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Volume 123 (1977)
- Issue 4 Pages 297-
- Issue 3 Pages 197-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 123, Issue 3
Displaying 1-12 of 12 articles from this issue
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HIKARU WATANABE, NOBUO HIWATASHI, SHOICHI YAMAGATA1977 Volume 123 Issue 3 Pages 197-213
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBased on the clinical results in 159 cases of ulcerative colitis experienced in our Department during the years 1954-1975, various clinical aspects such as incidence, symptoms. clinical findings, complications, treatment and prognosis were investigated. From- these observations, the following results were obtained: 1) Ulcerative colitis is not as rare as previously considered. It is slightly female predominant and seen most often in adolescents and adults. However, one of the most interesting findings is the secondary increase in incidence in older people, producing a bimodal curve. 2) One third of the total cases of ulcerative colitis belongs to the category of proctitis at the time of diagnosis. 3) Classical ulcerative colitis such as total colitis and left-sided colitis is characterized by mucous bloody stools as its chief symptom and often accompanied by fever, loss of weight, a rise in blood sedimentation rate, anemia, leucocytosis, hypoproteinemia, lowering of A/G ratio and hypopotassemia. These fingings, except for bloody stool, were not, commonly found in proctitis. However, findings of procto-sigmoidoscopy, cytologic examination, biopsy and radiological examination between classical ulcerative colitis and proctitis were similar. On the other hand, the lesion progressed to a part or all of the colon in 7 of 38 cases (18%) of proctitis during the observation period. Proctitis is, therefore, thought to be a part of ulcerative colitis. 4) The evaluation of medical treatment discloses that remission was obtained in 21 of 46 cases (46%) of total colitis, in 24 of 35 cases (69%) of left-sided colitis and in 31 of 38 cases (82%) of proctitis. Surgical intervention became necessary in 24 of 46 cases (52%) of total colitis, in 5 of 29 cases (17%) of left-sided colitis and in only one of 31 cases (3%) of proctitis. 5) Follow up studies revealed the recurrence of symptoms in many cases, although most patients were capable of maintaining normal lives.View full abstractDownload PDF (3950K) -
II-SEI WATANABE, BRUNO KONIG, Jr.1977 Volume 123 Issue 3 Pages 215-220
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA histological study was conducted on the innervation of the Cebus apella palatine mucosa. Ten monkeys were used for the present study. After perfusion with 10% formalin, the whole hard palate mucosa was removed in one piece and made into histological sections according to De Castro's method for silver impregnation. We concluded that the nerve fibers form free endings and organized corpuscles, like Meissner corpuscles. Free nerve endings are numerous in the hard palate mucosa and they show a great variety in form and size.View full abstractDownload PDF (2444K) -
EIZO YAMASHITA, HIROSHI MATSUMOTO1977 Volume 123 Issue 3 Pages 221-225
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe finger motions and quickness of braille reading were investigated by way of recording the finger tip pressure on the braille and its time process. Subjects were separated into two groups. One group consisted of 5 experienced blinds and the other group consisted of 5 blinds who were beginners in braille reading. The comparison of obtained results from two groups gave some evidence for the following conclusion. The finger tip pressure was considerably increased for careful or difficult reading.View full abstractDownload PDF (285K) -
HIROSHI KANEDA, TAKESHI HARUYAMA, SATORU CHIBA, YOSHIKI SUGAI, TAKASHI ...1977 Volume 123 Issue 3 Pages 227-234
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA 38-year-old man suffering from chronic recurrent hepatic encephalopathy due to liver cirrhosis complicated with chronic renal failure had been maintained well by regular hemodialysis treatment for 14 months. Only four episodes of hepatic encephalopathy occurred in that period. Each of four episodes of disturbed consciousness was accompanied by slightly elevated blood ammonia levels. Energetic serial dialysis for 5-7 days was necessary for its recovery. The factors causing hepatic encephalopathy did not appear to be easily dialysable as compared with those of uremic coma. It is concluded that the hemodialysis is quite an effective treatment for the recurrent type of hepatic encephalopathy.View full abstractDownload PDF (1900K) -
