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Volume 122 (1977)
- Issue 4 Pages 303-
- Issue 3 Pages 199-
- Issue 2 Pages 99-
- Issue 1 Pages 1-
Volume 122, Issue 1
Displaying 1-12 of 12 articles from this issue
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KOZUI MIYAZAWA, TAKASHI HANEDA, KUNIO SHIRATO, TAKAO HONNA, TAMOTSU TA ...1977 Volume 122 Issue 1 Pages 1-8
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCoronary sinus blood flow (CSBF) was measured by the dye dilution method in 18 patients with idiopathic cardiomyopathy including 13 with hypertrophic type and 5 with congestive type, and the capacity for increasing CSBF in response to handgrip exercise was studied in 14 patients. CSBF at rest ranged from 41 to 236ml/min/M2. Average CSBF of 114±12ml/min/M2 (112±14 in hypertrophic type and 119±25 in congestive type) was significantly larger than control value of 77±6 presented previously (p<0.01). Handgrip exercise at 30% maximal effort for 3min resulted in the increase in CSBF, averaging 23±8 ml/min/M2 (22±8%). However, in about one-half of cases, the percent increase in CSBF was much smaller than the percent increase in effort index which represents myocardial oxygen demand. The change of CSBF was not correlated with the changes of left ventricular systolic pressure, cardiac output, and stroke work. The diminished response of CSBF to isometric handgrip exercise was ascribed to the decreased coronary vascular reserve in this disorder.View full abstractDownload PDF (473K) -
TADASHI IGARI, MASATAKA TAKEDA, KIJURO OBARA, SHIGERU ONO1977 Volume 122 Issue 1 Pages 9-20
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe amount of urinary catecholamine of healthy subjects and patients with rheumatoid arthritis, particularly before and after synovectomy, was studied. (1) The urinary catecholamine of patients with rheumatoid arthritis showed a lower value than that of healthy subjects. The greater the amount of intra-articularly injected steroids was and the more severe the stage and class of rheumatoid arthritis were, the lower the level of adrenaline was and the more reduced the activity of phenylethanolamine-N-methyltransferase was. (2) The level of urinary noradrenaline in patients with rheumatoid arthritis was lower than that of healthy subjects, but there was no relationship between the level of noradrenaline and the amount of intraarticularly injected steroids. Considering that noradrenaline tended to approach to the normal level as the stage or class of rheumatoid arthritis was more severe, the level of urinary noradrenaline in patients with rheumatoid arthritis seems to reflect the existence of a certain compensatory system in the enzyme system of catecholamine metabolism rather than the influence of the adrenal cortex system. (3) The urinary catecholamine was decreased after synovectomy; especially, noradrenaline level was remarkably decreased. These results suggest that catecholamine plays an important role in the appearance of pain or other clinical signs in rheumatoid arthritis.View full abstractDownload PDF (555K) -
GOROH OKANO, TOYOAKI AKINO, YOHICHI MOCHIZUKI1977 Volume 122 Issue 1 Pages 21-33
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe lecithins of the primary hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene (DAB) and host liver of rat were isolated, and the individual molecular species were estimated quantitatively by combined thin-layer and gaschromatographic analysis and specific enzymic hydrolysis. The DAB-hepatoma lecithins appeared to have more specific positioning of fatty acids than the transplanted hepatoma lecithins which have been reported by Dyatlovitskaya et al. (1974). However, there were some striking differences to be noted between the DAB-hepatoma and host liver lecithins. The usual type of molecular species of lecithin, saturated-unsaturated species, was the main component in the hepatoma and host liver. The amounts of the unusual species having impaired positional specificity in fatty acid such as the saturated-saturated and the unsaturated-saturated species were high in the DAB-hepatoma when compared with host liver, although the content of the unsaturated-unsaturated species of lecithin were almost similar in both the tissues. The formation of the unusual species of lecithin in tumor tissues was discussed in relation to the impairing in the enzyme systems involved in lecithin synthesis.View full abstractDownload PDF (765K) -
HIROSHI KANEDA, NOBUHIDE MIMURA1977 Volume 122 Issue 1 Pages 35-42
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo study the carbohydrate metabolism in uremic patients, the intravenous glucose tolerance test (iv GTT) and insulin sensitivity test were investigated on 69 patients with chronic renal failure, 27 of whom were under the dialysis treatment. 1) Abnormal K-values averaging 1.05 were obtained in uremic patients (creatinine clearance less than 20ml/min). 2) Carbohydrate intolerance in uremic patients was corrected with regular dialysis and the improvement was correlated with the duration of dialyses. 3) The mechanisms of improvement in carbohyd-rate metabolism were different between the short-term dialysis group (less than 12 months of dialysis) and the long-term group (more than 12 months). Enhanced secretion of insulin seemed to be the main cause of this improvement in the former, while the correction of impaired sensitivity to insulin in peripheral tissues in the latter.View full abstractDownload PDF (435K) -
KAI TSUIKI, JUNICHIRO NAGASAWA, TAKASHI NAKAMURA1977 Volume 122 Issue 1 Pages 43-50
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA method is described to determine the transcoronary circulatory transport function (h(t)) from input (C'i(t)) and output (C'o(t)) dye-dilution curves obtained at the inlet and outlet of the coronary circulation. Assuming the mathematical linearity and stationarity of the coronary circulation, it is demonstrated that h(t) can be computed in terms of lagged normal density curve as a model from the sole measurement of the first to third moments of C'i(t) and C'o(t) when recorded by a pair of our dye sampling systems that have shown to have identical response to step function. The method is useful because of its simplicity in practice. The physiological meaning of the determination of h(t) is discussed. It could be helpful to the estimation of the change in coronary path-length distribution under some conditions, although the method is still of limited value at present, because the averaged path-length through the coronary circulation cannot be evaluated correctly.View full abstractDownload PDF (453K) -
