipoprotein analysis. Then, the aorta was taken out for determination of cholesterol and cholesterol ester. There was no significant difference between both groups in terms of weight gain, blood sugar and IRI, while cholesterol content in the aorta of G-group (2.68±0.12 mg/g wet weight) was significantly higher (p<0.05) than that of C-group (2.28±0.12 mg/g wet weight). HDL-cholesterol level was similar in both groups, while LDL-cholesterol of G-group (10.8±2.3 mg/100 ml) was higher than that of C-group (7.3±1.5 mg/100 ml). These results suggest that glibenclamide may have atherogenicity in normal rabbits probably because of an increment of LDL-cholesterol.View full abstractDownload PDF (238K) -
YOSHISUKE MARUHAMA, YOSHIO GOTO1980 Volume 130 Issue 3 Pages 243-252
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAdministration of Bay g 5421, a glucoside-hydrolase inhibiting oligosaccharide, was shown to decrease the elevation of blood glucose and plasma insulin after test meal ingestion in 2 healthy volunteers by delaying the rate of the starch absorption that was estimated by the serial breath hydrogen analysis. The clinical trial was carried out on 9 hyperlipidemic patients and 6 diabetic patients with a daily dosage of 300 mg of Bay g 5421 for 4 weeks. A significant decrease in plasma triglyceride and total cholesterol was observed in both hyperlipidemics and diabetics, while their body weight remained mostly unchanged. Both mild glucose intolerance and markedly increased insulin response during oral glucose tolerance test in the hyperlipidemics were significantly ameliorated after Bay g 5421 trial, whereas the diabetic glucose intolerance and blunted insulin secretion did not change significantly in the diabetics after the trial. Thus, Bay g 5421 seems to be the compound that is clinically more beneficial in hyperlipidemia rather than in diabetes mellitus.View full abstractDownload PDF (495K) -
JINICHI SUZUKI, YUICHI YAMAUCHI, MITSUKI KUROSAWA1980 Volume 130 Issue 3 Pages 253-264
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSerial immersion in a high sulfate hot spring was performed to psychosomatic patients four times daily for 10 days. Various hormones were measured and comparative studies were made before and after the serial immersion. The results were as follows: The basic secretions of TSH, T3, 11-OHCS, CA (Ad and NA) and gastrin decreased after serial immersion, but prolactin and GH secretions increased. There were increases in 11-OHCS, CA and gastrin with a single bathing. There was a major disruption in the circadian rhythm of 11- OHCS and its daytime secretion increased. From the above results, it appears that serial immersion in a high sulfate hot spring inhibits the secretion of hormones related to excitement of the sympathetic nervous system and increases secretion of hormones which bring about psychological stability. Therefore, psychosomatic patients are brought into a trophotropic state and cured. The “yuatari” or spa water stroke phenomenon can be considered to be the same as the alarm reaction of Selye, but only the results for CA supported this idea. However, it is possible that changes in other hormones will resemble those of CA if the number of immer-sions is increased. From the above results, it is evident that serial immersion in a high sulfate hot spring is a rational method of treating psychosomatic diseases from the endocrinological standpoint.View full abstractDownload PDF (713K) -
JUN MATSUMOTO, TOYOAKI MURATA, SOTARO SATO, TOSHIKATSU ICHIHARA, TAKES ...1980 Volume 130 Issue 3 Pages 265-272
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUremic pericardial effusion (UPE) was found by echocardiography in 61 (47%) out of 131 uremic patients. According to the echocardiographic findings, accompanying diseases and the response of UPE to the dialysis treatment, we tried to classify UPE into three main groups; uremia alone (40 patients-66%), uremia with infection (14 patients-23%), and uremia with other diseases (7 patients-11%). 1) UPE was recognized in 25 uremic patients (35%) among 65 subjects without dialysis treatment but having the serum creatinine levels higher than 5.0 mg/100 ml. The incidence of UPE was progressively increased with the elevation of serum creatinine levels (53% of patients with the serum creatinine levels higher than 10.0 mg/100 ml). 2) Uremia with infection group had some infectious signs; fever, leukocytosis, elevated erythrocyte sedimentation rate and sometimes pleuritis. 3) Uremia with other diseases group was those patients whose underlying diseases were other than chronic glomerulonephritis, such as hepatorenal syndrome, lupus nephritis, diabetic nephropathy and Alport's syn-drome. The echocardiographic detection of UPE proved to be convenient for early diagnosis of it and should be performed routinely in regularly dialysed patients.View full abstractDownload PDF (500K) -
TAKEO TAKAHASHI, YASUO TSUKAHARA1980 Volume 130 Issue 3 Pages 273-281