TOSHIO TAKAHASHI, KENICHI KONO, TOSHIHARU YAMAGUCHI1977 Volume 123 Issue 3 Pages 235-246
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUtilizing the lipid-absorbing ability of lymphatic capillaries, anticancer agents were given in the form of fat emulsion in order to deliver them to regional lymph nodes. The emulsion, in which the drug solution is contained as the innermost phase, yielded high drug concentration in the lymphatic system. Intratumoral injection of emulsified anticancer agent resulted in significantly prolonged retension of the drug within the tumor tissue. Therapeutic experiments of the emulsion also disclosed remarkable tumor reduc-tion and cure rate as compared with aqueous solution of drugs. Oral admini-stration of emulsified 5-Fluorouracil (5-FU) was also attempted for stomach cancer. With 5-FU, the maximum concentration of drug in thoracic lymph and stomach was greater when administered as an emulsion than as an aqueous solution, and a high concentration persisted longer. As a clinical trial of the emulsion method, eight patients with inoperable malignant growth were injected locally with emulsi-fied anticancer agents and 121 patients were given 5-FU emulsion orally. From the clinical and histological findings, it was thought that the emulsion enhanced the chemotherapeutic effect of the anticancer agent on lymph node metastasis.View full abstractDownload PDF (3569K) -
NOBUYUKI WATABE, FUMIHIKO HOSHINO, HIROSHI ITO, SHOKI TAKAHASHI, TOSHI ...1977 Volume 123 Issue 3 Pages 247-255
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSerial alveolography using a contrast medium for indirect lymphography was developed at our department. With this technique radiograms comparable to so-called barium-imbibed preparations of resected lung are possible. Furthermore, the procedure has the advantage of demonstrating serial radiographic changes as well as the local contrast medium wash-out or clearance, a local functional aspect of the lung, successively in a very short time. It is practical to accomplish simultaneous examinations in both morphological and functional (most probably concerned with the local pulmonary lymph) aspects with the new procedure. Significant differences in radiographic features have been demonstrated between the normal lung and chronic pulmonary emphysema or fibrotic pulmonary diseases.View full abstractDownload PDF (3652K) -
AKIYUKI OHKUBO, KYOKO OKIMOTO, YASUHIKO IWASAKI, KINORI KOSAKA, TAKEO ...1977 Volume 123 Issue 3 Pages 257-263
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe majority of patients with hepatic cirrhosis in Japan do not have a history of acute hepatitis or alcoholism. Twenty-nine patients with hepatic cirrhosis which were thought as random samples from cirrhotic patients without a history of acute hepatitis or alcoholism were Human Leukocyte Antigen (HLA) typed. Association of HLA-B5 and -BW22-J with hepatic cirrhosis of apparently unknown etiology was found in p<0.003, and p<0.01, respectively (128 controls). A predisposition linked to HLA-B5 or -13W22-J related gene or genes seems to play a role in the development of hepatic cirrhosis, at least in a substantial part of patients with hepatic cirrhosis of apparently unknown etiology in Japan.View full abstractDownload PDF (464K) -
MASATOSHI OHTAKE1977 Volume 123 Issue 3 Pages 265-270
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe serum zinc and copper concentrations were measured in 45 healthy Japanese infants with age ranging from 5 days to 12 months. At one month of age there was a significant decrease in serum zinc concentration, and this low level persisted until 6 months of age when a significant increase in serum zinc concentration was observed. Serum zinc concentrations remained relatively stable between 6 and 12 months of age. The concentration of serum copper in newborn infants was significantly lower than in healthy children (age: 6 to 12 years), but had risen by 5 months of age to the same levels. There were no significant differences in serum zinc and copper concentrations between male and female infants. However, there was a tendency for serum zinc levels in exclusively breastfed infants to be higher than those in bottlefed infants at 3 months of age and for serum copper levels in exclusively or partially breastfed infants to be higher than those in bottlefed infants at one month of age.View full abstractDownload PDF (312K) -
MINORU YASUJIMA, KEISHI ABE, YOICHI OTSUKA, SATORU CHIBA, KANCHO RITSU ...1977 Volume 123 Issue 3 Pages 271-278
