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Volume 200 (2003)
- Issue 4 Pages 167-
- Issue 3 Pages 111-
- Issue 2 Pages 67-
- Issue 1 Pages 1-
Volume 200, Issue 1
May
Displaying 1-9 of 9 articles from this issue
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Review
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Masakazu Ichinose2003 Volume 200 Issue 1 Pages 1-6
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSBoth bronchial asthma and chronic obstructive pulmonary disease (COPD) are recognized as inflammatory diseases, although the inflammatory process for each disease is different. In this review, I describe some inflammatory molecules that seem to be involved in the inflammatory process in each disease.View full abstractDownload PDF (101K)
Regular Contributions
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Eul-Sang Kim, Yang-Sook Ko, Junghun Kim, Naoko Matsuda-Inoguchi, Haruo ...2003 Volume 200 Issue 1 Pages 7-15
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSThis study was initiated to examine the accuracy of conventional food composition table-based estimation of intakes of energy, protein, lipid and carbohydrate, in comparison with chemical analysis. For this purpose, 66 women (at the ages of 29 to 54 years) in three locations in Jeju Island, Republic of Korea, volunteered to offer 24-hour food duplicate samples. A half of them were house-wives, and the remaining half were farmers or fishers. The duplicate samples were subjected 1) to the chemical analysis for daily intake of energy, protein, lipid and carbohydrate after official methods in Korea (measured values), and 2) to the estimation of intakes of the same items taking advantage of Korean Food Composition Tables (estimated values). The two sets of the results, i.e., the measured and estimated values, were compared by paired and unpaired t-test, and linear regression analysis. The estimated values correlated closely with the measured values, irrespective of energy or the three major nutrients. A close agreement was observed for energy intake (the estimated/measured ratio of >98%), and it was also the case for protein intake (101%). Under- and over-estimation was observed, however, in regard to carbohydrate (by −8%) and lipid intake (by +24%), respectively. It was concluded that the Korean Food Composition Tables are sufficiently accurate when applied for estimation of total energy intake as well as protein intake. Cares should be taken, however, in applying the tables for estimation of lipid and carbohydrate intake, because there may be the risk of over- and under-estimation for the former and the latter, respectively.View full abstractDownload PDF (140K) -
Ender Inci, Sabiha Civelek, Arzu Seven, Figen Inci, Nazim Korkut, G&uu ...2003 Volume 200 Issue 1 Pages 17-23
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSThis study was designed to investigate the oxidative stress parameters in laryngeal cancer and cancer-free adjacent tissues. Lipid peroxidation end product and the endogenous antioxidant components-CuZn superoxide dismutase (CuZnSOD) glutathione peroxidase (GSH Px), glutathione reductase (GSSG Rd) and glutathione (GSH)-were analysed by spectrophotometric and kinetic methods. Laryngeal cancer tissue exhibited higher lipid peroxidation than cancer free adjacent tissue. CuZn SOD and GSH Px activities and GSH level were significantly higher and GSSG Rd activity significantly lower in the cancer tissue. Detection of the antioxidant status may be useful to determine the tumour resistance to therapy, to choose the correct radiotherapy-/chemotherapy and to monitor the effectiveness of the therapetic strategy.View full abstractDownload PDF (186K) -
Ismail Meral, Raci Kacmaz2003 Volume 200 Issue 1 Pages 25-30
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSThe aim of the present study was to investigate the effect of diet treatment on serum glucose, triglyceride (TG), total cholesterol (TC), high density lipoprotein-(HDL) cholesterol, low density lipoprotein-(LDL) cholesterol and very low density lipoprotein-(VLDL) cholesterol levels, systolic and diastolic blood pressure and electrocardiograms (ECGs) in patients with type 2 diabetes mellitus (DM). Twenty healthy subjects (mean age 45.9±3.7 years) and newly diagnosed patients with type 2 diabetes prior to receiving diet treatment (mean age 47.6±6.2 years) were included in this study. Diabetic patients were given a standard dietary treatment that was composed of 50% to 55% carbonhydrate and 30% fat (1200 kcal for women and 1600 kcal for men) for 2 months. No diet treatment was applied for control. For both groups serum glucose, TG, TC, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol levels, systolic and diastolic blood pressure and ECGs were measured at the beginning and end of the diet treatment. Although diet treatment decreased the elevated serum glucose in diabetic patients, it still remained higher than that in the controls. Diet treatment also decreased the elevated TG and VLDL-cholesterol in diabetic patients to control values. Although heart rate and systolic blood pressure were higher, diastolic blood pressure was not different in diabetic patients than those in controls. Ventricular hypertrophy was also observed in ECGs of 10% of diabetic patients. Diet treatment normalized all of these findings, except systolic blood pressure. This study showed that diet treatment could not normalize the high systolic blood pressure in type 2 DM. Thus, an effective way of controlling blood pressure should be taken to improve healing in DM.View full abstractDownload PDF (96K) -
Hitoshi Kagaya, Shunichi Ito, Takehiro Iwami, Goro Obinata, Yoichi Shi ...2003 Volume 200 Issue 1 Pages 31-37
