The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Volume 200, Issue 3
July
Displaying 1-8 of 8 articles from this issue
Regular Contributions
  • Ismail Kati, Cengiz Bekir Demirel, Urfettin Abbasov Huseyinoglu, Emin ...
    2003 Volume 200 Issue 3 Pages 111-118
    Published: 2003
    Released on J-STAGE: September 10, 2004
    JOURNAL FREE ACCESS
    In this study, we compared haemodynamic changes, laryngeal mask airway (LMA) insertion time, and complications in patients anesthetized by inhalation of sevoflurane with those of intravenous induction with propofol. One hundred patients, aged between 20-40 years were enrolled in this study. Group 1 received propofol (2.5 mg/kg IV) and group 2 received sevoflurane (6%+50% N2O+50% O2) by inhalation using the tidal volume technique. LMA insertion time was found to be significantly longer in sevoflurane group than in propofol group. Mean arterial blood pressure was significantly lower within each group after induction in comparison to before induction values. In both groups, the LMA was successfully inserted in all patients. The quality of anaesthesia according to patients was significantly higher in the propofol group (80%) than in sevoflurane group (30%). Odor perception was significantly higher in sevoflurane group (84%) than in propofol group (38%). Apnoea was significantly higher in propofol group (40%) than in sevoflurane group (0%). Sevoflurane is an alternative to propofol for induction of anaesthesia and has a lower incidence of apnoea. Other complication rates are not higher than which propofol but the longer duration of induction time is a disadvantage.
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  • Ilyas Kayacioglu, Mehmet Ates, Yavuz Sensoz, Sevket Gorgulu, Mustafa I ...
    2003 Volume 200 Issue 3 Pages 119-128
    Published: 2003
    Released on J-STAGE: September 10, 2004
    JOURNAL FREE ACCESS
    Carrying out a mitral valve replacement (MVR) while preserving all chordae tendineae in patients with mitral regurgitation has been proven beneficial to the left ventricular performance. To evaluate the effectiveness of this technique in patients with mitral stenosis, a comparison of the echocardiographic data between patients who were operated on using this technique (Group Preservation=GroupP, n=15), and those operated on using the conventional method of MVR (Group Conventional=GroupC, n=15) was made. All patients were examined before surgery, 6 months after surgery and 8 years after surgery. The study population was limited to patients who had no evidence of coronary artery disease, aortic stenosis and-/or regurgitation and patients who had pure mitral stenosis. Echocardiographic measurements obtained both 6 months and 8 years postoperatively revealed a significant decrease in the left ventricular ejection fraction in GroupC (61.33±9.29% preoperatively, 53.2±10.3% postoperatively). The difference between the decrease in the left ventricular ejection fraction of the two groups was statistically significant (−0.71±6.28% in GroupP, −8.07±13.35% in GroupC). There was no evidence of prosthetic valve dysfunction and no operative deaths. Two patients died in GroupP, 3 patients died in GroupC within the 8 year period. The conclusion was reached, that if suitable, mitral valve replacement while preserving the chordae tendineae is expected to have a beneficial effect on postoperative left ventricular performance in patients with mitral stenosis.
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  • Tetsuaki Kawase, Masaki Ogura, Toshinori Sato, Toshimitsu Kobayashi, Y ...
    2003 Volume 200 Issue 3 Pages 129-135
    Published: 2003
    Released on J-STAGE: September 10, 2004
    JOURNAL FREE ACCESS
    It is well known that sound presented in the contralateral ear can elicit the activity of the olivocochlear (OC) efferent. In the present study, the effects of the addition of contralateral noise on the psychophysical measurements of auditory thresholds were investigated in human subjects with normal hearing. The results obtained in the present study indicate that the addition of contralateral noise at a level of only 20 or 30 dB sound pressure level (SPL) may cause a significant elevation of the auditory threshold in the mid-frequency area (usually 2-3 dB). When the level of contralateral noise was elevated, the elevation of the auditory threshold tended to be larger and the affected frequency area became wider. Although other factors that elevate the auditory thresholds, such as cross-talk effects and the acoustic reflex of the middle ear muscles, may be involved in the above-mentioned paradigm, especially when higher levels of contralateral noise are used, it is important to know the degree of OC-mediated threshold elevation in usual audiometric measurement.
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  • Zhen-Hua Jin, Toshihiko Kikuchi, Kohichi Tanaka, Toshimitsu Kobayashi
    2003 Volume 200 Issue 3 Pages 137-144
    Published: 2003
    Released on J-STAGE: September 10, 2004
    JOURNAL FREE ACCESS
    The immunohistochemical localization of glutamate transporter GLAST in the developing mouse cochlea was studied at different ages between 0 and 30 days after birth (DAB). In the adult mouse cochlea, intense GLAST-like immunoreactivity was found in the supporting cells adjacent to the inner hair cells of the organ of Corti, the type II and suprastrial fibrocytes of the cochlear lateral wall, the fibrocytes of the spiral limbus and the satellite cells surrounding the spiral ganglion cells. At 0 DAB, weak GLAST-like immunoreactivity was found in the supporting cells around the immature inner hair cells. Immature fibrocytes in the cochlea were also positively immunostained. At 3 DAB, weak immunostaining of GLAST appeared in the immature satellite cells in the spiral ganglion. The GLAST-like immunoreactivity in the supporting cells around the inner hair cells, in the fiborocytes in the spiral ligament and the spiral limbus and in the satellite cells in the spiral ganglion increased progressively during the second postnatal week, and reached the adult level at 15 DAB. This time course correlates with the electrophysiological onset and maturation of the mouse auditory function, which is mediated by glutamatergic neurotransmission. These results suggest that the expression of GLAST may be needed for the efficient removal and metabolism of the released glutamate in the cochlea and may play important roles in the onset and maturation of the auditory system.
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Case Reports
  • Hiroshi Nabeshima, Takashi Murakami, Yumi Sato, Yukihiro Terada, Nobuo ...
    2003 Volume 200 Issue 3 Pages 145-149
    Published: 2003
    Released on J-STAGE: September 10, 2004
    JOURNAL FREE ACCESS
    A 30-year-old-woman presented with uterine leiomyoma and primary sterility. Abdominal myomectomy was performed; however, one cervical leiomyoma was not resected because of a risk of excessive blood loss. Two years after the procedure, a secondary myomectomy using preoperative adjuvant uterine artery embolization (UAE) was performed because of pronounced menorrhagia and her hope for bearing children. The patient’s dysmenorrhea disappeared postoperatively and she conceived spontaneously 3 years after the secondary myomectomy. This case suggests that myomectomy using preadjuvant UAE may be an another approach for the treatment of leiomyoma in patients who wish bear children in the future.
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  • Tohru Nakahata, Hiroshi Tanaka, Kazushi Tsuruga, Jun Shimada, Koji Tsu ...
    2003 Volume 200 Issue 3 Pages 151-154
    Published: 2003
    Released on J-STAGE: September 10, 2004
    JOURNAL FREE ACCESS
    A previously healthy Japanese girl aged 4 years suddenly developed idiopathic nephrotic syndrome (INS) associated with acute renal failure (ARF). Despite prompt initiation of hemodialysis and prednisolone treatment, her ARF did not recover. A percutaneous renal biopsy performed within a month from the onset of INS revealed lesions of end-stage kidney, which is unusual for the acute stage of INS. Although the etiology of her ARF remains speculative, an acute exacerbation of an underlying chronic disease, such as non-nephrotic focal segmental glomerulosclerosis might be the cause.
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Short Reports
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