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Volume 153 (1987)
- Issue 4 Pages 285-
- Issue 3 Pages 179-
- Issue 2 Pages 79-
- Issue 1 Pages 1-
Volume 153, Issue 2
Displaying 1-11 of 11 articles from this issue
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TADASHI IGARI, MASAO TSUCHIZAWA, TADASHI SHIMAMURA1987 Volume 153 Issue 2 Pages 79-86
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIGARI, T., TSUCHIZAWA, M. and SHIMAMURA, T. Alteration of Tryptophan Metabolism in the Synovial Fluid of Patients with Rheumatoid Arthritis and Osteoarthritis. Tohoku J. exp. Med., 1987, 153 (2), 79-86-Tryptophan, its metabolites and related enzyme activity in synovial fluid, blood and urine in patients with rheumatoid arthritis (RA) and osteoarthritis (OA) were measured. The levels of tryptophan, kynurenine and anthranilic acid in the synovial fluid higher in RA were than in OA, whereas the xanthurenic acid level was equal in RA and OA. Indoleamine 2, 3-dioxygenase activity in the synovial membrane was higher in RA than in OA. 5-Hydroxytryptamine (5-HT) levels in the Synovial fluid and the blood and the 5-hydroxyindole acetic acid (5-HIAA) level in the Synovial fluid were essentially the same for both diseases. However, the 5-HIAA level in the serum of RA patients was higher than in those with OA, and the 5-HIAA level in the urine of RA patients was lower than in those with OA. In addition, monoamine oxidase-A and B activity in the Synovial fluid of RA patients was decreased than in those with OA. These findings suggest that metabolism of tryptophan is altered in patients with RA.View full abstractDownload PDF (565K) -
SHINICHI OKUYAMA, HITOSHI MISHINA1987 Volume 153 Issue 2 Pages 87-102
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSOKUYAMA, S. and MISHINA, H. Fanconi's Anemia as a Nature's Evolutionary Experiment on Carcinogenesis. Tohoku J. exp. Med., 1987, 153 (2), 87-102 -In order to obtain insights into the possible carcinogenetic mechanisms, the cancer incidence of Fanconi's anemia (FA) was surveyed in the literature, and the results were compared with those of other cancer-prone diseases of chromosomal breakage, and primary and secondary immunodeficiency syndromes along with an appropriate control population. With FA, there were 43% of leukemias but no lymphomatous diseases. Epithelial tumors consisting of hepatomas and squamous cell carcinomas were 17 and 38%, respectively. Their age distribution was 14.5± 6.7 years of age for leukemias; 18.5±9.3 for hepatomas and 23.8±6.9 for squamous cell carcinomas. Putting aside the hepatomas which may be iatrogenic, the neoplastic trend here again is to show the non-epithelial-epithelial tumor shift (Okuyama and Mishina 1986). Fanconi's anemia can thus be one of the chromosomal breakage syndromes whose leukemogenic and carcinogenetic processes are amplified by an increased DNA damage, NK cell depletion, and IgA deficiency as the result of deficient Cu, Zn-SOD and increased suerpoxide toxicity.View full abstractDownload PDF (1632K) -
Differential Polycythemia: A Comparative Study between Spurious Polycythemia and Pure ErythrocytosisYUKITAKA FUKUSHIMA, MITSUYUKI FUKUDA, TOHRU TAKAHASHI, KOSAKU YOSHIDA, ...1987 Volume 153 Issue 2 Pages 103-110
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSFUKUSHIMA, Y., FUKUDA, M., TAKAHASHI, T., YOSHIDA, K. and MIURA, A.B. Differential Polycythemia: A Comparative Study between Spurious Polycythemia and Pure Erythrocytosis. Tohoku J. exp. Med., 1987, 153 (2), 103-110-The definite differential diagnosis between spurious polycythemia (SP) and pure erythrocytosis (PE) was tested. Serum erythropoietin (EPO) levels in 6 patients with PE were 12.8±3.7mU/ml and were significantly lower than those of both 19 normal controls (28.5±15.0mU/ml) and 9 patients with SP (21.3±10.2mU/ml). Three of 11 patients with SP and 1 of 3 patients with PE had significantly higher marrow erythroid progenitor cells (CFU-Es) than those of the normal controls. Spontaneous CFU-E growth (CFU-E growth in the absence of added EPO) was found in 4 of 11 patients with SP, 1 of 3 patients with PE, and all patients with polycythemia vera. However, the number of spontaneous CFU-E was low in SP and PE. The measurements of serum EPO levels and CFU-E growth did not provide differentiation between PE and SP. Even if some patients, whose total red cell volumes are either higher than 12.5% above the mean predicted values or their CFU-E growth is great, are diagnosed as SP, consideration should be made that they might, in fact, have PE.View full abstractDownload PDF (741K) -
