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Volume 67 (1957 - 195･･･
- Issue 4 Pages 309-
- Issue 2-3 Pages 105-
- Issue 1 Pages 1-
Volume 67, Issue 2-3
Displaying 1-27 of 27 articles from this issue
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III. Liver Biopsy and Liver Function Tests in AlcoholicsTakashi Nakamura, Shozo Nakamura, Kanae Sugawara, Yoshiaki Katakura, T ...1958 Volume 67 Issue 2-3 Pages 105-113
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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Tsuneo Arakawa, Mizuo Oota, Yuji Sato1958 Volume 67 Issue 2-3 Pages 114
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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V. Anemia-inducing Substances in the Tissue of Gastric CarcinomaKiyota Oh-Uti, Kohei Suzuki, Iwao Yamaguchi1958 Volume 67 Issue 2-3 Pages 115-121
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSVarious fractions of the tissue of gastric carcinoma and of normal gastric mucosa (as controls) were tested for anemia-inducing activity in rabbits.
1. A crude extract of gastric carcinoma showed a higher anemiainducing activity than that of normal gastric mucosa.
2. Either of the dialyzable and the non-dialyzable fraction of gastric carcinoma contained an anemia-inducing factor. The factor in the former fraction seems to be a substance of small molecular weight, which is negative to the biuret and Molisch tests, whereas the factor in the latter seems to be a carbohydrate.View full abstractDownload PDF (369K) -
Tsuneo Arakawa, Mizuo Oota, Yuji Sato1958 Volume 67 Issue 2-3 Pages 122
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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Kiyota Oh-Uti, Jun-ichi Awataguchi1958 Volume 67 Issue 2-3 Pages 123-130
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe free amino acids in the gastric juice of patients with gastric and/or duodenal ulcer and gastric carcinoma were collected by means of ion exchange resin and examined by a paper-chromatographic method.
1. In the gastric juice of healthy stomachs occurred 11 free amino acids. The degree of occurrence, however, was of the order of moderate positiveness (+).
2. The gastric juice in cases of gastric and/or duodenal ulcer showed a slight tendency to increase in the number of occurring amino acids, but the degree of strong positiveness (++) occurred in only 1 case. The rate of occurrence after gastrectomy was nearly the same as before operation, but strong positiveness disappeared after gastrectomy.
3. In the gastric juice of gastric carcinoma cases, proline, threonine, and a peptide newly appeared in addition to the amino acids seen in ulcer cases; the degree of occurrence of leucine, valine, alanine, serine and glycine, and glutamic acid was remarkably high. The free amino acids in the remaining stomach after gastrectomy showed, in comparison with those before operation, a pronounced depression in the degree of occurrence; and their state of occurrence became similar to that seen in ulcer cases before operation.View full abstractDownload PDF (380K) -
Kiyota Oh-Uti, Katsutaro Kobayashi, Kunihiro Maki, Osamu Ogata, Iwao Y ...1958 Volume 67 Issue 2-3 Pages 131-139
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. The presence of specific antigens in the gastric juice of patients with gastric cancer has been demonstrated.
2. The gastric juice of the cancer patients has some specific antigens common with the gastric cancer tissue.
3. The specific antigens found in the gastric juice of the cancer patients were destroyed by heating, freezing, and treating with a weak acid, a strong alkali, and formalin.
4. Of various fractions obtained by the use of ammonium sulfate, the following three fractions were found to contain specific antigens: the precipitate obtained on half saturation, the supernatant obtained on full saturation, and the precipitate obtained on full saturation with ammonium sulfate.
5. Of various fractions obtained by the use of dioxane, only the precipitate produced by 46% dioxane showed specific antigenicity.
