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Volume 140 (1983)
- Issue 4 Pages 339-
- Issue 3 Pages 225-
- Issue 2 Pages 109-
- Issue 1 Pages 1-
Volume 140, Issue 2
Displaying 1-14 of 14 articles from this issue
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SUETSUGU MUE, TETSUHIRO OHMI, SHUNSUKE SUZUKI, GEN TAMURA, WATARU HIDA ...1983 Volume 140 Issue 2 Pages 109-119
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMUE, S., OHMI, T., SUZUKI, S., TAMURA, G., HIDA, W., SEKIZAWA, K., ISHIHARA, T., YAMAUCHI, K. and TAKISHIMA, T. The Effect of Adrenergic and Cholinergic Drugs on Methacholine- and Histamine-Induced Bronchoconstriction in Monkeys. Tohoku J. exp. Med., 1983, 140 (2), 109-119 - The effect of adrenergic and cholinergic drugs on bronchial contraction of monkeys was studied using bronchoconstriction induced by aerosol challenge with methacholine and histamine. Under the anesthesia with ketamine hydrochloride, changes in the total respiratory resistance were continuously measured in monkeys to estimate the bronchial response to both histamine and methacholine. Isoprenaline decreased bronchial susceptibility to aerosol challenge with both methacholine and histamine. Isoprenaline was also potent in antagonizing the bronchoconstriction induced by methacholine and histamine. Atropine decreased bronchial susceptibility to aerosol challenge with methacholine and also partially with histamine. Atropine also antagonized the bronchoconstriction induced by methacholine, but not by histamine. Phentolamine had neither inhibitory effects on the aerosol challenge with methacholine and histamine, nor produced an antagonistic effect on bronchoconstriction induced with methacholine and histamine.View full abstractDownload PDF (1191K) -
HIROTAKA OTA, MINEKO FUKUSHIMA, MASAHIRO MAKI1983 Volume 140 Issue 2 Pages 121-131
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOTA, H., FUKUSHIMA, M. and MAKI, M. Endocrinological and Histological Aspects of the Process of Polycystic Ovary Formation in the Rat Treated with Testosterone Propionate. Tohoku J. exp. Med., 1983, 140 (2), 121-131 - To elucidate the process underlying polycystic ovary (PCO) syndrome, we tried to produce experimental PCO by sterilizing rats with androgen and investigated the formation of PCO endocrinologically and histologically. Wistar-Imamichi strain female rats were given an injection of testosterone propionate 1.25mg on 5 days of age. On 5, 10, 20, 40, 60, 80, 100, 130, 160, 200 days after the injection the ovaries were obtained. Ovarian wedge resection was also performed at 100 and 200 day-rats. Serum gonadotropins, prolactin and steroids were measured with RIA and compared with ovarian pathology. Serum prolactin was increased drastically 40 days after the injection and maintained at a constant level higher than control. Through wedge resection, the serum LH level returned to normal, but FSH slightly increased. Serum estradiol decreased more markedly than estrone did. The 40 day-ovaries showed polycystic features, lack of corpus luteum, hyperthecosis, luteinization of stroma, while no thickening of tunica albuginea. In conclusion, the rats treated with testosterone propionate had many endocrinological and histological aspects similar to those of human PCO syndrome.View full abstractDownload PDF (2912K) -
SHIGERU TSUCHIYA, TETSUO SATO, SHINGI NAKAE, SHIGERU KATAMINE, TASUKE ...1983 Volume 140 Issue 2 Pages 133-144
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTSUCHIYA, S., SATO, T., NAKAE, S., KATAMINE, S., KONNO, T. and TADA, K. Epstein-Barr Virus-Induced Precursor B Cell Lines from Patients with Congenital Agammaglobulinemia. Tohoku J. exp. Med., 1983, 140 (2), 133-144 - We have established lymphoid cell lines with diversity of immunoglobulin expression by infection of bone marrow cells of four patients with congenital agammaglobulinemia with Epstein-Barr virus. Immunofluorescent study revealed that the cells of many of these lymphoid cell lines had characteristics of possible precursor B cells, permitting classification as follows: 1) cell lines without any surface or cytoplasmic immunoglobulins (17/28 lines), 2) cell lines which had only cytoplasmic μ heavy chains (line K4 and O2), 3) cell lines with both μ and δ heavy chains in the cytoplasm (line O6 and M5), 4) cell lines which bore surface μ chains and possessed cytoplasmic μ chains but lacked light chain expression (line S5), 5) cell lines which had surface and cytoplasmic δ and λ chains, and secreted the immunoglobulins (line K5), and 6) cell lines which had surface IgM and cytoplasmic μ and light chains, and secreted the immunoglobulins (5/28 lines). Biosynthetic studies with 14C-leucine confirmed the patterns of immunoglobulin expression found by immunofluorescent analysis. These cell lines may represent some stages of B cell development and provide useful information on the pathophysiology of congenital agammaglobulinemia.View full abstractDownload PDF (1994K) -
