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Volume 126 (1978)
- Issue 4 Pages 301-
- Issue 3 Pages 203-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 126, Issue 3
Displaying 1-11 of 11 articles from this issue
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SHOJI KONDO, EIJI TAKAHASHI, KATSUO KATO, SHUKUKO TAKAHASHI, MASAYUKI ...1978 Volume 126 Issue 3 Pages 203-213
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the city of Sendai, the height and weight of pupils at the ages of 11.5 to 12.0 years and 14.5 to 15.0 years have been measured in every spring and autumn since 1936. The analyses of the data summarized for 40 years revealed reduction in physique of the pupils in early 1940's and a marked growth acceleration in late 1940's till 1960's, followed by reduction in secular growth rates in late 1970's. The reduction is more prominent in the core part of the city. The results are compared with those from two extremes in Japan, i.e., megalopolitan areas and remote areas, and also those from European and North American countries.View full abstractDownload PDF (590K) -
SHIRO HAYASHI, TETSUYA NAGATA, ATSUSHI KIMURA, KOICHI TSURUMI1978 Volume 126 Issue 3 Pages 215-223
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe metabolism of ground substance in connective tissue of an 18-year-old boy with oculo-cerebro-renal syndrome was studied. He had characteristic clinical and laboratory findings described by Lowe et al. such as growth retardation, mental deficiency, glaucoma, cataracta, decreased muscle tone, metabolic acidosis, aminoaciduria and osteomalacia. The urinary excretion of acid glycosaminoglycans and of total hydroxyproline were 28mg/day (as glucuronic acid) and 280mg/day respectively on admission. Both values decreased to the upper limits of normal level transiently during treatment with alkali and vitamin D2. At that time, an improvement in bone abnormalities, a decrease of serum alkaline phosphatase, and an elevation of serum inorganic phosphate were observed. The therapy prevented him from progressive osteomalacia and cured him of it, but mucopolysac-chariduria and hydroxyprolinuria did not disappear. Analytical electrophoresis on cellulose acetate sheets showed that urinary acid glycosaminoglycans were composed of undersulfated chondroitin 4-/6-sulfate and heparan sulfate with a ratio of 6:4, on admission. After oral administration of alkali, the excretion of heparan sulfate decreased and undersulfated chondroitin 4-/6-sulfate was determined as a main component of urinary acid glycosaminoglycans. The clinical and laboratory data in this case suggested that the increased excretion of acid glycosaminoglycans and total hydroxyproline was caused by abnormal metabolism in connective tissues, especially by the bone abnormalities, in this syndrome.View full abstractDownload PDF (1911K) -
SHIRO HAYASHI, TETSUYA NAGATA, ATSUSHI KIMURA, KOICHI TSURUMI1978 Volume 126 Issue 3 Pages 225-234
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn 18-year-old boy with oculo-cerebro-renal syndrome excreted a large amount of acid glycosaminoglycans in urine. The identification and characterization of the acid glycosaminoglycans were carried out by the methods of preparative column electrophoresis, ion exchange chromato-graphy, gelfiltration, paper chromatography of the chondroitinase digests and chemical analysis. On admission to hospital, the main components of the urinary acid glyeosaminoglycans were undersulfated chondroitin 4-sulfate of large molecular weight and heparan sulfate. Three months after oral administration of the supplement of alkali, the excretion of heparan sulfate and the molecular size of chondroitin 4-sulfate decreased significantly, although the amount of urinary acid glycosaminoglycans remained at a high level (about 25mg/day). The decrease of heparan sulfate and the shift to a smaller molecule of chondroitin 4-sulfate were coincident with the improvement in clinical and laboratory findings. These results suggest that the abnormal metabolism of acid glycosaminoglycans is a characteristic manifestation in this case and the studies on ground substance metabolism might be an important approach to the pathogenesis of this syndrome.View full abstractDownload PDF (654K) -
KUNIHIRO OKAMURA, MASAKI KURAMOTO, YOHICHI HAMAZAKI, MASAKUNI SUZUKI1978 Volume 126 Issue 3 Pages 235-238
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSHuman chorionic gonadotropin (HCG) and steroid hormones were tested for their direct effects on murine lymphocyte humoral response to sheep RBCs using an in vitro culture system. A significant increase in plaque forming cells (PFC) was induced by the addition of HCG at a dose of either 50 i.u. or 500 i.u. However, no increase was observed by the addition of steroid hormones. HCG may contribute to the success of fetal allografts by increasing the number of blocking antibodies in the early stages of pregnancy.View full abstractDownload PDF (214K) -
