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Volume 125 (1978)
- Issue 4 Pages 305-
- Issue 3 Pages 205-
- Issue 2 Pages 103-
- Issue 1 Pages 1-
Volume 125, Issue 3
Displaying 1-11 of 11 articles from this issue
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MASATOSHI SAKKA, HAJIM KATSUTA, TOSHIKO TAKAOKA1978 Volume 125 Issue 3 Pages 205-211
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSCultured hepatoma cells of the rat were irradiated with 400 to 900 R of gamma-rays. They were kept at room temperature for several hours before transferred to normal culture condition at 37°C. The pedigree analysis of growing cells recorded by cinematography indicated a variety of lethal and non-lethal recovery events such as a decrease in lethal branch formation and an increase in locomotion. The so-called repair immediately after irradiation has many facets depending upon dose and duration of the low temperature treatment.View full abstractDownload PDF (369K) -
TATSUHITO TONO-OKA1978 Volume 125 Issue 3 Pages 213-222
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTissue factor activity was detected in human mononuclear cells cultured with E. coli endotoxin in vitro. The efficient concentration of endotoxin inducing significant tissue factor development was in excess of 10-3 μg/ml, and a dose response type relationship was seen between them. The activity developed after culturing for 2 hr and increased up to 6 hr, and thereafter no significant increase was observed. Although the activity was detected both in cell extract and on cell surface, the main activity seemed to exist on the cell surface. No correlation was observed between the synthetic rate of nucleic acid and the rate of development of the activity. Although the activity was detected also in a granulocyte preparation, it was significantly less than that in mononuclear cells. The development of activity was observed when lymphocytes were cultured in RPMI 1640 medium, MEM, and in autologous serum. However, the activity was not observed when cultured in Hanks solution and PBS, in which the main difference from RPMI was the absence of amino acids, and in autologous serum containing sodium citrate which was added for elimination of Ca++ from serum. Moreover, actinomycin D suppressed the development of activity, and the same was noted at low culture temperature. These results suggest that some metabolic change of the cell membrane triggered by endotoxin may induce the development of tissue factor in cells.View full abstractDownload PDF (611K) -
KAZUIE IINUMA, SEIKO TAMAHASHI, HIROMI OTOMO, AKIRA ONUMA, NORIMITSU T ...1978 Volume 125 Issue 3 Pages 223-231
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSImmediate EEG changes after intravenous administration of clonazepam and a correlation between the EEG changes and the effect of oral administration of the drug were studied in 21 children with minor seizures whose interictal EEG showed a paroxysmal abnormality. In 13 cases of infantile spasms whose EEG showed hypsarhythmia, paroxysmal discharges were completely or remarkably suppressed in 4 cases, partially suppressed in 3 cases, but not improved in 6 cases. Suppression bursts pattern was less improved. In 5 cases of Lennox syndrome, paroxysmal discharges were markedly improved in 3 cases. In a case of petit mal absence, parxoxysmal discharges were completely suppressed. In all 5 cases whose EEGs were completely improved, paroxysmal discharges reappeared 7 to 30 min after the intravenous injection. In 2 out of the 5 cases, paroxysmal discharges became severer at reappearance than before the injection. Among 12 cases whose EEG showed an improvement after the intravenous injection, their clinical seizures were improved in 9 cases, but the clinical effect was mostly transient. In the majority of the cases whose EEGs were not improved, no clinical effect was observed. There was a highly significaant correlation between immediate EEG changes and clinical effect of clonazepam (p<0.02 by the chisquare test).View full abstractDownload PDF (484K) -
MAKOTO SEIJI, MICHIKO SASAKI, YASUSHI TOMITA1978 Volume 125 Issue 3 Pages 233-245
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe decrease in tyrosinase activity following incubation of melanosomes isolated from mouse melanoma with dopa appeared to be related to the degree of in vitro melanization of melanosomes caused by incubation with dopa. The inactivation similarly occurred in the dopa-tyrosinase reaction system containing ascorbic acid, although in the presence of ascorbic acid the dopa-quinone is immediately converted back to dopa and therefore melanin formation does not take place. The mode of inactivation of tyrosinase in melanosomes appeared to be similar to the reaction inactivation which is known to occur in the reaction of plant tyrosinase. Superoxide anion (O-2) and singlet oxygen (1O2) were estimated but undetectable during the dopa-tyrosinase reaction. Thus the inactivation of tyrosinase is not caused by the reaction products or the oxygen radicals.View full abstractDownload PDF (846K) -
HIROSI SATO, ATSUNOBU YOKOSAWA, HIDEO ARAI, HIROMI NAGAI, NOBUKO KUMAN ...1978 Volume 125 Issue 3 Pages 247-252
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe antitumor activity of hotwater extract of delipidated BCG was investigated in mice inoculated with Sarcoma-180 cells and Ehrlich carcinoma cells, respectively. The hot-water extract was found to be effective when administered after and ineffective when administered before the inoculation of tumor cells. When this extract was given with anticancer drugs, such as Mitomycin C and cyclophosphamide, a combined effect was obtained in the treatment of Sarcoma-180 and of Ehrlich carcinoma.View full abstractDownload PDF (348K) -
