All issues
Volume 106 (1972)
- Issue 4 Pages 311-
- Issue 3 Pages 213-
- Issue 2 Pages 109-
- Issue 1 Pages 5-
Volume 106, Issue 3
Displaying 1-11 of 11 articles from this issue
- |<
- <
- 1
- >
- >|
-
TSUNEO ARAKAWA, TOSHIO YOSHIDA, TASUKE KONNO, YOSHIYUKI HONDA1972 Volume 106 Issue 3 Pages 213-218
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDefective incorporation of glycine-1-14C into urinary uric acid was demonstrated in a patient with formiminotransferase deficiency.View full abstractDownload PDF (291K) -
MASAKUNI SUZUKI, SHOGO OSAWA, MUTSUO HIRANO1972 Volume 106 Issue 3 Pages 219-231
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIntravenous injection of the crude extract from Lycii folium among components of Lycium chinense Miller induced ovulation in the adult female rabbit. Chemical properties of the active component of this crude extract were investigated by dialysis, ninhydrin reaction, adsorption by charcoal, cellulose column chromatography with methanol solution, precipitation by methanol solution, Amberlite IR-410 and IR-4B column chromatography, DEAE cellulose chromatography, gel filtration with Sephadex G-25 and G-50, starch electrophoresis, etc. While the nature and the mechanism of action of this substance still remain unknown, the detection of a substance with such action in plants and the elucidation of its chemical properties may provide a step for future developments in reproductive physiology.View full abstractDownload PDF (764K) -
MASAHIRO MAKI, KATSUJI SASAKI1972 Volume 106 Issue 3 Pages 233-248
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA synthetic esteroprotease inhibitor, 4-(2-carcoxyethyl) phenyl-trans-4-aminomethyl cyclohexane carboxylate hydrochloride (DV 1006) was studied in vitro, and compared with trans-4-aminomethyl cyclohexane carboxylic acid (AMCHA) and Trasylol. The results obtained were as follows: 1. The substance exerted a highly potent inhibiting activity on thrombin. The kinetic study employed a technique of Lineweaver and Burk revealed that the inhibition was competitive in fashion. 2. The substance inhibited either or both of process of the first phase of coagulation in which factors XIα-IX and IXα-X interactions were involved. 3. The substance was capable of to inhibiting both plasmin and plasminogen activation. A striking difference between DV 1006 and AMCHA was that the former inhibited casein digestion by plasmin, but the latter had esentially no effect. The caseinolysis induced by plasmin was inhibited competitively by DV 1006. 4. The AGLMelysis induced by urokinase was inhibited by DV 1006 and AMCHA at concentra tions of 10-4M and 10-2M, respectively. Trasylol had no effect on this reaction system. 5. The substance inhibited trypsin, seasprose and kallikrein, but did not inhibit chymotrypsin.View full abstractDownload PDF (1410K) -
KUNIAKI NARISAWA, YOSHIYUKI HONDA, TOSHIO YOSHIDA, TSUNEO ARAKAWA1972 Volume 106 Issue 3 Pages 249-251
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSResults of in vitro study using rat liver homogenates revealed that there was no inhibitory effect of diphenylhydantoin (50 γ per ml of the reaction mixture) upon histidase, urocanase, formiminotransferase, N5, 10-methylenetetrahydrofolate reductase, formyltetrahydrofolate synthetase, serine-hydroxymethylase and glycine cleavage enzyme.View full abstractDownload PDF (157K) -
ISAO URAMOTO1972 Volume 106 Issue 3 Pages 253-263
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCats were conditioned to press a bar for a food reward using a trace conditioning procedure. Comparison was made between two conditioning procedures. In one procedure, repetitive flashes were given contingently upon a correct response (Procedure B), and in the other no such photic stimulation was made (Procedure A). In the final stage of the conditioning, differences between two procedures were found; the distribution of response times was more concentrated with smaller means and variances in Procedure B than in Procedure A. Excitability of the visual cortex to a flash differed according to whether or not the flash was used as a response-contingent stimulus. To the response-contingent flash the primary component of visual cortical evoked potentials was augmented in amplitude with a reduction of peak latency. From these findings, temporal discrimination function of the animals was discussed. Behavioral correlates with modification of visual cortical evoked potentials were also discussed.View full abstractDownload PDF (733K) -
SHUNZO CHIBA, SHIGERU IKEDA, YOSHITAKA AGATSUMA, TOORU NAKAO, YOSHITO ...1972 Volume 106 Issue 3 Pages 265-270
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSComplement-fixation (CF) antibodies for cytomegalovirus (CMV), varicella-zoster virus (VZV) and herpes simplex virus (HSV) were investigated in the sera sequentially obtained from patients without malignancies. These subjects were receiving corticosteroid therapy and were not given other immunosuppressive drugs or blood transfusions. Active CMV infection reflected by a significant rise in CF antibody titer against CMV was demonstrated in 5 of 10 patients and in 1 of 21 control patients. Four of 5 patients who exhibited significant rise of antibody titer to CMV possessed detectable CF antibodies to CMV before receiving corticosteroid therapy. The antibody titer increased between 1 and 2 months after the beginning of the therapy, and gradually decreased after cessation of the therapy. The significant rise of antibody titer to CMV, however, was not associated with definite clinical symptoms. The results suggest that corticosteroid therapy might have induced reactivation of latent CMV infection leading to subclinical endogeneous reinfection. The incidence of active infection with VZV and HSV was less frequent than that with CMV, though an increase in CF antibody titers was observed in 2 patients to VZV and in 2 patients to HSV.View full abstractDownload PDF (380K) -