SHIGERU HISAMICHI, AKIO SHIRANE, NOBUYUKI SUGAWARA, SHIGERU ASAKI, TOO ...1978 Volume 126 Issue 3 Pages 239-246
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo establish the eariest sign of stomach cancer in endoscopy and to reveal the subsequent morphologic changes of the lesion, we studied retrospectively 41 cases of stomach cancer. The eariest sign consisted of redness, small polypoid lesions, flat mucosa with slight unevenness and small depressed lesions. There was no clear correlation between the observation period and the size of cancer lesion in cases of early stomach cancer. In cases of advanced cancer, however, the observation period correlated with the size of cancer lesion to a certain extent, and the correlation between the area of cancer (Y cm2) and the observation period (X months) gave a linear equation of Y=0.68 X-3.13.View full abstractDownload PDF (1026K) -
KENICHI KITANI, REIKO MIURA, SETSUKO KANAI1978 Volume 126 Issue 3 Pages 247-256
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effects of bucolome (BC, 1-cyclohexyl-5-n-butyl-2, 4, 6-trioxoperhydropyrimidine, a non-steroid antiinflam-matory agent), a potent choleretic, on the maximal biliary excretion rates (Tm) of sulfobromophthalein (BSP) and indocyanine green (ICG) were investigated in rats. With continuous infusion of BSP or ICG, Tm and bile flow rate in control rats and rats given BC (40-100min after 20mg/100g body weight i.p. injection) were compared. The BSP Tm was not significantly different in control and BC administered rats (BC rats), while the bile flow rate and endogenous bile salts excretion rate were significantly higher in BC rats. On the other hand, ICG Tm was significantly higher in BC rats, although ICG concentration in bile was significantly lower in BC rats. The rates of the rise in plasma concentration of the dyes were significantly lower in BC rats. However, the plasma concentration of ICG was significantly higher in BC rats at corresponding time intervals than in control rats throughout the experimental period. The difference in the effect of BC on the transport of these two dyes indicates variability in the regulatory mechanisms for hepatic anion transport.View full abstractDownload PDF (667K) -
SHIGERU SAW, TAMOTSU TAKISHIMA1978 Volume 126 Issue 3 Pages 257-266
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSElectron microscopic observations were made on lung tissue, broncho-pulmonary lavage fluid and sputum in 2 cases of pulmonary alveolar proteinasis. Diagnosis was established by open lung biopsy in both cases. In Case 1 the electron microscopic samples were obtained from the surgical specimen. In Case 2 an electron microscopic observation was made only on the lavage fluid and sputum. The alveolar air spaces were full of amorphous or fine granular-appearing material intermingled with two kinds of laminated bodies (abbreviated to “Lamella A” and “Lamella B”). Lamella A, about 0.2_??_4μm in diameter, presented a concentric laminated structure with approximately 300 Å periodicity and was found in the alveolar air spaces, lung washings and sputum. It corresponded to what has hitherto been reported in the same disease and was always located outside the cells. Lamella B showed a laminated structure of high electron density, appproximately 50 Å in periodicity, usually looking like a concentric circle with a diameter of 0.5 μm or less. It was intensely stained with methenamine silver. It was mainly observed in mesenchymal cells of the alveolar septa and free macrophages in the alveolar air spaces, although it also occurred in the type I and type II alveolar epithelial cells. Furthermore, the Lamella B could be found in the alveolar air spaces outside the cells and in the bronchopulmonary lavage fluid. This body has not been demonstrated previously and, although its significance in this disease is still uncertain, the structural similarity of the Lamella B to the intra-alveolar material suggests a possible role of it in the produc-tion of intra-alveolar material.View full abstractDownload PDF (5290K) -
KAZUOKI KONDO, JIRO MISUMI, RYUICHI NAKAMURA, IKUO SAITO, TAKAO SARUTA1978 Volume 126 Issue 3 Pages 267-272