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSJoint contractures decrease the patient's ability to walk, but usually other parts of the body compensate the affected joint contractures. When we restore the gait performance in paraplegic patients by means of functional electrical stimulation, however, we cannot expect complications of compensation. A computer simulation was done to clarify how the contractures affect the gait pattern when no complications of compensation were expected. A seven-segment link mechanical model was used for simulation of human walking in the sagittal plane. In turn, using a personal computer stance and swing-leg joint contractures of the ankle, knee, and/or hip were simulated. When stance-leg contracture was simulated, step length became short with increasing hip flexion contracture. The trunk was tilted backward during knee flexion or ankle plantarflexion contracture simulation. When the swing-leg contracture was simulated, step length became short with increasing knee flexion contracture. We found that hip or knee flexion contracture of ≤15°, or ankle plantarflexion contracture of <0° was required to maintain positive step length and forward movement of the center of gravity. These findings suggest that 15° of hip and knee flexion contracture, and 0° of ankle plantarflexion contracture are critical when gait restoration is performed by functional electrical stimulation.View full abstractDownload PDF (119K) -
Shinji Susa, Makoto Daimon, Hideyu Ono, Song Li, Tadashi Yoshida, Take ...2003 Volume 200 Issue 1 Pages 39-45
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSNucleotide sequence analyses of human coproporphyrinogen oxidase (CPO) have shown two possible translation initiation codons (TICs) in the region upstream from the region coding the mature polypeptide. These TICs lead to the precursor polypeptides of CPO (long and short pCPOs), which have 110 and 10 amino acids (long and short) presequences, respectively. To determine which TIC is the real one, import reactions to mitochondria of the two pCPOs synthesized using in vitro transcription-translation system were analyzed. The results showed that the long pCPO was imported into mitochondria and sorted properly to the intermembrane space, whereas the short pCPO was not. We also found several miss-readings in the reported nucleotide sequence of mouse CPO gene. This correction revealed that mouse pCPO has also a longer presequence, which are very similar to the long presequence of human. These results indicate that the long, but not short, presequence is the real one.View full abstractDownload PDF (149K) -
Kyoko Ban, Kohachiro Sugiyama, Kenji Goto, Fumihiko Mizutani, Hajime T ...2003 Volume 200 Issue 1 Pages 47-53
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSWe analyzed the PHKA2 gene in four Japanese families with hepatic phosphorylase kinase (PhK) deficiency. Mutational analysis of PHKA2 cDNA was performed by reverse-transcribed polymerase chain reaction (RT-PCR) and direct sequencing, and each mutation was confirmed on the genomic DNA. In boys with low erythrocyte PhK activity (i.e., X-linked liver glycogenosis [XLG] type I), deletion of exon 2 (splice site mutation of 79-1 G>T) or nonsense mutation of Q1169X or R497X was identified. However, missense mutation of R295C was identified in one boy with normal erythrocyte PhK activity (i.e., XLG type II). This mutation was not found in 100 control alleles, and was considered responsible for presentation of the XLG type II phenotype. Excluding Q1169X, all mutations detected in this study represented novel mutations. All mothers were found to be heterozygous carriers of the mutations. Gene analysis was confirmed to represent a useful procedure for diagnosing XLG type II, for which liver biopsy had previously been required to detect hepatic PhK deficiency.View full abstractDownload PDF (198K)
Case Reports
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Takashi Yamada, Hajime Kasamatsu, Hiroshi Mori2003 Volume 200 Issue 1 Pages 55-58
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSSpinal cord injury occurs predominantly in males, and endometrial cancer in a patient with spinal cord injury is very rare. A 71-year-old woman, gravida 7, para 4, who had incomplete quadriplegia due to a spinal cord injury, was admitted with a complaint of genital bleeding. Biopsies of the cervix and the endometrium revealed endometrioid adenocarcinoma. Total abdominal hysterectomy was performed under general anesthesia. Pathohistological analysis revealed endometrial adenocarcinoma (G1) with squamous metaplasia and International Federation of Gynecology and Obstetrics (FIGO) surgical stage 2b. Local recurrence was not obvious after the surgery. However, lung metastasis appeared on postoperative day 225, and she died from dyspnea on day 277. Uterine cancer screening is more necessary in long-term bedridden women.View full abstractDownload PDF (122K) -
Hiroshi Hidaka, Takeshi Oshima, Seiji Kakehata, Ken-ichi Watanabe, Mas ...2003 Volume 200 Issue 1 Pages 59-65
Published: 2003
Released on J-STAGE: October 01, 2004
JOURNAL FREE ACCESSTwo cases of plunging ranula are reported. Treatment consisted of the total removal of the sublingual gland and evacuation of the cystic contents by the intraoral approach. The cyst remained just after the surgery in both cases, but then gradually regressed and disappeared within two months after the surgery. These findings support total removal of the sublingual gland as being the best method of treatment. We believe that complete dissection of the cyst with cervical incision as well as drainage of the cystic contents are unnecessary when the diagnosis of the plunging ranula is confirmed.View full abstractDownload PDF (261K)
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