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Volume 197 (2002)
- Issue 4 Pages 189-
- Issue 3 Pages 125-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 197, Issue 1
May
Displaying 1-8 of 8 articles from this issue
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Review
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KAZUHISA TAKEUCHI2002 Volume 197 Issue 1 Pages 1-8
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSBlood pressure is determined by vascular resistance and circulating volume. Activation of vascular angiotensin II or thromboxane receptor is mostly involved in the former, and function of renal prostaglandin EP3 receptor or thiazide-sensitive sodium-chloride co-transporter is also in the latter. We have cloned rat genes for these blood pressure regulatory factors, and studied their gene expression. Here we review the molecular biology of those genes, based on our observations.View full abstractDownload PDF (623K)
Regular Contributions
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KADER KÖSE, CEVAD YAZICI, NIMET ÇAMBAY, ÖZCAN ASCIOGL ...2002 Volume 197 Issue 1 Pages 9-16
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSIn spite of unknown etiology, it is now accepted that reactive oxygen species (ROS) produced by neutrophils may be related to the pathogenesis of Behçet’s Disease (BD). The objective was to investigate whether increased production of ROS may affect erythrocyte oxidant/antioxidant system in patients with BD. The levels of malondialdehyde (MDA), one of the end products of lipid peroxidation, in plasma and erythrocyte, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), antioxidant enzymes, in erythrocyte, also C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured in 22 patients in active stage of the disease and also in 30 healthy controls. Increased CRP, ESR, and MDA levels in plasma and erythrocyte and increased SOD but decreased GSH-Px activities in erythrocytes were observed in the patients, when compared to the controls. In addition, significantly positive correlations between plasma and erythrocyte MDA levels, and erythrocyte MDA-CRP, MDA-ESR, MDA-SOD, SOD-ESR and SOD-CRP levels, but negative correlation between plasma MDA and erythrocyte GSH-Px, were found in BD patients. In may be suggested that increased production of ROS in BD, as reflected by higher plasma and erythrocyte MDA levels, may impair erythrocyte membrane integrity and also may lead to the alterations in the erythrocyte antioxidant defense system, as reflected by higher SOD and lower GSH-Px activities in erythrocytes.View full abstractDownload PDF (523K) -
EZEL USLU, SEVAL AYDIN, SINAN CARKMAN, HAFIZE UZUN, EDIZ ALTINLI, BEDI ...2002 Volume 197 Issue 1 Pages 17-26
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSIn the experimental stress literature, the results of investigations have not shown a specific sex-dependent vulnerability to stress ulceration. The aim of this study was to evaluate the importance of sex differences on stress ulcer development. Related to gender, the contributing factors for stress ulcer production such as luminal acidity, sialic acid as an marker of gastric mucosal protection, oxygen (O2)-derived free radicals and endogenous antioxidant defence mechanisms were also investigated. Fifty Wistar Albino rats weighting about 230 g and aged 7 or 8 months were divided equally into five groups: Group I normal male rats, group II castrated male rats, group III normal female rats in estrus phase, group IV normal female rats in diestrus phase and group V castrated female rats. Cold restraint model was used for 6 hours to produce stress ulcer. No statistically significant difference was found out between groups in view of gross and histopathologic damage. There was no significant difference between groups according to gastric luminal acidity, gastric mucosal sialic acid, gastric malonaldehyde (MDA) and catalase values. Gastric superoxide dismutase (SOD) activity was significantly lower in Group I in comparison to those of Group III and IV. Sex differences do not interfere stress ulcer formation. SOD activity in rat gastric tissue has varied significantly by hormonal milieu.View full abstractDownload PDF (516K) -
ERCAN KIRIMI, OGUZ TUNCER, BÜLENT ATAS, MEHMET EMIN SAKARYA, ABDU ...2002 Volume 197 Issue 1 Pages 27-33
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSThe cerebral blood flow velocities (CBFV) of infants with perinatal asphyxia and hypoxic ischemic encephalopathy (HIE) in the first 12 hours of their lives have been the chief focus of our concern in this study. Cerebral ischemia which can develop in the earlier hours of HIE, and the detection and diagnosis of this condition with color Doppler ultrasonography (cD-USG) will be put into discussion. Twenty-three full-term newborn infants who had perinatal asphyxia and HIE together with a control group constituting twenty full-term newborn infants who produced no problems, were included in our study. All of the infants underwent cD-USG in the postpartum period of the first 12 hours (mean 8.4 hours). Measurements being based upon peak systolic velocity (PSV), end diastolic velocity (EDV) and Pouecelout’s resistive index (RI) in anterior and middle cerebral arteries were conducted. The infants, having been discharged from the unit they were followed up for mean 9.8 months in the outpatient clinic. PSV and EDV counts in the postpartum first 