The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 92, Issue 1
Displaying 1-7 of 7 articles from this issue
  • Ototaka Higashi, Tadashi Hayashi, Kazuo Ohara, Yoshiyuki Honda, Tasuke ...
    1967 Volume 92 Issue 1 Pages 1-12
    Published: 1967
    Released on J-STAGE: November 28, 2008
    A 2-year-9-month-old Japanese boy was reported of the ‘pancreatic insuffi- ciency with bone marrow dysfunction syndrome’, which was first described by Shwachman, Diamond, Oski and Khaw in 1964.
    Main clinical features of our own patient consisted of failure to gain weight, steatorrhea, pancytopenia, the absence of trypsin, lipase and amylase activities in the pancreatic juice, and no increase in the sweat chloride concentration.
    At autopsy there were massive hemorrhages into the brains and gastrointes-tinal tracts and petechial hemorrhages in the lungs, pleurae, pen- and endocar-dium, psoas muscles and renal pelvis.
    Histological examination of the pancreas revealed that the tissue was mostly composed of adipose tissue containing the islets of Langerhans which were preserved well and had almost normal appearance.
    Histological examination of the bone marrow revealed the absence of mega- karyocytes.
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  • Goro Kosaki, Tsutomu Fukui, Hajime Tanaka, Takeshi Iwanaga, Junzaburo ...
    1967 Volume 92 Issue 1 Pages 13-25
    Published: 1967
    Released on J-STAGE: November 17, 2010
    It is reasonably assumed that a cancer-bearing host has a certain degree of defense activity against cancer, which is partly represented by stromal reactions and sinus histiocytosis of the regional lymph nodes. On the other hand, it is generally accepted that general defense activity such as allograft rejection is decreased in cases of far advanced cancer.
    On the assumption that stromal reactions are manifested in the host as an immunologic defensive response to cancer, if antigenicity of each cancer to the host were the same, the degree of allograft rejection would be closely correlated with that of stromal reactions.
    Observations were made of 50 cases consisting of 40 gastric cancers and 10 benign gastric diseases operated on during a period from 1965 to 1966. Fourteen days after transplantation of skin allograft the degree of rejection was histologically evaluated.
    In general, advanced cases showed weak rejection reactions against skin allografts. It was revealed that the cases with weak rejection reactions showed weak stromal reactions surrounding cancer foci, while the cases with strong rejection reactions showed either strong or weak stromal reactions. Accordingly it was concluded that the degree of allograft rejection reactions did not always correspond to the degree of stromal reactions. Discussions were made on such disagreement.
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  • Mizu Kojima, Kiyoshi Takahash, Kenji Honda
    1967 Volume 92 Issue 1 Pages 27-54
    Published: 1967
    Released on J-STAGE: November 28, 2008
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  • Yoichiro Sasai
    1967 Volume 92 Issue 1 Pages 55-62
    Published: 1967
    Released on J-STAGE: November 28, 2008
    By the application of Benditt-Arae's consideration as to enzyme kinetics in a histochemicai system, the effect of adenosine-3', 5'-phosphate on the histochemical system of phosphorylase in pemphigus vulgaris was examined. The addition of adenosine-3', 5'-phosphate in a concentration of 1 mM or over was effective in shortening the period of incubation time necessary for the appearance of the reaction. In sections removed from normall persons, the maximum effect was obtained when adenosine triphosphate and Mg++ were introduced to substrate solutions in a ratio of 1 to 1.5. However, in sections front pemphigus vulgaris, the addition of adenosine triphosphate in excess was more effective.
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  • Naoya Watanabe
    1967 Volume 92 Issue 1 Pages 63-72
    Published: 1967
    Released on J-STAGE: November 28, 2008
    Kininase activity in blood was estimated in 17 healthy subjects and 162 patients with various diseases. The assay method consists of the incubation of synthetic bradykinin with venous blood at 37°C for 10 minutes and the quantitation of remaining bradykinin with the guinea-pig ileum.
    In healthy subjects, kininase activities were 53-72% with the mean of 64.4±4.93%. Markedly high activities were observed in patients with hyperthyroidism and in those with liver diseases. In patients with bronchial asthma, relatively low activities were found. No sigfinieant changes in the activity were found in other diseases.
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  • Takashi Furuyama, Chikara Suzuki, Ryuji Shioji, Hiroshi Saito, Masaru ...
    1967 Volume 92 Issue 1 Pages 73-81
    Published: 1967
    Released on J-STAGE: November 28, 2008
    Angiotensin (5 ng/kg/min and 50 ng/kg/min) was infused directly into the left renal artery of anesthetized dogs in order to examine its effects on the renal func-tion. Urinary volume, creatinine clearance (GFR), PAH-clearance (RPF) and electrolyte excretion were decreased by infusion of angiotensin in a small dose. On the other hand extreme reductions of urinary volume, GFR, RPF and electrolyte excretion were observed immediately after the beginning of angiotensin infusion in a large dose, and were followed by gradual increases in these parameters during the administration of angiotensin (tachyphylaxis). In four out of six cases, urinary volume and sodium excretion surpassed the control values with increased extraction fraction of sodium. These results suggested that angiotensin affected the renal function mainly through two mechanisms: Firstly, the vasoconstrictive action of angiotensin on the renovascular system causes decrease in urinary output, and secondly the direct action on the tubular system causes natriuresis.
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  • Yoshikyo Ueda
    1967 Volume 92 Issue 1 Pages 83-107
    Published: 1967
    Released on J-STAGE: November 28, 2008
    The effect of simultaneous administration of p-dimethylaminoazobenzene (D. A. B.) and carbon tetrachloride (CCl4) was experimentally studied on rats.
    1) The morphological changes in the early stage of simultaneous administration of D. A. B. and CCl4 were characterized by an earlier appearance of cholangiofibrosis or of liver cirrhosis than in those produced by D. A. B. or CCl4 alone.
    2) Simultaneous administration of both agents invariably resulted in statisti-cally significant higher incidences of liver carcinoma, liver cirrhosis, liver carcinoma with liver cirrhosis, and nodular hvperplasia than the administration of D. A. B. alone.
    3) There was no histological difference between the liver carcinomas caused by combined use of D. A. B. and CCl4, and those by the administration of D. A. B. alone. 4) CCl4 caused a decrease in protein-bound azo-dye in the liver in the course of carcinogenesis by D. A. B.
    5) The mechanism of the activity of CCl4 in the development of D. A. B. -induced liver carcinoma was discussed on the basis of the relation between the incidence of liver carcinoma and the amount of protein-bound azo-dye in the liver.
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