The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 90, Issue 1
Displaying 1-9 of 9 articles from this issue
  • Chikako Sato
    1966 Volume 90 Issue 1 Pages 1-8
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The pupae of Sarcophaga peregrina received x-ray in the early pupal stage, and their oxygen consumption was measured throughout the pupal stage. Three patterns of radiation effects were found according to doses. With small irradiation doses, inhibitory effect on oxygen uptake was evident, but the survival time of the pupae was the same as that in non-irradiated, non-fed pupae. With medium irradiation doses, oxygen uptake of the pupae was maintained at an extremely low level throughout the pupal stage, but they survived far longer than the non-irradiated control pupae. With large irradiation doses, oxygen uptake was exponentially reduced after the irradiation, leading the pupae to death in the early pupal stage.
    It was an outstanding feature of the present experiments that the pupae with irradiation in medium doses survived longer than the control pupae.
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  • Motohiko Ichijo, Yasuhide Ujiie
    1966 Volume 90 Issue 1 Pages 9-24
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    The electrohysterography by means of an extracellular electrode is expected to be a useful method to disclose functional disorders of the uterine muscles. To find the basic patterns in the electrohysterogram of the rat's uterus, the reaction of the organ was studied after the administration of estradiol, estriol, progesterone or estradiol plus progesterone. Studies were also made on the uterus after castration and in pregnancy, parturition and puerperium. The electrohysterograms obtained in our experiments with rats could be classified into three types of ED, ET and P. The condition of the uterine muscles could be inferred from the analysis of the wave form, amplitude, interval diagram, interval of the bursts, number of the spike discharge, propagation velocity and conductivity on the electrohysterogram. The characteristic pattern of parturition was reproduced with estriol and posterior pituitary hormone better than with other hormones. The finding was of interest in understanding the mechanism of labor in association with electrohysterography.
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  • Takashi Kitabatake
    1966 Volume 90 Issue 1 Pages 25-34
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Survey cards were distributed to the leukemic patients in the departments of internal medicine and pediatrics of hospitals in Japan from 1961 to 1965, with requests for the name, sex, type and date of onset of disease, and type and frequency of prior medical irradiation. Of 1, 197 available cards collected, 49 or 4.09 per cent had a history of fluoroscopic examination and 19 or 1.59 per cent had a history of prior therapeutic irradiation. On the other hand, out of 2, 609 controls selected randomly from patients with non-malignant diseases or healthy persons, 146 or 5.60 per cent had a history of fluoroscopic examination and 13 or 0.50 per cent had a history of radiotherapy. Namely, the fluoroscopic irradiation rate was slightly higher in controls than in leukemic patients, although there was no statistically significant difference. Whereas, the therapeutic irradiation rate was significantly higher in leukemic patients than in controls. Next, the integral bone marrow dose received during fluoroscopy or radiotherapy was calculated, based on Miyakawa and Hashizume's data. The average bone marrow dose was estimated to be 2, 704 grads in leukemic patients and 762 grads in controls. Results of this survey indicated that prior radiotherapy could be related to leukemogenesis.
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  • Sentaro Shishito, Seigi Tsuchida
    1966 Volume 90 Issue 1 Pages 35-40
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A new technique for ileocystoplasty is described. The abdomen is opened through an abdominal median incision, and approximately 25cm of the ileum are isolated together with the mesentery attached to it. The isolated ileum is then bent into a U-shape and the ileal walls are incised and sutured so as to form an open bag. Following the incision of the bladder wall, this newly formed bag is anastomosed to the bladder. Thus, an enlarged bladder is artificially formed.
    This technique was employed with success in four cases of contracted tuberculous bladder and in one cases of neurogenic bladder.
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  • Minoru Adachi, Tatsuo Kasai, Tamako Adachi, Joyce N. Budna, Otakar J. ...
    1966 Volume 90 Issue 1 Pages 41-51
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Cigarette smoke strongly affects rabbit corneal cells in vitro. The cells from hypercholesteremic rabbits are damaged more severely by cigarette smoke than the cells from normocholesteremic rabbits.