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAdministration of 1.5mg/kg of estriol intramuscularly and 15mg/kg of stilbestrol disulfate intraperitoneally daily for 15 days caused an increase in plasma renin substrate (PRS), accompanied by an increase in plasma renin activity (PRA) and a slight decrease in plasma renin concentration (PRC). Contrary to the slight suppres-sion of PRC, juxtaglomerular granulation index (JGI) was significantly increased in rats treated by estrogen. In the rats which developed hypertension by estrogen, PRA, PRC and JGI were a little higher than those in the rats which remained normotensive after the same estrogon treatment, but these differences were not statistically significant. Therefore, it seems rather difficult to attribute the development of estrogen hypertension only to the quantitative changes in the renin-angiotensin system.View full abstractDownload PDF (1122K) -
TAKAO SAITO, YUKIO TANAKA, RYUICHI TONOGAI, YASUHITO YAMADA, SEISAKU S ...1978 Volume 126 Issue 3 Pages 273-287
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCoronary and systemic circulations, and contractility and oxygen consumption of the left ventricular myocardium were depressed as arterial enflurane concentration increased in acute experiments with 22 adult mongrel dogs. Uneven transmural blood flow in the left ventricular free wall did not appear and the inner/outer ratio remained near 1.0 until a very deep stage of the anesthesia was attained and as far as diastolic aortic pressure was maintained above 40mmHg, according to the microsphere injection study. Once diastolic pressure fell below 35-40mmHg, the ratios started to be reduced significantly. When arterial enflurane content reached 53.0± 2.1 mg/100ml (mean±S.E. ), the ratio became 0.84±. 0.08 (p<0.001), and simultaneously calculated DPTI/TTI ratio also showed a significant reduction from the control (0.79±0.03, p<0.001). The I/O and DPTI/TTI ratios, however, did not correlate significantly with each other until very deep enflurane anesthesia was attained. The lower limit of autoregulation of coronary vascular bed was suggested to be near 35-40mmHg of diastolic aortic pressure during deep enflurane anesthesia in the dog. Among systolic time intervals measured directly during the study, PEP and ICT showed significant negative correlations with Vmax and LV dp/dt max, while LVET neither changed nor correlated significantly with stroke volume or other parameters representing myocardial contractility during the course of enflurane anesthesia.View full abstractDownload PDF (1037K) -
KENICHI SHOJI, HIKARU WATANABE, YOSHIO GOTO, NAOYUKI YAMADA1978 Volume 126 Issue 3 Pages 289-293
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe study was made to ascertain whether the radiographs of the mandible of patients with familial polyposis of the colon show osteomas. Orthopantomography of the mandible was taken in 10 cases of familial polyposis of the colon and 6 cases of the unaffected family members. And radiographic and histological studies were performed in another autopsied case. As a result, radiographic studies revealed sclerotic masses of the mandible in 10 of the 11 cases. In some cases, the changes were also found in the maxilla. The number of sclerotic masses ranged from 2 to 11, and they were associated with odontomas in 2 cases and impacted teeth in one case. Two of the 6 unaffected family members were found to have one or two sclerotic masses. At autopsy of a case died of cancer of the sigmoid colon, a radiographic study of the excised mandible revealed 11 sclerotic masses measuring 5mm in diameter each, as well as one impacted tooth. A bucco-lingual cross action through the mandible in the canine area revealed central osteomas. Histological examination showed the osteomas were composed primarily of mature, lamellar bony tissue.View full abstractDownload PDF (1345K) -
AKIRA YAJIMA, KENSAKU TESHIMA, KUCHIRO NODA1978 Volume 126 Issue 3 Pages 295-299
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCellular samples (cervical scrapings) obtained with wooden spatulas from patients with carcinoma in situ, early invasive cancer, and advanced cancer of the uterine cervix were examined. The number of malignant cells in the preparation increased with extent of the lesion. The granular chromatin structures of the nuclei of abnormal cells were observed in almost all cases, and the occurrence of irregularly distributed coarsely granular chromatin increased gradually with the extent of the cancer. Hyperchromasia of malignant cell nuclei and irregular thickening of the nuclear envelope were seen in almost all cases of the lesions. The occurrence of malignant and dysplastic cells of the deep layer types decreased with progression of the lesion from carcinoma in situ to early invasive cancer, and to advanced cancer. There was also a relative increase in the ratio of malignant cells to dysplastic cells.View full abstractDownload PDF (278K)
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