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Volume 206 (2005)
- Issue 4 Pages 283-
- Issue 3 Pages 187-
- Issue 2 Pages 85-
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Volume 206, Issue 1
May
Displaying 1-10 of 10 articles from this issue
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Regular Contributions
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Mustafa Gul, Ergul Kurutas, Pinar Ciragil, Ali Cetinkaya, Metin Kilinc ...2005 Volume 206 Issue 1 Pages 1-6
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSTo investigate the effect of urinary tract infection on oxidative stress in diabetic patients, we measured the activities of antioxidant enzymes such as catalase and superoxide dismutase, and lipid peroxidation levels in urine specimens of type II diabetic patents with urinary tract infection. A total of 69 patients were included into this study: 23 non-diabetic patients with urinary tract infection, 28 patients with diabetes mellitus, and 18 diabetic patients with urinary tract infection. Twenty-five healthy subjects, matched for age, sex, body mass index and smoking status were also included as control. Urine cultures were performed by the standard techniques, and all grown bacteria were identified as Escherichia coli. Antioxidant enzymes and lipid peroxidation levels in urine were measured by spectrophotometric method. In urine samples of diabetic patients with or without urinary tract infection and in urine samples of non-diabetic patients with urinary tract infection, catalase and superoxide dismutase activities were lower and lipid peroxidation levels were higher than those of the healthy subjects (p < 0.05). Diabetic patients without urinary tract infection were similar to non-diabetic patients with urinary tract infection. Decreased antioxidant capacity and the increased levels of lipid peroxidation were profoundly higher in diabetic patients with urinary tract infection. These results indicate that urinary tract infection aggravates the oxidative stress in diabetic patients. Therefore we believe that diabetic patients with urinary tract infection need antioxidant treatment.View full abstractDownload PDF (249K) -
Mustafa Ozkan, Cemal Sag, Mehmet Yokusoglu, Mehmet Uzun, Oben Baysan, ...2005 Volume 206 Issue 1 Pages 7-13
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSIn spite of developments in interventional cardiology, the success rate of saphenous vein graft stenting is still low in patients with acute coronary syndromes. In this study, we aimed at finding out the effect of pretreatment with Tirofiban, a glycoprotein IIb/IIIa inhibitor, and clopidogrel, an adenosine diphosphate antagonist, on the outcome of saphenous vein graft stenting in patients with acute coronary syndrome. A total of 47 patients, who had lesions in saphenous vein grafts and acute coronary syndrome, could be randomized to treated group (n = 24), who received Tirofiban and clopidogrel for 48 hours before the intervention, and untreated group (n = 23), who did not receive Tirofiban and clopidogrel. In the untreated group, the intervention was performed just after the coronary angiography. All patients underwent stenting as the standard intervention. The groups were compared by Mann-Whitney's U-test or Chi-Square test. The level of statistical significance was set at 0.05. There were no significant differences regarding age, gender, and atherosclerotic risk factors between the two groups. In treated group, precutaneous coronary intervention was successful in all patients and no-reflow phenomenon occurred in only one patient. The rate of no-reflow or slow-flow phenomenon was significantly lower in treated group (one patient vs 9 patients, p = 0.004). One patient in untreated group experienced ventricular fibrillation, which was converted to sinus rhythm after defibrillation. During short-term follow-up, there were no acute myocardial infarction, coronary bypass surgery or death in both groups. There was no major bleeding. Minor bleeding was more frequent in treated group, but it did not achieve statistical significance (3 vs 1; p = 0.322). In conclusion, pretreatment with tirofiban and clopidogrel before percutaneous coronary intervention might result in better immediate outcomes in old saphenous vein grafts without any significant increase in bleeding complications.View full abstractDownload PDF (274K) -
Handan Isin Ozisik, Rifat Karlidag, Ersoy Hazneci, Sibel Kizkin, Cemal ...2005 Volume 206 Issue 1 Pages 15-22
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSBehçet's disease (BD) is a multisystem inflammatory disorder characterized by recurrent oral and genital ulcers and uveitis. BD patients without neurological involvement frequently have mild neurological symptoms. The aim of this study was to evaluate whether BD patients without neurological involvement have any changes in cognitive functions. Twenty BD patients without neurological involvement and 13 control subjects were included in the study and were analyzed by neurophysiological and neuropsychological examinations. The cognitive event-related potentials (P300) were recorded from the frontal, central and parietal areas of the right and left hemispheres of the patients and control subjects. Likewise, all individuals were evaluated with neuropsychological tests. In contrast to a study with similar design, we did not find any difference between the cognitive event-related potentials values of BD patients without neurological involvement and the control subjects. All BD patients without neurological involvement exhibit normal results of the neuropsychological test. In conclusion, the results of neuropsychological tests and cognitive event-related potentials values in BD patients without neurological involvement are indistinguishable from those in control subjects and no alteration of cognitive functions is present.View full abstractDownload PDF (455K) -