12 hours of 23 infants who were detected to have HIE were found to be significantly lower compared to the control group, whereas RI counts were found to be significantly higher (p<0.05). The counts obtained from the right and left cerebral arteries of the infants with HIE were found to be corraleted with each others. The neonates in the patient group were observed to have gone through this prognosis: Three of them died, three of them had cerebral palsy, one of them had infantile spasms, and three of them had developmental retardation. When we compared the CBFV of the 10 neonates who had poor prognosis, retrospectively with the other 13 neonates who had good prognosis, PSV and EDV were found to be significantly lower and RI significantly higher (p<0.05). In the light of the data we have obtained, cD-USG can be considered to be a highly practical device in evaluating CBVF of the infants with HIE. A skillful detection of the decrease in cerebral blood flow which can develop in the postasphyxial first 12 hours and the prospective treatments being based upon this approach would contribute to the diagnosis, treatment and prognosis of such cases.View full abstractDownload PDF (1543K) -
METIN GÜDEN, CÜNEYT ULUTIN, MURAT DEDE, SAFFET DILEK, YÜ ...2002 Volume 197 Issue 1 Pages 35-40
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSRectum reference dose points have a direct impact on the morbidity seen in gynecological intracavitary radiotherapy. The aim of this study is to obtain less morbidity by marking rectum with radio opaque solution. Fourteen patients with gynecological cancer who underwent external radiotherapy received 15 Gray (Gy) intracavitary radiotherapy. During the internal radiotherapy planning, radio opaque solution has been administered into the rectum to observe it on lateral radiogram. Thus rectum reference dose point and five points were marked at sites nearest to the sources. Nucletron Planning system was used for obtaining three-dimensional planning. After therapy patients were followed at every three months. Median follow-up was 18 months. Most frequently observed morbidities were grade 1-2 rectitis and cystitis in six patients. As a result, more accurate rectum dose values and less factors causing dose changing can provide better results for gynecological intracavitary brachytherapy.View full abstractDownload PDF (542K)
Case Reports
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HIROSHI OHGURO, IKUYO MARUYAMA, MITSURU NAKAZAWA2002 Volume 197 Issue 1 Pages 41-45
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSA case of pseudoadenomatous hyperplasia of ciliary body epithelium was reported in which malignant melanoma of ciliary body was suspected. Partial resection for histopathology was performed in conjunction with cataract extraction, anterior resection and photocoagulation. Histopathology of the tumor identified as pseudoadenomatous hyperplasia of ciliary body epithelium. Partial resection of ciliary body tumor may be an alternative method for its differential diagnosis rather than enucleation and iridocyclectomy.View full abstractDownload PDF (2883K) -
MASAHIRO IIKUBO, TAKASHI SASANO, NORIAKI SHOJI, MAYA SAKAMOTO2002 Volume 197 Issue 1 Pages 47-53
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSAs a new nonsurgical treatment for odontogenic maxillary sinusitis (OMS), irrigation of the maxillary sinus through the root canal of the causal tooth was carried out to the patient with OMS that had proved refractory to conservative treatments (i.e., root-canal treatment of the causal tooth and antibiotic therapy). Clinical signs, symptoms, and radiographs before and after the new treatment revealed evidence of good healing. The clinical signs and symptoms, such as oppressive pain in the cheek and retrorhinorrhoea, entirely disappeared immediately after the irrigation (which was done only once) without pain, and the obstructed ostiomeatal unit was aerated on the follow-up CT images. There was no side effect associated with saline irrigation, nor any recurrence of symptoms since the irrigation. We therefore propose the irrigation through the root canal of the causal tooth as a new treatment for periapical disease-induced maxillary sinusitis, a technique that should ensure proper ventilation and drainage by relieving obstruction of the ostiomeatal unit.View full abstractDownload PDF (1317K) -
VOLKAN ETUS, ÖZLEM KURTKAYA, AYDIN SAV, KONURALP ILBAY, SAVAS CEY ...2002 Volume 197 Issue 1 Pages 55-65
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSPrimitive neuroepithelial tumors are the least common among supratentorial tumors in children. They pose great diagnostic difficulty, preoperatively as well as pathologically. Being quite rare, cerebral neuroblastomas are accepted as a distinct pathological entity, which differs from other neuroectodermal tumors, although clinically, radiologically, and morphologically at operation they are indistinguishable. Also differentiation between primary cerebral neuroblastoma and the other primitive neuroectodermal tumors may be difficult on light microscopy and be misleading. A 9-year-old girl with primary cerebral neuroblastoma who was initially misdiagnosed is reported. The other cases from the literature are reviewed and the nature of this rare tumor and its differential diagnosis is discussed.View full abstractDownload PDF (2097K)
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