NSIALA MBAKI, NAOTO RIKITOMI, TSUYOSHI NAGATAKE, KEIZO MATSUMOTO1987 Volume 153 Issue 2 Pages 111-121
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMBAKI, N., RIKITOMI N., NAGATAKE T. and MATSUMOTO, K. Correlation between Branhamella catarrhalis Adherence to Oropharyngeal Cells and Seasonal Incidence of Lower Respiratory Tract Infections. Tohoku J. exp. Med., 1987, 153 (2), 111-121-Bacterial colonization of the oropharynx is the initial event in most lower respiratory tract infections. To study the role of bacterial adherence in lower respiratory tract infections caused by Branhamella catarrhalis (B. catarrhalis) in winter, in vitro adherence assays of the organism to human oropharyngeal cells were carried out in winter, spring, summer and autumn. A total of 57 adults of both sexes were studied from January to December 1985. Forty eight persons of 57 had chronic pulmonary diseases and the remaining 9 persons had other clinical entities and served as the control group. Predominance of lower respiratory tract infections caused by B. catarrhalis with high adherence rate was observed in winter. Adherence activity was moderate in spring and autumn and low in summer and accompanied by a similar incidence of lower respiratory tract infections with this bacteria. In addition, similar results were found in patients in whom investigations were done successively in the above four seasons. Bacterial adherence activity to cells however, was weak in winter in the control group. These results indicate that seasonal variation plays a significant role in the ability of B. catarrhalis to adhere to oropharyngeal cells. This is an important pathogenic factor correlated with the incidence of lower.respiratory tract infections in these patients.View full abstractDownload PDF (3215K) -
KUNITOSHI NAKAGAWA, KIYOAKI OUCHI, SHUJI MATSUBARA, LUIS HASHIMOTO, YO ...1987 Volume 153 Issue 2 Pages 123-132
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKAGAWA, K., OUCHI, K., MATSUBARA, S., HASHIMOTO, L. and YAJIMA, Y. The Significance of Activation of Reticuloendothelial Function on Hepatectomy. Tohoku J. exp. Med., 1987, 153 (2), 123-132-The prognosis of patients after massive hepatectomy is poor in certain cases whose hepatic reserve, including reticuloendothelial function, is deteriorated. We administered OK-432 before 70% hepatectomy on rats to activate the reticuloendothelial function and studied its effect on postoperative course. The elevations in plasma endotoxin, GOT and GTP were attenuated, and the deterioration of the complement activity after hepatectomy was greatly improved by OK-432 treatment. The RNA content in the liver was significantly increased by OK-432 administration. These findings suggest that activation of the reticuloendothelial function at the time of massive hepatectomy enhances endotoxin clearance from blood and thereby contributes in lessening the magnitude of hepatic injury, maintaining the serum complement, and improving liver protein synthesis.View full abstractDownload PDF (806K) -
KUNITOSHI NAKAGAWA, KIYOAKI OUCHI, SHUJI MATSUBARA, LUIS HASHIMOTO, YO ...1987 Volume 153 Issue 2 Pages 133-136
