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Volume 111 (1973)
- Issue 4 Pages 309-
- Issue 3 Pages 203-
- Issue 2 Pages 101-
- Issue 1 Pages 1-
Volume 111, Issue 3
Displaying 1-12 of 12 articles from this issue
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TSUNEO ARAKAWA, YOSHIYUKI HONDA, KUNIAKI NARZSAWA1973 Volume 111 Issue 3 Pages 203-210
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA decrease in serum folate levels of rats receiving diphenylhydantoin was partly due to a reflexion of a decreased level of N5-methyltetrahydrofolate in the liver of these rats. The decreased levels of Nb-methyltetrahydrofolate in the liver was resulted from an elevation of the N5-methyltetrahydrofolate-homocysteine transmethylase activity. The elevation of the enzyme activity was resulted from (a) an increased production of the N5-methyltetrahydrofolate-homocysteine transmethylase apoenzyme by induction following diphenylhydantoin administration, and (b) a probably increased supply with vitamin B12 to the liver which was mediated by an increased level of the serum transcobalamin II due to diphenylhydantoin administration.View full abstractDownload PDF (501K) -
KYUHEI IKEDA, TAKAYUKI IWABUCHI, TAKASHI KUTSUZAWA, TAKASHI NAKAMURA1973 Volume 111 Issue 3 Pages 211-217
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSMeasurements of cerebral blood flow using the nitrous oxide method were performed in 44 normal subjects and in 226 patients with apoplexy. In the apoplectic patients, the interval from the last onset of stroke varied from fourteen days to eight years. Cerebral blood flow in the patients with apoplexy was reduced to less than 80% of that in normal subjects. In the group of subacute stage, cerebral blood flow was more reduced than that of chronic stage. According to the mean arterial blood pressure at the examination, the values for cerebral blood flow were divided into 7 classes from 80 to 150mm Hg at an interval of 10mm Hg. The average value was calculated in each class. As a result, it was found that the cerebral blood flow was maintained relatively constant at the blood pressure within 80 to 150mm Hg. This may suggest the existence of autoregulation of cerebral blood flow. It was also found that there was no influence of aging on the relationship between the cerebral blood flow and the arterial blood pressure.View full abstractDownload PDF (413K) -
TOSHIRO SAKURADA, TORU YAMAGUCHI, KATSUMI YOSHIDA, MAKIKO YAMAMOTO, RE ...1973 Volume 111 Issue 3 Pages 219-227
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA 46-year-old housewife was admitted to the Tohoku University Hospital on July 2, 1972, because of fatigability, palpitation, weight loss and sweating. She had been administered orally 3.0 mCi of radioactive iodine for the treatment of hyperthyroidism in November, 1971. Both BMR (+30%) and thyroidal 24-hour uptake of 1311 (52%) were high. Resin sponge 131I-T3 uptake was 38%, serum total and free T4 were 11.8 μg/dl and 5.1 ng/dl, binding capacity of TBG and TBPA were 17.0 and 254 μg/dl, respectively. All these values were within normal range. 131I uptake of the thyroid was not suppressed by T3. Plasma TSH was not detectable by radioimmunoassay, but normal plasma TSH response was observed by the intravenous injection of 500 μg of TRH. Radioimmunoassay of T3 revealed elevated total and free T3, 365 ng/dl and 12, 800 pg/dl, respectively. Under the diagnosis of T3-thyrotoxicosis, daily dose of 10 drops of Lugol's solution was administered. After the treatment with Lugol's solution for four months, both BMR and serum total T3 became normal and her complaints disappeared, and no signs of hyper- and hypothyroid-ism were observed. The significance of iodide treatment is discussed in such cases.View full abstractDownload PDF (507K) -
YASUO CHIBA, KIYOTAKA HORINO, MASAO UMETSU, YASUHIKO WATAYA, SHUNZO CH ...1973 Volume 111 Issue 3 Pages 229-238
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe development of mumps saliva antibody and its relationship to oral virus excretionwere studied in the cases of natural infection. In most cases, saliva IgA antibody began to be detected from the 4 th day after the onset of disease, and its titer reached 1:8 or below by indi-rect immunofluorescent technique. IgM antibody also appeared almost at the same time to reach a titer of 1:4 or below, but its duration was shorter than that of IgA antibody. Mumps virus was isolated from saliva until the 5 th day after the onset of disease. In many cases the appearance of IgA fluorescent antibody in saliva coincided with the termination of virus excretion. The antibody produc-ed in serum was also measured in comparison with that in saliva in four cases. The highest serum IgG antibody titers during the course ranged from 1:128 to 1:512. In these cases, however, saliva IgG antibody was not detected at a 1:2 dilution. IgA antibody reached the titers ranging from 1:8 to 1:16 in serum and the titers ranging from 1:2 to 1:8 in saliva of all these cases. Antibody activity was detected in parotid fluid specimens which had been collected directly from Stensen's ducts. From these data, it was presumed that the specific antibody was produced in salivary glands by virus proliferation, and that the antibody response of salivary glands might play an important role in the inhibition of growth of mumps virus and its excretion into saliva.View full abstractDownload PDF (593K) -
