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Volume 100 (1970)
- Issue 4 Pages 305-
- Issue 3 Pages 201-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 100, Issue 1
Displaying 1-10 of 10 articles from this issue
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Rikuro Sasaki, Toshiaki Morishita, Shoichi Yamagata1970 Volume 100 Issue 1 Pages 1-13
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAutoradiographic studies on the synthesis of DNA in heart muscle cells of younger normal rats after administration of 3H-thymidine were made. The labeling index of heart muscle cells in 4 hours was 8.30% on the 2nd day of life and it gradually declined to 0.15% in 3 weeks. The labeling index of interstitial cells was 9.8% on the second day of life and it similarly declined to 1.0% in 3 weeks. These results are to be added as furthr evidence to cell division of heart muscle with postnatal growth of the heart.View full abstractDownload PDF (5947K) -
Rikuro Sasaki, Toshiaki Morishita, Shoichi Yamagata1970 Volume 100 Issue 1 Pages 15-21
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA new method to estimate the DNA synthetic time and mitotic time of heart muscle of rats from single autoradiographic specimen was described. If the postsynthetic time is negligible, the DNA synthetic time of heart muscle cells is 15-16 hours in 2-day-old, 1- and 2-week-old rats. The mitotic time of heart muscle cells is 7-11 hours. The DNA synthetic time of interstitial cells is 15-18 hours in 2-day, 1-, 2- and 3-week-old rats. The mitotic time of interstitial cells is 7-9 hours. The DNA synthetic time was also calculated from the estimation of cell number and the results were compared with the above mentioned values. In addition, a method to approach the postsynthetic time was mentioned.View full abstractDownload PDF (289K) -
Seigi Tsuchida, Hiroatsu Sugawara, Soitsu Fukuchi1970 Volume 100 Issue 1 Pages 23-29
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSLevels of plasma cortisol were determined by the competitive protein-binding radioassay technique in patients with chronic nephritis undergoing hemodialysis by Kolff's twin-coil kidney.
Marked rise in plasma cortisol occurred in most of the patients studied during artificial hemodialysis. The plasma cortisol level gradually diminished following completion of a six-hour dialysis and returned to predialysis levels 12 to 24 hours after the dialysis. This indicates that the patients adrenal function normally responds to dialytic stress with a secretion of cortisol fully making up for the dialytic loss of plasma cortisol. It, however, still remains probable that a decreased pituitary-adrenal responsiveness may cause an adrenal crisis as the hemodialysis proceeds.View full abstractDownload PDF (354K) -
Takeo Fukuda, Nobuo Katsuda, Kiyoshi Tanaka1970 Volume 100 Issue 1 Pages 31-37
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe majority of the midbrain reticular neurons of the rat altered their discharge patterns synchronously with a cortical EEG spike induced by intravenous injection of pentetrazol. The patterns were classified into four types, i.e., facilitated, inhibited, mixed and unaffected types.
Intravenous lidocaine suppressed both facilitatory and inhibitory components in the firing pattern. In particular, it reversed inhibitory to facilitatory pattern in some neurons. This may support the hypothesis that local anesthetics are liable to depress some inhibitory process in the central nervous system.View full abstractDownload PDF (333K) -
Hiroshi Onoki, Tetsuo Sato, Ichiki Kano, Keiko Mochizuki1970 Volume 100 Issue 1 Pages 39-46
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSHemodynamic consequences after the Rashkind and Miller balloon atrial septostomy were successfully evaluated by means of the dye dilution technic in three infants with the complete transposition of the great vessels.View full abstractDownload PDF (2021K) -
Takeshi Hoshi, Yukio Komatsu1970 Volume 100 Issue 1 Pages 47-59
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe sugar-evoked potential was recorded from everted sacs of the upper segment of toad intestine, and effects on this potential of anoxia, various metabolic inhibitors and ouabain were observed in a lowered external sodium concentratioai. Anoxia of a relatively short duration, KCN plus IAA, and ouabain caused a time-dependent decay of the evoked potential; inhibition of plateau formation, without affecting the imrnediat' potential increment significantly. DNP and prolonged anoxia depressed the size of the immediate increment, but the depression of the plateau was still more prominent. Fluoroacetate, KCN or IAA alone had no effect. Under inhibited conditions, phlorizin, applied at later phases of decaying sugar-evoked potential, produced a potential surge like the mirror-image of the decaying sugar-evoked potential and concurrent increases in sugar and sodium outflows. Similar surge could also be produced by lowering mucosal sugar concentration rapidly at a similar phase. These findings indicate that normal sugar-evoked potential is formed by two distinct mechanisms; relatively metabolism-independent and metabolism-dependent ones, and strongly suggest that the former responsible for the production of the immediate potential increment is directly associated with facilitated diffusion of sodium with sugar molecules on common mobile carriers.View full abstractDownload PDF (3897K) -
Jiro Kaizawa, Isao Takahashi1970 Volume 100 Issue 1 Pages 61-74
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe nerve fiber analysis of the rat dorsal and ventral spinal roots extending to the sciatic nerve and of the sciatic branches such as the lateral and medial gastro-cnemius nerves and the cutaneous nerve innervating the lateral aspect of thigh was done. Fiber counting was also made by microdissection method. To know the distribution of afferent and efferent components in a nerve, deefferentation was made by sectioning the relevant ventral roots. Main results obtained were as follows:
1) The sciatic nerve receives its constituent fibers mainly from L5 and partly from L4 and L6.
