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Volume 59 (1953 - 195･･･
- Issue 4 Pages 333-
- Issue 3 Pages 193-
- Issue 1-2 Pages 1-
Volume 59, Issue 3
Displaying 1-13 of 13 articles from this issue
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III. On the Organ-Specificity of Pentosenucleic AcidsHajime Masamune, Shigeru Tsuiki, Kohsiroh Tokutomi, Genji Kikuchi1954 Volume 59 Issue 3 Pages 193-206
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. Electrophoretically homogeneous pentosenucleic acids of pig liver and of pig kidney (cortex) -were prepared.
2. Those pentosenucleic acids did not give the positive precipitin reaction with the anti-pig gastric mucosa-rabbit serum, and on the other hand, the pig stomach (mucosa) pentosenucleic acid did not react with the anti-pig liver and anti-pig kidney-rabbit serum.
3. The pentosenucleic acid of the liver and kidney reacted with the anti-kidney and anti-liver serum, as such as well as after absorption with pig serum, each to each and moreover after absorption with liver and kidney in vitro antigen respectively, the antisera still contained a precipitin of the nucleic acid of the tissue with which immunization had been effected.
4. From these findings combined with those in the foregoing report, it might be pronounced that the pentosenucleic acids of kidney (cortex) and of liver possess a partially common and partially organ-specific antigenic structure contrary to the strictly organ-specific pentosenucleic acid of stomach (mucosa). The presumption is that the preparations of the kidney and liver nucleic acid were really uniform substances.View full abstractDownload PDF (1982K) -
Mamoru Suzuki, Hanji Sato, Nobuo Ogasawara1954 Volume 59 Issue 3 Pages 207-212
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. Motor nerve cells in the sacral cord: These are found in cornu ventrale. In the upper sacral cord, they may be divided into the lateral and medial groups, as in the lumbar cord, but the latter is poorly developed and disappears altogether in the lower sacral cord. The lateral group can be divided into the three subgroups of ventral, medial and dorsal, but the first is limited to the upper sacral cord in existence, being replaced by Onufrowitz's nucleus in the lower. This nucleus is not motor, but sympathetic in nature, histologically. The medial subgroup disappears in the lower sacral cord. On the contrary, the dorsal subgroup is well developed and reaches far down into the lowermost.
2. Sensory nerve cells in the sacral cord: In zona spongiosa, much as in the lumbar cord, elongated sensory nerve cells are seen arranged in 1 or 2 rows. There are some sensory cells scattered in substantia gelatinosa, but the distinction between the dorsal and ventral groups is blurred in the lower sacral cord. No Clarke's nucleus was found existing. The sensory nerve cells in cornu dorsale are in sporadic existence as in the lumbar cord, but spherical cells were not found in the sacral cord. In formatio reticularis, a few vegetative cells and some rounded sensory cells were observed, the latter corresponding to Kuru's sensoryvegetative nerve cells.
3. Vegetative nerve cells in the sacral cord: In the medial side of pars intermedia are found some parasympathetic nerve cells, though the division into the three groups, as in the lumbar cord, is here impracticable. Group of sympathetic and parasympathetic nerve cells, corresponding to the Bok's so-called nucleus cornu commissuralis anterioris, and better developed group of parasympathetic nerve cells corresponding to his nucleus cornu commissuralis posterioris were also observed. Suzuki's nucleus dorsalis canalis centralis was not found in the sacral cord.
The remarkably well-developed substantia gelatinosa and cornu dorsale in the sacral cord contain a large number of parasympathetic nerve cells. In the motor nerve cell groups in cornu ventrale also are found some sympathetic and parasympathetic nerve cells, though' in a number smaller than in the lumbar cord. We found a parasympathetic cell group in the place of Jacobsohn's nucleus sympathicus lateralis inferior, and a well developed cell group in the place of Jacobasohn's nucleus sympathicus mediosacralis, the latter being composed of a majority of parasympathetic and a minority of sympathetic cells. The grey matter in the lower sacral cord contains only vegetative, in particular parasympa-sympathetic cells, which composition continues down into, the coccygeal cord.View full abstractDownload PDF (2455K) -
among Residents of Miyagi Prefecture, Japan, 1951Mitsuo Segi, Ichiro Fukushima, Yoshihiko Mikami, Susumu Fujisaku, Mino ...1954 Volume 59 Issue 3 Pages 213-224
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. We distributed survey schedules to all the hospitals and medical offices in Miyagi Prefecture, Japan which has about 1, 663, 000 population and collected reports on all the cancer patients seen or treated during 1951. At the same time, we studied at the cases that cancer is recorded as cause of death out of the copies of the death notifications kept in all the Health Centers in the prefecture. The results obtained by the above mentioned two kinds of survey were enumerated.