TAKEO MUKADA, NOBUAKI SASANO, KOZO SATO1978 Volume 125 Issue 3 Pages 253-263
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn autopsy case of paraquat poisoning in an adult male died on the 6th day of intoxication was presented. Histological and electron microscopic observations demonstrated interstitial pneumonia with distinct interstitial fibrosis and the initial stage of alveolar fibrosis with coexisting edema and hyaline membrane formation. Striking hemorrhagic leukoencephalopathy, i.e. ‘purpura cerebri, ’ was noted throughout the central nervous system involving almost exclusively the white matter. It consisted of focal hemorrhages of various stages accompanied by demyelinating processes of various extent. Globular and/or amorphous proteinaceous materials of uncertain nature were demonstrated in the vascular lumina throughout the brain.View full abstractDownload PDF (3906K) -
KIYOOMI SUMI, TAKAHIRO SUGITA, TSUNESUKE SHIMOTSUJI, YOSHIKI SEINO, TA ...1978 Volume 125 Issue 3 Pages 265-269
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSerum 25-hydroxyvitamin D levels in young patients receiving anticonvulsants were assayed. They had neither retardation of physical and psychomotor development nor malnutrition. The patients treated with phenobarbital alone revealed rather high levels of serum 25-hydroxyvitamin D during 2 months after institution of the therapy, then they gradually returned to the normal level by the end of 3 to 5 months and thereafter decreased further, while a marked decrease of serum 25-hydroxyvitamin D levels was observed in patients receiving combined anticonvulsant (pheno-barbital, diphenylhydantoin and others) therapy even during 1 to 2 months after initiation of the treatment. Our results suggest that the patients who have combined anticonvulsant therapy will have more tendency to suffer from osteo-malacia than those who have phenobarbital alone.View full abstractDownload PDF (286K) -
HIROMICHI OHKAWA1978 Volume 125 Issue 3 Pages 271-279
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSSpontaneous electrical activity of the intestine smooth muscle of the cat consisted of slow waves and spikes. The spike activity and the slow wave generation were inhibited by pentagastrin and tetragastrin. Phasic contraction corresponding with the electrical activity was also abolished by pentagastrin and tetragastrin. Adrenaline showed the inhibitory action on the spike activity and phasic contraction, but slow waves persisted against adrenaline. Propranolol depressed this inhibitory action produced by adrenaline, while it did not block the inhibitory action by pentagastrin. The inhibitory effect of pentagastrin was not influenced by caffeine or theophylline. Imidazole depressed slightly the inhibitory action of pentagastrin. Verapamil inhibited the spike activity. Additional application of pentagastrin after verapamil produced further inhibition of both slow wave generation and phasic contraction. These results suggest that the inhibitory action produced by pentagastrin on the electrical and mechanical activities is directly on the smooth muscle cell membrane mediated through a mechanism other than via beta-receptors. It is also suggested that the primary action of pentagastrin is to inhibit the generation of slow waves of the intestinal smooth muscle.View full abstractDownload PDF (530K) -
MUNEKI SAKAKURA, YOSHIRO SAITO, MITSUAKI YOSHIOKA, KAZUO TAKEBE, ITARU ...1978 Volume 125 Issue 3 Pages 281-285
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSIt is well known that hypothalamic corticotropin releasing factor (CRF) activity shows a marked circadian rhythm with the peak around 16 o'clock and the minimal level around 8 o'clock, followed by almost parallel changes of plasma corticosterone. But the circadian variations of CRF activity at short intervals (22 or 23 min) around 16 o'clock has not been obvious. In this experiment, we demonstrated fluctuated changes of CRF content in the non-stressed rat hypothalamus with 22 or 23 min intervals around the peak at a quarter past 16 o'clock.View full abstractDownload PDF (303K) -
TADASHI IGARAI, YOZO NISHIMURA, KIJURO OBARA, SHIGERU ONO1978 Volume 125 Issue 3 Pages 287-301
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTo elucidate the role of vitamin B12 in the formation of anemia in patients with rheumatoid arthritis, serum B12 levels were investigated in patients with rheumatoid arthritis, patients with osteoarthritis and normal subject. Serum B, , level in patients with rheumatoid arthritis was significantly higher than that in patients with osteoarthritis and normal subjects. Serum B12 level increased in proportion to Steinbrocker's stages, and was related more closely to hemoglobin concentration than to erythrocyte count and had a high correlation with α1- and α2-globulin.View full abstractDownload PDF (634K) -
ERUO MISHINA, HIROKI WATANABE, KEIICHI MIYAKODA, HIROTAKA ARAKI, TERUF ...1978 Volume 125 Issue 3 Pages 303-304
Published: 1978
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWe examined the amount of 5-Fu absorbed through the gastric epithelium after oral administration in both dogs and patients with bladder tumors. The concentrations of 5-Fu in the serum, bladder wall, tumor mass and regional lymphnodes were sufficiently high to suppress the growth of tumor cells.View full abstractDownload PDF (100K)
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