TATSUYA MIKI1973 Volume 111 Issue 3 Pages 239-251
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing NZB/NZW F1 hybrid (B/W) mice, in model experiments for human systemic lupus erythematosus, the cytotoxic activity of thymocytes and splenic lymphocytes was studied against allogeneic target cells. Lymphocytes from female B/W mice were proved to have cytotoxic activity against target cells by the 51Cr release technique. The activity of splenic lymphocytes was a little higher than that of thymocytes. Antinuclear antibody (ANA) positive sera from B/W mice also accelerated the release of 51Cr from the target cells with the cooperation of complement. Pretreatment of B/W lymphocytes with DNA or addition of DNA to the culture medium did not affect their cytotoxicities. Natural thymocyto-toxic autoantibody was not found in B/W sera. The percentage of θ negative thymocytes in B/W mice (11-21%) was considerably higher than that in control mice (0-2%). From these results, it is supposed that the cell-mediated immunity against self-antigens besides autoantibodies constitutes a very important factor in the development of autoimmune diseases.View full abstractDownload PDF (2015K) -
KATSUHIRO OGAWA, TAKASHI MINASE, SHIGEAKI YOKOYAMA, TAMENORI ONO&Eacut ...1973 Volume 111 Issue 3 Pages 253-269
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEndogenous peroxidatic and phagocytic activities were studied on the sinusoidal lining cells in the perfusion fixed rat liver under normal and reticuloendothelial system (RES) stimulated conditions. All cells with cytostructural characteristics of the Kupffer cell showed endogenous peroxidase activity in the endoplasmic reticulum (ER) and perinuclear cisternae, while the endothelial cells were always negative in peroxidase reaction. When colloidal carbon or zymosan were given intravenously, Kupffer cells exhibited stickiness of their cell surfaces against these particles and avid phagocytic activity with the extension of pseudopods, but endothelial cells did not show any stickiness and incorporated carbon particles only a very small amount. These findings were obtained not only under the normal condition but also RES stimulated condition, and, on the basis of peroxidase reaction and phagocytic activity, no intermediate type of cells between the Kupffer cell and endothelial cell was found. Four days after RES stimulation by the admini-stration of estradiol or typhoid vaccine, the relative number of Kupffer cells to parenchymal cells increased about two-fold, but that of endothelial cells did not change significantly. The results presented in this article did not support the hypothesis that the endothelial cell might be a precursor of the Kupffer cell, but suggested that each of them might be the distinct line of cell.View full abstractDownload PDF (5862K) -
MORIYA OHKUMA, MAKOTO SEIJI1973 Volume 111 Issue 3 Pages 271-279
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSLipomelanic reticulosis of the lymph node associated with the skin diseases is well known. This work is aimed to explain the mechanism how melanin reaches the lymph node. If any solution is injected experimentally into the skin, the lymphatic capillary may be mechanically injured by the injection so that the endothelial permeability can be changed. To avoid or minimize such artifacts, melanosomes obtained from the Harding-Passey mouse melanoma by the density gradient centrifugation were injected into the abdominal cavity of mice. After fixed with the intra-aortal perfusion, the diaphragm, the mediastinal lymph nodes and blood obtained from the right atrium of the heart were investigated. Free melanosomes and phagocytized melanosomes in macrophages, features of which were identical with those of the melanosome pellet, were found in the abdominal cavity, in the connective tissue of the diaphragm and in the lymphatic lumen. The melanin. laden macrophages were also seen in the open junction of the diaphragmatic mesothelium. The intracellular melanosomes were detected in the diaphragmatic mesothelium, in the lymphatic endothelium of the diaphragm and in the phago-cytotic cells of the lymph node. The blood smear failed to show any melanin-like particles. Therefore, melanosomes are considered to have reached the lymph node not through the circulating blood but via lymphatics. The main pathway to the lymphatic lumen is thought to be through phagocytosis of the endothelium, although free melanosomes could also reach lymphatic lumen via the open junction of the endothelium.View full abstractDownload PDF (2464K) -
