The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 79, Issue 2
Displaying 1-11 of 11 articles from this issue
  • Characteristics of Primary Malignant Melanoma o fthe Leptomeninges
    Takao Fukuda
    1963 Volume 79 Issue 2 Pages 103-119
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    1) Thirty-four cases of cutaneous malignant melanoma were examined and were classified according to the following three groups.
    (1) spindle-cellular fascicular type
    (2) stellate-cellular type
    (3) polymorph-cellular type
    2) Three cases of primary malignant melanoma of the leptomeninges were examined and their histological characteristics were described.
    3) The histological differences between cutaneous and meningeal malignant melanomas and the differences in their behavior were pointed out.
    1) 34 Fälle von malignem Melanom der Haut wurden nach der histologischen Beschaffenheit in folgenden drei Typen klassifiziert.
    1) Spimdelzellulärer fascikulärer Typus
    2) Sternfärmig-zellulärer Typus
    3) Polymorph zellulärer Typus
    2) 3 Fälle von primärem malignem Melanom der Leptomeningen warden untersucht and ihre histologische Eigenheiten wurden betont.
    3) Die histologischen and biologischen Unterschiede zwischen dem dermalen and dem meningialen Melanome wurden diskutiert.
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  • Tooru Nakao, Toshio Nitta
    1963 Volume 79 Issue 2 Pages 120-124
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
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  • III. A Contribution to the Mechanism of Incoagulability of Menstrual and Intraperitoneal Blood
    Masahiro Maki, Haruo Saito
    1963 Volume 79 Issue 2 Pages 125-129
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    1. All menstrual blood samples were capable of high potency caseinolytic and fibrinolytic activity in their euglobulin fraction. All samples lacked fibrinogen and had low inhibitory action on trypsin. A significant amount of plasminogen activator in 1 M potassium thiocyanate extracts was detected on the standard fibrin plate. This fibrinolysis may play a very important role in maintaining fluidity of the menstrum.
    2. Blood samples obtained from the peritoneal cavity in cases of ruptured ectopie pregnancy had relatively low proteolytic activity in their euglobulin fraction. All samples lacked fibrinogen and had no potency of inhibitory action on trypsin. It is also suggested that the fluidity mechanism of the intraperitoneal blood is due to fibrinolysis and this fibrinolysis is enhanced by peritoneal plasminogen activator.
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  • II. Pantothenic Acid Intake of Farming and Fishing Villagers
    Kôzô Ishiguro
    1963 Volume 79 Issue 2 Pages 130-134
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    The intake of free pantothenic acid in a farming village showed no differences from that in a fishing village in Miyagi prefecture, Japan, but the intake of its derivatives of and above the pantetheine level was larger in the fishing village, particularly in autumn and winter.
    The intake was largest in autumn in both the villagers. The main sources of Pa A and its derivatives were vegetables and fishes (including shellfishes). However cereals proved to be poor sources of pantetheine and its higher derivatives.
    The auther expresses his thanks to Prof. E. Takahashi and Dr. S. Kamiyama who have given valuable suggestions.
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  • Keiya Tada, Haruko Hirono, Hisashi Miyazawa
    1963 Volume 79 Issue 2 Pages 135-141
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    The oxygen consumption and anaerobic glycolysis by the muscle from the patients with progressive muscular dystrophy were manometrically investigated.
    The oxygen consumption, on protein basis, of the affected muscle was within normal limits. Its anaerobic glycolysis was, on protein basis, considerably diminished. The decrease of anaerobic glycolysis seemed to be proportionate to the severity of muscular destruction.
    In addition to the disturbance in energy storage system due to the decrease of creatinephosphokina, se, the decrease of anaerobic glycolysis also may play a part in causing the decrease of muscular power in this particular disorder.
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  • Keiya Tada, Yoshiro Wada, Toshihiro Okamura
    1963 Volume 79 Issue 2 Pages 142-147
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    A case of maple sugar urine disease, the first case in Japan, was described. The urine of the patient contained an elevated amounts of leucine, isoleucine, valine and methionine.
    The chromosomal. analysis gave no abnormality.
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  • Tatsuo Koyanagi
    1963 Volume 79 Issue 2 Pages 148-151
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    The effect of methionine supplementation on the elevation of blood pressure induced by high salt diet was investigated. The results of experiment showed that the addition of 0.2% dl-methionine to the high salt diet with or without liberal supply of vitamin A had a beneficial effect in prevention of occurrence of hypertension.
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  • L. Orosz, J. Hankiss
    1963 Volume 79 Issue 2 Pages 152-157
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    The authors demonstrated in the experiments on human subjects the correlation between the diuretic effect of heparin and the ADH-system. In more than half of their cases heparin inhibited the antidiuretic effect of pitressin. From this finding, the authors emphasized that the effect of heparin on the watermetabolism is at least partly brought about by the ADH-system.
