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Volume 197 (2002)
- Issue 4 Pages 189-
- Issue 3 Pages 125-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 197, Issue 2
June
Displaying 1-8 of 8 articles from this issue
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Review
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MUTSUO YAMAYA2002 Volume 197 Issue 2 Pages 67-80
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSThe number of senile patients with therapy resistant bronchial asthma, chronic pulmonary emphysema increases due to the habit of smoking and increased number of older people, and these inflammatory pulmonary diseases are the leading causes of death worldwide. Rhinoviruses cause the majority of common colds, and provoke exacerbations of bronchial asthma and chronic pulmonary emphysema. Here, I review the pathogenesis and management of rhinovirus infection-induced exacerbation of senile bronchial asthma and chronic pulmonary emphysema.View full abstractDownload PDF (1151K)
Regular Contributions
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HAKAN ÇANKAYA, EROL EGELI, LEYLA KUNTSAL, HANEFI OZBEK, MURAT I ...2002 Volume 197 Issue 2 Pages 81-86
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSProviding maintenance of myringotomy patency without use of ventilation tubes in the treatment of secretory otitis media has been one of the important study areas. For this reason, laser and Mitomycin C (MMC) are used together in experimental studies. But there has been no ultrastructural studies concerning whether leakage of MMC to middle ear during application of this procedure has an ototoxic effect or not and if so, to what extent. In this study, we searched the ultrastructural changes which occurred in the middle ear by direct applications of MMC to the middle ear for different time durations. The study was carried out over thirty adult guinea pigs without ear diseases. Bilateral myringotomy was performed and MMC was applied only to the right middle ear of each guinea pig. The first group received MMC once for 10 minutes, the second group received it once for 20 minutes, and the third group took it each day for 10 minutes during a one week period. The left ears of the samples were accepted as the control group. On the 8th day, sacrification was carried out. After electron and light microscopy examination, significant changes in the inner ear were observed in the third group though no significant change was observed for the first and the second groups. As a result it was concluded that the application of MMC to the middle ear once for a short duration causes no toxic effect on the inner ear.View full abstractDownload PDF (1403K) -
MASAHIKO INOUE, YOSHIHIRO WAKAYAMA, JIAN WU LIU, MAKOTO MURAHASHI, SEI ...2002 Volume 197 Issue 2 Pages 87-93
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSAquaporin 4 (AQP4) is a recently discovered membrane bound water-selective channel and has been described at the light microscopic level to be predominantly expressed in the astrocytes of the brain, especially at the perivascular astrocyte endfoot processes. α1-Syntrophin, a member of dystrophin-associated protein, has also been reported at the light microscopic to be expressed level in the same site of astrocytes as AQP4 and interacts with other molecules through its PDZ domain. AQP4 expression has been reported to be absent at the sarcolemma and the perivascular astrocyte endfoot processes of α1-syntrophin knockout mice. Based on these observations, the molecular association between AQP4 and α1-syntrophin could be speculated. To test this hypothesis, we investigated the ultrasturctural localization of AQP4 and α1-syntrophin in the brain astrocytes by using double immunogold labeled electron microscopy. The results showed that AQP4 and α1-syntrophin colocalized frequently at the astrocyte membrane, especially at the perivascular astrocyte endfoot processes and suggested the presence of linkage between AQP4 and α1-syntrophin at the astrocyte plasma membrane.View full abstractDownload PDF (1376K) -
SULEYMAN ALICI, YESIM ERALP, PINAR SAIP, ANDAC ARGON, MERT BASARAN, ER ...2002 Volume 197 Issue 2 Pages 95-100
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSGestational trophoblastic diseases (GTD) represent a group of malignancies classified as invasive mole, choriocarcinoma, and placental-site trophoblastic tumors. The overall cure rate in the treatment of this malignant disorder now exceeds 90%. The aim of this study is retrospectively to evaluate the clinical characteristics and effectiveness of single-agent chemotherapy (CT) and combination chemotherapy according to the World Health Organization (WHO) risk groups of gestational trophoblastic diseases. Thirty one patients with GTD were treated in our institute between 1990-1998. Median age at presentation was 29 years (range 19-70 years). All patients were classified with respect to the WHO scoring system. According to this system, patients were divided into three clinical groups: low-risk nonmetastatic (low-risk group with good prognosis), low-risk metastatic, and high-risk metastatic (high risk group with poor prognosis). Eighteen patients in the nonmetastatic low-risk group with favorable prognostic factors received single agent CT (methotrexate and folinic acid), while 3 patients with metastatic low-risk and 10 patients in the metastatic high-risk group with poor prognosis received combination CT (EMA-CO). Complete response (CR) was obtained in all patients in the low risk group with good prognosis, whereas 9/13 (69%) patients in the poor prognosis group achieved CR and 4 (31%) had partial responses. This clinical classification system may be currently prefer for determining initial therapy in women with malignant gestational trophoblastic tumors. And, our report confirms that the alternating EMA/CO regimen is a well-tolerated and effective combination for the treatment of women with high-risk GTD.View full abstractDownload PDF (398K) -
