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Volume 177 (1995)
- Issue 4 Pages 271-
- Issue 3 Pages 183-
- Issue 2 Pages 93-
- Issue 1 Pages 1-
Volume 177, Issue 2
Displaying 1-9 of 9 articles from this issue
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KEI MUNAKATA, KUNIO SHIRATO, KEN ISHIKAWA, MASAHITO SAKUMA, MASAHARU K ...1995 Volume 177 Issue 2 Pages 93-106
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSMUNAKATA, K., SHIRATO, K., ISHIKAWA, K., SAKUMA, M., KANAZAWA, M., HANEDA, T. and TAKISHIMA, T. Significance of the Right Ventricular Free Wall in Dogs with and without Pulmonary Constriction. Tohoku J. Exp. Med., 1995, 177 (2), 93-106-To evaluate the role of the right ventricular (RV) free wall in cardiac function, RV and left ventricular (LV) wall segment lengths were measured by ultrasonic crystals in 10 open chest dogs with the pericardium preserved. Right coronary artery (RCA) was perfused separately by own blood and the flow was reduced stepwise until active shortening (ΔL) of the RV segment disappeared or RCA flow became zero (Ischemia). The experiment was repeated with and without pulmonary stenosis (PS). At Ischemia, RV and LV systolic pressures decreased. RV end-diastolic length increased and RVΔL decreased. LV end- diastolic length and LVΔL were reduced. LV stroke volume concurrently fell. These changes became more prominant with PS. The critical level of RCA flow, at which RVΔL began to change, was higher with PS (5.27±2.85ml/min, mean± S.D.) than without PS (1.44±1.16, p<0.01). Based on the relationships between RVΔL and percent changes in RV developed pressure and stroke volume, the degree of the decreases in RV developed pressure and stroke volume at RVΔL of zero were estimated to be about 20%. These results indicate that the RV free wall partly contributes to maintaining the RV function, especially during RV pressure overload.-critical coronary flow; pressure load; right ventricular function; stroke volumeView full abstractDownload PDF (1527K) -
KENJI HARADA, YASUSHI TAKAHASHI, TERUKAZU SHIOTA, HIROO NOGUCHI, GORO ...1995 Volume 177 Issue 2 Pages 107-115
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHARADA, K., TAKAHASHI, Y., SHIOTA, T., NOGUCHI, H. and TAKADA, G. Left Ventricular Regional Wall Motion in the Early Neonatal Period. Tohoku. J. Exp. Med., 1995, 177 (2), 107-115-To investigate the changes in regional wall motion of the left ventricle in the early neonatal period, serial echocardiography was performed in normal neonates at 2 and 120hr after birth. Quantitative analysis of the regional wall motion was performed by the centerline method. We measured right ventricular systolic time intervals, left ventricular stroke volume, flow velocity-time integral of the pulmonary artery, and size of the ductus arteriosus. The ductus arteriosus was 4.5±0.5mm at 2hr but was closed in all subjects by 120hr. At 2hr, there was hyperkinesis of the interventricular septum which disappeared by 120hr. The right ventricular systolic time intervals at 2hr showed a sign of pulmonary hypertension. At 2hr, the left ventricular stroke volume was at the highest level and the flow velocity-time intervals of pulmonary artery was at the lowest level. Thus the hyperkinesis of the interventricular septum at 2hr might reflect the circulatory changes that are characteristic of the early neonatal period.-echocardiography; neonate; left ventricular wall motionView full abstractDownload PDF (907K) -
TSUTOMU TAKAHASHI, MARIKO SUCHI, WATARU SATO, SVETLANA B. TEN, NORIO S ...1995 Volume 177 Issue 2 Pages 117-123
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSTAKAHASHI, T., SUCHI, M., SATO, W., TEN, S.B., SAKURAGAWA, N., DESNICK, R.J., SCHUCHMAN, E.H. and TAKADA, G. Identification and Expression of a Missense Mutation (Y446C) in the Acid Sphingomyelinase Gene from a Japanese Patient with Type A Niemann-Pick Disease. Tohoku J. Exp. Med., 1995, 177 (2), 117-123-Types A and B Niemann-Pick disease (NPD), an autosomal recessive lysosomal storage disorder, are caused by deficiency of acid sphingomyelinase (ASM). The recent identification of mutations in ASM gene causing types A and B NPD has led to the investigation of the phenotypic heterogeneity and the ethnic distribution of this disease, especially in Ashkenazi Jewish population. To characterize the mutations causing NPD in Japanese population, we analyzed the genomic sequence of ASM from a Japanese patient with type A NPD by PCR amplification and sequencing. A new mutation, Y446C, was identified. The authenticity of this lesion was demonstrated by the expression of the Y446C allele in COS-1 cells. No residual ASM activity was detected from the expression of the Y446C.-type A Niemann-Pick disease; acid sphingomyelinase gene mutationView full abstractDownload PDF (1391K) -