RYO KATORI, TAKEO HAYASHI, KEN KANAMASA, KINJI ISHIKAWA1977 Volume 122 Issue 1 Pages 51-58
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA non-invasive method for measuring cardiac output by an earpiece dye densitometer was proposed. The densitometer is dichromatic and has an air capsule to make subject's ear bloodless by inflation, so that it can calibrate indocyanine green dye concentration without blood sampling. Duplicate measurements of cardiac output showed a good agreement in 40 cases (r=0.97, standard deviation (S. D.)=8.9 per cent), which was comparable to the result of the cuvette method (r=0.98, S. D.=8.1 per cent). Simultaneous measurements of cardiac output by the earpiece method (x) and the standard cuvette method (y) revealed a good agreement (r=0.91, y=0.96x+0.34, S. D.=16.4 per cent) in 52 measurements of 25 cases. A similarly good correlation was obtained between the two methods during ergometer exercise in supine position in 5 cases. These suggest that this earpiece dye-dilution method is reliable for cardiac output measurement and advantageous for clinical use because of non-invasive technique.View full abstractDownload PDF (328K) -
TAKUSEI UMENAI, NAKAO ISHIDA1977 Volume 122 Issue 1 Pages 59-63
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCandida, which is not detectable in the urine of healthy individuals, was found in 6.5% of patient's urine. Most of the patients developing candiduria had higher-titered circulating antibody to the fungus than healthy persons did. There existed a definite relationship between the serum antibody titer and the duration of candiduria. These two variables reflected the status of the patient.View full abstractDownload PDF (200K) -
SETSUO KOMURA, SEISHO OSHIRO1977 Volume 122 Issue 1 Pages 65-68
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt appears possible to utilize the potassium in the aqueous humor as well as the potassium in the vitreous humor for the estimation of the postmortem interval, especially if the factors relating to the body temperature are taken into consideration.View full abstractDownload PDF (137K) -
KIYOTA OH-UTI, TAISUKE NISHIKAWA, MITSURU KONN, YOSHIRO SHISHIDO, KUNI ...1977 Volume 122 Issue 1 Pages 69-79
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBiochemical and immunological investigations were made on the nature of fluorocarbon-treated antigens obtained from placenta and cancer tissues. 1) By the diffusion in gel method, a specific antigen common to cancer tissues was found in placental tissue, but not in normal tissue. Immunoelectrophoretically, a characteristic precipitate line was found in a2-globulin region. 2) Further purification of the placental antigens was carried out by DEAE-cellulose chromatography. Four fractions positive to Folin reaction were detected. 3) Immunoelectrophoresis revealed that the active component was concentrated in a fraction eluted with 0.1 M NaCl in 0.05 M phosphate buffer, pH 5.8 (5.8-fraction). 4) Further purification of the active component was performed by using polyacrylamide gel electrophoresis. Chemical analysis indicated that it belonged to glycoprotein. 5) This substance did not induce anemia in rabbits and had no influence on the osmotic fragility of erythrocytes. These results indicate that this substance is different from the anemia-inducing substance which was previously reported by us.View full abstractDownload PDF (3009K) -
HIROSHI SATOH, SACHIKO SHISHIDO-KASHIWAZAKI, TSUGUYOSHI SUZUKI, NOBUO ...1977 Volume 122 Issue 1 Pages 81-86
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSUrine of a young healthy man was added with varying amounts of mercuric chloride, incubated for 10 to 375 min, and separated into superantant solution and precipitate by centrifugation at 105, 000 ×g for 60 min. Percentage of mercury amount in precipitate increased with the increase of mercury amount added. But this adsorption of mecury to urinary cells or particles could not completely account for the amount of mercury in human urine reported (Suzuki and Shishido 1975). The hypothesis that desquamation of tubular cells is a route of urinary mercury excretion in man is still sustained.View full abstractDownload PDF (256K) -
YUKIO YAMADA, SEIKI ITO, YOHICHI MATSUBARA, SHIGERU KOBAYASHI1977 Volume 122 Issue 1 Pages 87-92
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSBy an indirect immunoffuorescence technique using the somatostatin antibody, somatostatin-containing cells were demonstrated to exist in the human, dog and rat thyroids. These cells were located predominantly in the interfollicular areas and more scatteringly in the follicular areas. The source of these somatostatin-containing cells was discussed.View full abstractDownload PDF (1138K) -
MASANA OGATA, JUNKO MIZUGAKI, KAZUHISA TAKETA, SHIGEO TAKAHARA1977 Volume 122 Issue 1 Pages 93-97
Published: 1977
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCatalase activity in leucocytes was found to be half the normal value in hypocatalasemia and extremely low in acatalasemia. Glucose-6-phosphate dehydrogenase activity in erythrocytes was not significantly different between normal, hypocatalasemia and acatalasemia in three families of acatalasemia, but in one family lower activities than normal were found in hypocatalasemia and actalasemia erythrocytes. Other enzyme activities in blood, such as alkaline phosphatase, lactate dehydrogenase, glutamic oxaloacetic and glutamic pyruvic transaminases were not significantly different between normal subjects, hypocatalasemia and acatalasemia.View full abstractDownload PDF (282K)
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