KOICHI NAKAYAMA, NORIO TAIRA, KOROKU HASHIMOTO1972 Volume 106 Issue 3 Pages 271-274
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIn conscious dogs intra-arterial injection of aza-azepinophenothiazine (RPP-201) and acetylcholine into a branch of the superior mesenteric artery induced the vocalization response. No substantial difference was found between doses of acetylcholine for vocalization in the conscious state and those for strong intestinal contractions in the anesthetized state. In contrast, RPP-201 produced no intestinal spasm in doses which caused vocalization in the conscious state.View full abstractDownload PDF (207K) -
MASATOSHI SAKKA, HAJIM KATSUTA, TOSHIKO TAKAOKA1972 Volume 106 Issue 3 Pages 275-284
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCultured rat hepatoma cells were irradiated with 500 to 800 R of gamma rays and inhibition of cell growth was recorded on cinemicrograms. Analysis of constructed pedigrees of control and treated cells indicated that (1) usual type of frequency distribution of generation time did not apply to control cells, (2) death after irradiation took place quite at random, (3) natural death in control occurred more frequently in pedigrees with less divisions, and (4) in some instances pedigrees with more divisions were more resistant to radiation-induced death.View full abstractDownload PDF (610K) -
HAJIME HOSHI1972 Volume 106 Issue 3 Pages 285-305
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSPostnatal development of the splenic lymphoid tissue under normal and experimental conditions was investigated, using male White Leghorn chickens. It was evidenced that the white pulp of the chick spleen was composed of the periarterial and periellipsoidal lymphoid tissues, which were distinguishable from each other in the following aspects, i.e. mode of development, morphology of their constituting lymphoid cells, and relation to the germinal center formation. Along the venous channels in the splenic pulp, there often occurred perivenous lymphoid tissue of which structures were similar to those of the periarterial lymphoid tissue. To inhibit or retard the development of the bursal lymphopoiesis, the following experimental procedures were used: neonatal bursectomy and X-irradiation, hormonal bursectomy, neonatal whole body irradiation followed by repeated local irradiations of the lower part of the body. It was noted that the lack of the development of the periellipsoidal lymphoid tissue occurred under such experimental conditions. On the other hand, early extirpation or destruction of the thymus, i.e. neonatal thymectomy and X-irradiation or neonatal whole body irradiation with successive irradiations of the neck did not show any inhibitory effect on the development of the periellipsoidal lymphoid tissue. These findings strongly suggested the bursa-dependency of the periellipsoidal lymphoid tissue.View full abstractDownload PDF (4441K) -
AKIRA RIKIMARU, YASUE FUKUSHI, TAIZO SUZUKI1972 Volume 106 Issue 3 Pages 307-308
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSubstance R is a biologically active substance extracted by us from the bovine brain. This substance could also be extracted from the rabbit brain. It is assumed, therefore, that Substance R may exist not only in the bovine brain but also in the brains of other animals. Substance R extracted from the rabbit brain was similarly effective to that from the bovine brain in eliciting relaxation of the isolated guinea-pig taenia coli. Moreover, this substance caused relaxation of the isolated human taenia coli.View full abstractDownload PDF (80K) -
MASAO ENDOH, TOMOHIKO KIMURA, KOROKU HASHIMOTO1972 Volume 106 Issue 3 Pages 309-310
Published: 1972
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSEffect of periarterial nerve stimulation on the contraction, idioventricular rate and blood flow of the canine ventricular myocardium was investigated using the cross-circulated papillary muscle preparation with a constant perfusion pressure at 100mm Hg. Electrical stimulation of the periarterial nerve of the anterior septal artery (6-12 volts, 1-2 msee pulse-duration at 1-30 Hz) produced a pronounced increase of the isometric tension and idioventricular rate of the muscle with a little increase of the blood flow depending on the frequency of nerve stimulation. These effects of nerve stimulation were completely blocked by 0.3-1μg of tetrodotoxin which affected little the responses to norepinephrine (0.03μg) administered closearterially. These results show physiologically that sympathetic nerve innervates the ventricle through periarterial parts of the coronary artery and directly regulates the contraction, idioventricular automaticity and coronary flow of the canine ventricle.View full abstractDownload PDF (125K)
- |<
- <
- 1
- >
- >|