The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 54, Issue 3
Displaying 1-25 of 25 articles from this issue
  • Rai Satake
    1951 Volume 54 Issue 3 Pages 203-208
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    From the spindle cell sarcoma originated from the great omentum in a patient, which was obtainable in a form of pure cultivation and was not contaminated with necrotic mass if any, watery extract was prepared, and injected intracutaneously into the patients suffering from. the malign neoplasma.
    The cutaneous reaction was followed, and chiefly the induration estimated; its largeness at the end, of 24 and 48 hours after the injection was particularly noted.
    The results were clear cut, that is, commonly the sarcoma patients gives. the positive reaction while the carcinoma patient does not.
    The outcome thus harmonizes perfectly with that of Kaminer with the carcinoma extract. The present investigations deal with the sarcoma extract only, and Kaminer dealt with carcinoma only.
    The present outcome shows, otherwise expressed, that it is possible to obtain from the sarcoma tissue the substance which brings about the skin test, described in the text, insarcoma patients only, but not in carcinoma cases. It is highly probable that our success was due to the purity of the sarcoma tissue utilized here.
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  • Tamura and Takahashi's Disease
    Akira Tamura, Mataro Takahashi
    1951 Volume 54 Issue 3 Pages 209-213
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • 3rd Reprot
    Ioko Shimizu
    1951 Volume 54 Issue 3 Pages 214
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Koiti Motokawa, Mituru Ebe
    1951 Volume 54 Issue 3 Pages 215-221
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    Percentage increases in electrical excitability of the eye after exposure to white light are denoted, by ζ.
    1. At the fovea, ζ-time curves or excitability curves depend little on the duration of pre-illumination; the time interval. between the end of pre-illumination and the crest of the curve or crest time reamins constant irrespective of the intensity and duration of the light stimulus.
    2. On the contrary, at the periphery of the retina and at a sufficiently low intensity of pre-illumination, the crest time generally depends on the duration of pre-illumination in such a manner that it is shorter with increasing duration. The crest time remains, however, independent. of the duration of pre-illumination when it is measured from the beginning of the light stimulus.
    3. This finding suggests that the change in electrical excitability in the scotopic mechanism is caused by the on-effects of illumination, and this interpretation agrees with Grant's animal experiments suggesting that on-elements are characteristic for rods.
    4. The true crest time of the scotopic process is longer than that of any photopic process. In other word, the scotopic process is the slowest one in the retina.
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  • 10th Report
    Masami Kikuchi
    1951 Volume 54 Issue 3 Pages 222
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Toyoji Wada, Makoto Toyota
    1951 Volume 54 Issue 3 Pages 223-226
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    The technique of transorbital brain-ventricle puncture and the new method for pneumoventriculography were reported. At the same time, the ventriculograms in several cases have been demonstrated, in addition to some comments.
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  • Azuma Masukawa
    1951 Volume 54 Issue 3 Pages 227-236
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    From pig stomachs mucosa and submucosa were mechanically separated together and then roughly divided into themselves after swelling the mucosa by the aid of a dilute NaOH. The dilute alkali, which had drawn out the components of the epithelial cells in part, and the watery extracts of the mucosa and of sumbucosa were fractioned to obtain from each 1) a fraction containing a glucidamin or glucidamins precipitahle from water at pH 2.0, 2) that containing glucidamins soluble in glacial acetic acid and 3) the group carbohydrate. The corresponding products from the different sources proved similar in composition and other respects (optical rotation, anti-isoagglutinative force and else). The largest yields of them were given from the mucosa except that, among the fractions precipitable at, pH 2.0, the one that had been extracted by the alkali exceeded markedly the one from the mucosa (The crude material from the alkali did not exactly correspond to those from mucosa and submucosa).
    The finding probably leads to a general conclusion that the water-extractible high-molecular components of animal organs belong to paren-chymal cells.
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  • Toyoji Wada, Kiyo Kurosawa
    1951 Volume 54 Issue 3 Pages 237-238
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Shiuichi Hirano
    1951 Volume 54 Issue 3 Pages 239-241
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    I devised a modification of Sato and Sekiya's peroxidase reaction. Though the preparation of the required solutions is rather more complicated than those for the original method just mentioned, yet the time required for staining is shorter and leucocytes are more dinstinctly stained. Thus the method is, I believe, recommendable for practical hematological work.
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  • 11th Report
    Ippei Nagao
    1951 Volume 54 Issue 3 Pages 242
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Toyoji Wada, Ryohei Aneha
    1951 Volume 54 Issue 3 Pages 243-246
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    As complication of dorsomedial thalamotomy, hemiplegia, disturbance of consciousness, urinary incontinence, abnormality of reflex function, slight ataxia, slight disturbance of sensation, decreasing of appetite and weight, severe headache, etc. were observed, however excepting of hemiplegia, those side-effects seemed to be transient and to tend to extinguish within about a half month after operation. In adding to an existence of possibility of thalamotomy for clinical practice, that complete recovery of somatic condition might need at longest one month after operation, was concluded.
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  • Toyoji Wada, Tokuko Kayaba
    1951 Volume 54 Issue 3 Pages 247-249
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • 12th Report
    Ippei Nagao
    1951 Volume 54 Issue 3 Pages 250
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Toyoji Wada, Tatsunori Ejima
    1951 Volume 54 Issue 3 Pages 251-252
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Tatuzi Suzuki, Susumu Matumoto, Junji Sasaki, Sannosuke Nunokawa
    1951 Volume 54 Issue 3 Pages 253-260
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    In dogs, the suprarenal vein blood was collected without narcotizing. Adrenaline in the blood specimen was determined by means of the rabbit intestine segment method.