NORIKAZU IRIE, HIROSHI NAGASAKI, RYUICHI NAKAMURA1983 Volume 140 Issue 2 Pages 145-151
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIRIE, N., NAGASAKI, H. and NAKAMURA, R. Motor Reaction Time as a Measure of Rapid Force Generation of a Muscle. Tohoku J. exp. Med., 1983, 140 (2), 145-151 - Motor reaction time (MT) of the vastus medialis, latency from the EMG onset to initiation of the actual movement of the lower leg, was examined for 19 normal subjects during rapid extension of the knee joint at various angles from 90° to 0° in the sitting posture. Muscular tension produced by maximal voluntary contraction (MVC) was measured at 80° of the knee joint for 19 subjects. Also, EMG activities during period of MT were integrated at each angle of the knee for five subjects. MT correlated linearly with the integrated EMG, indicating that MT was a variable representing muscular force required for initiation of the movement. MT increased with extension of the knee and the increment was attributed to the increased effective load of the lower leg due to gravity in the range from 90° to 30° of knee flexion. Thus, MT could be defined solely by the external load against the movement in the mid-range of the joint angle. Moreover, at 80° knee flexion MT did not relate to MVC. It is suggested that MT provides a useful means to evaluate a muscular function in rapid movement and is applicable to both normal and pathological situations.View full abstractDownload PDF (984K) -
AKIRA OHNEDA, TAKASHI KOBAYASHI, JIRO NIHEI1983 Volume 140 Issue 2 Pages 153-159
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHNEDA, A., KOBAYASHI, T. and NIHEI, J. Effects of Ca Antagonists, Nifedipine, Niludipine and Verapamil, on Endocrine Function of the Pancreas. Tohoku J. exp. Med., 1983, 140 (2), 153-159 - To study the effects of two Ca antagonists, nifedipine and niludipine, on insulin and glucagon secretion, experiments were performed using an in situ local circulation of the canine pancreas. The test drugs were injected into the pancreatic artery in three graded doses (5, 10 and 100nmoles/kg) during arginine infusion, and blood samples were taken from the pancreatic vein. Verapamil, 10, 100 and 1, 000nmoles/kg, administered in the same way, was used as a control drug. Nifedipine, 5 to 100nmoles/kg, decreased plasma insulin (IRI) and increased plasma glucagon (IRG) in the pancreatic vein, but caused no marked changes of blood glucose levels in five dogs. Niludipine, 5 to 100nmoles/kg, injected into the pancreatic artery of 5 dogs, did not change blood glucose levels, but decreased slightly plasma IRI in the pancreatic vein and increased plasma IRG. Verapamil administered to 5 dogs caused no remarkable change of blood glucose or plasma IRG but decreased plasma IRI slightly. The maximum secretion of insulin was significantly lowered by nifedipine and niludipine, and that of pancreatic glucagon markedly increased by niludipine. The experiments revealed that Ca antagonists inhibit insulin secretion, and increase glucagon, and proved that calcium plays an important role in the A cell function of the pancreas.View full abstractDownload PDF (775K) -
SHINGI NAKAE, SHIGERU TSUCHIYA, HIDESADA OKUMURA, TASUKE KONNO, KEIYA ...1983 Volume 140 Issue 2 Pages 161-169
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKAE, S., TSUCHIYA, S., OKUMURA, H., KONNO, T. and TADA, K. Ecto-5'-Nucleotidase Activities in Lymphocytes and B Lymphoblastoid Cell Lines from Patients with Congenital Agammaglobulinemia. Tohoku J. exp. Med., 1983, 140 (2), 161-169 - Ecto-5'-nucleotidase (ecto-5'-NT) activity was measured in Epstein-Barn virus (EBV)-induced B lymphoblastoid cell lines (LCL) derived from bone marrow cells and peripheral lymphocytes of four patients with congenital agammaglobulinemia (CAG). In control subjects there was no appreciable difference in the range of ecto-5'-NT activity between immunoglobulin (Ig)-producing B LCL and their peripheral lymphocytes. Though peripheral lymphocytes of the patients showed lower ecto-5'-NT activities than those of control subjects, ecto-5'-NT activities in Ig-producing B LCL from peripheral lymphocytes of the patients fell into the same range as those in B LCL from control subjects. Ecto-5'-NT activities in non-Ig producing precursor B cell lines derived from bone marrow cells of the patients also registered within the range of the enzyme activity of Ig-producing B LCL from control subjects. B LCL from mothers of the patients, who were presumed to be heterozygotes, also had the same range of ecto-5'-NT activity as the control subjects. These results indicate that ecto-5'-NT does not appear to be involved in the pathogenesis of congenital agammaglobulinemia.View full abstractDownload PDF (1007K) -