MASAFUMI SHIRAI, KEIICHI SASAKI, AKIRA RIKIMARU1973 Volume 111 Issue 3 Pages 281-291
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA histochemical studies clarified the peripheral distribution of adrenergic and cholinergic nerves in the human male genital organs. In the human testis, there was a minimal distribu-tion of catecholamine fluorescent fibers and acetylcholinesterase positive fibers around the blood vessels and in the interstitium. In the epididymis and the vas deferens, both nerve fibers were abundant in the muscle layer and interstitium. However, no difference in the distribution of these nerve fibers was noted accord-ing to the anatomical site of these organs. In the prostate, acetylcholinesterase positive fibers were abundant; but catecholamine fluorescent fibers were relatively few, and found in the interstitium and the muscle layer. These two types of nerve fibers were not found in the epithelial cell layer of the organs.View full abstractDownload PDF (2373K) -
SUSUMU KATAGIRI, SUMIO ARAI, YORIO HINUMA1973 Volume 111 Issue 3 Pages 293-296
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSColony-forming cells were found in the peripheral blood of various patients and healthy individuals and grown in soft agar medium without conditioned medium or feeder layer. There were no significant differences between the disease group and normal subject group except that no colony formation was observed in the leukemia patients group.View full abstractDownload PDF (236K) -
AKIRA OHASHI, SHIGEAKI SATO1973 Volume 111 Issue 3 Pages 297-304
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn improved method of radiochemical assay of An Improved Method of Radiochemical Assay of δ-Aminolevulinate Synthetase and Its Application to the Study of the Level of Hepatic δ-Aminolevulinate Synthetase in Normal Rat-aminolevulinate (ALA) synthetase was described which enabled us to study the behaviour of ALA synthetase in the liver cytosol of normal rat. When hemin was administered to the normal rat, the level of ALA synthetase in the liver mitochondria decreased markedly and the level in the liver cytosol also decreased slightly. Therefore the total activity of ALA synthetase in the liver of normal rat declined sharply after the hemin administration. Under the physiological conditions in the normal rat, the regulatory role of hemin in the control of por-phyrin synthesis may be ascribed mainly to the inhibition of synthesis of ALA synthetase rather than the inhibition of transfer of ALA synthetase from the liver cytosol into mitochondria.View full abstractDownload PDF (501K) -
KAORU SAGISAKA, KAZUO TOKIWA1973 Volume 111 Issue 3 Pages 305-306
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThis paper deals with MN blood grouping of stains of organ homogenate and thin organ sections by means of an elution test in combination with antiglobulin test. Each stain of the liver, spleen, brain, heart, lung, thyroid, kidney and muscle homogenates gave evidently M and N blood group activities in accordance with those of sources. It was considered that non-specific adsorbing potency of the human organ was eliminated in the procedure of homogenate-staining. However, examination on sections showed frequently unsatisfactory results. It was attributed to non-specific adsorption of sections with anti-M and -N antibodies. The present findings may offer a valuable information to identify human tissues in forensic practice.View full abstractDownload PDF (128K) -
TSUYOSHI MUKOJIMA, SHUICHI INOUE, HISAYUKI MASUDA1973 Volume 111 Issue 3 Pages 307-308
Published: 1973
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA follow-up family study on asymptomatic carriers of the Australia antigen in a selected area in Akita prefecture was performed, and the following results obtained: One of them was suspected of the onset of hepatitis 9 months after the examination. The Australia antibody was found in the mothers of two asymptomatic carriers. Australia antigen carriers were found in the family of an asymptomatic carrier. The Australia antibidy was found in Australia antigen carriers 9 months after the examination.View full abstractDownload PDF (131K)
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