    In vitro, the effect increases with increasing concentration of cigarette smoke. This is reflected by the decrease in the number of positive cultures, by the delay of the initial outgrowth of cells, by the depression of growth value, by the distortion of growth curves, by the morphologic alterations, and by the depression of enzymatic activities of corneal epithelial cells.
    Quantitative reaction of rabbit corneal cells to cigarette smoke is similar to that of rabbit's aortic cells. The qualitative response of corneal epithelial cells to cigarette smoke was far less pronounced than that of aortic endothelial cells.
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  • Eiji Sekino, Akira Takano, Tadao Denbo, Sohei Suzuki, Susumu Ainai
    1966 Volume 90 Issue 1 Pages 53-60
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    Simultaneous observations were made of changes in metabolic and circulatory parameters of the total body, heart and brain under hypothermia. Linear decreases were seen in cardiac output, coronary and cerebral blood flows during hypothermia until the body temperature fell to 30°C, and the rate of each decrease was almost the same. However, our data obtained at body tem-perature of 25°C showed that the decrease in cardiac output was prominent, compared with that in cerebral and coronary blood flows. That is, the rate of distribution of the blood volume in the coronary and cerebral circulations predominated over that of cardiac output.
    This finding suggests that both the brain and heart muscle require relatively large quantities of oxygen even under the condition of hypothermia, and all metabolic and circulatory parameters change in a direction to maintain blood supply to the brain and heart muscle during hypothermia.
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  • Norio Suwa, Hitoshi Fukasawa, Ryuitsu Fujimoto, Masahiko Kawakami
    1966 Volume 90 Issue 1 Pages 61-75
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    A function in the form of F=A(eax-1) was proposed to predict the stress of pulmonary tissues over a wide range of strain. The expression could likewise be applied to a number of different tissues. In the expression, x was the strain, F the corresponding stress, A a constant determined by the quantity of the elastic system and a indicated the elastic property of the system. The latter constant was designated as elasticity constant. Its importance in the stress function consisted in its exclusive role to determine the pattern of the strain-stress relation. The elasticity constant was estimated around 4.0 with tissues composed mainly of elastic fibers. It was about 10 or more in tissues of predominantly collagenous type. As pulmonary tissues had values about 5.0 for a, it was concluded that the pulmonary elastic system was mainly constituted by elastic, not by collagenous, fibers. The possible influence of non-parallel orientation of fibers on the above stress function was analytically discussed. It was practically negligible so far as the estimation of elasticity constant was concerned. An attempt was made theoretically to derive the function on a hypothetical molecular model for the fiber.
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  • Norio Suwa, Katsuro Takahashi, Ryuitsu Fujimoto, Yasuhiko Sasaki
    1966 Volume 90 Issue 1 Pages 77-96
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
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  • Sakuzi Kodama
    1966 Volume 90 Issue 1 Pages 97-103
    Published: 1966
    Released on J-STAGE: November 28, 2008
    JOURNAL FREE ACCESS
    For the analytical investigation on an isolated mammalian heart, a method of perfusing the heart was devised, with which the heart could manifest its activities sufficiently as in the body.
    The method furnishes the heart with 2 systems, these being connected with each other in series as in the body: One system corresponds to the pulmonary circulation and the other to the systemic circulation. For the perfusion, one perfusion generator and three pulse-generator arrangements are devised. The perfusion generator serves to flow the perfusate through the whole perfusion systems-aortic-cava and pulmonary passages, some part of the perfusate being introduced directly into the coronary circulation system. Two pulse-generators are used to give pulsatory changes to the perfusing stream in the aortic and the pulmonary venous passages, if necessary, and one is used chiefly for coronary flow measurement.
    The method presented here may be regarded as a beginning for the analytical investigation on the heart with regard not only to its physical properties, but also to its metabolic and pharmacological characteristics.
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