TAKU KATO, JUN-ICHI FUJIYAMA, OSAMU KUDEKEN, KOTARO OYAMA, YOSHIRO YOS ...1983 Volume 140 Issue 2 Pages 171-180
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKATO, T., FUJIYAMA, J., KUDEKEN, O., OYAMA, K. and YOSHIDA, Y. Aortography by Radial Artery Injection in Infants with Anomalies of the Aortic Arch. Tohoku J. exp. Med., 1983, 140 (2), 171-180 - Aortography .by radial artery injection was performed in 22 infants and one child with congenital heart disease. The left radial artery was used in 20 cases and the right radial artery was used in 3 cases. This method visualized the following aortic arch anomalies: coarctation of the aorta in 4 patients, interrupted aortic arch in one, patent ductus arteriosus in 10, patency of the left Blalock-Taussig shunt in one and anomalous origin of the right subclavian artery in one. An injection of the contrast material into the right radial artery in one case failed to visualize coarctation of the aorta, which was confirmed by retrograde catheterization. Retrograde aortography has been necessary for diagnosis of aortic arch anomalies, but it is not so easy to perform and carries a risk of arterial thrombosis. Aortography by radial artery injection is relatively easy to perform, less invasive and has no severe complications. It is concluded that aortography by radial artery injection is a useful method for diagnosis of anomalies of the aortic arch in neonates and children.View full abstractDownload PDF (6089K) -
KENZO KOBAYASHI, TETSUO ARAKAWA, HAJIME NAKAMURA, SHINJI CHONO, HIROAK ...1983 Volume 140 Issue 2 Pages 181-185
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKOBAYASHI, K., ARAKAWA, T., NAKAMURA, H., CHONO, S., YAMADA, H., SATOH, H, and ONO, T. Effect of Gefarnate on Endogenous Prostacyclin, Prostaglandin E2 and Thromboxane in Water-Immersed Rats. Tohoku J. exp. Med., 1983, 140 (2), 181-185 - The level of endogenous prostacyclin (PGI2), prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) in rat gastric mucosa was determined by radioimmunoassay to examine whether gefarnate, an antiulcer agent, maintained the endogenous prostaglandin (PG) level in rats subjected to water-immersion stress. Seven-hr immersion induced gastric lesions and a marked reduction in PGI2 and PGE2. When gefarnate was injected subcutaneously before stress exposure, the mean ulcer index was reduced and the PGI2 and PGE2 levels were maintained. Our results suggest that the reduction of endogenous PGI2 and PGE2 is a major factor in water-immersion-induced ulcers in rats, and that gefarnate inhibits this ulcer formation by inhibiting a reduction in those PGs induced by water-immersion stress.View full abstractDownload PDF (558K) -
MINEO IWASA, TSUYOSHI YOKOI, KAORU SAGISAKA1983 Volume 140 Issue 2 Pages 187-192
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIWASA, M., YOKOI, T. and SAGISAKA, K. Individual Difference of Seminal Plasma Detected with Crossed Immunoelectrophoresis. Tohoku J. exp. Med., 1983, 140 (2), 187-192 - Seminal plasma from 120 subjects was examined by crossed immunoelectrophoresis using anti-seminal plasma. The samples were divided into two groups depending on a precipitation line which migrated fast in the first dimension electrophoresis. This precipitation line showed an incidence of 48 percent and was proved to have no acid phosphatase, esterase or lactate dehydrogenase activity and was not stained with Schiff's reagent. Analysis with column chromatography, Sephadex G-200 and Sephadex G-50, revealed that molecular weight of the protein was about 10, 000 dolton. The difference was not identified with the other methods; polyacrylamide gel electrophoresis and agarose immunoelectrophoresis.View full abstractDownload PDF (2764K) -
RYOZO KIMURA1983 Volume 140 Issue 2 Pages 193-196
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSKIMURA, R. Fluorescein Gonioangiography of Newly Formed Vessels in the Anterior Chamber Angle. Tohoku J. exp. Med., 1983, 140 (2), 193-196 -Fluorescein gonioangiography was performed in 20 eyes of 20 patients with various ocular disorders such as diabetic retinopathy, retinal vessel occlusion, traumatic angle recession, and granulomatous uveitis. It was clearly demonstrated that newly formed vessels in the anterior chamber angle originated from the ciliary body, and extended predominatingly onto the surface of the angle wall via ciliary body band.View full abstractDownload PDF (3447K) -