Mototsugu Ishii, Yoshichika Yoshioka, Wataru Ishida, Yoshihito Kaneko, ...2005 Volume 206 Issue 1 Pages 23-30
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSWe measured liver fat content by 3-Tesla magnetic resonance spectroscopy (MRS) in 34 non- to mild obese Japanese subjects with type 2 diabetes, who were not complicated with any liver diseases including clinical fatty liver (liver/spleen ratio of computed tomography [CT] < 0.9) and were not being treated with oral hypoglycemic agents, insulin, or lipid-lowering agents, and analyzed the relationship between liver fat content and body composition and plasma metabolite. The liver fat content is significantly correlated with variables relating to obesity (body mass index [BMI], body weight, fat mass, waist to hip ratio, visceral fat area, subcutaneous fat area, and serum triglyceride), insulin resistance (fasting plasma insulin and homeostasis model assessment of insulin resistance [HOMA-IR]), adipocytokines (serum plasminogen activator inhibitor-1 [PAI-1] and leptin), and serum cholinesterase, but not CT liver/spleen ratio, which is correlated only with fasting plasma glucose, BMI, and HOMA-IR. Multiple regression analysis revealed that the liver fat content is independently associated with serum PAI-1 level (p < 0.001) and BMI (p < 0.05), but not visceral fat area. MRS is a more sensitive method for quantifying liver fat content than CT in type 2 diabetic subjects with non- to mild obesity and without clinical fatty liver.View full abstractDownload PDF (400K) -
Satoshi Okamoto, Kiyoshi Ito, Hironobu Sasano, Takuya Moriya, Hitoshi ...2005 Volume 206 Issue 1 Pages 31-40
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSThe differential diagnosis between reactive mesothelial cells and ovarian carcinoma cells is often difficult in cytologic specimens. Immunocytochemical procedures have been utilized in assisting this differential diagnosis, with limitations. Furthermore, previous studies examined only serous type but not other histological types of ovarian carcinoma cases. Therefore, we evaluated the practical value of various epithelial and mesothelial markers in differential diagnosis of these two types of cells. Various types of ovarian carcinoma (serous, n = 22; mucinous, n = 10; endometrioid, n = 7; clear cell, n = 10) and benign mesothelial tissues (n = 15) were studied by immunohistochemistry. We then studied effective panels of antibodies by immunohistochemistry in 43 cytologic specimens of ascites or peritoneal lavage fluid consisting of 20 reactive mesothelium and 23 adenocarcinomas of the ovary. In the tissue specimens, Ber-EP4, a monoclonal antibody of epithelial antigen, and a polyclonal antibody against calretinin, which is expressed in mesothelium, are used in differentiating reactive mesothelial cells from ovarian carcinoma. In cytologic specimens, the sensitivity and specificity of Ber-EP4 were 100% and 90%, respectively. The sensitivity and specificity of the anti-calretinin antibody were 90% and 91%, respectively. Using multiple regression analysis, the correlation coefficient between epithelial antigen and calretinin reactivity was r = 0.938, with a significance level of p < 0.0001. In conclusion, the combined immunostaining of cytologic specimens for Ber-EP4 and the anti-calretinin antibody is helpful for the differential diagnosis between mesothelial cells and not only serous type, but also mucinous, endometrioid and clear cell types of ovarian cancer cells.View full abstractDownload PDF (576K) -
Chang-Wan Han, Yuki Yajima, Eun-Joo Lee, Kazuo Nakajima, Makiko Meguro ...2005 Volume 206 Issue 1 Pages 41-49
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSThe social environmental barriers are considered to be important because the “social participation” of people with impairments would be facilitated by the prevention and reduction of environmental barriers. The Craig Hospital Inventory of Environmental Factors (CHIEF) is one of the few scales to assess the environmental barriers. In this study, we developed the Korean version of CHIEF and evaluated its construct validity and utility in a sample of Korean community-dwelling elderly with or without stroke. We evaluated the construct validity of the CHIEF by testing the original five-factor structure using a confirmatory factor analysis in 400 elderly in Seoul, Korea. The utility of the CHIEF was then assessed by examining the relationships between individual characteristics, Barthel Index and perceived environmental barriers, measured by the CHIEF, using a structural equation modeling approach. The confirmatory factor analysis result demonstrated the validity of a second-order factor model of the CHIEF comprising the five factors as first-order factors. The perceived environmental barrier was a second-order factor when provided acceptable fit indices after two modifications. The structural equation modeling indicates that perceived environmental barriers are significantly related to activities of daily life but not age, gender, and the episode of stroke. The CHIEF is useful in measuring environmental factors for Korean older adults with or without stroke.View full abstractDownload PDF (538K) -
Ülkü Türk Börü, Abdulkadir Koçer, Arda ...2005 Volume 206 Issue 1 Pages 51-59