6. Each of the mucoprotein and the mucoproteose obtained from the gastric juice of the cancer patients showed specific antigenicity.View full abstractDownload PDF (473K) -
Hajime Masamune, Hiroya Kawasaki, Sin-iti Abe1958 Volume 67 Issue 2-3 Pages 140
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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CCVIII. Oligosaccharides Separated after Acetolysis of the Group Mucopolysaccharide from Pig Gastric Mucus Third Report: “Gastro-N-disaccharide”Hyogo Sinohara1958 Volume 67 Issue 2-3 Pages 141-147
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. A disaccharide “gastro-N-disaccharide” was isolated as a deacetylated acetolysis product of the group mucopolysaccharide from pig stomach mucus.
2. Its physical and chemical properties were examined.
3. It has been established to have the structure of galactose-4-α-N-acetylgalactosaminide by analysis, oxidation experiments with hypoiodite and periodate, Osaki-Turumi (Morgan-Elson) test and examination of its infrared spectral absorption.View full abstractDownload PDF (413K) -
Ikuro Tanaka, Hirobumi Akimoto, Hideaki Matsumoto1958 Volume 67 Issue 2-3 Pages 148
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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Koiti Motokawa, Mitsuo Komatsu1958 Volume 67 Issue 2-3 Pages 149-158
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSA process called “spreading induction” is started at the margin of a retinal image and propagated into the surrounding retinal areas. Thus a field of retinal induction is established around a retinal image.
1. The velocity of propagation was determined by measuring the latencies of the propagating process at various distances from the margin of a retinal image, and it was shown that the velocity depends greatly on the adaptation state of the retina, but only little on the intensity and hue of the light stimulus.
2. The value of velocity was 1.7mm. per sec. in the dark-adapted retina and 42mm. per sec. in the retina adapted to an illumination stronger than 1 lux.
3. When spreading induction comes across a white retinal image, it can totally be reflected at the margin of the retinal image. The critical angle of incidence for total reflection was determined, and on the basis of the law of refraction the velocity of spreading induction in the light-adapted part, the retinal image, was computed from the critical angle determined experimentally and the known velocity in the dark-adapted retina.
The so computed values were found to agree satisfactorily with those determined by the direct method.View full abstractDownload PDF (538K) -
Kiyota Oh-Uti, Kunihiro Maki, Junzo Ito, Yasumasa Aneha, Toshio Koyama1958 Volume 67 Issue 2-3 Pages 159-161
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe liver catalase activity of patients with malignant tumors was distinctly lower than that of patients with gastric or duodenal ulcer.View full abstractDownload PDF (109K) -
Sadao Yaegashi1958 Volume 67 Issue 2-3 Pages 163-172
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSTaking, as an index of excitation of the eyes, flickering sensation (electrical phosphenes) elicited by the sinusoidal alternating currents at 20 cps. passing through the head, the author studied precisely the relation of electric threshold of the eye to radiance of the adapting light of different wavelengths.
1. The electric threshold strength-log-radiance curve has a reversed S-shape. The course of the curve can be divided into three sections, each corresponding to three physiologically significant states of vision, that is, scotopia, mesopia and photopia.
2. The electrical excitability-wavelength curve for equal energy spectrum resembles greatly the scotopic luminosity curve in form.
As to the position of the crest on this curve, no shift takes place toward longer wavelength such as Purkinje shift even when the radiance of the adapting light is raised sufficiently.
3. Decrease in electric threshold of the eye for 20 cps. due to illumination with monochromatic rays is always accompanied with increase in saturation of the color, except for red. Both kinds of variations take place only within a relatively narrow mesopic range of illumination, where both rods and cones are in action concurrently.