2) In the dorsal roots examined, the fibers larger than 12μ occupy a rather small portion of the total composition, and the afferent component of the hind-limb muscle nerves practically lacks fibers larger than 12μ.
3) The cutaneous nerve is devoid of efferent fibers and larger fibers characteristic of muscle nerves.
4) The total number of a peripheral nerve composition corresponds quite well on both sides of an animal and among different animals.View full abstractDownload PDF (1703K) -
Akira Ohneda, Takayoshi Toyota, Shinichiro Sato, Shoichi Yamagata1970 Volume 100 Issue 1 Pages 75-84
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn the two-antibody assay system for insulin, insulin-free human plasma and human globulin fraction reduced the percentage of precipitated insulin-131I Insulin antibody in plasma was partially absorbed by means of anti-human globulin rabbit serum, which was not available for the removal of endogenous insulin antibody. In order to remove the inhibiting factor as well as the circulating insulin antibody, a simple method for the extraction of plasma insulin was described. The method consists of extraction by acid-ethanol and precipitation in cold acetone. The recovery rate of insulin-131I added to serum by the present method was 92%, and that of human insulin added to a pooled human plasma was in the range of 80 to 94%. The extract contained a small amount of albumin but not globulin. The extraction method completely separated the insulin from the insulin-antibody complex.
The mean values of the fasting extractable insulin in human plasma were 20.5, 19.3, 22.6 and 10.0μU per ml in normal subjects, mild, moderate and severe diabetic patients, respectively. In the latter group the insulin response to glucose load decreased. Extractable insulin in plasma of several diabetic patients with insulin antibody was, found to be 10 to 32μU per ml. The insulin level in plasma of insulin-dependent patient with antibody to insulin could be estimated by the present extraction method.View full abstractDownload PDF (1133K) -
Reiko Demura, Hiroshi Demura, Masanori Iino, Takashi Nunokawa, Kiyoshi ...1970 Volume 100 Issue 1 Pages 85-95
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPlasma growth hormone and 11-OHCS in response to insulin hypoglycemia were determined simultaneously in corticosteroid treated patients. Long-term daily administration of corticosteroids, more than 800 tablets and longer than 6 months, had a marked inhibitory effect on GH secretion. Lower doses or shorter term administration on daily basis resulted in less suppression. Intermittent administration with various schedules usually had a less inhibitory effect than daily administration. In intermittently administered patients, better responses were observed in a group tested on off-day than in a group tested on on-day of corticosteroids. A single administration of 1-8 mg of dexamethasone to normal subjects at a midnight before a test had a variable effect on GH secretion. Plasma GH responses to arginine infusion were also suppressed by long-term and high-dose administration of corticosteroids. The suppression of GH seemed to go parallel with that of pituitary-adrenal axis determined by plasma 11-OHCS in corticosteroid treated patients.View full abstractDownload PDF (566K) -
Shigetoshi Chiba, Koroku Hashimoto1970 Volume 100 Issue 1 Pages 97-98
Published: 1970
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEffects of hyperosmolality on AV conductivity were studied by the directperfusion of hypertonic glucose or mannitol solution into the AV node artery ofdogs in situ. Animals were bilaterally vagotomized. Infusion of hypertonic solution caused AV block. The minimum osmolality of plasma for inducing the first degree AV block was estimated at roughly 500mOsm/l. When the duration ofinfusion did not exceed one minute, the AV node restored its normal conductivity.Higher osmolality in plasma over 800mOsm/l usually caused a complete block ofthe AV conduction. AV block induced by infusion of a hypertonic solution in ashort time was reproducible in the same animals. An infusion over 10 minutescaused an irreversible AV block. The AV block induced by a hypertonic solutionwas not antagonized by atropine treatment.View full abstractDownload PDF (127K)
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