SATOSHI YOSHIDA, YOSHIKO KUBOTA, TAMOTSU TOBA, SABURO HORIUCHI, TADASH ...2002 Volume 197 Issue 2 Pages 101-109
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSTo elucidate the effects of interleukin-1β (IL-1β) on osteogenic protein-1 (OP-1) gene expression in a polylayer culture of rabbit articular chondrocytes, we measured rabbit OP-1 mRNA using quantitative TaqMan reverse transcriptase-polymerase chain reaction (RT-PCR) techniques. Rabbit articular chondrocytes were isolated and cultured in minimum essential medium eagle α modification containing 10% fetal bovine serum for 7 days. IL-1β was then added and cultures were continued for 48 or 96 hours. OP-1 gene expression was detected in cell cultures both with and without addition of IL-1β. However, the level of expression was very low in the control group. OP-1 gene expression was significantly increased about 450- to 800-fold in IL-1β-treated groups (0.1, 1, and 10 ng/ml) versus the control group. Evaluation of serial changes in OP-1 expression after addition of IL-1β (10 ng/ml) revealed that OP-1 gene expression increased rapidly after addition of IL-1β, reaching a peak at 48 hours, and then decreasing. Simultaneous assay of CD44 expression demonstrated a rapid increase, similar to that of OP-1 expression, following addition of IL-1β: this was followed by a more gradual increase. Assay of hyaluronan synthase-2 (HAS-2) expression following addition of IL-1β showed an increase after OP-1 expression had already reached a peak. Our results demonstrate that OP-1 expression is induced by IL-1β and suggest that this expression, like that of HAS-2, may play a role as a protective mechanism against inflammatory cytokines.View full abstractDownload PDF (670K) -
METIN GÜDEN, ERCAN KURT, CÜNEYT ULUTIN2002 Volume 197 Issue 2 Pages 111-114
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSBone metastases are observed in approximately 50% of patients with cancer and these are essential to influence the quality of life. As one of the most effective means of therapy for patients with bone metastases, radiotherapy can be applied as fractional and single dose. In this prospective study, we analyzed the pain relief after 6 Gy single dose irradiation in 62 patients with painful bone metastases. This was assessed by an 11-point scale questionnaire. In 88.7% of the treatments response was obtained after the single-dose radiotherapy (37.1% complete response, 51.6% partial response, 11.3% no response). In approximately 53% of the treatments the response initiated within one week. We concluded that a single dose of 6 Gy was very effective in the palliation of painful bone metastases.View full abstractDownload PDF (227K) -
YUTAKA MASUDA, JUNYA SUGAWARA, SHUN OHNUMA, TOSHIHIRO SUGIYAMA2002 Volume 197 Issue 2 Pages 115-118
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSA glycolipid having GalNAcα1-3GalNAc in the terminal increases a behavior climbing in a depression model, mouse forced swimming. Antidepressants, which sometimes induce hypomanic state in patients, increase the glycolipid and an anti-manic substance lithium decreases the glycolipid in mice. We detected the humoral GalNAcα1-3GalNAc-lipid reactivity of humans in different affective states. Although the reactivity was also showed in serums of the depression patients and the volunteers without affective disorders, the reactivity was remarkably increased in serums of hypomania patients. These strongly suggest that the humoral glycolipid increased the activities of the hypomania patients, but did not relate to the decrease of the activities in the depression patients.View full abstractDownload PDF (224K) -
BÜLENT ÖZBAY, HALUK DÜLGER2002 Volume 197 Issue 2 Pages 119-124
Published: 2002
Released on J-STAGE: April 19, 2004
JOURNAL FREE ACCESSThe purpose of this study was to examine the change in lipid peroxidation and antioxidant enzyme activities in healthy subjects and to evaluate the concentrations of superoxide dismutase, glutathione peroxidase and malondialdehyde, an end product of lipid peroxidation in exercise and smoking. Study included 257 appearently healthy individuals, 133 males and 124 females. In all subjects, malondialdehyde (MDA) levels were analyzed as an indicator of the lipid peroxidation activities. Superoxide dismutase, glutathione peroxidase activities were measured as an indicator of antioxidant activities. Oxidative stress was estimated by the method based on thiobarbituric acid reactivity. Erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were estimated on hemolysates by use of commercial available kits (Randox lab., Dublin, Ireland). For all groups serum lipid peroxidation and erythrocyte SOD and GSH-Px were obtained at the initial and the following periods. Serum MDA level was higher in the elderly than in the children and in the adults. MDA levels were higher in the smoking, acute exercise than their counterparts in the control groups. GSH-Px activity was significantly lower in the acute exercise group, and higher in the trained group than those as controls. SOD decreased in the elderly, smoking and acute exercise groups and increased in trained individuals. There was a significant increase in lipid peroxidation activity and a significant decrease in antioxidant enzyme activity in cases of acute exercise and smoking as well as the elderly.View full abstractDownload PDF (381K)
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