HIROMICHI OHKAWA1983 Volume 140 Issue 2 Pages 197-207
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHKAWA, H. Properties of the Inhibitory Junction Potentials Recorded from Smooth Muscle Cells of the Guinea-Pig Duodenum. Tohoku J. exp. Med., 1983, 140 (2), 197-207 - Inhibitory junction potentials (IJPs) in response to single or repetitive stimulation were recorded intracellularly from smooth muscles of the guinea-pig duodenum. The amplitude of the IJP was dependent on the stimulus intensity and duration. The hyperpolarization of up to 30mV was evoked by a single pulse. The mean values of the latency, the fall time, the rate of hyperpolarization, the half decay time and the time constant for decay of the IJPs evoked by 0.3msec stimulation were 67msec, 130msec, 86mV/ sec, 156msec and 194msec, respectively. The latency and the half decay time were slightly decreased by changes in the stimulus intensity and duration. When repetitive stimulation was applied at low frequencies, successive IJPs were evoked but their amplitudes were decreased gradually. The maximum amplitude of the hyperpolarization was increased with increasing the frequency of stimulation over than 10Hz. The spike activity due to rebound excitation was potentiated at high frequency. Over 90% of the cells exhibited only the IJP without atropinization. The excitatory junction potentials and the complex type in response to a brief pulse were recorded from a few cells. These results suggest the predominant nonadrenergic inhibition on the duodenal smooth muscles.View full abstractDownload PDF (955K) -
HIROMICHI OHKAWA1983 Volume 140 Issue 2 Pages 209-219
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOHKAWA, H. Inhibitory Junction Potentials of the Guinea-Pig Duodenum in the Treatment with Catecholamines. Tohoku J. exp. Med., 1983, 140 (2), 209-219 - The inhibitory junction potentials (IJPs) in response to single and repetitive stimulation were recorded from the smooth muscle cells of the guinea-pig duodenum intracellularly. In adrenaline and noradrenaline (10-8-10-5g/ml), the IJP could be evoked in spite of a hyperpolarization of the cell membrane. The amplitude of the IJP was slightly changed in these agents but not abolished. Similar results were obtained in isoprenaline (10-5g/ml) and phenylephrine (10-5g/ml). The IJPs evoked by single and repetitive stimulation were not blocked by phentolamine (10-7g/ml) and propranolol (10-5g/ml). In propranolol (10-7-10-5/g/ml), the membrane was depolarized and the amplitude and the rate of hyperpolarization in the IJP were decreased. The membrane potential was decreased and the amplitude of the IJP was slightly increased in the presence of guanethidine (10-5g/ml). The amplitude of the IJP was increased with increasing the concentration of tyramine (10-6-10-5g/ml). These results suggest that the transmitter released from the intramural inhibitory nerve in the duodenum is nonadrenergic and this type of inhibition seems to be independent from adrenergic inhibition.View full abstractDownload PDF (1034K) -
NAOFUMI IWATSUKI, YOSHIHISA KOGA, KEISUKE AMAHA1983 Volume 140 Issue 2 Pages 221-222
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIWATSUKI, N., KOGA, Y. and AMAHA, K. Enflurane Induces Contracture of in Vitro Muscle from a Patient with Malignant Hyperthermia. Tohoku J. exp. Med., 1983, 140 (2), 221-222 - The possibility of enflurane being an inducer of malignant hyperthermia (MH) was examined by using the contracture test in in vitro muscle from a patient with MH. An administration of 2% enflurane elicited contracture in MH muscle and an elimination of enflurane relaxed this contracture. This result, therefore, strongly suggested that enflurane is the one of the trigger-agents for MH.View full abstractDownload PDF (195K) -
OSAMU NISHIZAWA, ITARU MORIYA, SADAMOTO SATOH, TADASHI HARADA, SEIGI T ...1983 Volume 140 Issue 2 Pages 223-224
Published: 1983
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNISHIZAWA, O., MORIYA, I., SATOH, S., HARADA, T. and TSUCHIDA, S. Effect of Verapamil on the Lower Urinary Tract. Tohoku J. exp. Med. 1983, 140 (2), 223-224 - The effect of verapamil on the in-vivo bladder and urethra was investigated in female dogs. The bladder and urethral pressure responses to electrical stimulation of the pelvic and hypogastric nerves were decreased by verapamil.View full abstractDownload PDF (182K)
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