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSNAKAGAWA, K., OUCHI, K., MATSUBARA, S., HASHIMOTO, L. and YAJIMA, Y. Activation of Reticuloendothelial Function for Prevention of Endotoxemia after Hepatectomy in Cirrhotic Patients. Tohoku J. exp. Med., 1987, 153 (2), 133-136 -In order to prevent endotoxemia after hepatectomy in cirrhotic patients, we administered OK-432 before and after hepatectomy to activate the reticuloendothelial function and studied its effect on postoperative endotoxemia. In the cirrhotic group without OK-432 administration (7 patients), the value of endotoxin increased significantly after hepatectomy, compared to the cirrhotic group which received OK-432 administration (5 patients) and the non-cirrhotic group (12 patients), and the endotoxin level was still higher than the preoperative value even on the 14th day. On the other hand, the cirrhotic group with OK-432 administration and the non-cirrhotic group showed minimal increases of endotoxin levels at the first day, which returned to the preoperative values at the third day. Base on these findings, it is suggested that activation of the reticuloendothelial function bears substantial significance as one of the therapeutic modalities for prevention of endotoxemia after hepatectomy in cirrhotic patients.View full abstractDownload PDF (311K) -
KAZUO TAKADA, KEIJI TAKAHASHI, SHINOBU SATO, SHOJI YASUI1987 Volume 153 Issue 2 Pages 137-144
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKADA, K., TAKAHASHI, K., SATO, S. and YASUI, S. Cigarette Smoke Modifies Bleomycin-Induced Lung Injury to Produce Lung Emphysema. Tohoku J. exp. Med., 1987, 153 (2), 137-144-The effect of cigarette smoke exposure on the development of bleomycin (BLM)-induced pulmonary fibrosis was studied. Hamsters 3 weeks of age were divided into four groups, control (C), BLM treated (B), cigarette smoke exposure (T), and cigarette smoke plus BLM (TB). Cigarette smoke exposure was started 5 days after the beginning of feeding in a desiccator which received a flow of smoke. A single intratracheal dose of 0.5mg of BLM per 100g body weight was administered 30 days after feeding. Sixty days after feeding the animals were killed for measurement of pressure-volume (P-V) relationships and microscopic observations. At 60 days the deflation P-V curves in B and TB were shifted significantly downward and to the right of that of C and T, respectively. P-V curves in TB were shifted significantly upward and to the left of that of B, almost returning to that of C. Light-microscopic examination showed no evidence of emphysema in the lung of T. In contrast, in the lung of TB there were destruction of the alveolar walls, varying degrees of enlargement of alveolar spaces and fibrous thickening of the alveolar septa. These results suggest that BLM-induced lung injury may be modified by cigarette smoke to produce lung emphysema.View full abstractDownload PDF (1143K) -
HISAYA TADA, SHOICHI TAKEUCHI, MASATO TAKAGI, SHO ISOGAI1987 Volume 153 Issue 2 Pages 145-150
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTADA, H., TAKEUCHI, S., TAKAGI, M. and ISOGAI, S. The Effect of Glycemic Control on Plasma Soluble Fibrin Monomer Complexes and Fibronectin in Diabetic Patients. Tohoku J. exp. Med., 1987, 153 (2), 145-150-We have shown previously that increased concentrations of plasma soluble fibrin monomer complexes (SFMC) and elevated fibronectin (Fn) levels are closely related to the development of diabetic microangiopathy. The purpose of the present study was to explore whether or not changes in plasma glucose levels could have an effect on these protein constituents. Plasma glucose levels of 25 uncontrolled diabetic patients were brought under control with insulin and serial measurements of SFMC and Fn were made over a period of 4 weeks. Glucose values fell from an average of 312mg/100ml to 160mg/100ml. Ten patients with macroproteinuria (i.e.≥ 0.5g/24hr) showed initially elevated plasma SFMC and Fn concentrations. These levels fell significantly over the 4 week observation period: from 13.6mg/100ml to 9.4mg/100ml for SFMC and from 38.4mg/100ml to 34.5mg/100ml for Fn. The remaining 15 patients had nearly normal levels of both SFMC (7.9mg/100ml) and Fn (31.1mg/100ml) and glycemic control brought no further reduction. The data indicated that a) elevated SFMC and Fn levels are indeed associated with diabetic microangiopathy, especially in the presence of macroproteinuria; and b) adequate glycemic control is capable of normalizing the plasma concentration of these constituents.View full abstractDownload PDF (535K) -
HIROSHI SATO, MASAYUKI ITO, TATSUYA ABE, NOBUKO KUMANO, MASAKICHI MOTO ...1987 Volume 153 Issue 2 Pages 151-160