    At first, 30-38mg per kg of KCl was injected intravenously in 15 seconds. After about half an hour, 0.3mg per kg eserine was injected intravenously in 60 seconds, and 4-11 minutes later KCl in a same dose was again injected. The adrenaline secretion after the second KCl injection was compared with that of the first KCl injection.
    Before injection, the rate of adrenaline secretion from one gland was 0.02-0.03 γ per kg per min. At the first KCl injection, it increased to 0.22-0.57 γ per kg per min. After eserine, and before the second KCl injection, the rate of adrenaline secretion was 0.03-0.04 γ per kg per min. At the second KCl injection, it increased to 0.7-1.9 γ per kg per min.
    Thus it is clear that the accelerating action of KCl upon the adrenaline secretion is enhanced by eserine.
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  • Tatuzi Suzuki, Kazuo Saito, Yosiakira Kobayasi
    1951 Volume 54 Issue 3 Pages 261-267
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    The suprarenal vein blood of dogs was collected by. the method of Satake et al. without fastening and laparotomy and at first without ane-esthesia. Then evipan-sodium was injected intravenously in a dose of 40-50mg per kg. The adrenaline in the suprarenal vein blood was estimated by the rabbit intestine segment method. The blood sugar content was also. estimated.
    The evipan-sodium anesthesia does not cause any .significant alteration of adrenaline secretion rate and of blood sugar content.
    The effective and minimum-lethal dose for dogs are given in the text.
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  • 13th report
    Ippei Nagao
    1951 Volume 54 Issue 3 Pages 268
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Study on Rotatography and Crossgraphy
    Shinji Takahashi
    1951 Volume 54 Issue 3 Pages 269-282
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Shoichiro Ohara, Hiroshi Odashima
    1951 Volume 54 Issue 3 Pages 283-287
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    Since McCoy and Chopin succeeded in 1912 in isolating Bacterium tularense using egg-yolk as medium, many contributions have been made towards securing better media for cultivating this organism. Among them, Foshay1)2) and his associates, Gibby, Nicholes and Tamura3), succeeded recentlyy in, getting more suitable; liquid media. They are at present making further efforts to elucidate the effects of the components of the media upon the growths.
    In this country, though some amount of contribution has been made in this field of medicine, it is still difficult to directly cultivate Bacterium tularense from any given pathologic source, and egg-yolk has been considered to be the most suitable medium for this purpose.
    Pig-liver medium was devised, by Hiwatashi a short time ago and has hitherto been valued as suitable for subculture; but, as the one to be used for first isolation of the organisms got from human pathologic materials, it has not been given much credit.
    T. Ota, 4) after an attempt to isolate Bacterium tularense using the Hiwatashi medium in nine cases out of more than forty of tularemia which occurred 1949 in Chiba Prefecture, had to confess his failure.
    In the latest outbreak of Yato-byo in this part of Japan, we at first used egg-yolk medium for direct cultivation. But, since the spring of 1950, we have come to find a far better, medium in pig-liver. It certainly enables us to make further study of the morphology of the organism more easily, of which the present work is only a part.
    And it may well be stated that the direct isolation of Bacterium tularense from human lymph nodes presents a considerably good result and has its diagnostical value in case the materials can be secured within about a month after onsets and inoculated onto suitable media; though it will be difficult to do so after the lapse of over a month of the clinical course, even if animal examination is performed immediately after operation.
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  • (14th Report) In Vitro and In Vivo Activities of Several Kinds of Basic Antibiotics from Actinomycés upon Pasteurella Tularensis
    Akira Miyamori
    1951 Volume 54 Issue 3 Pages 288
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Tatuzi Suzuki
    1951 Volume 54 Issue 3 Pages 289-293
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    From the evidence reported by Satow that the glycemic action of histamine is quite different, in using the different manner. of applications, the interest was evoked, and the present studies were undertaken to know whether the similar evidence can be found or not concerning, the influence of histamine upon the adrenaline load of the suprarenal. gland.
    Rabbits were used. The adrenaline load of the suprarenal glands was estimated by the corrosive sublimate method of Suto-Kojima. Histamine was injected intravenously in a dose of 0.5mg per kg of body weight in 10 seconds or in 60 seconds. Some rabbits died several minutes after histamine injection and others were able to recover. In the former the suprarenals were removed soon after death and in the latter it was removed 30 minutes after injection. In these experiments we could not find any definite alteration of adrenaline load after histamine. Subcutaneous in-jection of histamine in a dose of 20mg per kg was also applied. In this series of experiments the reduction of adrenaline load was observed.
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  • Toshio Kurokawa, Takashi Masuda
    1951 Volume 54 Issue 3 Pages 294
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Tatuzi Suzuki
    1951 Volume 54 Issue 3 Pages 295-299
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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    The present investigation was undertaken to know the methylene blue method is reliable or not for the estimation of adrenaline in the general blood.
    The effect of adrenaline on the decolouration of methylene blue by muscle tissue had a large variation. Moreover we failed to find any evidence that the effect of serum of peripheral blood on the methylene blue decolouration is due to adrenaline. In fact, the effect of serum did not differ at all between that from the normal animals and those deprived of the suprarenals or totally sympathectomized.
    Therefore the methylene blue method is not available for the estimation of adrenaline in the general blood.
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  • Tamotus Yamaguchi
    1951 Volume 54 Issue 3 Pages 300
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
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  • Tatuzi Suzuki
    1951 Volume 54 Issue 3 Pages 301-303
    Published: August 25, 1951
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    In etherized dogs, the suprarenal vein blood specimens were collected by the cava-pocket method. Adrenaline content in these blood specimens was determined by the Bloor & Bullen's arseno-molybdic acid method and the rabbit intestine segment method. An almost the identical value of adrenaline was given by these two methods. But in some cases arseno-molybdic acid method gave a somewhat lower value than the rabbit in-testine segment method.
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