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Volume 176 (1995)
- Issue 4 Pages 191-
- Issue 3 Pages 131-
- Issue 2 Pages 69-
- Issue 1 Pages 1-
Volume 176, Issue 1
Displaying 1-7 of 7 articles from this issue
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YUTAKA IMAI1995 Volume 176 Issue 1 Pages 1-15
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSIMAI, Y. Clinical Significance and Cost-Effectiveness of 24-hour Ambulatory Blood Pressure Monitoring. Tohoku J. Exp. Med., 1995, 176 (1), 1-15-Ambulatory blood pressure (BP) monitoring as an adjunct to casual/clinic BP measurements is currently used widely for the diagnosis and treatment of hypertension. It has been established that ambulatory BP monitoring is essential to confirm “white coat” hypertension, drug-resistant hypertension, duration of drug action, short-term BP variation, and nocturnal and on-the-job BP levels. It is estimated that approximately 10, 000 ambulatory BP monitoring devices are currently used in Japan. That number would increase if 1) a standard algorithm with a theoretical basis to determine BP levels is introduced for ambulatory BP monitoring devices based on cuff-oscillometric method, 2) the reproducibility of ambulatory BP levels is confirmed, 3) refernce values for evaluating ambulatory BP monitoring levels are established, and 4) the clinical significance and prognostic value of ambulatory BP monitoring is established. If such problems is settled, the use of ambulatory BP monitoring in the diagnosis and treatment of hypertension would be national health insurance and would improve the prognostic accuracy of evaluating hypertension as well as the cost-effectiveness of screening, diagnosis and treatment of hypertension.View full abstractDownload PDF (1800K) -
KISHORE KUMAR BANERJEE, ANUPAM BISHAYEE, MALAY CHATTERJEE1995 Volume 176 Issue 1 Pages 17-24
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSBANERJEE, K.K., BISHAYEE, A. and CHATTERJEE, M. Effects of Human Placental Extract on Brain Monoamines and Monoamine Oxidase Activity in Rats. Tohoku J. Exp. Med., 1995, 176 (1), 17-24-Human placental extract, an agent clinically used world-wide in a number of physiological anomalies, has been claimed to be effective in children of slow learners. Since the monoaminergic neurotransmitter systems in the brain play an important role in the processes of learning and memory, we examined the effects of human placental extract on the levels of norepinephrine, dopamine and serotonine in rat brain as an attempt to evaluate the possible underlying biochemical mechanism of action of the extract. We also determined the changes of brain monoamine oxidase (MAO) activity following placental extract treatment. The results showed that subchronic (5, 10, 15 or 20) administration of placental extract (2-4ml/kg/day) had the effect of increasing all the monoamines and decreasing the MAO activity which could be the possible mode of action of the extract in slow learners.View full abstractDownload PDF (890K) -
AKIRA WATANABE, KOTARO OIZUMI, MASAKICHI MOTOMIYA, TOSHIHIRO NUKIWA1995 Volume 176 Issue 1 Pages 25-33
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSWATANABE, A., OIZUMI, K., MOTOMIYA, M. and NUKIWA, T. Daily Single-Dose Regimen and Alternate-Two-Week Triple-Dose/Day Regimen of Oral Ofloxacin for the Prophylaxis and Control of Exacerbations of Chronic Respiratory Tract Infections. Tohoku J. Exp. Med., 1995, 176 (1), 25-33-Two different oral ofloxacin regimens, a daily single-dose regimen with 200mg (Regimen I) and an every-two-week multidose regimen with 3×200mg/day (Regimen II) was compared as to the efficacy in controlling repeated acute exacerbations of chronic respiratory tract infections. Fifty-eight patients consisting of 19 patients each of bronchiectasis and pulmonary emphysema, 10 patients of chronic bronchitis, 5 patients of old pulmonary tuberculosis, 4 patients of diffuse panbronchiolitis and 1 patient of multiple pulmonary bullae were evaluated: 32 patients in Regimen I and 26 patients in Regimen II. The corrected mean incidence of exacerbations per case decreased from pre-study 2.47 to intra-study 0.59 in Regimen I, and from pre-study 2.66 to intra-study 0.95 in Regimen II, respectively, with a statistically significant difference (p<0.05, respectively). Only one of 12 persistent isolates of Pseudomonas aeruginosa acquired a certain degree of resistance to ofloxacin. Adverse reactions were found in six of 66 patients. We conclude that long-term administration of an new-quinolone, especially a daily single-dose regimen with ofloxacin, is useful to control acute exacerbations of chronic repiratory tract infections.View full abstractDownload PDF (816K) -
TAKEHIKO SUGITA, YASUHIRO MATSUMURA, JUTARO UMEHARA, MINORU SAKURAI1995 Volume 176 Issue 1 Pages 35-44
