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Volume 93 (1967)
- Issue 4 Pages 301-
- Issue 3 Pages 199-
- Issue 2 Pages 105-
- Issue 1 Pages 1-
Volume 93, Issue 2
Displaying 1-9 of 9 articles from this issue
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Ototaka Higashi, Yasushi Sato, Hidetoshi Takamatsu, Muneo Oyama1967 Volume 93 Issue 2 Pages 105-113
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe mean cellular peroxidase content (MCP) of monocytes, neutrophils or eosinophils in peripheral blood was investigated on children with iron deficienc anemia, and it was found that there was a significant correlation between the MCP of monocytes and the mean corpuscular hemoglobin (MCH) of erythrocytes and that MCPs of neutrophils and monocytes were restored to the normal levels, when hematologic response to iron therapy was brought about in iron deficiency anemias.View full abstractDownload PDF (340K) -
Keiya Tada, Yoshimasa Yokoyama, Hiroshi Nakagawa, Toshio Yoshida, Tsun ...1967 Volume 93 Issue 2 Pages 115-124
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTwo children (siblings) with mental retardation revealed an excessive output of xanthurenic acid, kynurenic acid, 3-hydroxykynurenine and kvnurenine in urine following tryptophan loading. The disturbance was normalized tem-porarily by treatment with large doses of vitamin B6. The levels of pyridoxal phosphate in sera from both the patients were found to be within normal limits.
It was found that the activity of kynureninase in the liver of the patient was markedly reduced without addition of pyridoxal phosphate but the activity was restored to a considerable extent by the addition of an excess of pyridoxal phosphate.
These findings suggest that the basic defect in the patients is an inability of apoenzyme (kynureninase) to combine normally with the coenzyme (pyridoxal phosphate). The present studies, in combination with the work of Frimpter et al. on cystathionuria, may give us biochemical understanding for so-called vitamin B6 dependency.View full abstractDownload PDF (519K) -
Tsutomu Watanuki, Masayuki Ogata, Minoru Yamada1967 Volume 93 Issue 2 Pages 125-129
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to find a positive correlation between the development of sarcoma of the bone and preceding local traumatic injury, the right femur of dd-strain mice was fractured at the diaphysis, and 0.2mg of 20-methylcholanthrene (MC) was injected into the bone marrow or callus at the site of fracture. Various types of sarcoma of the bone developed after various latent periods (57-202 days). A positive sarcoma induction seemed to be related to the histological pattern of the callus at the time of MC-administration.
In the callus composed of already mature cells, no sarcoma developed, while the tumor was induced in 45.5% of animals with the callus of immature cells after a short latent period. It was assumed that this difference would be due to the different nature of cells composing callus: An active proliferating ability with evident susceptibility to certain carcinogens would be inherent to immature cells but not to mature cells. This would be one of the important factors, which must be taken into consideration in the interpretation of so-called traumatic sarcoma.View full abstractDownload PDF (239K) -
Akira B. Miura, Akira Shibata, Sadao Takase, Seiju Onodera, Atsuo Suzu ...1967 Volume 93 Issue 2 Pages 131-137
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe hemolyzed erythrocytes were examined electron-microscopically in three cases of paroxysmal nocturnal hemoglobinuria (PNH), in which the diagnosis was established by their typical clinical courses and laboratory findings.
The methods of electron microscopic observation in this study were those of Matthes et al. and their modifications. Hemolyzed erythrocytes in PNH showed variable appearances. Some of them were, however, observed even in normal hemolyzed erythrocytes. The folds of erythrocyte membrane were recognized in almost all the cells. The surface of stroma was smooth, granular or patchy, and the precipitations of matrix had or had not taken place. In some of the cells from PNH patients, there were many round flecks up to 0.5μ, while they were only a few in number in normal hemolyzed cells. But the number of these cells was small even in PNH, and their significance is obscure.View full abstractDownload PDF (1105K) -
Takuji Kasamatsu, Sigehiro Kiyono, Kitsuya Iwama1967 Volume 93 Issue 2 Pages 139-152
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSElectrical activities of the cerebral cortex, spontaneous and evoked, were studied in free behaving cats after both eyes were enucleated. The observa-tions were continued mostly for one month after eye enucleation.
1) The evoked potentials were recorded from the visual and sensorimotor cortices (VC and SMC) before and after eye enucleation, keeping the stimulus parameters unchanged. The postsynaptic component (C4) of the VC evoked potential to stimulation of the lateral geniculate body or the optic radiation was potentiated after eye emucleation and this potentiation was maintained over 30 post-operative days with a gradual subsidence. The presynaptic component (C1) was also enhanced after eye enucleation, but this facilitation was far smaller than that of C4 component and was kept at the same level for a long period of post-enucleation.
2) The strength of potentiation of the VC evoked potential was different depending upon the vigilance level of experimental animals; the strongest potentiation was seen during light sleep and the weakest one during arousal.
3) The post-excitatory recovery process of the deafferented VC was more or less delayed as compared with that of the intact VC.
4) The visual deafferentation did not induce any marked change in the SMC evoked potential.