2. The case number reported from hospitals and medical offices was 2, 804 in total. However, since one patient is likely reported from two or more of hospitals and/or medical offices, the exact number was 1, 964. Among the patients, the number of residents of Miyagi Prefecture is 1, 515. As there are no any other hospitals equal to or larger than the Tohoku University Hospital in scale in adjacent prefectures, many persons visit this hospital from adjacent prefectures. It is presumed that few residents of Miyagi Prefecture ask to have examination and treatment 'to hospitals in other prefectures.
The number of such cases that “cancer” was recorded in any column of cause of death in the death certificates was 1, 254 (male 652, female 602). Among these cases, 507 were reported from hospitals and medical offices. In 1951, out of residents of Miyagi Prefecture, the exact number of known cancer cases was 2, 262 (male 1, 061, female 1, 201). Among them, 1, 350 presented first subjective symptom in the study year.
3. An incidence rate of cancer patients who felt their first subjective symptom in 1951 was 81 (male 83, female 79) per 100, 000 population. A prevalence rate of all the cancer cases, cancer deaths and cancer cured cases that physicians dealt with for some reasons in the study year was 136 (male 128, female 144) per 100, 000 population. A mortality rate of the cases that cancer were recorded in any column of cause of death in the death certificates was 75 (male 79, female 72) per 100, 000 population.
4. Viewing incidence cases by site, in male stomach (55% of total male incidence cases), liver and biliary passages (14%), and esophagus (7%) show large number in frequency. Leukemias and aleukemias, rectum, lymphomas, intestine, and lung succeed the former, but they have a small proportion. In female, stomach (32% of total female incidence cases), uterus (21%), liver and biliary passages (11%), and breast (7%), esophagus, rectum, and sarcomas succeed the former. Skirt and prostate cancer occurs markedly in small frequency.
5. The 12-month survival rate of newly diagnosed patients in 1951 is male, 43 per cent and female, 61 per cent. In stomach cancer male, 41 per cent and female, 43 per cent after twelve months and male, 53 per cent and female, 57 per cent after six months. Comparing a survival rate of a group of patients whose stomach and uterus cancer was operated to that of non-operated group of patients, it was recognized that a survival rate of the former is higher than that of the latter.
This work was carried out by a Grant from the Foundation for Scientific Research of the Ministry of Education. M. SegiView full abstractDownload PDF (600K) -
XV. On Group Lipoid from Human Liver Third ReportHajime Masamune, Tugio Maehara, Sen-itiroh Hakomori1954 Volume 59 Issue 3 Pages 225-229
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (672K) -
XVI. On Group Lipoid from Human Liver Fourth ReportHajime Masamune, Sen-itiroh Hakomori, Tugio Maehara, Yuh-iti Suzuki1954 Volume 59 Issue 3 Pages 231-246
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe group lipoid separated from Group A human livers in a practically pure state was saponified with 0.2N NaOH into four fractions. One of the fractions was eicosanol-l and a second a mixture. of several amino acids and α-glycero- and inositol-phosphoric acid, a third proved to contain palmitic acid, and a fourth was a “Partial Group Lipoid” that proved homogeneous after electrophoresis. Furthermore it was shown that the Partial Group Lipoid was made up of α-glycerophosphoric acid, ethanolamine, glutamic acid, serine, glycine, galactose, mannose, chondrosamine in molecular proportions of 2:1-2:2:1:1:3:2:2 and carboxylic acids.
Through the Grant Committee for Scientific Researches was given a grant from the Education Department in aid to us, which is gratefully acknowledged. H. Masamune.View full abstractDownload PDF (1240K) -
XVII. Composition of the Group Lipoid of Pig LungHidetake Hirata1954 Volume 59 Issue 3 Pages 247-256
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. The Group B lipoid of hog lung was subjected to alkaline cleavage and then fractioned.
2. The precipitate occurring on hydrolysis proved to mainly consist of tetracosanol-1.
3. The supernatant fluid was acidified and exhausted with ether. Into ether passed an acetone-insoluble group-active fragment and acetonesoluble organic acids palmitic acid and probable unsaturated acids.
4. The scission products that remained thereby in water were found to be aspartic and glutamic acid, glycine, alanine, arginine and inositoland α-glycero-phosphoric acid.