4. These results support Mita et al's view that the structures stimulated by the currents at 20 cps. may be bipolar cells.View full abstractDownload PDF (570K) -
I. On the Isolation and Some Properties of CellostatinSusumu Hamada1958 Volume 67 Issue 2-3 Pages 173-179
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSStreptomyces Sp. No. 150 produced two antibiotics in the culture broth, which were separated from one another with a cation exchange resin. The first substance was isolated as sulfate in a crystalline form, and characterized as a basic, water-soluble, antifungal substance with anti- _??_ tumor activity. The antibiotic seems to differ from any other formerly reported antifungal substances.7) It was recognized as a new antibiotic and named “Cellostatin”. The second substance is active to S. lutea, soluble in organic solvent, and inactive for the growth of tumors.View full abstractDownload PDF (297K) -
II. On Antitumor Effects of CellostatinSusumu Hamada, Shoji Sato1958 Volume 67 Issue 2-3 Pages 181-186
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSAn antitumor agent was produced by a strain of streptomyces, and its extraction was plotted with the antifungal activity as an indicator, Its destructive effect against ascites type of Ehrlich mouse carcinoma cells is correlated with its antifungal activity. But it needs scarcely to be said that the antifungal substance does not always inhibit the growth of tumors.4) In the previous paper5) the authors screened 273 strains of streptomyces for their production of antitumor substances prolonging the life of mice in-oculated with Ehrlich carcinoma. Out of these 11 strains which produced constantly such a antitumor agent, contained 5 strains which exhibited no antimicrobial activity. Nevertheless, it may be still worthy and convenient to utilize its antimicrobial properties if the both biological activities are correlated with one another. In the intraperitoneal administration of the antibiotic, it was proved that the ealier the treatment was given, the more effective the drug was. So Cellostatin suppressed the increase of ascites, and prolonged the survival periods with little or no inhibition of the solid tumor growth in the early treatment. In the cytological observation, it was seen that the destruction of the ascites tumor cells and the prolongation of survival periods of the treated mice were remarkable. These facts should be due to its direct destructive activity upon the cancer cells.View full abstractDownload PDF (277K) -
Toshikatsu Onodera1958 Volume 67 Issue 2-3 Pages 187-193
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. The specific gravity of the spinal fluid remained always below 1.008 in normal subjects, but in the 7 groups of patients of neural diseases, i.e. of hypertensives, of neurotics, of syphilitic diseases, of cerebrospinal tumors, of meningitis, of encephalitis japonica and of other miscellaneous neural diseases, the individual values were higher than 1.008 except in a very few cases and the average values by groups also ranged between the supernormal levels of 1.0082 and 1.0085.
2. Of the contents of electrolytes in spinal fluid, Na was always higher in the diseased groups than in normal subjects, the deviation running up from 5.8 mEq/L to the height of 10.4 mEq/L. K showed little change by disease groups, the deviation remaining within 0.2 mEq/L at the highest. In comparison with the normal subject, the diseased cases showed Cl values higher by 0.8-4.0 mEq/L, except the encephalitis japonica cases, who showed values below normal by 4.2 mEq/L.
3. From such anomalies in the specific gravity and the contents of electrolytes and total protein in the cases of neural diseases, we can infer that the increase and decrease in these values run parallel to each other.
4. Following alterative therapies, the specific gravity and the contents of electrolytes, especially, of Na and Cl, of the spinal fluid were found risen above the pretreatment levels.View full abstractDownload PDF (327K) -
CCIX. Analysis of Mutarotation of N-Glycosides Third Paper Acetylation of Aniline-N-α and -β-lactosideHajime Masamune, Shigeru Tsuiki1958 Volume 67 Issue 2-3 Pages 195-198
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe two anomers of aniline-N-lactoside give the same acetyl product with has been established to be heptaacetyl-aniline-N-β-lactoside.View full abstractDownload PDF (144K) -
CCX. A Systematic Fractionation of Pig Gastric Mucosa with Respect to Molish-positive Hexosamine-containing ComponentsHajime Masamune, Shigeru Tsuiki1958 Volume 67 Issue 2-3 Pages 199-208
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESS1. Pig stomach mucosa was systematically fractioned in a mildest way to isolate all the hexosamine-containing, Molisch-positive components.
2. One glucidamin and three mucopolysaccharides of which two are group-active were obtained.
3. The glucidamin is supposed to be Castle's intrinsic factor.View full abstractDownload PDF (1066K) -
Hironobu Hamada1958 Volume 67 Issue 2-3 Pages 209-217
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSRetinal induction of the light-adapted human retina was investigated.