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing the visual stimulator, the effects of the following visual stimuli in provoking generalized photoconvulsive responses (PCRs) were studied in 72 photosensitive cases with normal color sensation. The visual stimuli were either separate or combined stimulus of 15 Hz flicker, red-light, and dot and grating patterns with a constant brightness of 20 cd/m2. The number of the cases in which each of the 11 kinds of visual stimuli provoked PCRs was as follows: (1) flicker of white light, 9 (13%); (2) red-light, 0; (3) dot-pattern, 8 (11%) ; (4) grating-pattern, 16 (22%); (5) red-flicker, 65 (90%); (6) red-dot-pattern, 10 (14%); (7) red-grating-pattern, 10 (14%); (8) flickering-dot-pattern, 34 (47%); (9) flickering-grating-pattern, 36(50%); (10) red-flickering-dot-pattern, 31 (43%); and (11) red-flickering-grating-pattern, 37 (51%). The results of serial examinations in 29 cases were as follows: (1) 6 (21%), (2) 0, (3) 4 (14%), (4) 11 (38%), (5) 29 (100%), (6) 3 (10%), (7) 5 (17%), (8) 18 (62%), (9) 21 (72%), (10) 21 (72%) and (11) 19 (66%). These numbers indicate positive effects of visual stimuli in provoking PCRs in more than a single examination. From these results, it was concluded that, in addition to the activation with pattern stimuli, those with red-flicker as well as flickering-patterns are necessary for routine EEG examination.View full abstractDownload PDF (564K) -
KEIJI USUI, KOHTAROH TAKAHASHI, MORIKUNI FUKUDA, EIJI ISHIZAWA1980 Volume 130 Issue 3 Pages 283-289
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDuring 6 years from 1971 to 1976, 7 patients with pulmonary atresia or pseudotruncus arteriosus had undergone various shunt operations at Tohoku University Hospital; the survival rate was only 29%. There were difficulties in the pre- and post-operative management of the cases because of their deteriorated life conditions caused by PDA closure before the operation. Since the summer of 1976, we have experienced another 8 cases of such anomalies and administered prostaglandin-E1 to 5 of them as a non-surgical palliation before the shunt operation. Prostaglandin-E1, 0.01-0.1 μg/kg/min, was given intrave-nously with a micro-drip technique. The administration was followed by im-mediate and significant rise in PaO2, and SaO2. As a side effect, periodic apnea was observed. Respiratory management is indispensable in using prostaglandin-E1. This technique seems to be an effective treatment for such patients as a non-surgical palliation.View full abstractDownload PDF (1010K) -
KOTARO SAITO, KATSUO KUMAGAI1980 Volume 130 Issue 3 Pages 291-296
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIncorporation of 3H-thyrnidine into peripheral blood lymphocytes in the presence of plasma derived from a halothane-treated donor was measured in vitro in the patient who suffered from postoperative hepatitis after second exposure to halothane. A healthy subject was also studied as a control. Lymphocytes from the patient with an active stage of hepatitis, but not from the patient after recovery from the disease, were stimulated by halothane-plasma. In the lymphocytes from a healthy subject, no responses to the same plasma was found. These results suggest that the elicitation of halothane-sensitized lymphocytes was involved in the pathogenesis of liver damage in the patient.View full abstractDownload PDF (388K) -
GEN YOSHINO, TSUTOMU KAZUMI, SHIGEKI FUJII, SHIGEO KANEKO, MUNEYOSHI Y ...1980 Volume 130 Issue 3 Pages 297-301
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSMild and severe diabetes, confirmed by oral glucose tolerance tests, was induced in rats with streptozotocin, 50 and 65 mg/kg body weight, respectively. Insulin-secreting islet cell tumors produced by streptozotocin were transplanted underneath the kidney capsules of the diabetic rats. In 5 of 9 recipients given 50 mg/kg body weight of streptozotocin the mean blood glucose level 0. 5 hr following glucose loading significantly decreased 2 weeks after transplantation, although insulin responses remained flat and low. Concomitantly, daily urine volume and urine glucose decreased in these rats. The parameters of diabetes, however, returned toward the preoperative levels 4 weeks after the transplantation. On the contrary, none of the rats given 65 mg/kg body weight of streptozotocin showed any deviation of these parameters. Ten days after the operation visual observation revealed vascularization at trans-plantation sites and aldehyde-fuchsin-positive cells were seen in the peripheral portion of transplanted tumors. Transplants completely disappeared leaving white spots with fibrous tissue and cellular infiltration 29 days after the operation. The present study demonstrates that insulin-secreting islet cell tumors induced by streptozotocin possess the ability to reverse, though partially and temporarily, streptozotocin diabetes in the rat.View full abstractDownload PDF (329K) -
SHIN-ICHI OIKAWA, YOSHISUKE MARUHAMA1980 Volume 130 Issue 3 Pages 303-307
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe arterial smooth muscle cells and subcutaneous fibroblasts obtained from normal rats were cultured in the insulin-deprived and insulin-enriched medium with different glucose concentrations (1mg/ml, 3mg/ml and 5nag/ml) and the glucose uptake by these cells was observed for the period of 48 hr. Glucose uptake by the two mesenchymal cells was similarly highest during the first 12 hr and continued to keep at a constant rate during the 48 hr irrespective of the medium glucose concentrations and insulin addition. There were no differences between the smooth muscle cells and the fibroblasts in either the rate or the pattern of glucose uptake. The limited rate of glucose uptake in these cells suggests that hyperglycemia does not play an important role in the metabolic derangement of the mesenchymal cells or perhaps in the etiology of diabetic angiopathy.View full abstractDownload PDF (333K) -
KUNIHIKO GOTO, YUJI KUROKAWA, HARUO SATO1980 Volume 130 Issue 3 Pages 309-310
Published: 1980
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSHomologous high concentration serum was used for a culture of mucus producing transplantable adenocarcinoma. The mucus secretion of the tumor was maintained in the homologous high-concentration serum.View full abstractDownload PDF (910K)
- |<
- <
- 1
- >
- >|