5. Its large part precipitated when the group-active, essentially electrophoretically-homogeneous fragment (Partial Group Lipoid) was hydrolyzed with acid, and the supernatant here proved to contain aspartic and glutamic acid, serine, hexosamine (glucosamine and chondrosamine), ethanolamine, galactose and glycerophosphoric acid in molecular proportions of 1:2:2:2:1:4:5.View full abstractDownload PDF (1070K) -
I. Mitteilung Einfluss der Jahreszeiten auf den KongorotindexShoichi Yamagata, Kihachi Unoura, Toshio Aratani, Kiyomi Miura1954 Volume 59 Issue 3 Pages 257-263
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAus den Ergebnissen der obenerwähnten Untersuchungen von 431 Kaninchen ist das Folgende abzuleiten:
1) Der Kongorotindex bei normalen Kaninchen liegt meistens zwischen 40 and 60.
2) Der Kongorotindex zeigt kaum bedeutende Beziehung auf Geschlecht and Körpergewicht des Kaninchens.
3) Der Kongorotindex neigt im Sommer aufzusteigen, doch im Winter herabzufallen.
4) Bei Kongorotbelastungsproben vermehrt sich der Kongorotindex viel deutlicher im Sommer and Winter, dagegen im Frühling and Herbst viel geringer. In dergleichen Proben neigt die Prothrombinzahl im Sommer sich zu vermindern and im Herbst zu vermehren, obwohl ihre Schwankungen viel geringer sind.View full abstractDownload PDF (286K) -
II. Mitteilung Beziehung der Funktion der Kupfferschen Sternzellen zur Leberfunktion, mit besonderer Berücksichtigung des Einflusses der ZuckerbehandlungShoichi Yamagata, Ichiro Arai, Kihachi Unoura, Toshio Aratani, Kiyomi ...1954 Volume 59 Issue 3 Pages 265-273
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSFassen wir obige Versuchsergebnisse zusammen, so können wir wie folgend schliessen:
1) Bei der Blockade des RES durch Tusche and kolloidales Silber steigert sich der Kongorotindex and wird es bei der . Reizung des RES durch Communin (Shwartzman'sches Filtrat) and Natriumthiosulfat herabgesetzt, während die Prothrombinzahl fast unbeeinflusst bleibt.
2) Bei Leberschädigungen durch Chloroform, Phosphor, Ligatur des Choledochus and Lappenresektion der Leber werden eine Steigerung des Kongorotindex and eine Herabsetzung der Prothrombinzahl herbeigeführt.
3) Bei Stimulierung der Lebertätigkeit durch Glukose, Lävulose and Yakriton (das Entgiftungshormon der Leber) werden. eine Verminderung des Kongorotindex and eine Erhöhung der Prothrombinzahl verursacht, aber Thyroxin and Lecithin setzt den Kongorotindex and die Prothrombinzahl herab.
4) Redoxon (Vitamin C), Kativ (Vitamin K) and Hesperin (Vitamin P) sind imstande die Wirkung der Glukose and Lävulose auf die Funktion des RES zu verstärken.
5) Deshalb ist zu vermuten, dass der Kongorotindex einen Anzeiger der Funktion des RES and die Prothrombinzahl einen Funktionszustand der Leberzellen darsteilt.View full abstractDownload PDF (446K) -
III. Mitteilung Einfluss des vegetativen Nervensystems auf die Fuaktion des RES and der LeberShoichi Yamagata, Ichiro Arai, Kihachi Unoura, Toshio Aratani, Kiyomi ...1954 Volume 59 Issue 3 Pages 275-282
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAus obenerwähnten Ergebnissen können wir folgenderweise schliessen:
1) Von den peripheren vegetativen Nervengiften verursachen Adrenalin sowie Atropin eine Vermehrung des Kongorotindex bei Darreichung davon, dagegen Pilocarpin, Acetylcholin sowie Neogynergen eine Verminderung desjenigen. Im Gegensatz dazu steigt die Prothrombinzahl durch Adrenalin auf, aber fällt durch Pilocarpin herab, während diejenige fast unverändert bleiben bei anderen Nervengiften.
2) La Bezug auf Blockierungsmittel der vegetativen Nerven ruft Imidalin (Benzylimidazolin) eine Herabsetzung des Kongorotindex mit Steigerung der Prothrombinzahl hervor, dagegen Banthine (Methanthelin) eine Vermehrung des ersteren mit Verminderung des letzteren, wahrend bei Tonoplon (Tetraäthylammonium) der Kongorotindex Bowie Prothrombinzahl sich vermindert.