1. When red, green and blue lights are used for preillumination in the light-adapted state of the retina, the peak of the curve of electrical excitability lies at 1, 2 and 3 seconds respectively just as in the dark-adapted retina.
As the intensity of the adapting light increases from 0.004 lux to 30 lux, the magnitude of the curve decreases steadily.
2. The curves of retinal induction are not qualitatively different from those obtained from the dark-adapted eye.
The retinal induction decays with time in about 5-6 seconds in the retina adapted to a weak general illumination.
This is in contrast with the fact that the retinal induction of the dark-adapted retina remains unchanged for about 20 seconds.
3. The magnitude of retinal induction or contrast effect is smaller
as the adaptation level of the retina is higher.
4. In the retina light-adapted to a general illumination of 0.004 lux, the white light of 32 lux interposed between the inducing light and the white test light does not affect the direct induction.View full abstractDownload PDF (415K) -
Hiroshi Yamamoto1958 Volume 67 Issue 2-3 Pages 219-226
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSRetinal induction was studied in the light-adapted human retina by the method of electrostimulation.
1. The properties of retinal induction are qualitatively the same as in the dark-adapted retina except that its dissipation is more rapid.
2. There is an optimal intensity of adapting light for production of retinal induction.
3. Color induction occurs when the intensity of inducing colored light is above the color-threshold.
4. Below the color-threshold a colored patch may appear dark against the background. Then a curve of induction is found quite different from the curve of color induction.
A similar curve is obtained by a sequence of stimuli, black and white (brightness induction).
5. The critical intensity of inducing light changing from color induction to brightness induction is higher for blue and red lights and lower for
yellow and green lights.
6. In the transitory range of intensity from color induction to bright-ness induction a curve of certain type belonging to neither of those stated above is obtained.View full abstractDownload PDF (369K) -
Richard V. Ganslen, Leroy Sterling1958 Volume 67 Issue 2-3 Pages 227-234
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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Key Watanabe1958 Volume 67 Issue 2-3 Pages 235-243
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe color sensitivity to four spectral colors, red, green, yellow and blue around the spot of Mariotte was investigated under dark adaptation of the eye.
1. It was found that there is a color-blind zone around the blind spot, and that the zone is wider in the following order: Red>green>yellow>blue.
2. The zone is not strictly concentric with the blind spot, but wider towards the periphery than towards the fovea.
3. The extent of the zone increases by dark adaptation, especially in the vertical meridian and the upper and the lower parts of the zone rupture at a certain stage of dark adaptation.
This phenomenon is especially remarkable for red and green lights.
4. Reduction of the visual angle of the test patch has an effect similar to dark adaptation on the form and size of the color-blind zone.
5. The zones for red and green lights are more sensitive to changes of intensity of test light than those for yellow and blue liglts.
6. In short, the color sense around the blind spot depends on many factors such as the intensity, the wave-length, the size of the test stimulus, the state of dark adaptation, etc.View full abstractDownload PDF (1283K) -
Koiti Miura1958 Volume 67 Issue 2-3 Pages 245-252
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe electrical threshold of the eye was measured by the alternating current of 20 c. p. s. with flicker sensation caused by it as an index under various adaptation states.
1. The threshold-time curve during complete dark adaptation following light adaptation of 10 minutes to illumination of 9, 800 lux shows the following course: At first the threshold remained low for about 8 minutes, and then increased rapidly to attain a constant level in about 15 minutes. Thus, the curve showed an inflection at about 8 minutes.
2. The curve suffered from a modification when the retina was constantly exposed to a small point of light of 40' in visual angle following the same light adaptation as above.
The inflection at the middle stage became more obscure and the final level lower as local illumination was moved farther towards the periphery of the retina.
3. The effect of similar local illumination was investigated with colored lights.
When blue, green and red lights were used for local illumination, it was found that the red light showed an effect similar to white light confined to the fovea, but that the green and blue light acted as white light illuminating the periphery of the retina.
4. Next the effect of exposure to broad illumination was investigated upon the curve following the same light adaptation as above.