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  • Hiyoshimaru Oyamada
    1963 Volume 79 Issue 2 Pages 158-167
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    1) The validity of using the corrected hematocrit, which was obtained on the basis of assuming that 85μ3 is the ideal corpuscular volume for red blood cells, was discussed.
    2) Ninety-two patients were examined by the T3 uptake test, and comparison of the data, obtained by Hamolsky's and Adams' calculations as well as by modified ones applying the corrected hematocrit, was done.
    3) The work presented here showed fundamental difference in the locations of the boundaries between the three different diagnostic categories of thyroid function introduced by Adams et al. and Hamolsky et al.
    4) This report showed higher labeling of T3 by red blood cells than Hamolsky's reports. The range of K for the euthyroid group was narrower mthis work than in the Adams' report.
    5) The results obtained by using the corrected hematocrit on Hamolsky's and Adams' calculations showed better separation between the three diagnostic categories. As long as the corrected hematocrit was applied on Hamolsky's and Adams' calculations, both methods were equally valid to separate the three diagnostic categories.
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  • Norio Suwa, Takashi Niwa, Hitoshi Fukasawa, Yasuhiko Sasaki
    1963 Volume 79 Issue 2 Pages 168-198
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    1) Arterial blood flow was expressed as a power function of arterial radius. In the relation defined by Q=qrn, Q was blood flow, q an organ specific constant, and n had a value about 2.7 regardless of organ difference.
    2) On account of the above relation, Hagen-Poiseuille's formula was transformed to Δp=K•q•l'/r4-n Th in which K was an organ unspeeific constant determined by viscosity coefficient of blood and selected units, l' was the effective length and r was the radius of an arterial branch. In the transformed formula, pressure difference between both ends of an unbranching stretch of arteries Δp was given by the product of organ unspeeific and organ specific constants and a quantity determined by anatomical properties of arteries. By means of successive determinations of l'/r4-n by way of any arbitrarily selected route, the total blood pressure drop could be determined by ΣΔp=K•q•Σ l'/r4-n.
    3) The relation of the effective branch length l' and the radius r of an arterial system was expressed by l'=hri, in which h and i were organ specific constants. A higher value of i indicated a higher proportion of large arterial branches in the total arterial length.
    4) Assuming successive dichotomy of arterial branches, an arterial model was constructed with. radius as a continuous variable. Blood pressure drop between any two given radii could be estimated by the calculation on the model by:
    ΔP=K•q•h/1-δg [rg]r1r2 for g ≠ 0 and ΔP=K•q•h/-log δ [log r]r1r2 for g=0.
    5) Some organ differences in the pattern of blood pressure gradient and intravascular blood pressure values were confirmed and were discussed in reference to different anatomical properties of arterial systems. Renal. artery was characterized by pronounced acceleration of blood pressure drop in the arteriolar region and by only insignificant pressure drop in its large branches. On the contrary, considerable blood pressure drop took place in large arterial branches of mesenteric, femoral and cerebral arteries in contrast to comparatively mild pressure drop in the arteriolar region. The estimated blood pressure level in the arteriolar region was correlated to the effective length of arterial systems. It was found to be higher in the arterial group with short effective arterial length. It was suggested that arterial systems with high susceptibility to hypertensive arteriolar injuries belonged to arteries with high hood pressure level in the region of r=100μ to r=200μ.
    6) Artificial arterial dilatation due to resin infusion. could be defined by a power function of arterial radius. The function could be used as the correction equation of the radius of arterial casts, and the radius of living arteries was estimated on. the basis of blood pressure estimation with corrected arterial models.
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  • Report I. Increased Synthesis of δ-Aminolevulinic Acid in Allylisopropylacetamide-induced Porphyria Rat
    Takashi Miyakoshi, Goro Kikuchi
    1963 Volume 79 Issue 2 Pages 199-208
    Published: March 25, 1963
    Released on J-STAGE: November 28, 2008
    A chemical porphyria was induced in rat by feeding allylisopropylacetamide (AIA) and activities in liver mitochondria to synthesize aminoketones were studied.
    It was shown that the activity to synthesize δ-aminolevulinic acid (δ-ALA) was high in liver mitochondria from AIA-induced porphyria rat, while it was very low in normal rat. In contrast, both mitochondria from normal and AIA-treated rats produced large amounts of aminoacetone and no activity difference was noticed between normal and porphyria rats. The δ-ALA synthesizing activity of liver mitochondria varied significantly according to the reaction conditions employed; particularly the yield of δ-ALA was increased by omitting ADP or Pi from the reaction system under anaerobic conditions.
    Activities of terminal respiration systems in AIA-treated rat were found to be unaffected. δ-ALA was scarcely catabolyzed by liver mitochondrial preparations from either of normal and porphyria rats.
    Significance of succinyl-CoA supplying system in controling the activity of δ-ALA synthesis was discussed in relation to chemical porphyria.
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