3) Betreffs der Zentralnervengifte finden wir eine Verminderung des Kongorotindex durch Philopon (Pervitin) sowie Vagostigmin (Porstigmin), dagegen eine Vermehrung desjenigen durch Chloralgydrat, Magnesiumsulfat, Pikrotoxin sowie Luminal. Aber die Prothrombinzahl vermehrt sich durch Philopon (Pervitin), vermindert sich dagegen durch Chloralhydrat sowie Luminal, während diejenigen durch andere Gifte unverändert bleiben. Ausserdem wird die Wirkung des Philopons (Pervitins ) durch Luminal nicht ganz völling gehemmt.
4) Durch Punktion des Sympathicuszentrums nach Kurotsu'scher Methode wird eine Steigerung des Kongorotindex und der Prothrombinzahl hervorgerufen, dagegen eine Herabsetzung der beiden durch diejenige des parasympathischen Zentrums.
5) Daraus folgt, dass Sympathicus auf die Funktion der Leberzellen fördernd und auf diejenige des RES einschliesslich der Sternzellen hemmend, aber Parasympathicus auf die erstere hemmend und auf die letztere fördernd einwirkt.View full abstractDownload PDF (396K) -
Part 2. Cytological Differences between Carcinoma and SarcomaIchita Amaki1954 Volume 59 Issue 3 Pages 283-294
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (2798K) -
Report IV. Further Studies on the Neurohumoral Regulation of the Adrenal CortexShigeo Okinaka, Kiku Nakao, Mitsuo Nishikawa, Hiroshi Ibayashi, Chosei ...1954 Volume 59 Issue 3 Pages 295-306
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSDownload PDF (2972K) -
Second ReportKunio Yamakawa, Yasuo Shionoya, Toichi Nagai, Kazuo Kitamura, Satoshi ...1954 Volume 59 Issue 3 Pages 307-313
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. Intracardiac heart sounds of dogs and men were recorded on a tape-recorder and these recordings were heard by many cardiologists at the Annual Meeting of the Society of Angiocardiology of Japan in 1953.
2. The data obtained to date by the present authors indicate that there exists a certain amount of blood whirlpool inside the heart cavities and arteries. Although this whirlpool is mostly in audible range, the damping effect of heart and arterial walls makes it impossible to hear these sounds upon chest wall in normal healthy case.
3. When the catheter tip is placed in blood stream, chiefly course sounds due to blood whirlpool is recorded, and when the tip is contacted with the inner wall of the heart, chiefly vibrations of a solid structure is recorded. This latter is thought to be one similar to heart sounds obtained from chest wall.
The authors take this opportunity to express their gratitude to Prof. Tasaka for the reviewing of this manuscript.View full abstractDownload PDF (3813K) -
The First Case ever Reported of Qualitative Abnormity of PeroxidaseOtotaka Higashi1954 Volume 59 Issue 3 Pages 315-332
Published: February 25, 1954
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. In this paper the first case ever reported of qualitative abnormity of peroxidase of blood leucocytes was outlined and the name of “Congenital Gigantism of Peroxidase Granules” was suggested for this abnormity.
2. The Congenital Gigantism of Peroxidase Granules represents a monstrous malformation of the peroxidase granules-obvious aggregation of fine peroxidase blue granules producing gigantic clumpy effects in each cell-of all the myeloic leucocytes in the blood or/and bone marrow (Fig. 3, Fig. 4 and Fig. 5).
3. The Giemsa stained picture of the blood or/and marrow smears of this case was also in no way normal, while the morphological change was not always corresponding to the abnormal peroxidase granules (Cf. Fig. 6 and Fig. 7).
4. The oxidase granules of blood and marrow cells of this case showed a monstrous malformation similar to those of peroxidase granules. So the name of “Congenital Gigantism of Oxidase Granules” may be used instead.
5. The supravital method revealed a peculiar behavior of neutral red vacuoles in neutrophils, monocytes, lymphocytes and red blood corpusices (Cf. Fig. 8).
6. This patient had photophobia, xerodermia pigmentosum, albinismus fundi oculi utrisque and albinism of hair. He died at 11 months of age developing, besides bronchopneumonia, hepatosplenomegaly, jaundice, melena and pancytopenia.
7. The family pedigree of this patient is characteristic. The parents were of consanguinous marriage. Three sibs had the same congenital stigmata i.e. photophobia, pale color of hair, pigmentation of uncovered parts of the skin and died very early in life during some infection in the clinical conditions very similar to the present case. It is not difficult to suppose that these sibs had “Congenital Gigantism of Peroxidase Granules.”
8. The Congenital Gigantism of Peroxidase Granules might have a close connection with a short span of life of the patient.View full abstractDownload PDF (5013K)
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