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo investigate the interaction between the renin angiotensin aldosterone system and the renal prostaglandin (PG), urinary excretion of PGE, urinary excretion of main urinary metabolite (MUM) of PGF2α, urinary excretion of aldosterone, and plasma renin activity were measured before and after infusion of 1-Sar-8-Ile-Angiotensin II, a specific competitive inhibitor of angiotensin II, in 18 patients with essential hypertension under normal and low sodium diets. The values of urinary sodium excretion in these patients before the infusion of the peptide were 160.8±13.3 and 27.0±2.7 mEq per day on normal and low sodium diet, respectively. On normal sodium diet, urinary excretion of PGE was found to correlate with the level of plasma renin activity before the infusion (r=0.6977, p<0.01), and it was decreased slightly from 0.37±0.05 ng/min to 0.26±0.04 ng/min after the infusion of the antagonist. On low sodium diet, urinary excretion of PGE was not significantly changed by the infusion of the peptide and showed no correlation with the level of plasma renin activity before the infusion, while urinary excretion of PGE showed a significant correlation with the excretion of urinary aldosterone (r=0.6719, p<0.02). Excretion of PGF2αMUM decreased after the infusion of this peptide on both sodium diets, but the changes were not statis-tically significant. The present data suggest that angiotensin II influences the synthesis or release of renal PG in patients with essential hypertension on normal sodium diet, but not when they are on low sodium diet.View full abstractDownload PDF (430K) -
KAZUHIKO FUKUDA, ATSUSHI ISHII, YOSHIHIKO MATSUE, KENICHI FUNAKI, HIRO ...1977 Volume 123 Issue 3 Pages 279-285
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPregnancy and delivery of two patients with Wilson's disease are reported. Case 1 was a 20-year-old housewife who had been taking D-penicillamine for more than 10 years and had remained asymptomatic except an episode of dissociative reaction. She apparently survived longer than any of her three sisters who died of the same disease. She discontin-ued the use of D-penicillamine by herself when she was at the 22nd week of pregnancy. Case 2 was a 32-year-old housewife who developed an episode of mental disorder of short circuit reaction type with mild neurological symptoms and Kayser-Fleischer rings after the prolonged interval of medication since the first pregnancy and delivery. Three months after the complete recovery of neuropsychiatric symptoms she was at the 12th week of pregnancy and withheld penicillamine from herself. During the pregnancy they had not revealed any exacerbation in terms of clinical and laboratory findings. Each of them was delivered of a healthy baby. Although the pregnancy and delivery of both patients were successful, the authors recommended that they should not prolong the interval of medication to protect themselves against the onset or relapse of the illness.View full abstractDownload PDF (1235K) -
KAORU SAGISAKA, MINEO IWASA, HIROKO YAMASHITA, SADAO YAMADA1977 Volume 123 Issue 3 Pages 287-294
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt has been known that hemolysate is composed of not only hemoglobin but also non-hemoglobin proteins (NHP). NHP isolated effectively from hemolysate of adult and newborn by CM-Sephadex chromatography was investigated by polyacrylamide disc or slab electrophoresis. It was demonstrated on slab electrophoresis that adult NHP is composed of 4 zones (approximately 14 bands) with different mobilities and that adult NHP shows a considerably different pattern from cord NHP. The difference was observed also on the electrophoresis stained for esterase or lactate dehydrognease. Rabbit antiserum to adult NHP was adsorbed with cord NHP and specific antiserum for adult NHP was prepared. However, antiserum reacting with only cord NHP was not obtained from anti-cord NHP serum. These results suggested that adult specific components with passable antigenicity were present in adult NHP and that cord NHP had similar antigenicity as adult NHP.View full abstractDownload PDF (2545K) -
OSAMU YAMAGUCHI, SEIGI TSUCHIDA1977 Volume 123 Issue 3 Pages 295-296
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUsing a specially designed circuit with an UP-DOWN counter, a new method is birefly described for investigation of the upper urinary tract. It allows sequential measurements of the balance level between input and output of the pelviureteral system in animal experiments.View full abstractDownload PDF (107K)
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