HIDEYUKI HONDA, JUNJI TANI, TOHRU MIYAZAKI, YOSHIRO KOIWA, TAMOTSU TAK ...1995 Volume 177 Issue 2 Pages 125-137
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSHONDA, H., TANI, J., MIYAZAKI, T., KOIWA, Y., TAKISHIMA T. and SHIRATO, K. Increased Regional Systolic Myocardial Stiffness of the Left Ventricle during Coronary Artery Occlusion in a Dog: Analysis of the Finite Element Model. Tohoku J. Exp. Med., 1995, 177 (2), 125-137-(1) We measured the instantaneous systolic transfer function of an isolated canine left ventricle (LV) before and after the ligation of the left anterior descending coronary artery (LAD). The instantaneous transfer function before the ligation of the LAD showed a resonance curve whose peak frequency was 30 to 70Hz. On the other hand, the transfer function 40min after the ligation of the LAD showed a divided peak in the resonance curve. (2) We constructed a finite element model of a thick-walled spherical shell with a non-uniform structure. In this model, the myocardial elasticity and viscosity of the ischemic region are different from those of non- ischemic regions. One can calculate the theoretical transfer function using modal analysis and also estimate the elasticity and the viscous coefficient of both non- ischemic and ischemic myocardium by fitting the theoretical transfer function to the experimental one. (3) The estimated elasticity of the ischemic myocardium was three to five times larger than that of the non-ischemic myocardium. The estimated viscous coefficient of the ischemic myocardium was about half that of the non-ischemic myocardium. These results showed that ischemia alters the viscoelastic properties of the myocardium during systole as well as during diastole. -left ventricle; viscoelastic properties; transfer function; finite element methodView full abstractDownload PDF (1016K) -
TAKASHI SAWAI, MIWA UZUKI, NORIKO SATOH1995 Volume 177 Issue 2 Pages 139-151
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSSAWAI, T., UZUKI, M. and SATOH, N. Kidney Disease in Systemic Lupus Erythematosus (SLE) of Children-Morphometric Analysis of Kidneys from Autopsy Cases-. Tohoku J. Exp. Med., 1995, 177(2), 139-151-We have investigated the histopathological changes of kidney from 16 autopsy cases of children with systemic lupus erythematosus (SLE) using morphometric and immunohistochemical methods. These 16 cases accounted for 61% of the child autopsy cases with SLE registered in the data base “Annual of the Pathological Autopsy Cases in Japan” during the nine years from 1984 to 1992. Based on the histologic and morphometric findings, we divided the SLE-associated renal disease into three types: glomerular (3 cases), vascular (3 cases) and non-renal (10 cases) types. The glomerular and vascular types had renal lesions, while in the non-renal the main changes were found in extrarenal tissues. Of the 16 cases examined, three showed diffuse proliferative glomerulonephritis, with one of the three having crescentic formations in the glomeruli. Two of the three had wire-loop lesions. Recently the crescentic or wire-loop lesions are rarely experienced even in renal biopsy and autopsy of adult cases. The vascular type was characterized by necrotizing angiitis (1 case) and severe intimal thickening of interlobular arteries (2 cases), but they had no advanced glomerular lesion. Morphometric methods allowed us to demonstrate that the severity of arterial lesions, especially intimal thickening, does not correlate with that of glomerular lesions in children.- systemic lupus erythematosus (SLE); children; kidney; histopathology; morphometryView full abstractDownload PDF (2294K) -
TOMOHARU AKIBA, MITSURU NAKASATO, SATOSHI SATO, ATSUKO KIKAI1995 Volume 177 Issue 2 Pages 153-160
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSAKIBA, T., NAKASATO, M., SATO, S. and KIKAI, A. Angiographic Determination of Left and Right Ventricular Volumes and Left Ventricular Mass in Normal Infants and Children. Tohoku J. Exp. Med., 1995, 177 (2), 153-160-Left and right ventricular (LV and RV) volumes and LV mass were assessed by angiography in 63 infants and children without major cardiovascular abnormalities. LV and RV end-diastolic volumes (EDV) were excellently expressed as a function of body surface area (BSA) with an exponential equation: LVEDV=83.7 (BSA)1.29ml (r=0.96, p<0.001), RVEDV=87.9 (BSA)1.29ml (r=0.94, p<0.001). LV ejection fraction (E F) averaged 64±6 ( mean±standard deviation) %, and RVEF 56±5%, each of which was independent of BSA. LV mass was well expressed as a function of BSA with an exponential equation: LV mass=75.4 (BSA)1.22g (r=0.86, p< 0.001). LV mass/LVEDV was constant, and averaged 0.96±0.22g/ml. Thus, the values of LVEDV, RVEDV, and LV mass in infants and children with various heart diseases may be estimated with reasonable accuracy as a percentage of normal values predicted from their BSA by using the above-proposed exponential equations. The normal values of LVEF, RVEF and LV mass/LVEDV themselves can be compared with these parameters in pediatric patients with heart diseases because of their independence of BSA.-ventricular volumes; ejection fraction; left ventricular mass; angiography; normal infants and childrenView full abstractDownload PDF (648K) -