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSMigraine is more common in female and onset of migraine is most commonly seen in the second and third decades of life. In this study, we aimed to estimate the prevalence and characteristics of migraine among women of ages between 15 to 45 years in Turkey. This is the first study to target this age group. The women were interviewed on a door-to-door basis, from early morning to late evening. Once responded positively to headache, an in-depth interview was performed questioning for migraine features. Diagnosis was made from a questionnaire by eight neurologists. One thousand eight hundred thirty five (1,835) out of 96,000 women living in Maltepe which is a town of Istanbul participated in this study. The prevalence of migraine in females aged 15-45 (reproductive ages) was 15.8% (95% CI, 0.142-0.176). This study showed that migraine onset occurred at a mean age of 22.7, 33% having family history, and with migraine with and without aura having near equal frequencies. The prevalence of migraine in women of reproductive ages in Istanbul as found in our study is lower than that reported in United States and Europe countries, but higher than that in Middle and Far Eastern countries.View full abstractDownload PDF (341K) -
Masafumi Katayama, Masaru Shoji, Susumu Satomi2005 Volume 206 Issue 1 Pages 61-71
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSComparative cultures of normal and malignant cells are important for understanding the growth properties of tumors. Although many cell lines have been established from esophageal cancers, the growth properties of normal and cancer-derived esophageal epithelial cells have not been compared extensively. We succeeded in establishing an assay system in serum-free conditions for normal human esophageal epithelial cells (HEE cells) and 14 cancer-derived esophageal epithelial cell lines (TE-cell lines). The growth properties of these cells were characterized upon stimulation with various growth-related factors. Among these factors, acidic fibroblast growth factor (aFGF) was the most effective stimulant for both the HEE cells and all the TE-cell lines. Most TE-cell lines required a higher concentration of calcium for their growth than did the HEE cells. Transforming growth factor-β1 (TGF-β1) inhibited the growth of HEE cells and 7 TE-cell lines; however, the other 7 TE-cell lines were resistant to the inhibitory effect of TGF-β1. Interestingly, epidermal growth factor (EGF) had a much greater stimulatory effect on the TGF-β1-resistant cells than the TGF-β1-sensitive cells. Although ethanolamine enhanced the growth-promoting ability of EGF or aFGF in the TGF-β1-sensitive cells, it had no effect on the TGF-β1-resistant cells. These findings suggested a possible cross talk between TGF-β1 and EGF signaling, and an important role of ethanolamine in the signaling pathways of growth factors. This serum-free culture system will contribute to clarify the altered signaling pathways of esophageal cancer.View full abstractDownload PDF (440K) -
Necmi Çekin, Ahmet Hilal, Mete K. Gülmen, Hakan Kar, Musta ...2005 Volume 206 Issue 1 Pages 73-80
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSThe objective of this study is to determine the characteristics of and changes in the medicolegal childhood deaths that occurred in the provincial center of Adana, and to contribute to the establishment of a database for the development of national and international policies. The study is a retrospective research examining the 1,110 cases in the age group 0 to 18, which were specified as medicolegal deaths in the provincial center of Adana-Turkey between the years 2000-2004. The cases were examined according to age, sex, causes of deaths, the origins and scenes of occurrence. Among all the deaths, 523 cases (47.2%) were seen in the age group of 0-6 years. Accidents account for 900 cases (81.1%), and blunt traumas (594 cases) represent the most common cause of deaths. The share of traffic accidents in total blunt traumas was found to be 441 cases (74.2%). And 270 (24.3%) of all medicolegal deaths occured as a result of household accidents. The present study has also indicated that the home and surroundings represent the highest-risk areas. As a conclusion, setting up childhood injury prevention committees and providing training programs for parents will be effective for the prevention of childhood injuries and deaths.View full abstractDownload PDF (523K)
Case Report
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Lokman Uzun, Mehmet Birol Ugur, Suat Can Ulukent, Huseyin Ozdemir, Raf ...2005 Volume 206 Issue 1 Pages 81-84
Published: 2005
Released on J-STAGE: April 01, 2005
JOURNAL FREE ACCESSThis article presents a case of Behçet's Disease (BD) with vascular involvement of the neck, which mimicks a metastatic neck mass in the initial presentation. A 58-year-old man presented with dysphagia, weight loss, bulging on the lateral wall of the left pyriform sinus, and a firm and fixated neck mass suggestive of metastasis. Computed tomography of the neck demonstrated a solid mass, around the bifurcation of the carotid artery together with a pseudoaneurysm of the left external carotid artery. The mass was about four centimeters in diameter and extended to hypopharynx medially. Biopsy from neck mass and hypopharynx revealed no specific pathology. During follow-up the firm and fixated mass changed into a completely pulsatile one in the following three weeks. Reassessment of the patient's past history in detail revealed that he had had recurrent oro-genital ulcers, arthralgia and recurrent skin lesions. The pathergy test was positive. The patient was diagnosed to be BD and treatment consisting of colchicine 1 mg/day, peroral was started. He had a favorable outcome after treatment and was asymptomatic at follow-up of 24 months. It is unusual for BD to present as a neck mass but yet it must be considered in the differential diagnosis of neck masses. The present case report demonstrates how such a mass may mimic metastatic tumoral involvement and cause diagnostic dilemma.View full abstractDownload PDF (298K)
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