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSATO, H., ITO, M., ABE, T., KUMANO, N., MOTOMIYA, M. and KONNO, K. Antitumor Activity of Cyclophosphamide and Lipopolysaccharide in Tumor-Bearing Mice Pretreated with BCG. Tohoku J. exp. Med., 1987, 153 (2), 151-160 -Antitumor effects of cyclophosphamide (CY) and lipopolysaccharide (LPS) were investigated in BCG-treated mice. C3H/He mice and CDF1 mice were injected with BCG and were inoculated subcutaneously with syngeneic mouse hepatoma and mastocytoma P815 respectively. A subsequent injection of LPS caused hemorrhagic necrosis and retarded growth of tumor. When mice were treated with LPS plus suboptimal dose of CY, tumor growth was retarded and survival time was prolonged. The antitumor effects were more remarkable when mice were treated with CY prior to the injection of LPS. Without BCG pretreatment, LPS showed no antitumor activity in mice. Sera from mice treated with BCG plus PLS was cytotoxic for cultured tumor cells. However treatment of mice with CY did not increase the in vitro cytotoxicity. In this experimental condition, CY had no effect on delayed type hypersensitivity when evaluated by the footpad reaction to purified protein derivative (PPD). These results seem to indicate that the antitumor effects of the treatment with CY and LPS in BCG-treated mice are mediated by the reduction of tumor burden by CY and a serum factor induced by LPS.View full abstractDownload PDF (911K) -
KEIKO TANAKA, MASAMI TANAKA, TADASHI MIYATAKE, AKIO YAMAMOTO, KOZO KUR ...1987 Volume 153 Issue 2 Pages 161-167
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTANAKA, K., TANAKA, M., MIYATAKE, T., YAMAMOTO, A., KURAHASHI, K. and MATSUNAGA, M. Antibodies to Brain Proteins in a Patient with Subacute Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome. Tohoku J. exp. Med., 1987, 153 (2), 161-167-The serum IgG of a 50-year-old woman with lung cancer associated with subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome showed the antibody activity to rat brain proteins. Using an immunoblotting method, the patient serum reacted with 98kDa neutral cytoplasmic protein and 68kDa membrane protein. These proteins were different in molecular weight from those we described previously (Tanaka et al. 1986), which suggests that proteins reacting with serum antibody are variable individually among patients with subacute cerebellar degeneration. These proteins from human brain could not be stained by the patient's serum IgG since these antigen proteins needed to be prepared quickly after death under protease inhibitors and were thought to be easily degraded.View full abstractDownload PDF (1230K) -
MORIO AIHARA, IKUO KUDO, HIROSHI ISHIGAKI, KAORU UENO, YOSHIHIKO SAWAD ...1987 Volume 153 Issue 2 Pages 169-177
Published: 1987
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAIHARA, M., KUDO, I., ISHIGAKI, H., UENO, K., SAWADA, Y., YOSHIDA, Y., COOPER, H.A. & WAGNER, R.H. Two Affinity Immunoelectrophoretic Methods for Studying Collagen Interaction with von Willebrand Factor Antigen. Tohoku J. exp. Med., 1987, 153 (2), 169-177-Two new immunoelectrophoretic methods are described for studying the interaction of collagen fibrils with von Willebrand factor antigen (vWF:Ag). In the first, the sample was electrophoresed through a collagen-agarose wedge into an antibody-agarose area, and immunoprecipitin lines was detected by staining. Different immunoprecipitin patterns were obtained with the vWF:Ag of normal plasma, commercial FVIII preparations, and von Willebrand disease (vWD) type ha plasma as the result of collagen binding of vWF:Ag. In the other method, the sample was electrophoresed into agarose for preliminary separation of forms, followed by migration in the second dimension through a collagen spacer gel into an antibody-agarose area. This method demonstrated preferential binding of high molecular weight forms of vWF:Ag in normal plasma and slight binding of the lower molecular weight forms of antigen found in vWD type ha plasma. The affinity wedge method is a convenient general method for finding quickly a useful concentration of affinity reagent.View full abstractDownload PDF (2061K)
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