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSUGITA, T., MATSUMURA, Y., UMEHARA, J. and SAKURAI, M. Proximal Tibiofibular Joint: A Radiographic and Computed Tomographic Study. Tohoku J. Exp. Med., 1995, 176 (1), 35-44-In 671 knees of 351 patients, the proximal tibiofibular joint was radiologically investigated. To clearly detect the contour of the joint, radiographs were obtained under fluoroscopic control with the lower extremity internally rotated. The contour was classified into three types: the joint lines of both tibia and fibula are straight (A); the joint line of the fibula is convex (B); the joint line of the tibia is convex (C). The rotation and the inclination of the joint were measured. Of the 671 knees, CT examination was also carried out in 51 knees. The obliquity of the joint was measured and the location of the fibula as related to the tibia was evaluated by CT. We also examined the relationships between the contour and the rotation, inclination, obliquity of the joint and the location of the fibula, and determined the characteristics of type B and C as compared with type A. The characteristics of type B were as follows: (1) this type was mainly seen in younger patients, (2) the rotation was the lowest and the inclination was the highest among the three types, (3) in CT the joint line was more saggital and the fibula was located more anteriorly. The characteristics of type C were as follows: (1) this type was seen in older patients, (2) the rotation was the highest and the inclination was the lowest among the three types, (3) in CT the joint line was more frontal and the fibula was located more posteriorly.View full abstractDownload PDF (2561K) -
HIROYOSHI AYABE, YUTAKA TAGAWA, HIROHARU TSUJI, TADAYUKI OKA, SHINSUKE ...1995 Volume 176 Issue 1 Pages 45-52
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAYABE, H., TAGAWA, Y., TSUJI, H., OKA, T., HARA, S., KAWAHARA, K. and TOMITA, M. Regional Lung Function Following Upper Sleeve Lobectomy for Bronchogenic Carcinoma. Tohoku J. Exp. Med., 1995, 176 (1), 45-52- Regional lung function of the operated side following upper sleeve lobectomy (n= 8) and simple upper lobectomy (n=7) for lung cancer was evaluated. Regional ventilation was studied with Krypton 81m and regional pulmonary blood flow was studied with Technetium 99m. Measurements were taken from 12 to 24 months after operation. The ventilation rate of the operated side following right upper sleeve lobectomy (n=5) was 42.9±6.7% and the perfusion rate was 37.4±4.6%. The regional ventilation rate of the operated side after simple right upper lobectomy (n=3) was 45.9±10.5% and the perfusion rate was 46.2±5.2%. For the patients with left upper sleeve lobectomy (n=3), these ratios were 29.9±11.1% and 19.2±3.6%, respectively. For the patients with simple left upper lobectomy (n=4), these ratios were 27.3±4.5% and 22.3±3.3%. There were no stastical differences between the group with upper sleeve lobectomy and that with simple upper lobectomy. Regional function improved gradually with time. In conclusion, the regional lung function of the operated side following sleeve lobectomy was well preserved and showed no difference when compared with the regional function after simple lobectomy for lung cancer.View full abstractDownload PDF (960K) -
CHIKASHI SHIBATA, IWAO SASAKI, HIROO NAITO, MICHINAGA TAKAHASHI, TAKAS ...1995 Volume 176 Issue 1 Pages 53-60
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSHIBATA, C., SASAKI, I., NAITO, H., TAKAHASHI, M., DOI, T., OHTANI, N., KOYAMA, K. and MATSUNO, S. Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs. Tohoku J. Exp. Med., 1995, 176 (1), 53-60 -The aim of the present study was to investigate the effect of motilin at various doses on colonic motility in the interdigestive state. Colonic motility was investigated in five dogs equipped with strain gauge force transducers on the gastric antrum, and on the proximal, middle, and distal colon. Exogenously infused motilin (0.2, 0.5, 1.0 and 2.0μg/kg-hr) dose-dependently increased colonic motility, but the doses of motilin that significantly enhanced colonic motility were 1.0 and 2.0μg/kg-hr in all areas of the colon. Motilin at 0.2μg/kg-hr increased the plasma motilin concentration to almost equal to the physiological peak values. The excitatory effect of motilin (2.0μg/kg-hr) was abolished by atropine but was not affected by hexamethonium. These results indicate that exogenously infused motilin, which increased plasma motilin concenration to above the physiological peak level, stimulated colonic motility by affecting postsynaptic cholinergic neurons.View full abstractDownload PDF (743K) -
SHUNJI ISHIWATA, KUNIHIKO ITOH, TAKAHUMI YAMAGUCHI, NAKAO ISHIDA, MICH ...1995 Volume 176 Issue 1 Pages 61-68
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSISHIWATA, S., ITOH, K., YAMAGUCHI, T., ISHIDA, N. and MIZUGAKI, M. Comparison of Serum and Urinary Levels of Modified Nucleoside, 1- Methyladenosine, in Cancer Patients Using a Monoclonal Antibody-Based Inhibition ELISA. Tohoku J. Exp. Med., 1995, 176(1), 61-68-To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3, 3', 5, 5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The second blocking was done just before the addition of the secondary antibody. The standard curve of the modified ELISA system showed good linearity between 1 and 1, 000ng/ml, and the detection limit was 50pg/well. Using the ultrafiltrated- serum samples, serum 1-methyladenosine levels in healthy individuals and cancer patients were determined. The mean level of 1-methyladenosine in 31 healthy individuals was 28.3±7.9ng/ml, and cut off value was set at 44.1ng/ml (Mean+ 2SD). In cancer patients, elevated levels of serum 1-methyladenosine above the cut off value were detected in 4 out of 25 cases tested, though 11 cases had elevated urinary 1-methyladenosine levels above the cut off value (3.23nmol/μmol reatinine). Since 1-methyladenosine has no interaction with serum proteins and its molecular weight is quite low, it might be rapidly excreted into the urine.View full abstractDownload PDF (807K)
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