5) During arousal 10-16c/s waves appeared as a dominant component of the EEG of the deafferented VC and during deep sleep bursts of 14-20c/s spindle-like waves were seen with seemingly normal phasic waves (cortical deep sleep waves). A decrease in the wave components faster than 30 c/s was evident during arousal and deep sleep. In the sensorimotor cortical EEG those fast wave components were increased.View full abstractDownload PDF (797K) -
Masao Wada, Hiroshi Kikuchi, Gotaro Tashiro, Makoto Takahashi1967 Volume 93 Issue 2 Pages 153-161
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBy using the band method and four blocking agents, it was demonstrated that the sweat response to intradermal injections of tetramethylammonium (TMA) in human skin consists of two components: at a concentration of 10-5, TMA elicits the sweat response mainly by acting on the sweat glands; and 5×10-4 or higher concentrations, it produces an axon reflex sweating in addition by acting on the receptors responsible for the axon reflex. The optimum concentration for the axon reflex was found to be 10-4.
The initiation of the axon reflex by TMA was inhibited by procaine, hexamethonium and tetraethylammonium (TEA) possibly at the site of the receptors responsible. The sweat response elicited by the direct action of TMA was scarcely interfered with by these agents in the concentrations sufficient to inhibit completely the axon reflex. Atropine in relatively low concentrations suppressed the sweating produced by the direct action of TMA, whereas it blocked the axon reflex response by acting on the receptors at relatively high concentrations.View full abstractDownload PDF (1232K) -
Toshio Sato, Yasuo Suda, Shintaro Watanabe, Kenji Koyama, Hidemi Yamau ...1967 Volume 93 Issue 2 Pages 163-178
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn order to clarify the significane of the spleen in relation to hematologic disturbances in Banti's syndrome, comparative studies between splenic arterial and venous blood elements and histologic examination of the spleen were carried out in fifteen cases of Banti's syndrome and ten control cases. The following results were obtained.
1) In cases of Banti's syndrome, red cell count, hemoglobin content, hem-atocrit value, red cell fragility, average diameter of red cells, white cell count, differential white cell count, platelet count, plasma protein value, erythrocyte sedimentation rate and transaminase activity showed little difference from those of the control cases except for less pronounced tendency toward increase of white cell count in splenic venous blood.
2) The difference in oxygen contents between splenic arterial and venous blood in Banti's syndrome was greater than those of the control cases. This difference was more evident in type III than in type II of the Banti spleen.
3) Histologic examination of the spleen of Banti's syndrome and the control cases revealed that phagocytosis or fragmentation of blood cells were hardly noticeable in both groups.
4) Concerning the erythrocyte distribution in the splenic tissue, a larger number of red cells were seen in the pulp cords in cases of Banti's syndrome than in those of the control. This was particularly so in the spleen of type III as compared with type II.View full abstractDownload PDF (2213K) -
Takashi Nakamura, Shozo Nakamura, Tatsuya Aikawa, Osamu Suzuki, Atsush ...1967 Volume 93 Issue 2 Pages 179-189
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSClinical features of 52 patients with alcoholic hepatic diseases were described. Of these patients 27 had alcoholic hepatic cirrhosis. As compared with hepatic cirrhosis due to icteric viral hepatitis, vascular spider, ascites and edema were found more frequently in alcoholic cirrhosis. Hepatic biopsy showed preponderance of cirrhotic changes of postnecrotic type.
Twenty-five patients had alcoholic fatty liver with or without fibrosis. Hepatic enlargement was observed in 64% of the total patients, and abnormalities of the bromsulphalein test in 86%. Decreased hepatic blood flow, elevated hepatic venous pressure and increased per cent intrahepatic shunt were demonstrated in some patients.
Seven patients with hepatic cirrhosis and 5 with fatty liver and fibrosis were found to have acute alcoholic hepatitis. Hepatic enlargement was observed in all such cases, and jaundice in 92%. The bromsulphalein test and serum glutamic oxalacetic transaminase were abnormal in all the cases. Serum glutamic oxalacetic transaminase levels were higher than serum glutamic pyruvic trans-aminase levels in 71% of the patients. Zieve's syndrome was found in one of the patients with acute alcoholic hepatitis.View full abstractDownload PDF (1010K) -
Takashi Nakamura, Shozo Nakamura, Tatsuya Aikawa, Noboru Karoji, Osamu ...1967 Volume 93 Issue 2 Pages 191-197
Published: 1967
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSHepatic enlargement, abnormal bromsulphalein test and histological hepatic changes (fatty liver, fibrosis and cirrhosis) were found not only in heavy drinkers visiting the hospital with complaints of hepatic diseases but also in those with psychiatric complaints and with other complaints not directly indicative of hepatic or psychiatric diseases. These results are different from those of heavy drinkers among apparently healthy subjects. This difference is ascribed to accompanying protein deficiency in the group of the diseased.
Heavy drinkers with complaints other than those of hepatic diseases who had been drinking alcohol up to the time of medical examination showed abnormal results in the bromsulphalein test mainly in cases of daily alcoholic intake of more than 66 g (3 go of sake). Histological evidence of hepatic changes was found in heavy drinkers over 35 years of age with daily alcoholic intake of more than 88 g (4 go of sake).View full abstractDownload PDF (346K)
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