MITSURO CHIBA, MASAHIRO IIZUKA, YASUO HORIE, NOBUAKI ISHII, TOSHIO SUZ ...1995 Volume 177 Issue 2 Pages 161-170
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSCHIBA, M., IIZUKA, M., HORIE, Y., ISHII, N., SUZUKI, T. and MASAMUNE, O. Further Studies of HLA-DR Antigens on Colonic Epithelium in Ulcerative Colitis. Tohoku J. Exp. Med., 1995, 177 (2), 161-170-The aim of this study was to determine whether HLA-DR antigens are expressed on colonic epithelium in macroscopically involved areas in all cases of ulcerative colitis and whether the expression precedes inflammation (colitis). Thirty-four cases of active ulcerative colitis were studied including two cases in which island-like lesions were observed proximally apart from the main lesion, and three cases in which distal colitis became entire colitis in 8 months or less. Detection of HLA-DR antigens on colonic epithelium was performed with the immunoperoxidase method using anti-HLA-DR monoclonal antibodies. HLA-DR antigens were expressed on colonic epithelium in macroscopically involved areas in all 34 cases. In the macroscopically normal areas, the antigens were modestly expressed in six of 16 specimens (cases) in the presence of microscopic inflammation. The antigens were expressed on colonic epithelium in island-like lesions, but not in the intervening mucosa between the proximal island-like lesions and the distal main lesion. HLA-DR antigens were not expressed on colonic epithelium in the proximal non-inflamed mucosa where colitis later developed. These results lead to the conclusion that HLA-DR antigen expression does not precede, but is associated with the inflammation.-HLA-DR antigens; ulcerative colitis; immunology; class II antigens; colonic epitheliumView full abstractDownload PDF (11880K) -
HIROKAZU ARAI, KENJI HARADA, MASAMICHI TAMURA, TOSHIHIRO OKAMURA, GORO ...1995 Volume 177 Issue 2 Pages 171-177
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSARAI, H., HARADA, K., TAMURA, M., OKAMURA, T. and TAKADA, G. Polysplenia Syndrome with Common Atrioventricular Canal and Persistent Truncus Arteriosus. Tohoku J. Exp. Med., 1995, 177 (2), 171-177 - A case of an infant with a rare combination of polysplenia syndrome with common atrioventricular canal and persistent truncus arteriosus is presented. In our present case, severe common atrioventricular valve regurgitation was identified, as in previous cases. To our knowledge, echocardiographic and autopsy findings of this association has not been previously reported. The persistent truncus arteriosus is extremely rare in the setting of the polysplenia syndrome, but the present case report demonstrates that these anomalies may, at times, occur. - polysplenia; persistenttruncus arteriosus; common atrioventricular canalView full abstractDownload PDF (1439K) -
HIDEMI YAMAUCHI, YASUNORI KIKUCHI, KENJI KAKIZAKI1995 Volume 177 Issue 2 Pages 179-181
Published: 1995
Released on J-STAGE: August 31, 2006
JOURNAL FREE ACCESSYAMAUCHI, H., KIKUCHI, Y, and KAKIZAKI, K. Relation between the Stromal Volume and Liver Metastasis in Ductal Cell Carcinoma of the Pancreas. Tohoku J. Exp. Med., 1995, 177 (2), 179-181 - In 23 patients with ductal cell carcinoma of the pancreas, the volume density of the stromal area was estimated by morphometry on photomicrographs of cancer tissue taken at surgery. The patients were divided into three groups: those with metachronous liver metastasis (Group A, n=8), with simultaneous liver metastasis (Group B, n=4) and those without liver metastasis (Group C, n=11). The analysis illustrated a significantly lower fraction of stromal element in Groups A and B as compared to Group C at a statistical level of 0.01 (Ryan test). The scirrhous pancreatic carcinoma tended to resist liver metastasis after various therapeutic modalities including pancreatic resection. - ductal cell carcinoma of the pancreas; liver metastasis; fiber elementView full abstractDownload PDF (3319K)
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