The curves by illumination of 0.1 lux, 1 lux and 10 lux were low and almost steady, but those by 100 and 1, 000 lux were generally much higher.
From these experiments it is likely that the threshold as determined by the A. C. of 20 c. p. s. is lowered when visual cells, especially rods are excited to some extent.View full abstractDownload PDF (364K) -
Report I The Hematopoiesis of the Bone Marrow in LeucocytosisAkira Saito, Tsuneji Ono1958 Volume 67 Issue 2-3 Pages 253-263
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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Report II The Hematopoiesis of the Bone Marrow in LeucopeniaAkira Saito, Kenji Shimoyama1958 Volume 67 Issue 2-3 Pages 265-280
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
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Hide Teshima1958 Volume 67 Issue 2-3 Pages 281-292
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSWith 50 normal humans, electromyographic study by means of surface electrodes was made on the activity of the abdominal wall muscles in various postures and during various movements.
1. In the supine position, whether with the legs drawn up or with the legs extended, no discharge due to muscular activity was recognized. Gentle pressure applied to the abdominal wall also did not evoke discharge.
2. During the movement of flection and extension of the trunk (such as head raising from the supine position and backward leaning in the standing position) there was seen a remarkable discharge mainly in the recti. In those cases in which the abdomen was strained (such move-ments as deliberate application of a strain to the abdomen in the supine position, deep breathing, voicing, and sitting with the legs extended), remarkable discharges were seen in the external and internal obliques.
3. The electromyographic patterns of activity for sitting straight in Japanese fashion, sitting cross-legged, sitting on a chair were essentially the same as that obtained in the supine position at rest. In the standing position at rest, on the other hand, there was seen a discharge 10-15 μV in amplitude in the internal obliques; in the position of sitting with the legs extended, slightly increased discharges in the internal and external obliques (10-20, 15-20 μV respectively) and in the lower part of the recti (5-15 μV), as compared with the discharges in the supine position at rest.
4. There was seen in the recti a tendency that discharge was apt to appear in the middle, lower, and upper parts in order of increasing readiness.View full abstractDownload PDF (615K) -
Tatuzi Suzuki, Ikuro Tanaka, Chikamasa Ninagawa, Teruo Nakamura, Shige ...1958 Volume 67 Issue 2-3 Pages 293-298
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe experiments were performed in unanesthetized dogs. The adrenal venous blood was sampled by the lumbar route method of Satake and others and was assayed for adrenaline by the rabbit intestinal segment method. The following results were obtained: The increase in the adrenaline secretion causable by insulin hypoglycemia was found to be wholly abolished by the total section of the spinal cord at the level of C7-C8. In dogs subjected to the hemisection of the spinal cord at the same level as above, the adrenaline secretion was increased by insulin hypoglycemia in the contralateral as well as in the ipsilateral adrenal gland.
It is concluded that the descending spinal pathway of the adrenalino-secretory fibers decussates partially below the lower cervical segments.View full abstractDownload PDF (321K) -
Mitsuo Komatsu1958 Volume 67 Issue 2-3 Pages 299-307
Published: February 25, 1958
Released on J-STAGE: November 28, 2008
JOURNAL FREE ACCESSThe effect of combined stimuli, black and white, upon the electrical excitability of the human retina was investigated under various conditions of light adaptation.
1. The electrical excitability of the resting retina increases in accordance with the degree of light adaptation when the intensity of adapting light is below 25 lux.
2. The effect of a circular bright stimulus to increase electrical excitability is enhanced when the patch is enclosed by a black ring (simultane-ous induction).
3. Dissipation of induction is facilitated by adapting light.
4. There is an optimum adaptation state for brightness induction. The optimum intensity is about one per cent of the intensity of the white light following a black stimulus.
5. A subnormal electrical excitability is seen for the first 7 sec. during presentation of a black patch in the light adapted eye. The electrical excitability returns then to the initial level spontaneously even when the black stimulus continues.View full abstractDownload PDF (470K)
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